Transcription factor landscape - Cell line - Neuroblastoma

17 different cell lines are representing neuroblastoma in the atlas, different ages and collection site are represented, find more details about the different cell lines here. For each of the neuroblastoma related cell line, up- and downregulated cancer-related pathways can be explored based on the transcriptomics data.

The mean value of the different cell lines are used as representation, when classifying gene expression based on specificity in the different cancer types represented by cell lines. To explore the expression profile in the indivudial cell lines- click the bar in the bar chart and you will reach the overivew of the different cell lines.

Here we provide the expression overview of all 69 transcription factors that show elevated expression levels in neuroblastoma compared to other cancer cell lines. The gene expression overview, across different cancer types, is accopanied by the top 3 nearest neighbours based on RNA expression and correlation in the clustering analysis.

Enriched transcription factors

Gene

Expression

Expression clustering

PHOX2A

Cancer enriched (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HAND2	Heart and neural crest derivatives expressed 2	0.9714	17
SLC6A2	Solute carrier family 6 member 2	0.9567	17
CHRNA3	Cholinergic receptor nicotinic alpha 3 subunit	0.9392	17

PHOX2B

Cancer enriched (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TLX2	T cell leukemia homeobox 2	0.9527	17
PHOX2A	Paired like homeobox 2A	0.9222	17
CHRNA3	Cholinergic receptor nicotinic alpha 3 subunit	0.9103	17

TLX2

Cancer enriched (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PHOX2B	Paired like homeobox 2B	0.9527	17
PHOX2A	Paired like homeobox 2A	0.9385	17
MAB21L1	Mab-21 like 1	0.9251	17

INSM2

Cancer enriched (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PLPPR5	Phospholipid phosphatase related 5	0.9098	17
PPEF1	Protein phosphatase with EF-hand domain 1	0.8290	1
MAB21L1	Mab-21 like 1	0.7738	17

MYCN

Cancer enriched (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TLX2	T cell leukemia homeobox 2	0.8484	17
ENSG00000284934	Novel protein	0.8441	17
HAND2	Heart and neural crest derivatives expressed 2	0.8368	17

FEV

Cancer enriched (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GDAP1L1	Ganglioside induced differentiation associated protein 1 like 1	0.7874	17
STMN2	Stathmin 2	0.7834	17
IGLON5	IgLON family member 5	0.7560	17

HAND2

Cancer enriched (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PHOX2A	Paired like homeobox 2A	0.9714	17
SLC6A2	Solute carrier family 6 member 2	0.9512	17
NPY2R	Neuropeptide Y receptor Y2	0.9373	17

NEUROG2

Cancer enriched (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
POPDC2	Popeye domain containing 2	0.7250	17
GNG8	G protein subunit gamma 8	0.6601	17
ENSG00000288708	Novel protein	0.6222	17

SCRT2

Cancer enriched (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SCN3B	Sodium voltage-gated channel beta subunit 3	0.7252	17
ADCYAP1R1	ADCYAP receptor type I	0.7032	17
PDE2A	Phosphodiesterase 2A	0.6958	24

FERD3L

Cancer enriched (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SMIM28	Small integral membrane protein 28	0.8460	17
ZAR1	Zygote arrest 1	0.8209	17
MARCHF11	Membrane associated ring-CH-type finger 11	0.7983	17

ISL1

Cancer enriched (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ELAVL3	ELAV like RNA binding protein 3	0.8123	17
TTBK1	Tau tubulin kinase 1	0.7934	17
DPP6	Dipeptidyl peptidase like 6	0.7858	17

HMX1

Cancer enriched (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MYCN	MYCN proto-oncogene, bHLH transcription factor	0.6684	17
NPY2R	Neuropeptide Y receptor Y2	0.6287	17
GFRA2	GDNF family receptor alpha 2	0.6280	17

SCRT1

Cancer enriched (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PSD	Pleckstrin and Sec7 domain containing	0.7467	17
BSN	Bassoon presynaptic cytomatrix protein	0.7308	17
AP3B2	Adaptor related protein complex 3 subunit beta 2	0.7247	17

MYT1L

Cancer enriched (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
DCX	Doublecortin	0.7148	17
GJD2	Gap junction protein delta 2	0.6456	17
UNC79	Unc-79 homolog, NALCN channel complex subunit	0.6315	17

NHLH2

Cancer enriched (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CNTN2	Contactin 2	0.7849	17
PPP1R17	Protein phosphatase 1 regulatory subunit 17	0.7466	17
GPR179	G protein-coupled receptor 179	0.7306	17

