Expression of CD9 in urothelial cancer - The Human Protein Atlas

BLADDER UROTHELIAL CARCINOMA (TCGA) - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

CD9 is not prognostic in Bladder Urothelial Carcinoma (TCGA)

Stage:

Survival analysis

Current cut offⁱ :

Best expression cut offⁱ : 535.7

Median expressionⁱ : N/A

Median follow up timeⁱ : N/A

P scoreⁱ N/A

5-year survival highⁱ N/A

5-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average pTPM

689.2

Number of samples

169

Samples

Sample	Description	pTPM
TCGA-BT-A20V-01A	59 years, female, black or african american, stage:Stage IV, dead, 154 days	5571.6
TCGA-ZF-AA5N-01A	62 years, female, white, stage:Stage IV, dead, 168 days	2261.0
TCGA-BT-A20N-01A	72 years, male, stage:Stage III, dead, 795 days	2069.7
TCGA-GU-A42Q-01A	67 years, male, white, stage:Stage III, dead, 344 days	1790.0
TCGA-E5-A4TZ-01A	64 years, male, white, stage:Stage IV, dead, 467 days	1703.7
TCGA-4Z-AA82-01A	59 years, male, black or african american, stage:Stage IV, dead, 1556 days	1678.3
TCGA-2F-A9KO-01A	63 years, male, white, stage:Stage IV, dead, 734 days	1576.7
TCGA-DK-A3X2-01A	85 years, male, white, stage:Stage IV, dead, 547 days	1512.4
TCGA-BT-A0YX-01A	70 years, female, white, stage:Stage III, dead, 400 days	1385.2
TCGA-HQ-A5ND-01A	78 years, male, stage:Stage IV, dead, 274 days	1382.8
TCGA-CU-A5W6-01A	70 years, male, white, stage:Stage III, dead, 56 days	1365.4
TCGA-GU-AATQ-01A	68 years, male, white, stage:Stage III, dead, 213 days	1284.9
TCGA-FD-A3SL-01A	60 years, male, white, stage:Stage IV, dead, 712 days	1256.1
TCGA-DK-AA6Q-01A	61 years, female, white, stage:Stage IV, dead, 413 days	1232.3
TCGA-GU-A767-01A	81 years, male, white, stage:Stage IV, dead, 144 days	1213.1
TCGA-DK-A1A3-01A	60 years, male, white, stage:Stage IV, dead, 665 days	1184.4
TCGA-FD-A6TG-01A	73 years, male, white, stage:Stage IV, dead, 93 days	1184.4
TCGA-DK-A1AB-01A	74 years, female, white, stage:Stage IV, dead, 508 days	1167.7
TCGA-FD-A6TH-01A	63 years, male, white, stage:Stage IV, dead, 131 days	1166.7
TCGA-BT-A2LD-01A	78 years, female, white, stage:Stage IV, dead, 623 days	1165.6
TCGA-K4-A5RI-01A	67 years, female, white, stage:Stage III, dead, 356 days	1139.4
TCGA-GU-AATO-01A	75 years, male, white, stage:Stage IV, dead, 324 days	1112.6
TCGA-GU-A42R-01A	68 years, male, white, stage:Stage IV, dead, 577 days	1091.6
TCGA-DK-A1A5-01A	79 years, male, white, stage:Stage II, dead, 65 days	1077.7
TCGA-FD-A3SS-01A	66 years, male, white, stage:Stage IV, dead, 391 days	1061.3
TCGA-ZF-AA4U-01A	70 years, male, white, stage:Stage III, dead, 262 days	1057.0
TCGA-HQ-A5NE-01A	57 years, male, stage:Stage III, dead, 370 days	1052.6
TCGA-ZF-A9RD-01A	75 years, female, white, stage:Stage IV, dead, 408 days	1031.4
