Transcription factor landscape - Cell line - lymphoma

76 different cell lines are representing lymphoma in the atlas, different ages, collection site and cancer subtypes are represented, find more details about the different cell lines here. For each of the rhabdoid related cell line, up- and downregulated cancer-related pathways can be explored based on the transcriptomics data.

The mean value of the different cell lines are used as representation, when classifying gene expression based on specificity in the different cancer types represented by cell lines. To explore the expression profile in the indivudial cell lines- click the bar in the bar chart and you will reach the overivew of the different cell lines.

Here we provide the expression overview of all 50 transcription factors that show elevated expression levels in lymphoma compared to other cancer cell lines. The gene expression overview, across different cancer types, is accopanied by the top 3 nearest neighbours based on RNA expression and correlation in the clustering analysis.

Enriched transcription factors

Gene

Expression

Expression clustering

SPIB

Cancer enriched (Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
IGKV2D-30	Immunoglobulin kappa variable 2D-30	0.9013	55
IGKV2D-24	Immunoglobulin kappa variable 2D-24 (non-functional)	0.8991	55
GPR33	G protein-coupled receptor 33	0.8949	55

ETV3L

Cancer enriched (Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CLDN14	Claudin 14	0.9780	21
COL6A5	Collagen type VI alpha 5 chain	0.9501	21
TRAJ42	T cell receptor alpha joining 42	0.9439	21

SPIC

Cancer enriched (Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CXCL10	C-X-C motif chemokine ligand 10	0.8887	55
BATF	Basic leucine zipper ATF-like transcription factor	0.8514	55
CLEC4C	C-type lectin domain family 4 member C	0.8498	55

DMRT1

Cancer enriched (Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SUPT20HL1	SUPT20H like 1	0.9428	71
GZMB	Granzyme B	0.9315	71
CLDN24	Claudin 24	0.9303	71

MEF2B

Cancer enriched (Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HLA-DOB	Major histocompatibility complex, class II, DO beta	0.8523	46
PSMA8	Proteasome 20S subunit alpha 8	0.8361	46
STAP1	Signal transducing adaptor family member 1	0.8248	46

BACH2

Cancer enriched (Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ENSG00000285947	Novel protein	0.8439	46
HRK	Harakiri, BCL2 interacting protein	0.8322	46
IGLV10-54	Immunoglobulin lambda variable 10-54	0.8254	46

BATF

Cancer enriched (Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CXCL10	C-X-C motif chemokine ligand 10	0.8535	55
SPIC	Spi-C transcription factor	0.8514	55
CLEC4C	C-type lectin domain family 4 member C	0.8118	55

BCL6

Cancer enriched (Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ELL3	Elongation factor for RNA polymerase II 3	0.9169	46
ZPBP2	Zona pellucida binding protein 2	0.8713	46
SERPINA9	Serpin family A member 9	0.8635	46

Enriched transcription factors

Gene

Expression

Expression clustering

IKZF1

Group enriched (Leukemia, Lymphoma, Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PAX5	Paired box 5	0.5982	6
PTGDR	Prostaglandin D2 receptor	0.5858	6
ARHGAP25	Rho GTPase activating protein 25	0.5830	55

OTP

Group enriched (Lymphoma, Rhabdoid)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
FOXP3	Forkhead box P3	0.9788	59
IL5	Interleukin 5	0.9314	59
DYDC1	DPY30 domain containing 1	0.8727	59

CEBPE

Group enriched (Leukemia, Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ADGRG3	Adhesion G protein-coupled receptor G3	0.8794	71
CLEC4D	C-type lectin domain family 4 member D	0.8721	71
AOAH	Acyloxyacyl hydrolase	0.8626	71

SPI1

Group enriched (Leukemia, Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MYO1F	Myosin IF	0.7665	14
TYROBP	Transmembrane immune signaling adaptor TYROBP	0.7153	49
RAB44	RAB44, member RAS oncogene family	0.7098	14

TBX21

Group enriched (Leukemia, Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
OR6S1	Olfactory receptor family 6 subfamily S member 1	0.8729	55
IFNA2	Interferon alpha 2	0.8665	55
SLAMF1	Signaling lymphocytic activation molecule family member 1	0.8635	55

TFEC

Group enriched (Leukemia, Lymphoma, Rhabdoid)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CXCL10	C-X-C motif chemokine ligand 10	0.8486	55
IGKV2D-30	Immunoglobulin kappa variable 2D-30	0.8361	55
ARHGAP25	Rho GTPase activating protein 25	0.8265	55

