Transcription factor landscape - Cell line - Rhabdoid

14 different cell lines are representing rhabdoid in the atlas, 13 cell lines belong comes from malignant rhabdoid tumours and one is from an atypical teratoid rhabdoid tumor, find more details about the different cell lines here. For each of the rhabdoid related cell line, up- and downregulated cancer-related pathways can be explored based on the transcriptomics data.

The mean value of the different cell lines are used as representation, when classifying gene expression based on specificity in the different cancer types represented by cell lines. To explore the expression profile in the indivudial cell lines- click the bar in the barchard and you will reach the overivew of the different cell lines.

Here we provide the expression overview of all 39 transcription factors that show elevated expression levels in rhabdoid compared to other cancer cell lines. The gene expression overview, across different cancer types, is accopanied by the top 3 nearest neighbours based on RNA expression and correlation in the clustering analysis.

Enriched transcription factors
Gene Expression Expression clustering
TAL2
Cancer enriched (Rhabdoid)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
OSTN Osteocrin 0.8514 5
TMEM88 Transmembrane protein 88 0.8028 5
CELA3B Chymotrypsin like elastase 3B 0.7890 5
MEOX2
Cancer enriched (Rhabdoid)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
TECRL Trans-2,3-enoyl-CoA reductase like 0.9177 3
MRGPRX1 MAS related GPR family member X1 0.8980 3
SLC26A7 Solute carrier family 26 member 7 0.8915 3
SHOX
Cancer enriched (Rhabdoid)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
PI16 Peptidase inhibitor 16 0.8714 64
COMP Cartilage oligomeric matrix protein 0.8674 64
HSPB7 Heat shock protein family B (small) member 7 0.8651 64

Enriched transcription factors
Gene Expression Expression clustering
OTP
Group enriched (Lymphoma, Rhabdoid)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
FOXP3 Forkhead box P3 0.9788 59
IL5 Interleukin 5 0.9314 59
DYDC1 DPY30 domain containing 1 0.8727 59
TCF21
Group enriched (Bone cancer, Liver cancer, Rhabdoid)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
INMT Indolethylamine N-methyltransferase 0.8776 64
CHRM2 Cholinergic receptor muscarinic 2 0.8632 64
PF4V1 Platelet factor 4 variant 1 0.8626 64
DBX1
Group enriched (Rhabdoid, Sarcoma)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
STATH Statherin 0.8622 33
FGF8 Fibroblast growth factor 8 0.8419 33
MUSTN1 Musculoskeletal, embryonic nuclear protein 1 0.8158 33
SOX17
Group enriched (Liver cancer, Ovarian cancer, Rhabdoid, Uterine cancer)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
LIX1 Limb and CNS expressed 1 0.8005 15
SPON1 Spondin 1 0.7934 15
COL26A1 Collagen type XXVI alpha 1 chain 0.7854 15
TFEC
Group enriched (Leukemia, Lymphoma, Rhabdoid)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
CXCL10 C-X-C motif chemokine ligand 10 0.8486 55
IGKV2D-30 Immunoglobulin kappa variable 2D-30 0.8361 55
ARHGAP25 Rho GTPase activating protein 25 0.8265 55
PAX2
Group enriched (Kidney cancer, Ovarian cancer, Rhabdoid, Uterine cancer)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
C10orf62 Chromosome 10 open reading frame 62 0.7155 15
BIVM-ERCC5 BIVM-ERCC5 readthrough 0.7139 15
FAM149A Family with sequence similarity 149 member A 0.7038 15
GLI1
Group enriched (Bone cancer, Brain cancer, Rhabdoid, Sarcoma)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
BSPH1 Binder of sperm protein homolog 1 0.7406 38
SOX18 SRY-box transcription factor 18 0.7312 38
IL17B Interleukin 17B 0.7254 38
MEOX1
Group enriched (Ovarian cancer, Rhabdoid, Sarcoma, Uterine cancer)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
EMX2 Empty spiracles homeobox 2 0.8123 15
SPON1 Spondin 1 0.7829 15
OPRPN Opiorphin prepropeptide 0.7747 15
TBX2
Group enriched (Neuroblastoma, Rhabdoid, Skin cancer)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
ARMC9 Armadillo repeat containing 9 0.6941 5
MCHR1 Melanin concentrating hormone receptor 1 0.5550 5
TCF21 Transcription factor 21 0.5515 64
EOMES
Group enriched (Lymphoma, Rhabdoid)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
MAGEB4 MAGE family member B4 0.9383 50
LTA Lymphotoxin alpha 0.9340 50
CMA1 Chymase 1 0.9325 50
SOX8
Group enriched (Rhabdoid, Sarcoma, Skin cancer)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
MEGF10 Multiple EGF like domains 10 0.8973 33
ENSG00000284779 Novel protein 0.8809 33
MYMK Myomaker, myoblast fusion factor 0.8793 33

