Transcription factor landscape - Immune cell - T-cells

Transcriptome analysis shows that 51% (n=10281) of all human proteins (n=20162) are detected in t-cells and 445 of these genes show an elevated expression in any t-cells compared to other cell type groups. Learn more about genes with elevated expression here.

In-depth analysis of transcription factor genes expressed in t-cells highlights 43 transcription factors with elevated expression in t-cells compared to other immune lineages. In total, 18 transcription factors are classified as enriched in t-cells.

Here we provide the expression overview of all transcription factors that show enriched expression levels in t-cells compared to other cell types. The gene expression overview, across different cell types is accopanied by the top 3 nearest neighbours based on single cell RNA expression and correlation in the clustering analysis.

Enriched transcription factors

Gene

Expression

Expression clustering

FOXP3

Lineage enriched (T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
KIF4A	Kinesin family member 4A	1.0000	9
ENSG00000290184	Novel protein	1.0000	9
GAGE12B	G antigen 12B	1.0000	9

MEOX1

Lineage enriched (T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HSPA8	Heat shock protein family A (Hsp70) member 8	1.0000	9
JAKMIP1	Janus kinase and microtubule interacting protein 1	1.0000	9
CCNA2	Cyclin A2	1.0000	9

RORC

Lineage enriched (T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TRAJ33	T cell receptor alpha joining 33	1.0000	1
KIAA1671	KIAA1671	1.0000	1
CPNE7	Copine 7	1.0000	1

RHOXF1

Lineage enriched (T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HSPA8	Heat shock protein family A (Hsp70) member 8	1.0000	9
JAKMIP1	Janus kinase and microtubule interacting protein 1	1.0000	9
CCNA2	Cyclin A2	1.0000	9

HOXC5

Lineage enriched (T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
N/A

GSC

Lineage enriched (T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GZMK	Granzyme K	0.9762	1
CCL5	C-C motif chemokine ligand 5	0.9762	1
TRGC2	T cell receptor gamma constant 2	0.9762	1

ZNF683

Lineage enriched (T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
COL6A2	Collagen type VI alpha 2 chain	1.0000	1
A2M	Alpha-2-macroglobulin	1.0000	1
LONRF3	LON peptidase N-terminal domain and ring finger 3	1.0000	1

BCL11B

Lineage enriched (T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CD8A	CD8a molecule	1.0000	11
IGHJ2	Immunoglobulin heavy joining 2	1.0000	11
GIMAP5	GTPase, IMAP family member 5	1.0000	11

FOXB1

Lineage enriched (T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
N/A

IKZF4

Lineage enriched (T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
NEIL3	Nei like DNA glycosylase 3	1.0000	9
JAKMIP1	Janus kinase and microtubule interacting protein 1	1.0000	9
CCNA2	Cyclin A2	1.0000	9

PBX4

Lineage enriched (T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PDCD1	Programmed cell death 1	1.0000	9
NPDC1	Neural proliferation, differentiation and control 1	1.0000	9
CHN1	Chimerin 1	1.0000	9

NR3C2

Lineage enriched (T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SLC39A14	Solute carrier family 39 member 14	1.0000	43
TRAJ61	T cell receptor alpha joining 61 (non-functional)	1.0000	43
GPRASP1	G protein-coupled receptor associated sorting protein 1	1.0000	43

BATF

Lineage enriched (T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TRBV16	T cell receptor beta variable 16	1.0000	9
LIMA1	LIM domain and actin binding 1	1.0000	9
TRBV7-4	T cell receptor beta variable 7-4	1.0000	9

BNC2

Lineage enriched (T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
N/A

TSHZ2

Lineage enriched (T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TRBV12-5	T cell receptor beta variable 12-5	1.0000	31
TRBV5-7	T cell receptor beta variable 5-7 (non-functional)	1.0000	31
CFAP95	Cilia and flagella associated protein 95	1.0000	31

LEF1

Lineage enriched (T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TRAV30	T cell receptor alpha variable 30	1.0000	39
TRAV18	T cell receptor alpha variable 18	1.0000	39
PRKAR1B	Protein kinase cAMP-dependent type I regulatory subunit beta	1.0000	39

RORA

Lineage enriched (T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZNF831	Zinc finger protein 831	1.0000	1
XPOT	Exportin for tRNA	1.0000	1
SH2D1A	SH2 domain containing 1A	1.0000	1

ZNF80

Lineage enriched (T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
N/A

Enriched transcription factors

Gene

Expression

Expression clustering

EOMES

Group enriched (Nk-cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
KIR3DL1	Killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1	1.0000	15
TRGC1	T cell receptor gamma constant 1	1.0000	15
TRGJP2	T cell receptor gamma joining P2	1.0000	15

GATA3

Group enriched (Nk-cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZNF831	Zinc finger protein 831	1.0000	1
XPOT	Exportin for tRNA	1.0000	1
SH2D1A	SH2 domain containing 1A	1.0000	1

ID3

Group enriched (B-cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ENSG00000281179	Novel gene identicle to IGHV1OR15-1	1.0000	43
IGHV1OR15-1	Immunoglobulin heavy variable 1/OR15-1 (non-functional)	1.0000	43
H3C3	H3 clustered histone 3	0.9762	43

MSC

Group enriched (B-cells, Dendritic cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PTTG1	PTTG1 regulator of sister chromatid separation, securin	1.0000	16
TNFRSF19	TNF receptor superfamily member 19	0.9762	16
PCLAF	PCNA clamp associated factor	0.9762	16

