Transcription factor landscape - Brain region - Endothelial cells

Transcriptome analysis shows that 68% (n=13764) of all human proteins (n=20162) are detected in endothelial cells and 970 of these genes show an elevated expression in any endothelial cells compared to other brain cell types. Learn more about genes with elevated expression in endothelial cells here. In-depth analysis of transcription factor genes expressed in endothelial cells highlights 91 transcription factors with elevated expression in endothelial cells compared to other cell types. In total, 16 transcription factors are classified as enriched in endothelial cells.

Here we provide the expression overview of all transcription factors that show enriched expression levels in neuronal clusters compared to other brain cluster types.

Enriched transcription factors
Gene Expression
NR5A2
Cell type enriched (Endothelial cell)
BCL6B
Cell type enriched (Endothelial cell)
ERG
Cell type enriched (Endothelial cell)
ETS2
Cell type enriched (Endothelial cell)
FOXF1
Cell type enriched (Endothelial cell)
FOXL2
Cell type enriched (Endothelial cell)
GATA2
Cell type enriched (Endothelial cell)
HLX
Cell type enriched (Endothelial cell)
ID1
Cell type enriched (Endothelial cell)
MECOM
Cell type enriched (Endothelial cell)
NFKBIA
Cell type enriched (Endothelial cell)
SMAD6
Cell type enriched (Endothelial cell)
SOX17
Cell type enriched (Endothelial cell)
SOX18
Cell type enriched (Endothelial cell)
SOX7
Cell type enriched (Endothelial cell)
ZNF366
Cell type enriched (Endothelial cell)

Enriched transcription factors
Gene Expression
FOXC1
Group enriched (Endothelial cell, Fibroblast, Pericyte, Vascular associated smooth muscle cell)
PGR
Group enriched (Endothelial cell, Ependymal cell, Fibroblast, Pericyte, Vascular associated smooth muscle cell)
ARID5A
Group enriched (Central nervous system macrophage, Endothelial cell, Leukocyte, Pericyte, Vascular associated smooth muscle cell)
ATF3
Group enriched (Endothelial cell, Ependymal cell, Vascular associated smooth muscle cell)
ATOH8
Group enriched (Astrocyte, Bergmann glia, Committed oligodendrocyte precursor, Endothelial cell, Fibroblast, Oligodendrocyte precursor cell, Vascular associated smooth muscle cell)
BNC2
Group enriched (Central nervous system macrophage, Endothelial cell, Fibroblast)
EBF1
Group enriched (Endothelial cell, Fibroblast, Pericyte, Vascular associated smooth muscle cell)
ELK3
Group enriched (Central nervous system macrophage, Endothelial cell, Leukocyte, Upper rhombic lip)
EPAS1
Group enriched (Endothelial cell, Pericyte, Vascular associated smooth muscle cell)
ETS1
Group enriched (Endothelial cell, Leukocyte, Pericyte, Vascular associated smooth muscle cell)
FLI1
Group enriched (Central nervous system macrophage, Endothelial cell, Leukocyte)
FOS
Group enriched (Astrocyte, Central nervous system macrophage, Endothelial cell, Ependymal cell, Vascular associated smooth muscle cell)
FOSL1
Group enriched (Central nervous system macrophage, Endothelial cell)
FOSL2
Group enriched (Endothelial cell, Leukocyte, Vascular associated smooth muscle cell)
FOXF2
Group enriched (Endothelial cell, Fibroblast, Pericyte, Vascular associated smooth muscle cell)
HES1
Group enriched (Astrocyte, Bergmann glia, Endothelial cell, Ependymal cell, Fibroblast, Pericyte, Vascular associated smooth muscle cell)
HHEX
Group enriched (Central nervous system macrophage, Endothelial cell)
HIF3A
Group enriched (Astrocyte, Bergmann glia, Endothelial cell, Oligodendrocyte precursor cell)
IRF1
Group enriched (Endothelial cell, Leukocyte)
MEF2A
Group enriched (Central nervous system macrophage, Endothelial cell)
SIX5
Group enriched (Astrocyte, Bergmann glia, Choroid plexus epithelial cell, Endothelial cell, Ependymal cell, Fibroblast, Pericyte, Vascular associated smooth muscle cell)
SMAD9
Group enriched (Astrocyte, Bergmann glia, Endothelial cell, Hippocampal dentate gyrus, Midbrain-derived inhibitory)
TBX3
Group enriched (Endothelial cell, Pericyte, Vascular associated smooth muscle cell)
TCF15
Group enriched (Endothelial cell, Pericyte, Vascular associated smooth muscle cell)
TCF7L1
Group enriched (Astrocyte, Bergmann glia, Choroid plexus epithelial cell, Committed oligodendrocyte precursor, Endothelial cell, Ependymal cell, Fibroblast, Pericyte, Vascular associated smooth muscle cell)
TEAD4
Group enriched (Endothelial cell, Vascular associated smooth muscle cell)
TFAP2C
Group enriched (Astrocyte, Endothelial cell, Fibroblast)