Enriched transcription factors

Gene

Expression

Expression clustering

TFAP2B

Group enriched (Bone cancer, Breast cancer, Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CHRM1	Cholinergic receptor muscarinic 1	0.6244	17
TMEM229A	Transmembrane protein 229A	0.5835	12
CRABP1	Cellular retinoic acid binding protein 1	0.5670	17

HAND1

Group enriched (Neuroblastoma, Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TRBV2	T cell receptor beta variable 2	0.8582	59
TRAV13-2	T cell receptor alpha variable 13-2	0.8265	59
MS4A6E	Membrane spanning 4-domains A6E	0.8265	59

TBX2

Group enriched (Neuroblastoma, Rhabdoid, Skin cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ARMC9	Armadillo repeat containing 9	0.6941	5
MCHR1	Melanin concentrating hormone receptor 1	0.5550	5
TCF21	Transcription factor 21	0.5515	64

DRGX

Group enriched (Neuroblastoma, Sarcoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
DCLK3	Doublecortin like kinase 3	0.9176	11
CLEC18B	C-type lectin domain family 18 member B	0.8881	11
CLEC18A	C-type lectin domain family 18 member A	0.8838	11

NKX2-6

Group enriched (Neuroblastoma, Sarcoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RBMY1B	RNA binding motif protein Y-linked family 1 member B	0.7427	17
PIRT	Phosphoinositide interacting regulator of transient receptor potential channels	0.7373	17
HTR3B	5-hydroxytryptamine receptor 3B	0.7175	17

ASCL1

Group enriched (Lung cancer, Neuroblastoma, Prostate cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SCGN	Secretagogin, EF-hand calcium binding protein	0.8816	10
OR51G2	Olfactory receptor family 51 subfamily G member 2	0.8777	10
OR51C1P	Olfactory receptor family 51 subfamily C member 1 pseudogene	0.8528	10

GATA3

Group enriched (Bladder cancer, Breast cancer, Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GPR139	G protein-coupled receptor 139	0.7347	27
CACNG4	Calcium voltage-gated channel auxiliary subunit gamma 4	0.7152	27
ESR1	Estrogen receptor 1	0.7151	27

INSM1

Group enriched (Lung cancer, Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PAX4	Paired box 4	0.8800	10
VWA5B2	Von Willebrand factor A domain containing 5B2	0.8546	10
HEPACAM2	HEPACAM family member 2	0.8441	10

NEUROD4

Group enriched (Lung cancer, Neuroblastoma, Uterine cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
NEUROD1	Neuronal differentiation 1	0.7520	1
CABP7	Calcium binding protein 7	0.7493	10
ELAVL2	ELAV like RNA binding protein 2	0.7287	17

SOX11

Group enriched (Bone cancer, Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GPC2	Glypican 2	0.6849	17
DPYSL5	Dihydropyrimidinase like 5	0.6664	17
TMEFF1	Transmembrane protein with EGF like and two follistatin like domains 1	0.6645	17

Enriched transcription factors

Gene

Expression

Expression clustering

CSRNP3

Cancer enhanced (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
STMN4	Stathmin 4	0.5655	16
UCN3	Urocortin 3	0.5477	16
ARC	Activity regulated cytoskeleton associated protein	0.5454	17

CUX2

Cancer enhanced (Bone cancer, Lymphoma, Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MYO9A	Myosin IXA	0.5380	46
C8orf89	Chromosome 8 open reading frame 89	0.5321	46
MAPK10	Mitogen-activated protein kinase 10	0.5315	46

EBF3

Cancer enhanced (Bone cancer, Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TAFA5	TAFA chemokine like family member 5	0.5732	12
INKA2	Inka box actin regulator 2	0.5330	64
EGFLAM	EGF like, fibronectin type III and laminin G domains	0.5132	12

EBF4

Cancer enhanced (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ETNK2	Ethanolamine kinase 2	0.5301	27
SLC4A3	Solute carrier family 4 member 3	0.4786	69
VPS37D	VPS37D subunit of ESCRT-I	0.4762	27

EGR4

Cancer enhanced (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
FEV	FEV transcription factor, ETS family member	0.5507	17
SERTM2	Serine rich and transmembrane domain containing 2	0.5478	17
FBXL16	F-box and leucine rich repeat protein 16	0.4871	17

ESRRG

Cancer enhanced (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CPNE9	Copine family member 9	0.7726	70
CDKN1C	Cyclin dependent kinase inhibitor 1C	0.7191	70
VIP	Vasoactive intestinal peptide	0.7085	70

EVX2

Cancer enhanced (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
FERD3L	Fer3 like bHLH transcription factor	0.7610	17
SMIM28	Small integral membrane protein 28	0.7500	17
TMEM151B	Transmembrane protein 151B	0.7364	17

