Transcription factor landscape - Cell line - testis cancer

One cell line represent testis cancer in the atlas, find more details about the cell line here. The expression profile of the cell line can be explored in comparison to the bulk RNAseq transcriptomics data from TCGA's Testicular Germ Cell Tumors (TGCT), defining the cell line expression similarity to solid tumour expression profile.

Here we provide the expression overview of all 49 transcription factors that show elevated expression levels in testis cancer compared to other cancer cell lines. The gene expression overview, across different cancer types, is accopanied by the top 3 nearest neighbours based on RNA expression and correlation in the clustering analysis.

Enriched transcription factors

Gene

Expression

Expression clustering

NANOG

Cancer enriched (Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GDF3	Growth differentiation factor 3	0.9965	34
NANOGP8	Nanog homeobox retrogene P8	0.9820	34
ZSCAN10	Zinc finger and SCAN domain containing 10	0.9692	34

FOXI3

Cancer enriched (Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
DPPA3	Developmental pluripotency associated 3	0.8070	34
GPR32	G protein-coupled receptor 32	0.7801	34
HTRA4	HtrA serine peptidase 4	0.7644	34

POU5F1

Cancer enriched (Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ANKDD1B	Ankyrin repeat and death domain containing 1B	0.6684	15
PTH1R	Parathyroid hormone 1 receptor	0.6427	15
DCAF12L1	DDB1 and CUL4 associated factor 12 like 1	0.6258	15

ZFP42

Cancer enriched (Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HTRA4	HtrA serine peptidase 4	0.7140	34
GH2	Growth hormone 2	0.7110	34
GPR32	G protein-coupled receptor 32	0.7080	34

GCM1

Cancer enriched (Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HTRA4	HtrA serine peptidase 4	0.9505	34
GPR32	G protein-coupled receptor 32	0.9501	34
ISM2	Isthmin 2	0.9487	34

DNMT3L

Cancer enriched (Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HTRA4	HtrA serine peptidase 4	0.9231	34
DPPA3	Developmental pluripotency associated 3	0.9215	34
GPR32	G protein-coupled receptor 32	0.9213	34

PRDM14

Cancer enriched (Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
VRTN	Vertebrae development associated	0.9781	34
ZSCAN10	Zinc finger and SCAN domain containing 10	0.9580	34
NANOG	Nanog homeobox	0.9465	34

ZIC3

Cancer enriched (Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PRDM14	PR/SET domain 14	0.8463	34
VRTN	Vertebrae development associated	0.8293	34
HES3	Hes family bHLH transcription factor 3	0.8158	34

ZSCAN10

Cancer enriched (Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
VRTN	Vertebrae development associated	0.9696	34
NANOG	Nanog homeobox	0.9692	34
GDF3	Growth differentiation factor 3	0.9605	34

DNMT3B

Cancer enriched (Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ERVFRD-1	Endogenous retrovirus group FRD member 1, envelope	0.7720	34
TRIM71	Tripartite motif containing 71	0.7669	34
NR6A1	Nuclear receptor subfamily 6 group A member 1	0.7437	34

ZFP57

Cancer enriched (Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TEX37	Testis expressed 37	0.5673	34
HTRA4	HtrA serine peptidase 4	0.5561	34
GPR32	G protein-coupled receptor 32	0.5508	34

ZNF729

Cancer enriched (Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZNF676	Zinc finger protein 676	0.9205	4
ZNF98	Zinc finger protein 98	0.8955	4
ZNF99	Zinc finger protein 99	0.8391	4

ZNF18

Cancer enriched (Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GID4	GID complex subunit 4 homolog	0.6174	42
NCOR1	Nuclear receptor corepressor 1	0.5993	42
ZNF624	Zinc finger protein 624	0.5966	42

ZNF90

Cancer enriched (Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZNF93	Zinc finger protein 93	0.8456	4
ZNF486	Zinc finger protein 486	0.8066	4
ZNF85	Zinc finger protein 85	0.7616	4

Enriched transcription factors

Gene

Expression

Expression clustering

FOXE3

Group enriched (Adrenocortical cancer, Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
KDM4E	Lysine demethylase 4E	0.6666	4
ARHGEF33	Rho guanine nucleotide exchange factor 33	0.6498	4
RIT2	Ras like without CAAX 2	0.6450	66