TCF7

Group enriched (Nk-cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
BCL9	BCL9 transcription coactivator	1.0000	43
TRAJ61	T cell receptor alpha joining 61 (non-functional)	1.0000	43
GPRASP1	G protein-coupled receptor associated sorting protein 1	1.0000	43

HOPX

Group enriched (Nk-cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
XCL2	X-C motif chemokine ligand 2	1.0000	15
TBXT	T-box transcription factor T	1.0000	15
ZNF333	Zinc finger protein 333	1.0000	15

ZNF239

Group enriched (B-cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CTH	Cystathionine gamma-lyase	1.0000	43
RPSAP58	Ribosomal protein SA pseudogene 58	1.0000	43
PDE7A	Phosphodiesterase 7A	1.0000	43

TBX21

Group enriched (Nk-cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
XCL2	X-C motif chemokine ligand 2	1.0000	15
TBXT	T-box transcription factor T	1.0000	15
ZNF333	Zinc finger protein 333	1.0000	15

GFI1

Group enriched (Dendritic cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TRGV5	T cell receptor gamma variable 5	1.0000	1
IFNL1	Interferon lambda 1	1.0000	1
KLRK1	Killer cell lectin like receptor K1	0.9762	1

NR1D1

Group enriched (Monocytes, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PAM	Peptidylglycine alpha-amidating monooxygenase	0.9762	1
KLHL25	Kelch like family member 25	0.9762	1
GPR137C	G protein-coupled receptor 137C	0.9762	1

STAT4

Group enriched (Nk-cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SPEF2	Sperm flagellar 2	1.0000	1
DPP4	Dipeptidyl peptidase 4	1.0000	1
GZMM	Granzyme M	1.0000	1

HSF5

Group enriched (B-cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
METAP1D	Methionyl aminopeptidase type 1D, mitochondrial	1.0000	43
ST6GAL1	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	1.0000	43
EIF4A2	Eukaryotic translation initiation factor 4A2	0.9762	43

IKZF2

Group enriched (Granulocytes, Nk-cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TMEM87A	Transmembrane protein 87A	1.0000	5
WDR44	WD repeat domain 44	0.9762	5
RPA1	Replication protein A1	0.9762	5

IKZF3

Group enriched (B-cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MTBP	MDM2 binding protein	1.0000	24
SLC9B2	Solute carrier family 9 member B2	1.0000	24
TMOD1	Tropomodulin 1	1.0000	24

IRF4

Group enriched (B-cells, Dendritic cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
NPIPA9	Nuclear pore complex interacting protein family, member A9	1.0000	23
TLR10	Toll like receptor 10	1.0000	23
PARM1	Prostate androgen-regulated mucin-like protein 1	1.0000	23

PRDM1

Group enriched (Granulocytes, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
BTN3A2	Butyrophilin subfamily 3 member A2	1.0000	1
RASA3	RAS p21 protein activator 3	0.9762	1
NFYB	Nuclear transcription factor Y subunit beta	0.9762	1

TOX

Group enriched (Granulocytes, Nk-cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
DSCC1	DNA replication and sister chromatid cohesion 1	1.0000	16
TMEM244	Transmembrane protein 244	1.0000	16
RGPD2	RANBP2 like and GRIP domain containing 2	1.0000	16

ZBTB16

Group enriched (B-cells, Nk-cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SEPTIN7	Septin 7	1.0000	24
ZNF625	Zinc finger protein 625	1.0000	24
TRDV3	T cell receptor delta variable 3	1.0000	24

ZNF600

Group enriched (Nk-cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
EOMES	Eomesodermin	1.0000	15
TRGC1	T cell receptor gamma constant 1	1.0000	15
TRGJP2	T cell receptor gamma joining P2	1.0000	15

ETV7

Group enriched (Granulocytes, Monocytes, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TNFRSF9	TNF receptor superfamily member 9	0.9762	33
GPR19	G protein-coupled receptor 19	0.9762	33
TAB2	TGF-beta activated kinase 1 (MAP3K7) binding protein 2	0.9524	33

RARG

Group enriched (Dendritic cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TC2N	Tandem C2 domains, nuclear	1.0000	27
CCNI2	Cyclin I family member 2	1.0000	27
CD247	CD247 molecule	1.0000	27

SATB1

Group enriched (Nk-cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZC4H2	Zinc finger C4H2-type containing	1.0000	24
ERICH6	Glutamate rich 6	1.0000	24
CCDC28B	Coiled-coil domain containing 28B	1.0000	24

ZNF549

Group enriched (B-cells, Nk-cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MZF1	Myeloid zinc finger 1	1.0000	24
SYNRG	Synergin gamma	1.0000	24
ATP6V1G2	ATPase H+ transporting V1 subunit G2	1.0000	24

ZNF563

Group enriched (B-cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RPS29	Ribosomal protein S29	1.0000	43
TMEM121	Transmembrane protein 121	1.0000	43
PHGDH	Phosphoglycerate dehydrogenase	1.0000	43

Enriched transcription factors

Gene

Expression

Expression clustering

MYBL1

Lineage enhanced (T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
NKG7	Natural killer cell granule protein 7	1.0000	15
PRF1	Perforin 1	1.0000	15
POGLUT3	Protein O-glucosyltransferase 3	1.0000	15