Transcription factor landscape - Cell line - Leukemia

93 different cell lines are representing leukemia in the atlas, different ages, collection site and cancer subtypes are represented, find more details about the different cell lines here. The expression profile of the different cell lines can be explored in comparison to the bulk RNAseq transcriptomics data from TCGA's Acute Myeloid Leukemia (LAML), defining the cell lines most similar to the tumour expression profile.

The mean value of the different cell lines are used as representation, when classifying gene expression based on specificity in the different cancer types represented by cell lines. To explore the expression profile in the indivudial cell lines- click the bar in the bar chart and you will reach the overivew of the different cell lines.

Here we provide the expression overview of all 54 transcription factors that show elevated expression levels in leukemia compared to other cancer cell lines. The gene expression overview, across different cancer types, is accopanied by the top 3 nearest neighbours based on RNA expression and correlation in the clustering analysis.

Enriched transcription factors

Gene

Expression

Expression clustering

GATA1

Cancer enriched (Leukemia)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TFR2	Transferrin receptor 2	0.8749	47
OOSP4A	Oocyte secreted protein family member 4A	0.8351	47
ITGA2B	Integrin subunit alpha 2b	0.8083	47

KLF1

Cancer enriched (Leukemia)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MFSD2B	Major facilitator superfamily domain containing 2B	0.9266	47
RHAG	Rh associated glycoprotein	0.8570	47
GDF2	Growth differentiation factor 2	0.8314	47

GFI1B

Cancer enriched (Leukemia)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ITGA2B	Integrin subunit alpha 2b	0.8130	47
TAL1	TAL bHLH transcription factor 1, erythroid differentiation factor	0.7677	47
GATA1	GATA binding protein 1	0.7464	47

BHLHE23

Cancer enriched (Leukemia)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TRBV16	T cell receptor beta variable 16	0.9353	59
IGHV3-16	Immunoglobulin heavy variable 3-16 (non-functional)	0.9333	59
NDST3	N-deacetylase and N-sulfotransferase 3	0.9004	59

TAL1

Cancer enriched (Leukemia)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CPA3	Carboxypeptidase A3	0.7916	47
GYPE	Glycophorin E (MNS blood group)	0.7858	47
GP6	Glycoprotein VI platelet	0.7746	47

NFE2

Cancer enriched (Leukemia)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GYPB	Glycophorin B (MNS blood group)	0.8013	47
GYPE	Glycophorin E (MNS blood group)	0.7913	47
SLFN14	Schlafen family member 14	0.7874	47

ZNF683

Cancer enriched (Leukemia)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TRGV8	T cell receptor gamma variable 8	0.9602	59
TRAV12-1	T cell receptor alpha variable 12-1	0.9567	59
KRT72	Keratin 72	0.9526	59

Enriched transcription factors

Gene

Expression

Expression clustering

IKZF1

Group enriched (Leukemia, Lymphoma, Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PAX5	Paired box 5	0.5982	6
PTGDR	Prostaglandin D2 receptor	0.5858	6
ARHGAP25	Rho GTPase activating protein 25	0.5830	55

CEBPE

Group enriched (Leukemia, Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ADGRG3	Adhesion G protein-coupled receptor G3	0.8794	71
CLEC4D	C-type lectin domain family 4 member D	0.8721	71
AOAH	Acyloxyacyl hydrolase	0.8626	71

SPI1

Group enriched (Leukemia, Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MYO1F	Myosin IF	0.7665	14
TYROBP	Transmembrane immune signaling adaptor TYROBP	0.7153	49
RAB44	RAB44, member RAS oncogene family	0.7098	14

TBX21

Group enriched (Leukemia, Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
OR6S1	Olfactory receptor family 6 subfamily S member 1	0.8729	55
IFNA2	Interferon alpha 2	0.8665	55
SLAMF1	Signaling lymphocytic activation molecule family member 1	0.8635	55