TCGA-FD-A5C0-01A	61 years, male, white, stage:Stage IV, dead, 550 days	1020.5
TCGA-G2-A2ES-01A	85 years, male, white, stage:Stage II, dead, 1004 days	998.0
TCGA-DK-AA6L-01A	48 years, male, white, stage:Stage IV, dead, 1163 days	965.6
TCGA-4Z-AA7S-01A	66 years, male, black or african american, stage:Stage III, dead, 1064 days	949.7
TCGA-XF-A9SL-01A	69 years, male, white, stage:Stage IV, dead, 2020 days	920.5
TCGA-BL-A3JM-01A	62 years, male, white, stage:Stage III, dead, 205 days	920.1
TCGA-GV-A3QF-01A	79 years, male, white, stage:Stage IV, dead, 617 days	916.7
TCGA-FD-A3SR-01A	68 years, male, white, stage:Stage IV, dead, 602 days	892.8
TCGA-C4-A0F7-01A	77 years, male, stage:Stage IV, dead, 62 days	882.1
TCGA-ZF-AA56-01A	79 years, female, white, stage:Stage III, dead, 259 days	877.3
TCGA-FD-A3SM-01A	70 years, male, white, stage:Stage IV, dead, 547 days	866.7
TCGA-BL-A13J-01A	65 years, male, white, stage:Stage IV, dead, 81 days	866.1
TCGA-GV-A3JV-01A	66 years, male, white, stage:Stage IV, dead, 434 days	858.2
TCGA-G2-A3IB-01A	66 years, male, black or african american, stage:Stage II, dead, 220 days	849.3
TCGA-2F-A9KR-01A	59 years, female, stage:Stage III, dead, 3183 days	848.4
TCGA-XF-A8HI-01A	57 years, female, white, stage:Stage IV, dead, 544 days	844.9
TCGA-XF-A9SV-01A	82 years, male, white, stage:Stage IV, dead, 388 days	836.9
TCGA-YC-A9TC-01A	71 years, male, white, stage:Stage IV, dead, 20 days	836.0
TCGA-XF-A8HH-01A	61 years, female, white, stage:Stage IV, dead, 57 days	831.5
TCGA-E7-A3X6-01A	70 years, male, white, stage:Stage II, dead, 904 days	824.3
TCGA-5N-A9KI-01A	76 years, female, white, stage:Stage III, dead, 76 days	824.0
TCGA-2F-A9KP-01A	66 years, male, white, stage:Stage IV, dead, 364 days	819.2
TCGA-ZF-A9RE-01A	78 years, female, white, stage:Stage II, dead, 106 days	813.7
TCGA-FD-A3SJ-01A	59 years, male, white, stage:Stage IV, dead, 739 days	808.4
TCGA-CU-A0YR-01A	83 years, male, white, stage:Stage IV, dead, 460 days	807.4
TCGA-XF-A8HC-01A	79 years, male, asian, stage:Stage IV, dead, 200 days	801.1
TCGA-XF-A9SZ-01A	79 years, male, white, stage:Stage IV, dead, 859 days	792.2
TCGA-FD-A6TI-01A	73 years, male, white, stage:Stage IV, dead, 294 days	780.3
TCGA-BT-A2LB-01A	73 years, female, white, stage:Stage III, dead, 492 days	778.2
TCGA-DK-A2HX-01A	80 years, female, white, stage:Stage IV, dead, 1420 days	778.0
TCGA-FD-A6TF-01A	80 years, female, white, stage:Stage IV, dead, 69 days	768.0
TCGA-BT-A20U-01A	70 years, female, white, stage:Stage III, dead, 455 days	765.5
TCGA-FD-A62O-01A	74 years, male, white, stage:Stage IV, dead, 216 days	761.2
TCGA-GC-A3BM-01A	70 years, male, white, stage:Stage II, dead, 651 days	758.9
TCGA-FD-A3B3-01A	74 years, female, white, stage:Stage III, dead, 974 days	756.9
