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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Enzymes FDA approved drug targets Human disease related genes Metabolic proteins Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
q11.2
Chromosome location (bp)
27756766 - 27800529
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body 1,2,3,4. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM 5. Involved in inflammation, enhances the synthesis of pro-inflammatory mediators such as IL6 and IL8 6....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Calmodulin-binding, Oxidoreductase
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of the digestive system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666[response to hypoxia] GO:0001912[positive regulation of leukocyte mediated cytotoxicity] GO:0002227[innate immune response in mucosa] GO:0004517[nitric-oxide synthase activity] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005777[peroxisome] GO:0005782[peroxisomal matrix] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006527[arginine catabolic process] GO:0006801[superoxide metabolic process] GO:0006809[nitric oxide biosynthetic process] GO:0006954[inflammatory response] GO:0007263[nitric oxide mediated signal transduction] GO:0007623[circadian rhythm] GO:0009617[response to bacterium] GO:0009725[response to hormone] GO:0010181[FMN binding] GO:0010629[negative regulation of gene expression] GO:0012506[vesicle membrane] GO:0016491[oxidoreductase activity] GO:0018119[peptidyl-cysteine S-nitrosylation] GO:0020037[heme binding] GO:0030863[cortical cytoskeleton] GO:0031284[positive regulation of guanylate cyclase activity] GO:0032310[prostaglandin secretion] GO:0032496[response to lipopolysaccharide] GO:0032755[positive regulation of interleukin-6 production] GO:0032757[positive regulation of interleukin-8 production] GO:0034617[tetrahydrobiopterin binding] GO:0034618[arginine binding] GO:0042127[regulation of cell population proliferation] GO:0042177[negative regulation of protein catabolic process] GO:0042742[defense response to bacterium] GO:0042803[protein homodimerization activity] GO:0043457[regulation of cellular respiration] GO:0044249[cellular biosynthetic process] GO:0045454[cell redox homeostasis] GO:0045776[negative regulation of blood pressure] GO:0046872[metal ion binding] GO:0048471[perinuclear region of cytoplasm] GO:0050660[flavin adenine dinucleotide binding] GO:0050661[NADP binding] GO:0050796[regulation of insulin secretion] GO:0050829[defense response to Gram-negative bacterium] GO:0051712[positive regulation of killing of cells of another organism] GO:0071222[cellular response to lipopolysaccharide] GO:0071346[cellular response to interferon-gamma] GO:0071466[cellular response to xenobiotic stimulus] GO:1900015[regulation of cytokine production involved in inflammatory response]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cancers Cancers of the digestive system Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Phobius predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cancers Cancers of the digestive system Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
