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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
11
Cytoband
p13
Chromosome location (bp)
31784779 - 31817961
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Acts as a transcriptional repressor of NFATC1-mediated gene expression (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Developmental protein, DNA-binding, Repressor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
This gene encodes paired box protein Pax-6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to a conserved paired box domain, a hallmark feature of this gene family, the encoded protein also contains a homeobox domain. Both domains are known to bind DNA and function as regulators of gene transcription. Activity of this protein is key in the development of neural tissues, particularly the eye. This gene is regulated by multiple enhancers located up to hundreds of kilobases distant from this locus. Mutations in this gene or in the enhancer regions can cause ocular disorders such as aniridia and Peter's anomaly. Use of alternate promoters and alternative splicing results in multiple transcript variants encoding different isoforms. Interestingly, inclusion of a particular alternate coding exon has been shown to increase the length of the paired box domain and alter its DNA binding specificity. Consequently, isoforms that carry the shorter paired box domain regulate a different set of genes compared to the isoforms carrying the longer paired box domain. [provided by RefSeq, Mar 2019]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q66SS1 [Target identity:100%; Query identity:100%] Paired box gene 6 isoform a; Paired box protein Pax-6 isoform a
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Helix-turn-helix domains Disease related genes Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001221[transcription coregulator binding] GO:0001568[blood vessel development] GO:0001654[eye development] GO:0003322[pancreatic A cell development] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007417[central nervous system development] GO:0007601[visual perception] GO:0009611[response to wounding] GO:0009887[animal organ morphogenesis] GO:0010628[positive regulation of gene expression] GO:0019901[protein kinase binding] GO:0021517[ventral spinal cord development] GO:0030154[cell differentiation] GO:0035035[histone acetyltransferase binding] GO:0042593[glucose homeostasis] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048663[neuron fate commitment] GO:0048856[anatomical structure development] GO:0050768[negative regulation of neurogenesis] GO:0061072[iris morphogenesis] GO:0061303[cornea development in camera-type eye] GO:0070412[R-SMAD binding] GO:1904798[positive regulation of core promoter binding] GO:1990837[sequence-specific double-stranded DNA binding]
F1T0F8 [Target identity:100%; Query identity:100%] Paired box protein Pax-6
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SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Helix-turn-helix domains Disease related genes Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001221[transcription coregulator binding] GO:0001568[blood vessel development] GO:0001654[eye development] GO:0003322[pancreatic A cell development] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007417[central nervous system development] GO:0007601[visual perception] GO:0009611[response to wounding] GO:0009887[animal organ morphogenesis] GO:0010628[positive regulation of gene expression] GO:0019901[protein kinase binding] GO:0021517[ventral spinal cord development] GO:0030154[cell differentiation] GO:0035035[histone acetyltransferase binding] GO:0042593[glucose homeostasis] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048663[neuron fate commitment] GO:0048856[anatomical structure development] GO:0050768[negative regulation of neurogenesis] GO:0061072[iris morphogenesis] GO:0061303[cornea development in camera-type eye] GO:0070412[R-SMAD binding] GO:1904798[positive regulation of core promoter binding] GO:1990837[sequence-specific double-stranded DNA binding]
Q66SS1 [Target identity:100%; Query identity:100%] Paired box gene 6 isoform a; Paired box protein Pax-6 isoform a
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Helix-turn-helix domains Disease related genes Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001221[transcription coregulator binding] GO:0001568[blood vessel development] GO:0001654[eye development] GO:0003322[pancreatic A cell development] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007417[central nervous system development] GO:0007601[visual perception] GO:0009611[response to wounding] GO:0009887[animal organ morphogenesis] GO:0010628[positive regulation of gene expression] GO:0019901[protein kinase binding] GO:0021517[ventral spinal cord development] GO:0030154[cell differentiation] GO:0035035[histone acetyltransferase binding] GO:0042593[glucose homeostasis] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048663[neuron fate commitment] GO:0048856[anatomical structure development] GO:0050768[negative regulation of neurogenesis] GO:0061072[iris morphogenesis] GO:0061303[cornea development in camera-type eye] GO:0070412[R-SMAD binding] GO:1904798[positive regulation of core promoter binding] GO:1990837[sequence-specific double-stranded DNA binding]
A0A1W2PQA8 [Direct mapping] Paired box protein Pax-6
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
A0A1X7SBT0 [Direct mapping] Paired box protein Pax-6
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
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GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0048856[anatomical structure development]
A0A1W2PPJ2 [Direct mapping] Paired box protein Pax-6
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II]
F1T0F8 [Target identity:100%; Query identity:100%] Paired box protein Pax-6