TCGA-FD-A3B4-01A	55 years, female, black or african american, stage:Stage III, dead, 510 days	752.3
TCGA-FD-A62P-01A	76 years, male, white, stage:Stage II, dead, 191 days	751.5
TCGA-XF-AAMX-01A	87 years, female, black or african american, stage:Stage III, dead, 206 days	749.3
TCGA-XF-AAMZ-01A	81 years, female, white, stage:Stage IV, dead, 1348 days	744.4
TCGA-4Z-AA81-01A	80 years, male, white, stage:Stage II, dead, 1270 days	744.3
TCGA-XF-A9SK-01A	65 years, male, white, stage:Stage IV, dead, 486 days	709.9
TCGA-ZF-AA4R-01A	67 years, male, white, stage:Stage IV, dead, 1036 days	709.6
TCGA-CU-A72E-01A	76 years, male, white, stage:Stage IV, dead, 413 days	709.2
TCGA-G2-A2EC-01A	58 years, female, black or african american, stage:Stage II, dead, 696 days	705.6
TCGA-UY-A78M-01A	81 years, female, asian, stage:Stage IV, dead, 690 days	694.3
TCGA-BT-A20W-01A	71 years, male, white, stage:Stage II, dead, 254 days	684.2
TCGA-GC-A3I6-01A	45 years, male, white, stage:Stage III, dead, 630 days	666.4
TCGA-CU-A0YO-01A	84 years, male, white, stage:Stage IV, dead, 149 days	654.1
TCGA-FJ-A3Z9-01A	72 years, male, white, stage:'--, dead, 385 days	653.4
TCGA-FD-A5BZ-01A	77 years, female, white, stage:Stage IV, dead, 835 days	641.8
TCGA-4Z-AA86-01A	66 years, male, black or african american, stage:Stage IV, dead, 311 days	629.6
TCGA-DK-A3IQ-01A	74 years, male, white, stage:Stage III, dead, 539 days	628.2
TCGA-FD-A3N5-01A	69 years, male, black or african american, stage:Stage II, dead, 685 days	623.3
TCGA-E7-A97P-01A	73 years, male, asian, stage:Stage II, dead, 437 days	619.5
TCGA-CF-A47T-01A	58 years, female, asian, stage:Stage II, dead, 385 days	618.6
TCGA-BT-A20T-01A	63 years, male, white, stage:Stage IV, dead, 453 days	604.7
TCGA-ZF-A9R9-01A	58 years, male, white, stage:Stage IV, dead, 864 days	598.9
TCGA-FD-A43Y-01A	65 years, male, white, stage:Stage III, dead, 474 days	597.0
TCGA-BT-A3PK-01A	80 years, male, white, stage:Stage II, dead, 303 days	577.4
TCGA-XF-AAN1-01A	75 years, female, stage:Stage III, dead, 941 days	571.6
TCGA-ZF-AA4N-01A	74 years, male, white, stage:Stage II, dead, 88 days	571.5
TCGA-FD-A3B5-01A	86 years, male, black or african american, stage:Stage IV, dead, 272 days	562.9
TCGA-UY-A78K-01A	60 years, male, white, stage:Stage IV, dead, 536 days	554.1
TCGA-XF-A9SJ-01A	83 years, male, white, stage:Stage IV, dead, 98 days	552.1
TCGA-FD-A62S-01A	60 years, female, black or african american, stage:Stage III, dead, 406 days	551.1
TCGA-BT-A3PH-01A	76 years, male, white, stage:Stage IV, dead, 142 days	550.5
TCGA-G2-A3IE-01A	51 years, male, white, stage:Stage II, dead, 612 days	550.4
TCGA-5N-A9KM-01A	73 years, female, white, stage:Stage III, dead, 530 days	549.2