FOXN4

Cancer enhanced (Neuroblastoma, Prostate cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TEKT2	Tektin 2	0.6159	10
PKD2L1	Polycystin 2 like 1, transient receptor potential cation channel	0.5806	10
POU4F2	POU class 4 homeobox 2	0.5657	10

FOXR2

Cancer enhanced (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
POTEH	POTE ankyrin domain family member H	0.7322	51
POTEM	POTE ankyrin domain family member M	0.7020	51
SSX2	SSX family member 2	0.6943	51

GATA2

Cancer enhanced (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CRYGD	Crystallin gamma D	0.6524	47
MEX3B	Mex-3 RNA binding family member B	0.6425	47
FEV	FEV transcription factor, ETS family member	0.6065	17

HOXD3

Cancer enhanced (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HOXD4	Homeobox D4	0.8102	15
HOXD8	Homeobox D8	0.7459	17
HOXD9	Homeobox D9	0.5778	12

HOXD4

Cancer enhanced (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HOXD3	Homeobox D3	0.8102	17
HOXD8	Homeobox D8	0.7558	17
HOXD9	Homeobox D9	0.6014	12

HOXD8

Cancer enhanced (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HOXD4	Homeobox D4	0.7558	15
HOXD3	Homeobox D3	0.7459	17
HOXD9	Homeobox D9	0.6726	12

HOXD9

Cancer enhanced (Bone cancer, Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HOXD10	Homeobox D10	0.8098	12
HOXD11	Homeobox D11	0.7485	12
HOXD8	Homeobox D8	0.6726	17

IRX6

Cancer enhanced (Neuroblastoma, Skin cancer, Thyroid cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GFRA4	GDNF family receptor alpha 4	0.7410	16
SSTR4	Somatostatin receptor 4	0.7360	16
OTOS	Otospiralin	0.7350	16

LHX8

Cancer enhanced (Bile duct cancer, Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TRIM51G	Tripartite motif-containing 51G	0.8743	1
ENSG00000290147	Novel protein	0.8680	1
GALP	Galanin like peptide	0.8572	1

MEIS1

Cancer enhanced (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TRIM64B	Tripartite motif containing 64B	0.5158	17
EYA4	EYA transcriptional coactivator and phosphatase 4	0.5128	5
PRRT4	Proline rich transmembrane protein 4	0.5018	17

MEIS2

Cancer enhanced (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RGS5	Regulator of G protein signaling 5	0.5755	17
UNC5C	Unc-5 netrin receptor C	0.5738	17
HAND2	Heart and neural crest derivatives expressed 2	0.5725	17

MEIS3

Cancer enhanced (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SAMD14	Sterile alpha motif domain containing 14	0.5622	17
PIANP	PILR alpha associated neural protein	0.5548	17
REEP2	Receptor accessory protein 2	0.5514	5

MYT1

Cancer enhanced (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RUNDC3A	RUN domain containing 3A	0.7424	17
CCDC92B	Coiled-coil domain containing 92B	0.7411	17
CACNG2	Calcium voltage-gated channel auxiliary subunit gamma 2	0.6794	16

NEUROD1

Cancer enhanced (Lung cancer, Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
NTN3	Netrin 3	0.8153	1
CERKL	Ceramide kinase like	0.7887	17
NEUROD4	Neuronal differentiation 4	0.7520	10

PROX1

Cancer enhanced (Liver cancer, Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CA6	Carbonic anhydrase 6	0.7050	70
TBX10	T-box transcription factor 10	0.6979	70
FAM3B	FAM3 metabolism regulating signaling molecule B	0.6953	10

PURG

Cancer enhanced (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PIANP	PILR alpha associated neural protein	0.6589	17
NPY2R	Neuropeptide Y receptor Y2	0.6366	17
PNMA8C	PNMA family member 8C	0.6355	17

RCOR2

Cancer enhanced (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CAMKV	CaM kinase like vesicle associated	0.7072	1
TLCD3B	TLC domain containing 3B	0.6663	1
C16orf92	Chromosome 16 open reading frame 92	0.6283	17

RORB

Cancer enhanced (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZC4H2	Zinc finger C4H2-type containing	0.5281	6
LEF1	Lymphoid enhancer binding factor 1	0.5225	6
YPEL1	Yippee like 1	0.4987	6

SATB1

Cancer enhanced (Leukemia, Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
IL3RA	Interleukin 3 receptor subunit alpha	0.5783	21
CISH	Cytokine inducible SH2 containing protein	0.5304	21
IKZF4	IKAROS family zinc finger 4	0.5219	21

