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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Enzymes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
q33.1
Chromosome location (bp)
201116154 - 201176687
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Apoptosis, Host-virus interaction
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
O15519 [Direct mapping] CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apoptosis regulator subunit p12
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A0A024R3Y4 [Target identity:100%; Query identity:100%] CASP8 and FADD-like apoptosis regulator, isoform CRA_c; Testis secretory sperm-binding protein Li 233m
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Enzymes Peptidases Cysteine-type peptidases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001666[response to hypoxia] GO:0002020[protease binding] GO:0004197[cysteine-type endopeptidase activity] GO:0005123[death receptor binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006508[proteolysis] GO:0006915[apoptotic process] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007519[skeletal muscle tissue development] GO:0008047[enzyme activator activity] GO:0008234[cysteine-type peptidase activity] GO:0010667[negative regulation of cardiac muscle cell apoptotic process] GO:0010976[positive regulation of neuron projection development] GO:0014732[skeletal muscle atrophy] GO:0014842[regulation of skeletal muscle satellite cell proliferation] GO:0014866[skeletal myofibril assembly] GO:0031264[death-inducing signaling complex] GO:0031265[CD95 death-inducing signaling complex] GO:0032869[cellular response to insulin stimulus] GO:0033574[response to testosterone] GO:0042060[wound healing] GO:0042981[regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043403[skeletal muscle tissue regeneration] GO:0044877[protein-containing complex binding] GO:0045121[membrane raft] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0060544[regulation of necroptotic process] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0071364[cellular response to epidermal growth factor stimulus] GO:0071392[cellular response to estradiol stimulus] GO:0071456[cellular response to hypoxia] GO:0071549[cellular response to dexamethasone stimulus] GO:0071732[cellular response to nitric oxide] GO:0072126[positive regulation of glomerular mesangial cell proliferation] GO:0097153[cysteine-type endopeptidase activity involved in apoptotic process] GO:0097190[apoptotic signaling pathway] GO:0097194[execution phase of apoptosis] GO:0097199[cysteine-type endopeptidase activity involved in apoptotic signaling pathway] GO:0097200[cysteine-type endopeptidase activity involved in execution phase of apoptosis] GO:0097342[ripoptosome] GO:1901740[negative regulation of myoblast fusion] GO:1902042[negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1903055[positive regulation of extracellular matrix organization] GO:1903427[negative regulation of reactive oxygen species biosynthetic process] GO:1903845[negative regulation of cellular response to transforming growth factor beta stimulus] GO:1903944[negative regulation of hepatocyte apoptotic process] GO:1904036[negative regulation of epithelial cell apoptotic process] GO:2000347[positive regulation of hepatocyte proliferation] GO:2001237[negative regulation of extrinsic apoptotic signaling pathway]
O15519 [Direct mapping] CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apoptosis regulator subunit p12
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Enzymes Peptidases Cysteine-type peptidases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002020[protease binding] GO:0004197[cysteine-type endopeptidase activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006508[proteolysis] GO:0006915[apoptotic process] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007519[skeletal muscle tissue development] GO:0008047[enzyme activator activity] GO:0008234[cysteine-type peptidase activity] GO:0014732[skeletal muscle atrophy] GO:0014842[regulation of skeletal muscle satellite cell proliferation] GO:0014866[skeletal myofibril assembly] GO:0031264[death-inducing signaling complex] GO:0042060[wound healing] GO:0042981[regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043403[skeletal muscle tissue regeneration] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0060544[regulation of necroptotic process] GO:0097153[cysteine-type endopeptidase activity involved in apoptotic process] GO:0097190[apoptotic signaling pathway] GO:0097194[execution phase of apoptosis] GO:0097199[cysteine-type endopeptidase activity involved in apoptotic signaling pathway] GO:0097200[cysteine-type endopeptidase activity involved in execution phase of apoptosis] GO:0097342[ripoptosome] GO:1901740[negative regulation of myoblast fusion] GO:1902042[negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:2001237[negative regulation of extrinsic apoptotic signaling pathway]