TCGA-BT-A20P-01A	81 years, female, white, stage:Stage III, dead, 544 days	542.4
TCGA-CU-A0YN-01A	60 years, male, white, stage:Stage III, dead, 393 days	542.0
TCGA-4Z-AA80-01A	73 years, male, white, stage:Stage II, dead, 19 days	539.3
TCGA-GV-A40E-01A	75 years, male, white, stage:Stage II, dead, 261 days	535.7
TCGA-ZF-A9R3-01A	53 years, female, white, stage:Stage II, dead, 949 days	531.6
TCGA-FD-A3SQ-01A	62 years, male, white, stage:Stage IV, dead, 1423 days	521.3
TCGA-K4-A4AC-01A	83 years, male, white, stage:Stage II, dead, 278 days	518.1
TCGA-XF-A9SP-01A	59 years, male, white, stage:Stage III, dead, 454 days	514.7
TCGA-ZF-AA4T-01A	65 years, male, white, stage:Stage IV, dead, 599 days	509.0
TCGA-DK-A3IM-01A	76 years, male, white, stage:Stage III, dead, 248 days	499.3
TCGA-XF-AAML-01A	75 years, male, white, stage:Stage II, dead, 232 days	493.2
TCGA-XF-A8HG-01A	69 years, male, white, stage:Stage III, dead, 467 days	491.5
TCGA-ZF-AA52-01A	70 years, male, white, stage:Stage III, dead, 1077 days	465.4
TCGA-XF-A9SH-01A	65 years, female, asian, stage:Stage II, dead, 1971 days	465.4
TCGA-FD-A3B6-01A	75 years, male, white, stage:Stage II, dead, 1005 days	458.4
TCGA-ZF-A9RN-01A	67 years, female, white, stage:Stage III, dead, 615 days	454.7
TCGA-XF-A9SX-01A	63 years, female, white, stage:Stage IV, dead, 719 days	451.8
TCGA-BT-A20Q-01A	73 years, male, white, stage:Stage IV, dead, 593 days	450.4
TCGA-E7-A541-01A	66 years, male, white, stage:Stage II, dead, 778 days	440.2
TCGA-DK-A3IL-01A	79 years, female, white, stage:Stage IV, dead, 413 days	428.6
TCGA-GU-A762-01A	87 years, male, white, stage:Stage IV, dead, 232 days	413.6
TCGA-FD-A6TD-01A	77 years, male, white, stage:Stage III, dead, 386 days	408.2
TCGA-XF-AAMT-01A	75 years, female, white, stage:Stage IV, dead, 90 days	405.9
TCGA-XF-AAME-01A	64 years, female, white, stage:Stage II, dead, 2828 days	404.9
TCGA-FJ-A3ZE-01A	65 years, male, white, stage:Stage IV, dead, 324 days	403.4
TCGA-BT-A20J-01A	75 years, male, white, stage:Stage II, dead, 579 days	400.9
TCGA-XF-AAN2-01A	73 years, male, white, stage:Stage II, dead, 1869 days	399.9
TCGA-XF-A9SW-01A	85 years, male, white, stage:Stage IV, dead, 362 days	392.0
TCGA-4Z-AA7N-01A	65 years, male, white, stage:Stage III, dead, 1367 days	391.4
TCGA-FD-A5BV-01A	47 years, female, white, stage:Stage III, dead, 163 days	385.4
TCGA-FD-A3SO-01A	68 years, male, white, stage:Stage IV, dead, 168 days	357.9
TCGA-G2-A2EO-01A	69 years, male, white, stage:Stage III, dead, 1804 days	355.0
TCGA-4Z-AA7Q-01A	79 years, male, white, stage:Stage III, dead, 510 days	354.0
TCGA-BT-A20X-01A	56 years, male, white, stage:Stage IV, dead, 251 days	349.0
TCGA-XF-AAMW-01A	79 years, female, white, stage:Stage IV, dead, 253 days	345.2