HAND1

Group enriched (Neuroblastoma, Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TRBV2	T cell receptor beta variable 2	0.8582	59
TRAV13-2	T cell receptor alpha variable 13-2	0.8265	59
MS4A6E	Membrane spanning 4-domains A6E	0.8265	59

SOX3

Group enriched (Brain cancer, Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
C7orf57	Chromosome 7 open reading frame 57	0.7825	72
DIRAS3	DIRAS family GTPase 3	0.6841	72
LHCGR	Luteinizing hormone/choriogonadotropin receptor	0.6743	72

PKNOX2

Group enriched (Bone cancer, Sarcoma, Skin cancer, Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
COL9A1	Collagen type IX alpha 1 chain	0.6955	54
MEGF10	Multiple EGF like domains 10	0.6647	33
SOX8	SRY-box transcription factor 8	0.6575	33

Enriched transcription factors

Gene

Expression

Expression clustering

ARID3B

Cancer enhanced (Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
NR6A1	Nuclear receptor subfamily 6 group A member 1	0.5713	34
LIN28A	Lin-28 homolog A	0.5423	34
SALL4	Spalt like transcription factor 4	0.5389	34

DLX6

Cancer enhanced (Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
DLX5	Distal-less homeobox 5	0.9386	10
DYNC1I1	Dynein cytoplasmic 1 intermediate chain 1	0.7570	10
CDKAL1	CDK5 regulatory subunit associated protein 1 like 1	0.6623	65

FOXH1

Cancer enhanced (Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
LIN28A	Lin-28 homolog A	0.7609	34
OR6K6	Olfactory receptor family 6 subfamily K member 6	0.6901	34
ZSCAN10	Zinc finger and SCAN domain containing 10	0.6821	34

FOXI1

Cancer enhanced (Breast cancer, Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RGS21	Regulator of G protein signaling 21	0.5790	24
AMY2A	Amylase alpha 2A	0.5628	24
POU2F3	POU class 2 homeobox 3	0.5562	24

FOXO4

Cancer enhanced (Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GCM1	Glial cells missing transcription factor 1	0.7378	34
ISM2	Isthmin 2	0.7358	34
DPPA3	Developmental pluripotency associated 3	0.7355	34

GRHL3

Cancer enhanced (Gallbladder cancer, Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SPRR3	Small proline rich protein 3	0.6783	53
OVOL1	Ovo like transcriptional repressor 1	0.6055	53
GJB6	Gap junction protein beta 6	0.5974	53

HIF3A

Cancer enhanced (Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PLIN4	Perilipin 4	0.5300	44
NPR1	Natriuretic peptide receptor 1	0.5041	44
PRXL2A	Peroxiredoxin like 2A	0.5005	44

JARID2

Cancer enhanced (Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ERVFRD-1	Endogenous retrovirus group FRD member 1, envelope	0.4676	34
PSTPIP1	Proline-serine-threonine phosphatase interacting protein 1	0.4206	14
SLC7A3	Solute carrier family 7 member 3	0.4205	34

KDM5D

Cancer enhanced (Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
UTY	Ubiquitously transcribed tetratricopeptide repeat containing, Y-linked	0.8611	47
DDX3Y	DEAD-box helicase 3 Y-linked	0.8214	47
ZFY	Zinc finger protein Y-linked	0.7887	47

L3MBTL1

Cancer enhanced (Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
FBXL2	F-box and leucine rich repeat protein 2	0.4658	56
PABPC1L	Poly(A) binding protein cytoplasmic 1 like	0.4588	56
NODAL	Nodal growth differentiation factor	0.4561	32

MIXL1

Cancer enhanced (Lymphoma, Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SERPINA11	Serpin family A member 11	0.6450	18
ZPBP2	Zona pellucida binding protein 2	0.6111	46
SAMD7	Sterile alpha motif domain containing 7	0.5958	55

MSX2

Cancer enhanced (Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ISM2	Isthmin 2	0.6761	34
LGALS16	Galectin 16	0.6707	34
ACTA1	Actin alpha 1, skeletal muscle	0.6609	34

NKX1-2

Cancer enhanced (Gallbladder cancer, Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
NPBWR1	Neuropeptides B and W receptor 1	0.6227	53
DNAH2	Dynein axonemal heavy chain 2	0.5560	53
MUC21	Mucin 21, cell surface associated	0.5429	53

NR6A1

Cancer enhanced (Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TRIM71	Tripartite motif containing 71	0.8634	34
DPPA3	Developmental pluripotency associated 3	0.7612	34
LIN28A	Lin-28 homolog A	0.7600	34