Enzymes Peptidases Cysteine-type peptidases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002020[protease binding] GO:0004197[cysteine-type endopeptidase activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006508[proteolysis] GO:0006915[apoptotic process] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007519[skeletal muscle tissue development] GO:0008047[enzyme activator activity] GO:0008234[cysteine-type peptidase activity] GO:0014732[skeletal muscle atrophy] GO:0014842[regulation of skeletal muscle satellite cell proliferation] GO:0014866[skeletal myofibril assembly] GO:0031264[death-inducing signaling complex] GO:0042060[wound healing] GO:0042981[regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043403[skeletal muscle tissue regeneration] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0060544[regulation of necroptotic process] GO:0097153[cysteine-type endopeptidase activity involved in apoptotic process] GO:0097190[apoptotic signaling pathway] GO:0097194[execution phase of apoptosis] GO:0097199[cysteine-type endopeptidase activity involved in apoptotic signaling pathway] GO:0097200[cysteine-type endopeptidase activity involved in execution phase of apoptosis] GO:0097342[ripoptosome] GO:1901740[negative regulation of myoblast fusion] GO:1902042[negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:2001237[negative regulation of extrinsic apoptotic signaling pathway]
O15519 [Direct mapping] CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apoptosis regulator subunit p12
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Enzymes Peptidases Cysteine-type peptidases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0002020[protease binding] GO:0004197[cysteine-type endopeptidase activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006508[proteolysis] GO:0006915[apoptotic process] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007519[skeletal muscle tissue development] GO:0008047[enzyme activator activity] GO:0008234[cysteine-type peptidase activity] GO:0014732[skeletal muscle atrophy] GO:0014842[regulation of skeletal muscle satellite cell proliferation] GO:0014866[skeletal myofibril assembly] GO:0031264[death-inducing signaling complex] GO:0042060[wound healing] GO:0042981[regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043403[skeletal muscle tissue regeneration] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0060544[regulation of necroptotic process] GO:0097153[cysteine-type endopeptidase activity involved in apoptotic process] GO:0097190[apoptotic signaling pathway] GO:0097194[execution phase of apoptosis] GO:0097199[cysteine-type endopeptidase activity involved in apoptotic signaling pathway] GO:0097200[cysteine-type endopeptidase activity involved in execution phase of apoptosis] GO:0097342[ripoptosome] GO:1901740[negative regulation of myoblast fusion] GO:1902042[negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:2001237[negative regulation of extrinsic apoptotic signaling pathway]
E9PAP3 [Direct mapping] CASP8 and FADD-like apoptosis regulator
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THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
O15519 [Direct mapping] CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apoptosis regulator subunit p12
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A0A024R3Y4 [Target identity:100%; Query identity:100%] CASP8 and FADD-like apoptosis regulator, isoform CRA_c; Testis secretory sperm-binding protein Li 233m
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Enzymes Peptidases Cysteine-type peptidases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002020[protease binding] GO:0004197[cysteine-type endopeptidase activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006508[proteolysis] GO:0006915[apoptotic process] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007519[skeletal muscle tissue development] GO:0008047[enzyme activator activity] GO:0008234[cysteine-type peptidase activity] GO:0014732[skeletal muscle atrophy] GO:0014842[regulation of skeletal muscle satellite cell proliferation] GO:0014866[skeletal myofibril assembly] GO:0031264[death-inducing signaling complex] GO:0042060[wound healing] GO:0042981[regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043403[skeletal muscle tissue regeneration] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0060544[regulation of necroptotic process] GO:0097153[cysteine-type endopeptidase activity involved in apoptotic process] GO:0097190[apoptotic signaling pathway] GO:0097194[execution phase of apoptosis] GO:0097199[cysteine-type endopeptidase activity involved in apoptotic signaling pathway] GO:0097200[cysteine-type endopeptidase activity involved in execution phase of apoptosis] GO:0097342[ripoptosome] GO:1901740[negative regulation of myoblast fusion] GO:1902042[negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:2001237[negative regulation of extrinsic apoptotic signaling pathway]
O15519 [Direct mapping] CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apoptosis regulator subunit p12
Show all