TFEC

Group enriched (Leukemia, Lymphoma, Rhabdoid)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CXCL10	C-X-C motif chemokine ligand 10	0.8486	55
IGKV2D-30	Immunoglobulin kappa variable 2D-30	0.8361	55
ARHGAP25	Rho GTPase activating protein 25	0.8265	55

LYL1

Group enriched (Leukemia, Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GBGT1	Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (FORS blood group)	0.7059	47
INKA1	Inka box actin regulator 1	0.6649	35
HHEX	Hematopoietically expressed homeobox	0.6476	14

PAX5

Group enriched (Leukemia, Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
NIBAN3	Niban apoptosis regulator 3	0.8332	46
BLNK	B cell linker	0.8224	55
TCL1A	TCL1 family AKT coactivator A	0.8165	46

ERG

Group enriched (Leukemia, Prostate cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
LRRC70	Leucine rich repeat containing 70	0.7254	48
FLI1	Fli-1 proto-oncogene, ETS transcription factor	0.7061	48
ARRDC5	Arrestin domain containing 5	0.6476	6

IRF8

Group enriched (Leukemia, Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CNR2	Cannabinoid receptor 2	0.6375	55
NUDT7	Nudix hydrolase 7	0.6138	14
SWAP70	Switching B cell complex subunit SWAP70	0.6052	46

BCL11B

Group enriched (Bone cancer, Leukemia)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TRAV6	T cell receptor alpha variable 6	0.6663	12
OR4E1	Olfactory receptor family 4 subfamily E member 1	0.6515	12
C22orf15	Chromosome 22 open reading frame 15	0.6357	12

TBXT

Group enriched (Leukemia, Lung cancer, Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
LCN1	Lipocalin 1	0.6990	7
IL4I1	Interleukin 4 induced 1	0.4915	50
UGT2B17	UDP glucuronosyltransferase family 2 member B17	0.4796	55

ZBTB16

Group enriched (Leukemia, Prostate cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
IGHD3-22	Immunoglobulin heavy diversity 3-22	0.6734	14
SELP	Selectin P	0.6592	47
MPL	MPL proto-oncogene, thrombopoietin receptor	0.6507	47

ARID5A

Group enriched (Leukemia, Lymphoma, Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TNFRSF8	TNF receptor superfamily member 8	0.7390	21
PROB1	Proline rich basic protein 1	0.7166	21
SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	0.6991	21

NR5A1

Group enriched (Head and neck cancer, Leukemia, Liver cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
OR4N5	Olfactory receptor family 4 subfamily N member 5	0.8024	47
CATSPERD	Cation channel sperm associated auxiliary subunit delta	0.7981	47
PSKH2	Protein serine kinase H2	0.7857	47

RHOXF2

Group enriched (Leukemia, Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RHOXF2B	Rhox homeobox family member 2B	0.9077	51
NAA11	N-alpha-acetyltransferase 11, NatA catalytic subunit	0.6889	51
GAGE12H	G antigen 12H	0.6865	51

RHOXF2B

Group enriched (Gastric cancer, Leukemia, Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RHOXF2	Rhox homeobox family member 2	0.9077	51
EPX	Eosinophil peroxidase	0.6403	51
NAA11	N-alpha-acetyltransferase 11, NatA catalytic subunit	0.5515	51

Enriched transcription factors

Gene

Expression

Expression clustering

BCL11A

Cancer enhanced (Leukemia, Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CD72	CD72 molecule	0.6838	35
ZCCHC7	Zinc finger CCHC-type containing 7	0.6135	35
SPATA48	Spermatogenesis associated 48	0.5935	35

BCL6B

Cancer enhanced (Leukemia, Ovarian cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ECSCR	Endothelial cell surface expressed chemotaxis and apoptosis regulator	0.8276	48
ROBO4	Roundabout guidance receptor 4	0.8042	48
CDH5	Cadherin 5	0.7916	48

