GENERAL INFORMATIONi
Gene namei FGR
Synonyms c-fgr, p55c-fgr, SRC2
Gene descriptioni FGR proto-oncogene, Src family tyrosine kinase
Protein classi Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 1
Cytoband p35.3
Chromosome location (bp) 27612064 - 27635185
Number of transcriptsi 5
Ensembl ENSG00000000938 (version 109)
Entrez gene 2268
HGNC HGNC:3697
UniProt P09769 (UniProt - Evidence at protein level)
neXtProt NX_P09769
GeneCards FGR
Antibodypedia FGR antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as a negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as a positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Together with CLNK, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity). show less
Molecular function (UniProt)i Kinase, Transferase, Tyrosine-protein kinase
Biological process (UniProt)i Immunity, Innate immunity
Ligand (UniProt)i ATP-binding, Nucleotide-binding
Gene summary (Entrez)i This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
FGR-201
ENSP00000363115
ENST00000374003
P09769
[Direct mapping] Tyrosine-protein kinase Fgr
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Potential drug targets
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001784 [phosphotyrosine residue binding]
GO:0001819 [positive regulation of cytokine production]
GO:0002376 [immune system process]
GO:0002768 [immune response-regulating cell surface receptor signaling pathway]
GO:0002862 [negative regulation of inflammatory response to antigenic stimulus]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [signaling receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005758 [mitochondrial intermembrane space]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008360 [regulation of cell shape]
GO:0009615 [response to virus]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016235 [aggresome]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0030154 [cell differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032587 [ruffle membrane]
GO:0034774 [secretory granule lumen]
GO:0034987 [immunoglobulin receptor binding]
GO:0034988 [Fc-gamma receptor I complex binding]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042995 [cell projection]
GO:0043306 [positive regulation of mast cell degranulation]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0045087 [innate immune response]
GO:0045088 [regulation of innate immune response]
GO:0045859 [regulation of protein kinase activity]
GO:0046777 [protein autophosphorylation]
GO:0050764 [regulation of phagocytosis]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0070062 [extracellular exosome]
Show all
 529 aa
59.5 kDa 		No 0
FGR-202
ENSP00000363116
ENST00000374004
P09769
[Direct mapping] Tyrosine-protein kinase Fgr
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Potential drug targets
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001784 [phosphotyrosine residue binding]
GO:0001819 [positive regulation of cytokine production]
GO:0002376 [immune system process]
GO:0002768 [immune response-regulating cell surface receptor signaling pathway]
GO:0002862 [negative regulation of inflammatory response to antigenic stimulus]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [signaling receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005758 [mitochondrial intermembrane space]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008360 [regulation of cell shape]
GO:0009615 [response to virus]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016235 [aggresome]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0030154 [cell differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032587 [ruffle membrane]
GO:0034774 [secretory granule lumen]
GO:0034987 [immunoglobulin receptor binding]
GO:0034988 [Fc-gamma receptor I complex binding]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042995 [cell projection]
GO:0043306 [positive regulation of mast cell degranulation]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0045087 [innate immune response]
GO:0045088 [regulation of innate immune response]
GO:0045859 [regulation of protein kinase activity]
GO:0046777 [protein autophosphorylation]
GO:0050764 [regulation of phagocytosis]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0070062 [extracellular exosome]
Show all
 529 aa
59.5 kDa 		No 0
FGR-203
ENSP00000363117
ENST00000374005
P09769
[Direct mapping] Tyrosine-protein kinase Fgr
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Potential drug targets
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001784 [phosphotyrosine residue binding]
GO:0001819 [positive regulation of cytokine production]
GO:0002376 [immune system process]
GO:0002768 [immune response-regulating cell surface receptor signaling pathway]
GO:0002862 [negative regulation of inflammatory response to antigenic stimulus]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [signaling receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005758 [mitochondrial intermembrane space]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008360 [regulation of cell shape]
GO:0009615 [response to virus]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016235 [aggresome]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0030154 [cell differentiation]
GO:0030282 [bone mineralization]
GO:0030335 [positive regulation of cell migration]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032587 [ruffle membrane]
GO:0032815 [negative regulation of natural killer cell activation]
GO:0034774 [secretory granule lumen]
GO:0034987 [immunoglobulin receptor binding]
GO:0034988 [Fc-gamma receptor I complex binding]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042995 [cell projection]
GO:0043306 [positive regulation of mast cell degranulation]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0045087 [innate immune response]
GO:0045088 [regulation of innate immune response]
GO:0045859 [regulation of protein kinase activity]
GO:0046777 [protein autophosphorylation]
GO:0048705 [skeletal system morphogenesis]
GO:0050764 [regulation of phagocytosis]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0051450 [myoblast proliferation]
GO:0070062 [extracellular exosome]
Show all
 529 aa
59.5 kDa 		No 0
FGR-204
ENSP00000382126
ENST00000399173
P09769
[Direct mapping] Tyrosine-protein kinase Fgr
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Potential drug targets
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001784 [phosphotyrosine residue binding]
GO:0001819 [positive regulation of cytokine production]
GO:0002376 [immune system process]
GO:0002768 [immune response-regulating cell surface receptor signaling pathway]
GO:0002862 [negative regulation of inflammatory response to antigenic stimulus]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [signaling receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005758 [mitochondrial intermembrane space]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008360 [regulation of cell shape]
GO:0009615 [response to virus]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016235 [aggresome]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0030154 [cell differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032587 [ruffle membrane]
GO:0034774 [secretory granule lumen]
GO:0034987 [immunoglobulin receptor binding]
GO:0034988 [Fc-gamma receptor I complex binding]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042995 [cell projection]
GO:0043306 [positive regulation of mast cell degranulation]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0045087 [innate immune response]
GO:0045088 [regulation of innate immune response]
GO:0045859 [regulation of protein kinase activity]
GO:0046777 [protein autophosphorylation]
GO:0050764 [regulation of phagocytosis]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0070062 [extracellular exosome]
Show all
 529 aa
59.5 kDa 		No 0
FGR-205
ENSP00000407670
ENST00000457296
Q5TGY6
[Direct mapping] Tyrosine-protein kinase
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0016235 [aggresome]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
Show all
 312 aa
34.6 kDa 		No 0

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