Transcription factor landscape - Brain region - Blood & immune cells

Blood & immune cells are in the brain comparison represented by leukocytes, a general name for immune cells. The immune cells of the brain were originally included in the miscellaneous super cluster, but in this resrouce they are included as a separate cell type cluster. The expression profile of leukocytes overlaps to a certain degree with the central nervous system macrophages, which includes both microglia and perivascular macrophages.

Transcriptome analysis shows that 68% (n=13765) of all human proteins (n=20162) are detected in leukocytes and 1039 of these genes show an elevated expression in any leukocytes compared to other brain cell types. Learn more about genes with elevated expression in leukocytes here. In-depth analysis of transcription factor genes expressed in leukocytes highlights 64 transcription factors with elevated expression in leukocytes compared to other cell types. In total, 13 transcription factors are classified as enriched in leukocytes.

Here we provide the expression overview of all transcription factors that show enriched expression levels in neuronal clusters compared to other brain cluster types.