LYL1

Group enriched (Leukemia, Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GBGT1	Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (FORS blood group)	0.7059	47
INKA1	Inka box actin regulator 1	0.6649	35
HHEX	Hematopoietically expressed homeobox	0.6476	14

PAX5

Group enriched (Leukemia, Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
NIBAN3	Niban apoptosis regulator 3	0.8332	46
BLNK	B cell linker	0.8224	55
TCL1A	TCL1 family AKT coactivator A	0.8165	46

IRF4

Group enriched (Lymphoma, Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PRDM1	PR/SET domain 1	0.7675	51
LIMD1	LIM domain containing 1	0.5869	51
SLAMF7	SLAM family member 7	0.5684	51

IRF8

Group enriched (Leukemia, Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CNR2	Cannabinoid receptor 2	0.6375	55
NUDT7	Nudix hydrolase 7	0.6138	14
SWAP70	Switching B cell complex subunit SWAP70	0.6052	46

IKZF3

Group enriched (Lymphoma, Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MAP4K1	Mitogen-activated protein kinase kinase kinase kinase 1	0.6740	46
POU2F2	POU class 2 homeobox 2	0.6577	55
RASGRP3	RAS guanyl releasing protein 3	0.6421	46

BATF3

Group enriched (Adrenocortical cancer, Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GZMH	Granzyme H	0.7636	71
H2AB1	H2A.B variant histone 1	0.7482	50
IL1R2	Interleukin 1 receptor type 2	0.7405	71

TBXT

Group enriched (Leukemia, Lung cancer, Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
LCN1	Lipocalin 1	0.6990	7
IL4I1	Interleukin 4 induced 1	0.4915	50
UGT2B17	UDP glucuronosyltransferase family 2 member B17	0.4796	55

ARID5A

Group enriched (Leukemia, Lymphoma, Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TNFRSF8	TNF receptor superfamily member 8	0.7390	21
PROB1	Proline rich basic protein 1	0.7166	21
SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	0.6991	21

EOMES

Group enriched (Lymphoma, Rhabdoid)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MAGEB4	MAGE family member B4	0.9383	50
LTA	Lymphotoxin alpha	0.9340	50
CMA1	Chymase 1	0.9325	50

SP140

Group enriched (Lymphoma, Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CLEC17A	C-type lectin domain containing 17A	0.7667	55
FGD2	FYVE, RhoGEF and PH domain containing 2	0.7606	55
TNFRSF13B	TNF receptor superfamily member 13B	0.7590	55

POU2F2

Group enriched (Lymphoma, Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CD37	CD37 molecule	0.8430	55
SPIB	Spi-B transcription factor	0.8354	55
TLR9	Toll like receptor 9	0.8220	55

ZBTB32

Group enriched (Lymphoma, Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CCL4	C-C motif chemokine ligand 4	0.9293	55
EBI3	Epstein-Barr virus induced 3	0.9260	55
CCL22	C-C motif chemokine ligand 22	0.9223	55

Enriched transcription factors

Gene

Expression

Expression clustering

ATF5

Cancer enhanced (Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CD83	CD83 molecule	0.6262	55
SPIB	Spi-B transcription factor	0.6256	55
CXCR5	C-X-C motif chemokine receptor 5	0.6083	55

BCL11A

Cancer enhanced (Leukemia, Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CD72	CD72 molecule	0.6838	35
ZCCHC7	Zinc finger CCHC-type containing 7	0.6135	35
SPATA48	Spermatogenesis associated 48	0.5935	35

CUX2

Cancer enhanced (Bone cancer, Lymphoma, Neuroblastoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MYO9A	Myosin IXA	0.5380	46
C8orf89	Chromosome 8 open reading frame 89	0.5321	46
MAPK10	Mitogen-activated protein kinase 10	0.5315	46

E2F5

Cancer enhanced (Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
OR13A1	Olfactory receptor family 13 subfamily A member 1	0.7245	46
HLA-DOB	Major histocompatibility complex, class II, DO beta	0.7196	46
STAP1	Signal transducing adaptor family member 1	0.7066	46

EBF1

Cancer enhanced (Leukemia, Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SH2D4B	SH2 domain containing 4B	0.8679	6
DNTT	DNA nucleotidylexotransferase	0.8563	6
GRID2IP	Grid2 interacting protein	0.8392	6

EGR2

Cancer enhanced (Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
NOD2	Nucleotide binding oligomerization domain containing 2	0.5662	71
TRAV13-1	T cell receptor alpha variable 13-1	0.5639	71
BCL2A1	BCL2 related protein A1	0.5621	55

