Transcription factor landscape - Brain region - Mesenchymal cells

Mesenchymal cells in the brain expression comparison is represented by fibroblasts.

Transcriptome analysis shows that 70% (n=14123) of all human proteins (n=20162) are detected in mesenchymal cells and 665 of these genes show an elevated expression in any mesenchymal cells compared to other brain cell types. Learn more about genes with elevated expression in mesenchymal cells here. In-depth analysis of transcription factor genes expressed in mesenchymal cells highlights 63 transcription factors with elevated expression in mesenchymal cells compared to other cell types. In total, 1 transcription factors are classified as enriched in mesenchymal cells.

Here we provide the expression overview of all transcription factors that show enriched expression levels in neuronal clusters compared to other brain cluster types.

Enriched transcription factors
Gene Expression
GSC
Cell type enriched (Fibroblast)

Enriched transcription factors
Gene Expression
FOXC1
Group enriched (Endothelial cell, Fibroblast, Pericyte, Vascular associated smooth muscle cell)
GBX1
Group enriched (Eccentric medium spiny neuron, Fibroblast, Splatter)
PGR
Group enriched (Endothelial cell, Ependymal cell, Fibroblast, Pericyte, Vascular associated smooth muscle cell)
ALX3
Group enriched (Fibroblast, Pericyte, Vascular associated smooth muscle cell)
ATOH8
Group enriched (Astrocyte, Bergmann glia, Committed oligodendrocyte precursor, Endothelial cell, Fibroblast, Oligodendrocyte precursor cell, Vascular associated smooth muscle cell)
BNC2
Group enriched (Central nervous system macrophage, Endothelial cell, Fibroblast)
EBF1
Group enriched (Endothelial cell, Fibroblast, Pericyte, Vascular associated smooth muscle cell)
FOXC2
Group enriched (Fibroblast, Pericyte, Vascular associated smooth muscle cell)
FOXD1
Group enriched (Fibroblast, Pericyte, Vascular associated smooth muscle cell)
FOXD2
Group enriched (Fibroblast, Pericyte, Vascular associated smooth muscle cell)
FOXF2
Group enriched (Endothelial cell, Fibroblast, Pericyte, Vascular associated smooth muscle cell)
FOXL1
Group enriched (Fibroblast, Pericyte, Vascular associated smooth muscle cell)
GLI2
Group enriched (Astrocyte, Bergmann glia, Ependymal cell, Fibroblast)
HES1
Group enriched (Astrocyte, Bergmann glia, Endothelial cell, Ependymal cell, Fibroblast, Pericyte, Vascular associated smooth muscle cell)
HIC1
Group enriched (Fibroblast, Pericyte)
MEOX2
Group enriched (Astrocyte, Fibroblast, Vascular associated smooth muscle cell)
NFATC4
Group enriched (Astrocyte, Bergmann glia, Fibroblast, Pericyte, Vascular associated smooth muscle cell)
NKX6-1
Group enriched (Ependymal cell, Fibroblast, Pericyte, Vascular associated smooth muscle cell)
NR2F2
Group enriched (Fibroblast, Midbrain-derived inhibitory, Pericyte, Vascular associated smooth muscle cell)
PRRX1
Group enriched (Astrocyte, Bergmann glia, Committed oligodendrocyte precursor, Fibroblast, Oligodendrocyte precursor cell, Pericyte)
PRRX2
Group enriched (Fibroblast, Oligodendrocyte precursor cell, Vascular associated smooth muscle cell)
SIX1
Group enriched (Fibroblast, Pericyte, Vascular associated smooth muscle cell)
SIX5
Group enriched (Astrocyte, Bergmann glia, Choroid plexus epithelial cell, Endothelial cell, Ependymal cell, Fibroblast, Pericyte, Vascular associated smooth muscle cell)
SP5
Group enriched (Cerebellar inhibitory, Fibroblast, Midbrain-derived inhibitory)
TBX15
Group enriched (Fibroblast, Pericyte, Vascular associated smooth muscle cell)
TCF7L1
Group enriched (Astrocyte, Bergmann glia, Choroid plexus epithelial cell, Committed oligodendrocyte precursor, Endothelial cell, Ependymal cell, Fibroblast, Pericyte, Vascular associated smooth muscle cell)
TFAP2C
Group enriched (Astrocyte, Endothelial cell, Fibroblast)
TP63
Group enriched (Ependymal cell, Fibroblast, Pericyte)
ZNF648
Group enriched (Choroid plexus epithelial cell, Fibroblast, Lamp5-lhx6 and chandelier)

Enriched transcription factors
Gene Expression
NR2E3
Cell type enhanced (Endothelial cell, Fibroblast)
ZIC1
Cell type enhanced (Bergmann glia, Fibroblast, Pericyte)
ZIC4
Cell type enhanced (Bergmann glia, Fibroblast, Pericyte, Upper rhombic lip)
ZIC2
Cell type enhanced (Endothelial cell, Fibroblast, Upper rhombic lip)
PAX9
Cell type enhanced (Fibroblast)
ZIC3
Cell type enhanced (Bergmann glia, Endothelial cell, Fibroblast)
LBX2
Cell type enhanced (Endothelial cell, Fibroblast, Pericyte)
AIRE
Cell type enhanced (Deep-layer near-projecting, Fibroblast)
ALX1
Cell type enhanced (Ependymal cell, Fibroblast, Pericyte)
ALX4
Cell type enhanced (Ependymal cell, Fibroblast, Vascular associated smooth muscle cell)
BATF2
Cell type enhanced (Endothelial cell, Fibroblast, Pericyte)
CREB3L2
Cell type enhanced (Choroid plexus epithelial cell, Fibroblast)
EBF2
Cell type enhanced (Fibroblast, Splatter)
EBF3
Cell type enhanced (Fibroblast, Splatter)
FOXQ1
Cell type enhanced (Endothelial cell, Fibroblast, Pericyte)
FOXS1
Cell type enhanced (Fibroblast, Pericyte, Vascular associated smooth muscle cell)
GATA6
Cell type enhanced (Endothelial cell, Fibroblast, Vascular associated smooth muscle cell)
GLI3
Cell type enhanced (Astrocyte, Ependymal cell, Fibroblast)
HEY1
Cell type enhanced (Endothelial cell, Fibroblast)
HOXB2
Cell type enhanced (Fibroblast, Leukocyte, Lower rhombic lip)
KLF4
Cell type enhanced (Endothelial cell, Fibroblast, Vascular associated smooth muscle cell)
KLF5
Cell type enhanced (Fibroblast, Medium spiny neuron)
NR2F1
Cell type enhanced (Fibroblast, Pericyte)
OSR1
Cell type enhanced (Fibroblast, Hippocampal ca4)
OSR2
Cell type enhanced (Fibroblast)
PRDM6
Cell type enhanced (Fibroblast)
SALL4
Cell type enhanced (Fibroblast)
SNAI1
Cell type enhanced (Fibroblast)
TBX18
Cell type enhanced (Fibroblast, Pericyte, Vascular associated smooth muscle cell)
TCF21
Cell type enhanced (Fibroblast, Hippocampal dentate gyrus)
TWIST1
Cell type enhanced (Endothelial cell, Fibroblast)
TWIST2
Cell type enhanced (Central nervous system macrophage, Fibroblast, Vascular associated smooth muscle cell)
ZNF676
Cell type enhanced (Fibroblast, Hippocampal ca4, Oligodendrocyte)