CEBPA

Cancer enhanced (Leukemia, Liver cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
LINC02218	Long intergenic non-protein coding RNA 2218	0.6823	14
CD300LF	CD300 molecule like family member f	0.6739	14
CLEC12A	C-type lectin domain family 12 member A	0.6667	14

EBF1

Cancer enhanced (Leukemia, Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SH2D4B	SH2 domain containing 4B	0.8679	6
DNTT	DNA nucleotidylexotransferase	0.8563	6
GRID2IP	Grid2 interacting protein	0.8392	6

FLI1

Cancer enhanced (Leukemia, Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PECAM1	Platelet and endothelial cell adhesion molecule 1	0.7308	48
ERG	ETS transcription factor ERG	0.7061	6
ESAM	Endothelial cell adhesion molecule	0.6561	48

FOXB1

Cancer enhanced (Leukemia, Prostate cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
UBASH3A	Ubiquitin associated and SH3 domain containing A	0.7115	59
KRT73	Keratin 73	0.5810	59
RBPJL	Recombination signal binding protein for immunoglobulin kappa J region like	0.5773	59

FOXD4L1

Cancer enhanced (Leukemia)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
DEFA4	Defensin alpha 4	0.7871	14
SPNS3	Sphingolipid transporter 3 (putative)	0.6785	14
HAL	Histidine ammonia-lyase	0.6295	14

GFI1

Cancer enhanced (Leukemia)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CLEC5A	C-type lectin domain containing 5A	0.7802	14
CD300LF	CD300 molecule like family member f	0.7538	14
CLEC12A	C-type lectin domain family 12 member A	0.7450	14

HHEX

Cancer enhanced (Leukemia)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
LYL1	LYL1 basic helix-loop-helix family member	0.6476	14
GIPC3	GIPC PDZ domain containing family member 3	0.5289	14
CYTL1	Cytokine like 1	0.5236	14

HLX

Cancer enhanced (Leukemia)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CACNA2D4	Calcium voltage-gated channel auxiliary subunit alpha2delta 4	0.5499	46
DISC1	DISC1 scaffold protein	0.5395	71
LCN8	Lipocalin 8	0.5391	6

HMX2

Cancer enhanced (Leukemia)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HMX3	H6 family homeobox 3	0.8517	24
POU2F3	POU class 2 homeobox 3	0.8000	24
PSD2	Pleckstrin and Sec7 domain containing 2	0.7822	24

HMX3

Cancer enhanced (Cervical cancer, Leukemia)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HMX2	H6 family homeobox 2	0.8517	24
PSD2	Pleckstrin and Sec7 domain containing 2	0.7618	24
SH2D6	SH2 domain containing 6	0.7518	24

IKZF2

Cancer enhanced (Leukemia, Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TRAJ7	T cell receptor alpha joining 7	0.6130	59
TRAV16	T cell receptor alpha variable 16	0.5935	59
TRAJ6	T cell receptor alpha joining 6	0.5856	59

IRX1

Cancer enhanced (Brain cancer, Leukemia)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HPSE2	Heparanase 2 (inactive)	0.7099	47
ICAM4	Intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)	0.6971	47
DHH	Desert hedgehog signaling molecule	0.6406	47

LEF1

Cancer enhanced (Leukemia)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
IGHV1-58	Immunoglobulin heavy variable 1-58	0.7913	6
IGHV8-51-1	Immunoglobulin heavy variable IGHV8-51-1 (non-functional)	0.7772	59
TTC24	Tetratricopeptide repeat domain 24	0.7667	6

MEF2C

Cancer enhanced (Leukemia, Lymphoma, Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TEC	Tec protein tyrosine kinase	0.6806	6
PTK2B	Protein tyrosine kinase 2 beta	0.6641	55
PPP3CC	Protein phosphatase 3 catalytic subunit gamma	0.6570	6