Enriched transcription factors
Gene Expression Expression clustering
HES7
Cancer enhanced (Rhabdoid)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
C1QL4 Complement C1q like 4 0.5164 3
FGF11 Fibroblast growth factor 11 0.4746 5
CEP78 Centrosomal protein 78 0.4365 3
HIC1
Cancer enhanced (Rhabdoid)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
ENSG00000277836 0.7672 46
FCMR Fc mu receptor 0.7628 46
IGLV3-1 Immunoglobulin lambda variable 3-1 0.7498 46
HOXC6
Cancer enhanced (Rhabdoid)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
ENSG00000273049 Novel protein, readthrough between HOXC10 and HOXC5 0.8734 3
HOXC9 Homeobox C9 0.8315 3
HOXC8 Homeobox C8 0.7862 64
HOXC8
Cancer enhanced (Rhabdoid)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
HOXC6 Homeobox C6 0.7862 3
SHOX Short stature homeobox 0.7249 64
HOXC9 Homeobox C9 0.7073 3
HOXC9
Cancer enhanced (Rhabdoid)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
HOXC6 Homeobox C6 0.8315 3
ENSG00000273049 Novel protein, readthrough between HOXC10 and HOXC5 0.7984 3
RTL9 Retrotransposon Gag like 9 0.7536 3
LHX2
Cancer enhanced (Rhabdoid)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
SHISA8 Shisa family member 8 0.6413 10
OR2T34 Olfactory receptor family 2 subfamily T member 34 0.5493 54
TMEM132E Transmembrane protein 132E 0.5086 54
LHX9
Cancer enhanced (Rhabdoid)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
IRS4 Insulin receptor substrate 4 0.5413 3
OLIG3 Oligodendrocyte transcription factor 3 0.4792 65
PIK3C2G Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma 0.4719 5
LMX1B
Cancer enhanced (Breast cancer, Rhabdoid)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
PRLR Prolactin receptor 0.6615 27
P2RX2 Purinergic receptor P2X 2 0.6526 27
ETNK2 Ethanolamine kinase 2 0.6477 27
NFATC4
Cancer enhanced (Rhabdoid)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
LUM Lumican 0.6559 5
C11orf87 Chromosome 11 open reading frame 87 0.5722 5
DDR2 Discoidin domain receptor tyrosine kinase 2 0.5562 44
NR2F1
Cancer enhanced (Rhabdoid)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
EPHA7 EPH receptor A7 0.6498 5
KERA Keratocan 0.6266 5
FAM171B Family with sequence similarity 171 member B 0.6163 5
PEG3
Cancer enhanced (Prostate cancer, Rhabdoid)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
ZIM2 Zinc finger imprinted 2 0.7846 5
PRND Prion like protein doppel 0.7506 5
CETN1 Centrin 1 0.7495 5
PLAGL1
Cancer enhanced (Rhabdoid)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
COL3A1 Collagen type III alpha 1 chain 0.5767 64
PRKG1 Protein kinase cGMP-dependent 1 0.5673 64
C8orf34 Chromosome 8 open reading frame 34 0.5029 33
PRRX1
Cancer enhanced (Brain cancer, Rhabdoid)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
COL6A1 Collagen type VI alpha 1 chain 0.7162 64
PLPP3 Phospholipid phosphatase 3 0.6999 64
OMD Osteomodulin 0.6988 44
PTF1A
Cancer enhanced (Rhabdoid)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
VWC2L Von Willebrand factor C domain containing 2 like 0.7694 10
FFAR2 Free fatty acid receptor 2 0.7590 10
ENSG00000290217 Novel protein 0.7269 10
SOX14
Cancer enhanced (Colorectal cancer, Rhabdoid)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
SLC7A8 Solute carrier family 7 member 8 0.5872 3
OTOP1 Otopetrin 1 0.5853 32
PCDH19 Protocadherin 19 0.5697 32
SP9
Cancer enhanced (Adrenocortical cancer, Rhabdoid)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
MLNR Motilin receptor 0.5695 4
SCN1A Sodium voltage-gated channel alpha subunit 1 0.5219 10
BARX1 BARX homeobox 1 0.5073 10
TBR1
Cancer enhanced (Brain cancer, Rhabdoid)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
PDE6H Phosphodiesterase 6H 0.8384 1
EFCAB10 EF-hand calcium binding domain 10 0.8316 1
PCARE Photoreceptor cilium actin regulator 0.8313 1
TBX1
Cancer enhanced (Rhabdoid)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
EDN3 Endothelin 3 0.7288 65
TRAV40 T cell receptor alpha variable 40 0.7250 65
TRAV38-2DV8 T cell receptor alpha variable 38-2/delta variable 8 0.7196 65
TLX1
Cancer enhanced (Bone cancer, Rhabdoid)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
GDF10 Growth differentiation factor 10 0.6273 12
TPTE2 Transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 0.6049 12
XKR4 XK related 4 0.5946 12
ZIC1
Cancer enhanced (Rhabdoid)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
ZIC4 Zic family member 4 0.8755 5
ZSWIM2 Zinc finger SWIM-type containing 2 0.7134 5
CCDC102B Coiled-coil domain containing 102B 0.7107 5
ZIM2
Cancer enhanced (Rhabdoid)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
PEG3 Paternally expressed 3 0.7846 5
RERG RAS like estrogen regulated growth inhibitor 0.5996 27
CETN1 Centrin 1 0.5390 5
ZNF154
Cancer enhanced (Rhabdoid, Testis cancer)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
LCT Lactase 0.5411 59
OR10T2 Olfactory receptor family 10 subfamily T member 2 0.5209 59
ZNF671 Zinc finger protein 671 0.5174 4
ZNF467
Cancer enhanced (Rhabdoid)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
CD34 CD34 molecule 0.6130 14
SPINT3 Serine peptidase inhibitor, Kunitz type 3 0.5419 14
FGD5 FYVE, RhoGEF and PH domain containing 5 0.5340 48
ZNF521
Cancer enhanced (Leukemia, Rhabdoid)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
ANGPT1 Angiopoietin 1 0.5132 14
DYNLT5 Dynein light chain Tctex-type family member 5 0.5065 14
LGALS12 Galectin 12 0.4957 14
ZSCAN1
Cancer enhanced (Rhabdoid)
3 nearest neighbours based on cell line RNA expression
Neighbouri Descriptioni Correlationi Clusteri
ZNF732 Zinc finger protein 732 0.6668 4
ZNF135 Zinc finger protein 135 0.6559 4
ZSCAN18 Zinc finger and SCAN domain containing 18 0.6447 4