We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
12
Cytoband
p13.33
Chromosome location (bp)
911736 - 990053
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
DNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
DNA damage, DNA recombination, DNA repair
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair. A pseudogene of this gene is present on chromosome 2. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P43351 [Direct mapping] DNA repair protein RAD52 homolog
Show all
Q5DR82 [Target identity:100%; Query identity:100%] RAD52 homolog (S. cerevisiae), isoform CRA_c; Rhabdomyosarcoma antigen MU-RMS-40.23; cDNA FLJ77029, highly similar to Homo sapiens RAD52 homolog (S. cerevisiae) (RAD52), transcript variant alpha, mRNA
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000724[double-strand break repair via homologous recombination] GO:0000730[DNA recombinase assembly] GO:0003677[DNA binding] GO:0003697[single-stranded DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006281[DNA repair] GO:0006302[double-strand break repair] GO:0006310[DNA recombination] GO:0006312[mitotic recombination] GO:0006974[cellular response to DNA damage stimulus] GO:0010792[DNA double-strand break processing involved in repair via single-strand annealing] GO:0032991[protein-containing complex] GO:0032993[protein-DNA complex] GO:0034599[cellular response to oxidative stress] GO:0042802[identical protein binding] GO:0045002[double-strand break repair via single-strand annealing] GO:2000819[regulation of nucleotide-excision repair]
P43351 [Direct mapping] DNA repair protein RAD52 homolog
Show all
Q5DR82 [Target identity:100%; Query identity:100%] RAD52 homolog (S. cerevisiae), isoform CRA_c; Rhabdomyosarcoma antigen MU-RMS-40.23; cDNA FLJ77029, highly similar to Homo sapiens RAD52 homolog (S. cerevisiae) (RAD52), transcript variant alpha, mRNA
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000724[double-strand break repair via homologous recombination] GO:0000730[DNA recombinase assembly] GO:0003677[DNA binding] GO:0003697[single-stranded DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006281[DNA repair] GO:0006302[double-strand break repair] GO:0006310[DNA recombination] GO:0006312[mitotic recombination] GO:0006974[cellular response to DNA damage stimulus] GO:0010792[DNA double-strand break processing involved in repair via single-strand annealing] GO:0032991[protein-containing complex] GO:0032993[protein-DNA complex] GO:0034599[cellular response to oxidative stress] GO:0042802[identical protein binding] GO:0045002[double-strand break repair via single-strand annealing] GO:2000819[regulation of nucleotide-excision repair]
P43351 [Direct mapping] DNA repair protein RAD52 homolog
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000724[double-strand break repair via homologous recombination] GO:0000730[DNA recombinase assembly] GO:0003677[DNA binding] GO:0003697[single-stranded DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006281[DNA repair] GO:0006302[double-strand break repair] GO:0006310[DNA recombination] GO:0006312[mitotic recombination] GO:0006974[cellular response to DNA damage stimulus] GO:0010792[DNA double-strand break processing involved in repair via single-strand annealing] GO:0032991[protein-containing complex] GO:0032993[protein-DNA complex] GO:0034599[cellular response to oxidative stress] GO:0042802[identical protein binding] GO:0045002[double-strand break repair via single-strand annealing] GO:2000819[regulation of nucleotide-excision repair]
P43351 [Direct mapping] DNA repair protein RAD52 homolog
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000724[double-strand break repair via homologous recombination] GO:0000730[DNA recombinase assembly] GO:0003677[DNA binding] GO:0003697[single-stranded DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006281[DNA repair] GO:0006302[double-strand break repair] GO:0006310[DNA recombination] GO:0006312[mitotic recombination] GO:0006974[cellular response to DNA damage stimulus] GO:0010792[DNA double-strand break processing involved in repair via single-strand annealing] GO:0032991[protein-containing complex] GO:0032993[protein-DNA complex] GO:0034599[cellular response to oxidative stress] GO:0042802[identical protein binding] GO:0045002[double-strand break repair via single-strand annealing] GO:2000819[regulation of nucleotide-excision repair]
P43351 [Direct mapping] DNA repair protein RAD52 homolog
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000724[double-strand break repair via homologous recombination] GO:0000730[DNA recombinase assembly] GO:0003677[DNA binding] GO:0003697[single-stranded DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006281[DNA repair] GO:0006302[double-strand break repair] GO:0006310[DNA recombination] GO:0006312[mitotic recombination] GO:0006974[cellular response to DNA damage stimulus] GO:0010792[DNA double-strand break processing involved in repair via single-strand annealing] GO:0032991[protein-containing complex] GO:0032993[protein-DNA complex] GO:0034599[cellular response to oxidative stress] GO:0042802[identical protein binding] GO:0045002[double-strand break repair via single-strand annealing] GO:2000819[regulation of nucleotide-excision repair]
The Human Protein Atlas project is funded