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SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Helix-turn-helix domains Disease related genes Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001221[transcription coregulator binding] GO:0001568[blood vessel development] GO:0001654[eye development] GO:0003322[pancreatic A cell development] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007417[central nervous system development] GO:0007601[visual perception] GO:0009611[response to wounding] GO:0009887[animal organ morphogenesis] GO:0010628[positive regulation of gene expression] GO:0019901[protein kinase binding] GO:0021517[ventral spinal cord development] GO:0030154[cell differentiation] GO:0035035[histone acetyltransferase binding] GO:0042593[glucose homeostasis] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048663[neuron fate commitment] GO:0048856[anatomical structure development] GO:0050768[negative regulation of neurogenesis] GO:0061072[iris morphogenesis] GO:0061303[cornea development in camera-type eye] GO:0070412[R-SMAD binding] GO:1904798[positive regulation of core promoter binding] GO:1990837[sequence-specific double-stranded DNA binding]
Q66SS1 [Target identity:100%; Query identity:100%] Paired box gene 6 isoform a; Paired box protein Pax-6 isoform a
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Helix-turn-helix domains Disease related genes Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001221[transcription coregulator binding] GO:0001568[blood vessel development] GO:0001654[eye development] GO:0003322[pancreatic A cell development] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007417[central nervous system development] GO:0007601[visual perception] GO:0009611[response to wounding] GO:0009887[animal organ morphogenesis] GO:0010628[positive regulation of gene expression] GO:0019901[protein kinase binding] GO:0021517[ventral spinal cord development] GO:0030154[cell differentiation] GO:0035035[histone acetyltransferase binding] GO:0042593[glucose homeostasis] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048663[neuron fate commitment] GO:0048856[anatomical structure development] GO:0050768[negative regulation of neurogenesis] GO:0061072[iris morphogenesis] GO:0061303[cornea development in camera-type eye] GO:0070412[R-SMAD binding] GO:1904798[positive regulation of core promoter binding] GO:1990837[sequence-specific double-stranded DNA binding]
F1T0F8 [Target identity:100%; Query identity:100%] Paired box protein Pax-6
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SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Helix-turn-helix domains Disease related genes Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001221[transcription coregulator binding] GO:0001568[blood vessel development] GO:0001654[eye development] GO:0003322[pancreatic A cell development] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007417[central nervous system development] GO:0007601[visual perception] GO:0009611[response to wounding] GO:0009887[animal organ morphogenesis] GO:0010628[positive regulation of gene expression] GO:0019901[protein kinase binding] GO:0021517[ventral spinal cord development] GO:0030154[cell differentiation] GO:0035035[histone acetyltransferase binding] GO:0042593[glucose homeostasis] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048663[neuron fate commitment] GO:0048856[anatomical structure development] GO:0050768[negative regulation of neurogenesis] GO:0061072[iris morphogenesis] GO:0061303[cornea development in camera-type eye] GO:0070412[R-SMAD binding] GO:1904798[positive regulation of core promoter binding] GO:1990837[sequence-specific double-stranded DNA binding]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0048856[anatomical structure development]
SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
F1T0F8 [Target identity:100%; Query identity:100%] Paired box protein Pax-6
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SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Helix-turn-helix domains Disease related genes Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001221[transcription coregulator binding] GO:0001568[blood vessel development] GO:0001654[eye development] GO:0003322[pancreatic A cell development] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007417[central nervous system development] GO:0007601[visual perception] GO:0009611[response to wounding] GO:0009887[animal organ morphogenesis] GO:0010628[positive regulation of gene expression] GO:0019901[protein kinase binding] GO:0021517[ventral spinal cord development] GO:0030154[cell differentiation] GO:0035035[histone acetyltransferase binding] GO:0042593[glucose homeostasis] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048663[neuron fate commitment] GO:0048856[anatomical structure development] GO:0050768[negative regulation of neurogenesis] GO:0061072[iris morphogenesis] GO:0061303[cornea development in camera-type eye] GO:0070412[R-SMAD binding] GO:1904798[positive regulation of core promoter binding] GO:1990837[sequence-specific double-stranded DNA binding]
A0A1W2PPJ2 [Direct mapping] Paired box protein Pax-6
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II]
A0A1W2PP27 [Direct mapping] Paired box protein Pax-6
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II]
A0A1W2PS91 [Direct mapping] Paired box protein Pax-6
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SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
A0A1W2PQM7 [Direct mapping] Paired box protein Pax-6
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
A0A1W2PPG3 [Direct mapping] Paired box protein Pax-6
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II]
A0A1W2PRU4 [Direct mapping] Paired box protein Pax-6
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II]
A0A1W2PQ31 [Direct mapping] Paired box protein Pax-6
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II]