MYB

Cancer enhanced (Leukemia, Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RAG1	Recombination activating 1	0.7266	6
RAG2	Recombination activating 2	0.6982	6
TOP2B	DNA topoisomerase II beta	0.6854	6

OLIG1

Cancer enhanced (Leukemia, Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PRAM1	PML-RARA regulated adaptor molecule 1	0.7701	14
SIGLEC1	Sialic acid binding Ig like lectin 1	0.7451	14
FCAR	Fc alpha receptor	0.7427	14

OLIG2

Cancer enhanced (Leukemia, Sarcoma, Skin cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
C3AR1	Complement C3a receptor 1	0.6799	49
C3orf80	Chromosome 3 open reading frame 80	0.6536	49
LTC4S	Leukotriene C4 synthase	0.6306	49

POU4F1

Cancer enhanced (Leukemia, Sarcoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
FOXO6	Forkhead box O6	0.6768	11
SEMA6C	Semaphorin 6C	0.5913	6
LRRC30	Leucine rich repeat containing 30	0.5561	33

RFX8

Cancer enhanced (Leukemia, Sarcoma, Thyroid cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ARL5C	ADP ribosylation factor like GTPase 5C	0.6939	14
SIRPD	Signal regulatory protein delta	0.6746	14
RXFP2	Relaxin family peptide receptor 2	0.6445	14

SATB1

Cancer enhanced (Leukemia, Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
IL3RA	Interleukin 3 receptor subunit alpha	0.5783	21
CISH	Cytokine inducible SH2 containing protein	0.5304	21
IKZF4	IKAROS family zinc finger 4	0.5219	21

SIX6

Cancer enhanced (Leukemia, Uterine cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CD40LG	CD40 ligand	0.7594	59
TRBJ2-1	T cell receptor beta joining 2-1	0.7511	59
MYO7B	Myosin VIIB	0.7501	59

STAT5A

Cancer enhanced (Leukemia)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SAMSN1	SAM domain, SH3 domain and nuclear localization signals 1	0.6587	47
CFAP161	Cilia and flagella associated protein 161	0.6422	47
AQP10	Aquaporin 10	0.5681	47

TCF7

Cancer enhanced (Leukemia)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZAP70	Zeta chain of T cell receptor associated protein kinase 70	0.8472	59
OR10T2	Olfactory receptor family 10 subfamily T member 2	0.7941	59
CD1B	CD1b molecule	0.7889	59

UNCX

Cancer enhanced (Bone cancer, Leukemia)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PDZD7	PDZ domain containing 7	0.6834	11
C1orf232	Chromosome 1 open reading frame 230	0.6646	11
USH2A	Usherin	0.6426	11

VENTX

Cancer enhanced (Leukemia, Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TRPM2	Transient receptor potential cation channel subfamily M member 2	0.6216	14
TIFAB	TIFA inhibitor	0.6110	14
LINGO3	Leucine rich repeat and Ig domain containing 3	0.6011	6

WT1

Cancer enhanced (Leukemia, Ovarian cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
EMX2	Empty spiracles homeobox 2	0.6743	15
OPRPN	Opiorphin prepropeptide	0.6140	15
MEOX1	Mesenchyme homeobox 1	0.6090	15

ZEB2

Cancer enhanced (Leukemia, Skin cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MS4A6A	Membrane spanning 4-domains A6A	0.5472	14
CCL23	C-C motif chemokine ligand 23	0.5157	14
SERPINI2	Serpin family I member 2	0.4901	14

ZNF439

Cancer enhanced (Leukemia)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZNF878	Zinc finger protein 878	0.6871	4
ZNF433	Zinc finger protein 433	0.6830	4
ZNF491	Zinc finger protein 491	0.6653	4

ZNF521

Cancer enhanced (Leukemia, Rhabdoid)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ANGPT1	Angiopoietin 1	0.5132	14
DYNLT5	Dynein light chain Tctex-type family member 5	0.5065	14
LGALS12	Galectin 12	0.4957	14