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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
p13.1
Chromosome location (bp)
7225342 - 7234517
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Developmental protein
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Wnt signaling pathway
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
O14641 [Direct mapping] Segment polarity protein dishevelled homolog DVL-2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001843[neural tube closure] GO:0001934[positive regulation of protein phosphorylation] GO:0001947[heart looping] GO:0003007[heart morphogenesis] GO:0003151[outflow tract morphogenesis] GO:0005109[frizzled binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006355[regulation of DNA-templated transcription] GO:0007379[segment specification] GO:0007507[heart development] GO:0008104[protein localization] GO:0016020[membrane] GO:0016055[Wnt signaling pathway] GO:0016235[aggresome] GO:0016328[lateral plasma membrane] GO:0016604[nuclear body] GO:0019901[protein kinase binding] GO:0019904[protein domain specific binding] GO:0022007[convergent extension involved in neural plate elongation] GO:0022603[regulation of anatomical structure morphogenesis] GO:0030136[clathrin-coated vesicle] GO:0030674[protein-macromolecule adaptor activity] GO:0031267[small GTPase binding] GO:0031410[cytoplasmic vesicle] GO:0035282[segmentation] GO:0035556[intracellular signal transduction] GO:0035567[non-canonical Wnt signaling pathway] GO:0042802[identical protein binding] GO:0043507[positive regulation of JUN kinase activity] GO:0043547[positive regulation of GTPase activity] GO:0043621[protein self-association] GO:0044340[canonical Wnt signaling pathway involved in regulation of cell proliferation] GO:0045177[apical part of cell] GO:0045334[clathrin-coated endocytic vesicle] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050790[regulation of catalytic activity] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0060029[convergent extension involved in organogenesis] GO:0060070[canonical Wnt signaling pathway] GO:0060071[Wnt signaling pathway, planar cell polarity pathway] GO:0061098[positive regulation of protein tyrosine kinase activity] GO:0090103[cochlea morphogenesis] GO:0090179[planar cell polarity pathway involved in neural tube closure] GO:0150012[positive regulation of neuron projection arborization]
The Human Protein Atlas project is funded