Enriched transcription factors
Gene Expression
NR2E3
Cell type enhanced (Endothelial cell, Fibroblast)
LEF1
Cell type enhanced (Endothelial cell, Pericyte)
ZIC2
Cell type enhanced (Endothelial cell, Fibroblast, Upper rhombic lip)
YBX3
Cell type enhanced (Endothelial cell, Vascular associated smooth muscle cell)
ZIC3
Cell type enhanced (Bergmann glia, Endothelial cell, Fibroblast)
ZIC5
Cell type enhanced (Bergmann glia, Choroid plexus epithelial cell, Endothelial cell, Upper rhombic lip)
LBX2
Cell type enhanced (Endothelial cell, Fibroblast, Pericyte)
TBX1
Cell type enhanced (Endothelial cell)
BATF2
Cell type enhanced (Endothelial cell, Fibroblast, Pericyte)
BCL3
Cell type enhanced (Endothelial cell, Leukocyte)
BHLHE40
Cell type enhanced (Astrocyte, Endothelial cell, Vascular associated smooth muscle cell)
CEBPD
Cell type enhanced (Endothelial cell, Vascular associated smooth muscle cell)
CSRNP1
Cell type enhanced (Endothelial cell)
ELF1
Cell type enhanced (Central nervous system macrophage, Endothelial cell, Leukocyte)
FOXO1
Cell type enhanced (Choroid plexus epithelial cell, Endothelial cell)
FOXP1
Cell type enhanced (Endothelial cell)
FOXQ1
Cell type enhanced (Endothelial cell, Fibroblast, Pericyte)
GATA6
Cell type enhanced (Endothelial cell, Fibroblast, Vascular associated smooth muscle cell)
HEY1
Cell type enhanced (Endothelial cell, Fibroblast)
HLF
Cell type enhanced (Endothelial cell)
ID3
Cell type enhanced (Astrocyte, Endothelial cell, Vascular associated smooth muscle cell)
IRF6
Cell type enhanced (Cerebellar inhibitory, Endothelial cell, Ependymal cell)
IRF7
Cell type enhanced (Central nervous system macrophage, Endothelial cell, Leukocyte)
JUN
Cell type enhanced (Astrocyte, Endothelial cell, Vascular associated smooth muscle cell)
JUNB
Cell type enhanced (Endothelial cell, Vascular associated smooth muscle cell)
KLF10
Cell type enhanced (Endothelial cell)
KLF11
Cell type enhanced (Endothelial cell, Pericyte, Vascular associated smooth muscle cell)
KLF2
Cell type enhanced (Endothelial cell, Leukocyte, Vascular associated smooth muscle cell)
KLF4
Cell type enhanced (Endothelial cell, Fibroblast, Vascular associated smooth muscle cell)
KLF6
Cell type enhanced (Endothelial cell)
LYL1
Cell type enhanced (Central nervous system macrophage, Endothelial cell)
MAFF
Cell type enhanced (Endothelial cell, Vascular associated smooth muscle cell)
MIER2
Cell type enhanced (Endothelial cell)
MIXL1
Cell type enhanced (Endothelial cell)
NFKB2
Cell type enhanced (Endothelial cell, Leukocyte, Vascular associated smooth muscle cell)
NR4A1
Cell type enhanced (Endothelial cell, Vascular associated smooth muscle cell)
PPARD
Cell type enhanced (Central nervous system macrophage, Endothelial cell)
PPP1R13L
Cell type enhanced (Endothelial cell)
RELB
Cell type enhanced (Endothelial cell)
SMAD7
Cell type enhanced (Endothelial cell)
SOX13
Cell type enhanced (Endothelial cell, Oligodendrocyte precursor cell, Vascular associated smooth muscle cell)
SP100
Cell type enhanced (Central nervous system macrophage, Endothelial cell, Leukocyte)
SP140L
Cell type enhanced (Central nervous system macrophage, Endothelial cell, Leukocyte)
TEAD2
Cell type enhanced (Endothelial cell, Pericyte, Vascular associated smooth muscle cell)
TWIST1
Cell type enhanced (Endothelial cell, Fibroblast)
ZBTB16
Cell type enhanced (Endothelial cell)
ZBTB42
Cell type enhanced (Endothelial cell, Ependymal cell, Leukocyte, Vascular associated smooth muscle cell)
ZNF423
Cell type enhanced (Cerebellar inhibitory, Endothelial cell)