ESR2

Cancer enhanced (Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MEF2B	Myocyte enhancer factor 2B	0.7431	46
PSMA8	Proteasome 20S subunit alpha 8	0.7020	46
GNA13	G protein subunit alpha 13	0.6757	46

FOXO1

Cancer enhanced (Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
BACH2	BTB domain and CNC homolog 2	0.6375	46
VPREB3	V-set pre-B cell surrogate light chain 3	0.6260	6
GPR18	G protein-coupled receptor 18	0.6251	46

FOXP3

Cancer enhanced (Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
OTP	Orthopedia homeobox	0.9788	59
IL5	Interleukin 5	0.9550	59
CCR4	C-C motif chemokine receptor 4	0.8919	59

HOPX

Cancer enhanced (Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MUC21	Mucin 21, cell surface associated	0.5755	53
SFTPA2	Surfactant protein A2	0.5656	53
SFTPA1	Surfactant protein A1	0.5188	53

IKZF2

Cancer enhanced (Leukemia, Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TRAJ7	T cell receptor alpha joining 7	0.6130	59
TRAV16	T cell receptor alpha variable 16	0.5935	59
TRAJ6	T cell receptor alpha joining 6	0.5856	59

IRF5

Cancer enhanced (Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PLA2G2D	Phospholipase A2 group IID	0.7124	21
BATF3	Basic leucine zipper ATF-like transcription factor 3	0.6937	50
STX11	Syntaxin 11	0.6887	71

MEF2C

Cancer enhanced (Leukemia, Lymphoma, Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TEC	Tec protein tyrosine kinase	0.6806	6
PTK2B	Protein tyrosine kinase 2 beta	0.6641	55
PPP3CC	Protein phosphatase 3 catalytic subunit gamma	0.6570	6

MIXL1

Cancer enhanced (Lymphoma, Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SERPINA11	Serpin family A member 11	0.6450	18
ZPBP2	Zona pellucida binding protein 2	0.6111	46
SAMD7	Sterile alpha motif domain containing 7	0.5958	55

MYB

Cancer enhanced (Leukemia, Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RAG1	Recombination activating 1	0.7266	6
RAG2	Recombination activating 2	0.6982	6
TOP2B	DNA topoisomerase II beta	0.6854	6

NFATC1

Cancer enhanced (Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
FCRLA	Fc receptor like A	0.6906	46
CD52	CD52 molecule	0.6874	46
C9orf57	Chromosome 9 open reading frame 57	0.6580	46

NFKBID

Cancer enhanced (Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SPIB	Spi-B transcription factor	0.8187	55
SH3TC1	SH3 domain and tetratricopeptide repeats 1	0.8063	55
FCRL5	Fc receptor like 5	0.8002	55

PRDM15

Cancer enhanced (Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
APOL5	Apolipoprotein L5	0.8611	46
IGKV5-2	Immunoglobulin kappa variable 5-2	0.8226	46
FCRL1	Fc receptor like 1	0.8070	46

REL

Cancer enhanced (Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CD83	CD83 molecule	0.7803	55
CNR2	Cannabinoid receptor 2	0.7325	55
CXCR5	C-X-C motif chemokine receptor 5	0.7156	55

RUNX3

Cancer enhanced (Lymphoma, Myeloma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RGS1	Regulator of G protein signaling 1	0.6707	55
TNFRSF14	TNF receptor superfamily member 14	0.6052	9
TRAF1	TNF receptor associated factor 1	0.5898	55

TFEB

Cancer enhanced (Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HVCN1	Hydrogen voltage gated channel 1	0.8119	55
SCIMP	SLP adaptor and CSK interacting membrane protein	0.7672	55
OR2T2	Olfactory receptor family 2 subfamily T member 2	0.7581	55

ZNF107

Cancer enhanced (Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
IGLV10-54	Immunoglobulin lambda variable 10-54	0.7400	46
BACH2	BTB domain and CNC homolog 2	0.7366	46
ZNF92	Zinc finger protein 92	0.7208	46

ZNF296

Cancer enhanced (Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
BCL2L11	BCL2 like 11	0.6863	55
SPIB	Spi-B transcription factor	0.6476	55
MPEG1	Macrophage expressed 1	0.6080	55

ZNF80

Cancer enhanced (Lymphoma)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
KIR2DL4	Killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	0.7952	71
CD300H	CD300H molecule (gene/pseudogene)	0.7593	71
SLC26A4	Solute carrier family 26 member 4	0.7573	71