POU6F2

Cancer enhanced (Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SLCO1A2	Solute carrier organic anion transporter family member 1A2	0.6209	56
GABRG2	Gamma-aminobutyric acid type A receptor subunit gamma2	0.6026	56
GPR148	G protein-coupled receptor 148	0.5461	10

SALL2

Cancer enhanced (Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZIC3	Zic family member 3	0.5713	34
PRDM14	PR/SET domain 14	0.5594	34
HES3	Hes family bHLH transcription factor 3	0.5542	34

SALL4

Cancer enhanced (Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
LIN28A	Lin-28 homolog A	0.6635	34
UTF1	Undifferentiated embryonic cell transcription factor 1	0.6587	5
SKIDA1	SKI/DACH domain containing 1	0.6379	5

TCF15

Cancer enhanced (Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GCSAML	Germinal center associated signaling and motility like	0.5657	49
SLC18A2	Solute carrier family 18 member A2	0.5513	49
RHEX	Regulator of hemoglobinization and erythroid cell expansion	0.5450	49

TET1

Cancer enhanced (Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TRIM71	Tripartite motif containing 71	0.5537	34
LIN28B	Lin-28 homolog B	0.5351	34
DNMT3B	DNA methyltransferase 3 beta	0.5331	34

VENTX

Cancer enhanced (Leukemia, Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TRPM2	Transient receptor potential cation channel subfamily M member 2	0.6216	14
TIFAB	TIFA inhibitor	0.6110	14
LINGO3	Leucine rich repeat and Ig domain containing 3	0.6011	6

ZKSCAN7

Cancer enhanced (Neuroblastoma, Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZNF660	Zinc finger protein 660	0.5543	17
RTL1	Retrotransposon Gag like 1	0.5228	17
NACAD	NAC alpha domain containing	0.5131	17

ZNF117

Cancer enhanced (Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ERV3-1	Endogenous retrovirus group 3 member 1, envelope	0.8582	57
ZNF138	Zinc finger protein 138	0.4993	39
ZNF429	Zinc finger protein 429	0.4623	4

ZNF154

Cancer enhanced (Rhabdoid, Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
LCT	Lactase	0.5411	59
OR10T2	Olfactory receptor family 10 subfamily T member 2	0.5209	59
ZNF671	Zinc finger protein 671	0.5174	4

ZNF286A

Cancer enhanced (Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
FOXO3B	Forkhead box O3B	0.8878	42
ZNF624	Zinc finger protein 624	0.6531	42
ZSWIM7	Zinc finger SWIM-type containing 7	0.6502	42

ZNF334

Cancer enhanced (Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
COL9A2	Collagen type IX alpha 2 chain	0.5362	11
OPTC	Opticin	0.5244	10
NNAT	Neuronatin	0.5199	11

ZNF423

Cancer enhanced (Neuroblastoma, Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PRR35	Proline rich 35	0.5578	65
LRRC55	Leucine rich repeat containing 55	0.5545	65
TRAJ49	T cell receptor alpha joining 49	0.5336	65

ZNF454

Cancer enhanced (Neuroblastoma, Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZNF354C	Zinc finger protein 354C	0.8062	4
ZNF732	Zinc finger protein 732	0.7144	4
ZNF677	Zinc finger protein 677	0.7002	4

ZNF560

Cancer enhanced (Adrenocortical cancer, Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZNF729	Zinc finger protein 729	0.7335	4
ZNF676	Zinc finger protein 676	0.7144	4
ZNF728	Zinc finger protein 728	0.7075	4

ZNF624

Cancer enhanced (Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
NCOR1	Nuclear receptor corepressor 1	0.6785	42
ZNF286A	Zinc finger protein 286A	0.6531	42
GID4	GID complex subunit 4 homolog	0.6354	42

ZNF660

Cancer enhanced (Neuroblastoma, Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZKSCAN7	Zinc finger with KRAB and SCAN domains 7	0.5543	17
SPSB4	SplA/ryanodine receptor domain and SOCS box containing 4	0.5004	33
DCHS1	Dachsous cadherin-related 1	0.4897	17

ZNF676

Cancer enhanced (Testis cancer)

3 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZNF729	Zinc finger protein 729	0.9205	4
ZNF723	Zinc finger protein 723	0.8426	4
ZNF728	Zinc finger protein 728	0.8377	4