Enzymes Peptidases Cysteine-type peptidases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020[protease binding] GO:0004197[cysteine-type endopeptidase activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006508[proteolysis] GO:0006915[apoptotic process] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007519[skeletal muscle tissue development] GO:0008047[enzyme activator activity] GO:0008234[cysteine-type peptidase activity] GO:0014732[skeletal muscle atrophy] GO:0014842[regulation of skeletal muscle satellite cell proliferation] GO:0014866[skeletal myofibril assembly] GO:0031264[death-inducing signaling complex] GO:0042060[wound healing] GO:0042981[regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043403[skeletal muscle tissue regeneration] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0060544[regulation of necroptotic process] GO:0097153[cysteine-type endopeptidase activity involved in apoptotic process] GO:0097190[apoptotic signaling pathway] GO:0097194[execution phase of apoptosis] GO:0097199[cysteine-type endopeptidase activity involved in apoptotic signaling pathway] GO:0097200[cysteine-type endopeptidase activity involved in execution phase of apoptosis] GO:0097342[ripoptosome] GO:1901740[negative regulation of myoblast fusion] GO:1902042[negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:2001237[negative regulation of extrinsic apoptotic signaling pathway]
O15519 [Direct mapping] CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apoptosis regulator subunit p12
Show all
Enzymes Peptidases Cysteine-type peptidases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020[protease binding] GO:0004197[cysteine-type endopeptidase activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006508[proteolysis] GO:0006915[apoptotic process] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007519[skeletal muscle tissue development] GO:0008047[enzyme activator activity] GO:0008234[cysteine-type peptidase activity] GO:0014732[skeletal muscle atrophy] GO:0014842[regulation of skeletal muscle satellite cell proliferation] GO:0014866[skeletal myofibril assembly] GO:0031264[death-inducing signaling complex] GO:0042060[wound healing] GO:0042981[regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043403[skeletal muscle tissue regeneration] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0060544[regulation of necroptotic process] GO:0097153[cysteine-type endopeptidase activity involved in apoptotic process] GO:0097190[apoptotic signaling pathway] GO:0097194[execution phase of apoptosis] GO:0097199[cysteine-type endopeptidase activity involved in apoptotic signaling pathway] GO:0097200[cysteine-type endopeptidase activity involved in execution phase of apoptosis] GO:0097342[ripoptosome] GO:1901740[negative regulation of myoblast fusion] GO:1902042[negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:2001237[negative regulation of extrinsic apoptotic signaling pathway]
Enzymes Peptidases Cysteine-type peptidases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0002020[protease binding] GO:0004197[cysteine-type endopeptidase activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006508[proteolysis] GO:0006915[apoptotic process] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007519[skeletal muscle tissue development] GO:0008047[enzyme activator activity] GO:0008234[cysteine-type peptidase activity] GO:0014732[skeletal muscle atrophy] GO:0014842[regulation of skeletal muscle satellite cell proliferation] GO:0014866[skeletal myofibril assembly] GO:0031264[death-inducing signaling complex] GO:0042060[wound healing] GO:0042981[regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043403[skeletal muscle tissue regeneration] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0060544[regulation of necroptotic process] GO:0097153[cysteine-type endopeptidase activity involved in apoptotic process] GO:0097190[apoptotic signaling pathway] GO:0097194[execution phase of apoptosis] GO:0097199[cysteine-type endopeptidase activity involved in apoptotic signaling pathway] GO:0097200[cysteine-type endopeptidase activity involved in execution phase of apoptosis] GO:0097342[ripoptosome] GO:1901740[negative regulation of myoblast fusion] GO:1902042[negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:2001237[negative regulation of extrinsic apoptotic signaling pathway]
O15519 [Direct mapping] CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apoptosis regulator subunit p12
Show all
Enzymes Peptidases Cysteine-type peptidases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020[protease binding] GO:0004197[cysteine-type endopeptidase activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006508[proteolysis] GO:0006915[apoptotic process] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007519[skeletal muscle tissue development] GO:0008047[enzyme activator activity] GO:0008234[cysteine-type peptidase activity] GO:0014732[skeletal muscle atrophy] GO:0014842[regulation of skeletal muscle satellite cell proliferation] GO:0014866[skeletal myofibril assembly] GO:0031264[death-inducing signaling complex] GO:0042060[wound healing] GO:0042981[regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043403[skeletal muscle tissue regeneration] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0060544[regulation of necroptotic process] GO:0097153[cysteine-type endopeptidase activity involved in apoptotic process] GO:0097190[apoptotic signaling pathway] GO:0097194[execution phase of apoptosis] GO:0097199[cysteine-type endopeptidase activity involved in apoptotic signaling pathway] GO:0097200[cysteine-type endopeptidase activity involved in execution phase of apoptosis] GO:0097342[ripoptosome] GO:1901740[negative regulation of myoblast fusion] GO:1902042[negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:2001237[negative regulation of extrinsic apoptotic signaling pathway]
The Human Protein Atlas project is funded