A0A1W2PQG3 [Direct mapping] Paired box protein Pax-6
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II]
F1T0F8 [Target identity:100%; Query identity:100%] Paired box protein Pax-6
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SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Helix-turn-helix domains Disease related genes Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001221[transcription coregulator binding] GO:0001568[blood vessel development] GO:0001654[eye development] GO:0003322[pancreatic A cell development] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007417[central nervous system development] GO:0007601[visual perception] GO:0009611[response to wounding] GO:0009887[animal organ morphogenesis] GO:0010628[positive regulation of gene expression] GO:0019901[protein kinase binding] GO:0021517[ventral spinal cord development] GO:0030154[cell differentiation] GO:0035035[histone acetyltransferase binding] GO:0042593[glucose homeostasis] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048663[neuron fate commitment] GO:0048856[anatomical structure development] GO:0050768[negative regulation of neurogenesis] GO:0061072[iris morphogenesis] GO:0061303[cornea development in camera-type eye] GO:0070412[R-SMAD binding] GO:1904798[positive regulation of core promoter binding] GO:1990837[sequence-specific double-stranded DNA binding]
A0A1W2PSB5 [Direct mapping] Paired box protein Pax-6
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II]
A0A1W2PP89 [Direct mapping] Paired box protein Pax-6
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
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GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II]
D1KF47 [Direct mapping] Paired box protein 6 isoform c; Paired box protein Pax-6
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
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GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0048856[anatomical structure development]
A0A1W2PPH0 [Direct mapping] Paired box protein Pax-6
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
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GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II]
A0A1W2PQJ8 [Direct mapping] Paired box protein Pax-6
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
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GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II]
A0A1W2PQ31 [Direct mapping] Paired box protein Pax-6
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
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GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
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GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II]
F1T0F8 [Target identity:100%; Query identity:100%] Paired box protein Pax-6
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SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Helix-turn-helix domains Disease related genes Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001221[transcription coregulator binding] GO:0001568[blood vessel development] GO:0001654[eye development] GO:0003322[pancreatic A cell development] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007417[central nervous system development] GO:0007601[visual perception] GO:0009611[response to wounding] GO:0009887[animal organ morphogenesis] GO:0010628[positive regulation of gene expression] GO:0019901[protein kinase binding] GO:0021517[ventral spinal cord development] GO:0030154[cell differentiation] GO:0035035[histone acetyltransferase binding] GO:0042593[glucose homeostasis] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048663[neuron fate commitment] GO:0048856[anatomical structure development] GO:0050768[negative regulation of neurogenesis] GO:0061072[iris morphogenesis] GO:0061303[cornea development in camera-type eye] GO:0070412[R-SMAD binding] GO:1904798[positive regulation of core promoter binding] GO:1990837[sequence-specific double-stranded DNA binding]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
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GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II]
Q66SS1 [Target identity:100%; Query identity:100%] Paired box gene 6 isoform a; Paired box protein Pax-6 isoform a
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Helix-turn-helix domains Disease related genes Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001221[transcription coregulator binding] GO:0001568[blood vessel development] GO:0001654[eye development] GO:0003322[pancreatic A cell development] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007417[central nervous system development] GO:0007601[visual perception] GO:0009611[response to wounding] GO:0009887[animal organ morphogenesis] GO:0010628[positive regulation of gene expression] GO:0019901[protein kinase binding] GO:0021517[ventral spinal cord development] GO:0030154[cell differentiation] GO:0035035[histone acetyltransferase binding] GO:0042593[glucose homeostasis] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048663[neuron fate commitment] GO:0048856[anatomical structure development] GO:0050768[negative regulation of neurogenesis] GO:0061072[iris morphogenesis] GO:0061303[cornea development in camera-type eye] GO:0070412[R-SMAD binding] GO:1904798[positive regulation of core promoter binding] GO:1990837[sequence-specific double-stranded DNA binding]
A0A1W2PR58 [Direct mapping] Paired box protein Pax-6
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SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
A0A1W2PPM5 [Direct mapping] Paired box protein Pax-6
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
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GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0048856[anatomical structure development]
A0A1W2PQA8 [Direct mapping] Paired box protein Pax-6
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