SIX3

Cancer enhanced (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ATOH7	Atonal bHLH transcription factor 7	0.5454	1
NXNL1	Nucleoredoxin like 1	0.5401	1
RBP3	Retinol binding protein 3	0.5361	1

SMAD9

Cancer enhanced (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MAB21L2	Mab-21 like 2	0.6278	1
SYN2	Synapsin II	0.6251	17
SRRM4	Serine/arginine repetitive matrix 4	0.5742	17

TBX20

Cancer enhanced (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
DOC2B	Double C2 domain beta	0.6497	17
DNAJB8	DnaJ heat shock protein family (Hsp40) member B8	0.6400	17
TLX2	T cell leukemia homeobox 2	0.6338	17

TBX3

Cancer enhanced (Neuroblastoma, Prostate cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CHRM1	Cholinergic receptor muscarinic 1	0.5101	17
MYRIP	Myosin VIIA and Rab interacting protein	0.4944	60
AADAT	Aminoadipate aminotransferase	0.4847	60

TCF4

Cancer enhanced (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
BLNK	B cell linker	0.5119	55
SPIB	Spi-B transcription factor	0.4868	55
MYH11	Myosin heavy chain 11	0.4818	55

TGIF2LX

Cancer enhanced (Myeloma, Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PPP4R3C	Protein phosphatase 4 regulatory subunit 3C	0.6637	51
ENSG00000275869		0.5986	51
TRPC7	Transient receptor potential cation channel subfamily C member 7	0.5771	10

TLX3

Cancer enhanced (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TRBV5-7	T cell receptor beta variable 5-7 (non-functional)	0.7759	59
TRAV4	T cell receptor alpha variable 4	0.7687	59
TRBV5-5	T cell receptor beta variable 5-5	0.7682	59

TWIST1

Cancer enhanced (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HAND2	Heart and neural crest derivatives expressed 2	0.6935	17
NPY2R	Neuropeptide Y receptor Y2	0.6850	17
UNC5C	Unc-5 netrin receptor C	0.6474	17

ZFHX2

Cancer enhanced (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GRIK3	Glutamate ionotropic receptor kainate type subunit 3	0.4705	10
PRR36	Proline rich 36	0.4698	10
TCEAL5	Transcription elongation factor A like 5	0.4671	17

ZKSCAN7

Cancer enhanced (Neuroblastoma, Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZNF660	Zinc finger protein 660	0.5543	17
RTL1	Retrotransposon Gag like 1	0.5228	17
NACAD	NAC alpha domain containing	0.5131	17

ZNF157

Cancer enhanced (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
BSX	Brain specific homeobox	0.5922	10
GAD2	Glutamate decarboxylase 2	0.5877	10
TAGLN3	Transgelin 3	0.5716	10

ZNF423

Cancer enhanced (Neuroblastoma, Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PRR35	Proline rich 35	0.5578	65
LRRC55	Leucine rich repeat containing 55	0.5545	65
TRAJ49	T cell receptor alpha joining 49	0.5336	65

ZNF454

Cancer enhanced (Neuroblastoma, Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZNF354C	Zinc finger protein 354C	0.8062	4
ZNF732	Zinc finger protein 732	0.7144	4
ZNF677	Zinc finger protein 677	0.7002	4

ZNF536

Cancer enhanced (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
C11orf96	Chromosome 11 open reading frame 96	0.6452	17
RNF150	Ring finger protein 150	0.5836	17
SV2C	Synaptic vesicle glycoprotein 2C	0.5794	17

ZNF660

Cancer enhanced (Neuroblastoma, Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZKSCAN7	Zinc finger with KRAB and SCAN domains 7	0.5543	17
SPSB4	SplA/ryanodine receptor domain and SOCS box containing 4	0.5004	33
DCHS1	Dachsous cadherin-related 1	0.4897	17

ZNF711

Cancer enhanced (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SATL1	Spermidine/spermine N1-acetyl transferase like 1	0.6081	10
IGFBPL1	Insulin like growth factor binding protein like 1	0.5904	17
TMEFF1	Transmembrane protein with EGF like and two follistatin like domains 1	0.5372	17

ZNF727

Cancer enhanced (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZNF492	Zinc finger protein 492	0.6885	4
ZNF98	Zinc finger protein 98	0.6874	4
ZNF540	Zinc finger protein 540	0.6651	4

ZNF853

Cancer enhanced (Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
EBF4	EBF family member 4	0.4545	27
ZDHHC4	Zinc finger DHHC-type palmitoyltransferase 4	0.4498	67
DMRT3	Doublesex and mab-3 related transcription factor 3	0.4313	72