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GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II]
A0A1W2PRS6 [Direct mapping] Paired box protein Pax-6
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
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GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0048856[anatomical structure development]
Q66SS1 [Target identity:100%; Query identity:100%] Paired box gene 6 isoform a; Paired box protein Pax-6 isoform a
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Helix-turn-helix domains Disease related genes Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001221[transcription coregulator binding] GO:0001568[blood vessel development] GO:0001654[eye development] GO:0003322[pancreatic A cell development] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007417[central nervous system development] GO:0007601[visual perception] GO:0009611[response to wounding] GO:0009887[animal organ morphogenesis] GO:0010628[positive regulation of gene expression] GO:0019901[protein kinase binding] GO:0021517[ventral spinal cord development] GO:0030154[cell differentiation] GO:0035035[histone acetyltransferase binding] GO:0042593[glucose homeostasis] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048663[neuron fate commitment] GO:0048856[anatomical structure development] GO:0050768[negative regulation of neurogenesis] GO:0061072[iris morphogenesis] GO:0061303[cornea development in camera-type eye] GO:0070412[R-SMAD binding] GO:1904798[positive regulation of core promoter binding] GO:1990837[sequence-specific double-stranded DNA binding]
A0A1W2PRW7 [Direct mapping] Paired box protein Pax-6
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
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GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II]
F1T0F8 [Target identity:100%; Query identity:100%] Paired box protein Pax-6
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SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Helix-turn-helix domains Disease related genes Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000132[establishment of mitotic spindle orientation] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000979[RNA polymerase II core promoter sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001221[transcription coregulator binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001568[blood vessel development] GO:0001654[eye development] GO:0001709[cell fate determination] GO:0001764[neuron migration] GO:0001933[negative regulation of protein phosphorylation] GO:0002052[positive regulation of neuroblast proliferation] GO:0002067[glandular epithelial cell differentiation] GO:0002088[lens development in camera-type eye] GO:0003002[regionalization] GO:0003309[type B pancreatic cell differentiation] GO:0003322[pancreatic A cell development] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003700[DNA-binding transcription factor activity] GO:0003723[RNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006306[DNA methylation] GO:0006338[chromatin remodeling] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006366[transcription by RNA polymerase II] GO:0006468[protein phosphorylation] GO:0007224[smoothened signaling pathway] GO:0007405[neuroblast proliferation] GO:0007406[negative regulation of neuroblast proliferation] GO:0007409[axonogenesis] GO:0007411[axon guidance] GO:0007417[central nervous system development] GO:0007420[brain development] GO:0007435[salivary gland morphogenesis] GO:0007601[visual perception] GO:0008283[cell population proliferation] GO:0009611[response to wounding] GO:0009786[regulation of asymmetric cell division] GO:0009887[animal organ morphogenesis] GO:0009950[dorsal/ventral axis specification] GO:0009952[anterior/posterior pattern specification] GO:0009953[dorsal/ventral pattern formation] GO:0010467[gene expression] GO:0010468[regulation of gene expression] GO:0010628[positive regulation of gene expression] GO:0016573[histone acetylation] GO:0019901[protein kinase binding] GO:0021517[ventral spinal cord development] GO:0021543[pallium development] GO:0021778[oligodendrocyte cell fate specification] GO:0021796[cerebral cortex regionalization] GO:0021798[forebrain dorsal/ventral pattern formation] GO:0021902[commitment of neuronal cell to specific neuron type in forebrain] GO:0021905[forebrain-midbrain boundary formation] GO:0021978[telencephalon regionalization] GO:0021983[pituitary gland development] GO:0021986[habenula development] GO:0021987[cerebral cortex development] GO:0023019[signal transduction involved in regulation of gene expression] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030216[keratinocyte differentiation] GO:0030334[regulation of cell migration] GO:0030858[positive regulation of epithelial cell differentiation] GO:0030900[forebrain development] GO:0031490[chromatin DNA binding] GO:0031625[ubiquitin protein ligase binding] GO:0032808[lacrimal gland development] GO:0033365[protein localization to organelle] GO:0035035[histone acetyltransferase binding] GO:0042462[eye photoreceptor cell development] GO:0042593[glucose homeostasis] GO:0043010[camera-type eye development] GO:0043565[sequence-specific DNA binding] GO:0045165[cell fate commitment] GO:0045664[regulation of neuron differentiation] GO:0045665[negative regulation of neuron differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048505[regulation of timing of cell differentiation] GO:0048596[embryonic camera-type eye morphogenesis] GO:0048663[neuron fate commitment] GO:0048708[astrocyte differentiation] GO:0048856[anatomical structure development] GO:0050680[negative regulation of epithelial cell proliferation] GO:0050767[regulation of neurogenesis] GO:0050768[negative regulation of neurogenesis] GO:0060041[retina development in camera-type eye] GO:0061072[iris morphogenesis] GO:0061303[cornea development in camera-type eye] GO:0061351[neural precursor cell proliferation] GO:0070410[co-SMAD binding] GO:0070412[R-SMAD binding] GO:0071837[HMG box domain binding] GO:0080111[DNA demethylation] GO:1904798[positive regulation of core promoter binding] GO:1990830[cellular response to leukemia inhibitory factor] GO:1990837[sequence-specific double-stranded DNA binding] GO:2000178[negative regulation of neural precursor cell proliferation]
A0A1W2PQL7 [Direct mapping] Paired box protein Pax-6
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SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
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GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0048856[anatomical structure development]
A0A1W2PSA8 [Direct mapping] Paired box protein Pax-6
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
Q66SS1 [Target identity:100%; Query identity:100%] Paired box gene 6 isoform a; Paired box protein Pax-6 isoform a
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Helix-turn-helix domains Disease related genes Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001221[transcription coregulator binding] GO:0001568[blood vessel development] GO:0001654[eye development] GO:0003322[pancreatic A cell development] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007417[central nervous system development] GO:0007601[visual perception] GO:0009611[response to wounding] GO:0009887[animal organ morphogenesis] GO:0010628[positive regulation of gene expression] GO:0019901[protein kinase binding] GO:0021517[ventral spinal cord development] GO:0030154[cell differentiation] GO:0035035[histone acetyltransferase binding] GO:0042593[glucose homeostasis] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048663[neuron fate commitment] GO:0048856[anatomical structure development] GO:0050768[negative regulation of neurogenesis] GO:0061072[iris morphogenesis] GO:0061303[cornea development in camera-type eye] GO:0070412[R-SMAD binding] GO:1904798[positive regulation of core promoter binding] GO:1990837[sequence-specific double-stranded DNA binding]
A0A1W2PRG3 [Direct mapping] Paired box protein Pax-6
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
A0A1W2PPN2 [Direct mapping] Paired box protein Pax-6
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SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
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GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0048856[anatomical structure development]
A0A1W2PPH0 [Direct mapping] Paired box protein Pax-6
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
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GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II]
A0A1W2PNS7 [Direct mapping] Paired box protein Pax-6
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
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GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II]
A0A1W2PRA4 [Direct mapping] Paired box protein Pax-6
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SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014)
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GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0048856[anatomical structure development]
F1T0F8 [Target identity:100%; Query identity:100%] Paired box protein Pax-6
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SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Helix-turn-helix domains Disease related genes Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001221[transcription coregulator binding] GO:0001568[blood vessel development] GO:0001654[eye development] GO:0003322[pancreatic A cell development] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007417[central nervous system development] GO:0007601[visual perception] GO:0009611[response to wounding] GO:0009887[animal organ morphogenesis] GO:0010628[positive regulation of gene expression] GO:0019901[protein kinase binding] GO:0021517[ventral spinal cord development] GO:0030154[cell differentiation] GO:0035035[histone acetyltransferase binding] GO:0042593[glucose homeostasis] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048663[neuron fate commitment] GO:0048856[anatomical structure development] GO:0050768[negative regulation of neurogenesis] GO:0061072[iris morphogenesis] GO:0061303[cornea development in camera-type eye] GO:0070412[R-SMAD binding] GO:1904798[positive regulation of core promoter binding] GO:1990837[sequence-specific double-stranded DNA binding]
Q66SS1 [Target identity:100%; Query identity:100%] Paired box gene 6 isoform a; Paired box protein Pax-6 isoform a
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Helix-turn-helix domains Disease related genes Human disease related genes Congenital malformations Congenital malformations of eye Nervous system diseases Eye disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001221[transcription coregulator binding] GO:0001568[blood vessel development] GO:0001654[eye development] GO:0003322[pancreatic A cell development] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007417[central nervous system development] GO:0007601[visual perception] GO:0009611[response to wounding] GO:0009887[animal organ morphogenesis] GO:0010628[positive regulation of gene expression] GO:0019901[protein kinase binding] GO:0021517[ventral spinal cord development] GO:0030154[cell differentiation] GO:0035035[histone acetyltransferase binding] GO:0042593[glucose homeostasis] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048663[neuron fate commitment] GO:0048856[anatomical structure development] GO:0050768[negative regulation of neurogenesis] GO:0061072[iris morphogenesis] GO:0061303[cornea development in camera-type eye] GO:0070412[R-SMAD binding] GO:1904798[positive regulation of core promoter binding] GO:1990837[sequence-specific double-stranded DNA binding]
The Human Protein Atlas project is funded