TCGA-XF-AAMJ-01A	70 years, male, asian, stage:Stage III, dead, 1670 days	344.6
TCGA-XF-A9SU-01A	74 years, female, white, stage:Stage IV, dead, 182 days	341.9
TCGA-XF-A9T8-01A	64 years, male, white, stage:Stage III, dead, 418 days	340.7
TCGA-CF-A9FL-01A	85 years, male, asian, stage:Stage III, dead, 565 days	339.9
TCGA-XF-A8HF-01A	80 years, male, white, stage:Stage III, dead, 2954 days	339.2
TCGA-DK-AA6W-01A	78 years, male, white, stage:Stage II, dead, 415 days	336.1
TCGA-GU-A42P-01A	72 years, male, white, stage:Stage IV, dead, 332 days	329.2
TCGA-FD-A3B7-01A	66 years, male, black or african american, stage:Stage III, dead, 122 days	314.7
TCGA-GV-A3QH-01A	67 years, male, white, stage:Stage II, dead, 258 days	311.9
TCGA-SY-A9G0-01A	82 years, male, white, stage:Stage IV, dead, 1008 days	309.1
TCGA-ZF-A9R0-01A	82 years, male, white, stage:Stage III, dead, 680 days	308.6
TCGA-S5-A6DX-01A	83 years, male, white, stage:Stage IV, dead, 56 days	304.4
TCGA-XF-AAN0-01A	68 years, male, white, stage:Stage IV, dead, 1718 days	303.7
TCGA-DK-A3IU-01A	58 years, male, white, stage:Stage II, dead, 706 days	292.3
TCGA-UY-A78N-01A	80 years, male, white, stage:Stage IV, dead, 2641 days	287.4
TCGA-DK-A3IK-01A	87 years, male, white, stage:Stage IV, dead, 146 days	280.4
TCGA-DK-AA75-01A	82 years, male, white, stage:Stage III, dead, 340 days	277.1
TCGA-XF-AAMH-01A	80 years, male, white, stage:Stage IV, dead, 344 days	269.0
TCGA-BT-A0S7-01A	75 years, male, white, stage:Stage III, dead, 200 days	254.3
TCGA-DK-A3IN-01A	72 years, male, white, stage:Stage III, dead, 250 days	250.4
TCGA-XF-AAN7-01A	60 years, male, white, stage:Stage IV, dead, 565 days	227.3
TCGA-E7-A4XJ-01A	66 years, male, asian, stage:Stage II, dead, 68 days	220.1
TCGA-XF-AAN4-01A	77 years, female, white, stage:Stage III, dead, 823 days	184.2
TCGA-4Z-AA7R-01A	73 years, male, black or african american, stage:Stage IV, dead, 522 days	170.7
TCGA-DK-A2I2-01A	63 years, female, white, stage:Stage IV, dead, 237 days	167.6
TCGA-ZF-AA54-01A	71 years, male, white, stage:Stage III, dead, 590 days	150.7
TCGA-FD-A5BX-01A	82 years, male, white, stage:Stage IV, dead, 173 days	149.4
TCGA-FD-A5BT-01A	84 years, male, white, stage:Stage III, dead, 328 days	146.9
TCGA-XF-AAN8-01A	74 years, female, white, stage:Stage III, dead, 118 days	129.8
TCGA-2F-A9KW-01A	67 years, female, white, stage:Stage III, dead, 254 days	129.4
TCGA-FJ-A871-01A	49 years, male, white, stage:Stage III, dead, 272 days	118.1
TCGA-XF-A9T2-01A	54 years, male, white, stage:Stage III, dead, 575 days	102.0
TCGA-BL-A13I-01A	57 years, female, white, stage:Stage III, dead, 223 days	99.8
TCGA-G2-AA3C-01A	66 years, male, white, stage:Stage IV, dead, 211 days	78.7
TCGA-C4-A0EZ-01A	69 years, female, stage:Stage IV, dead, 273 days	75.0
TCGA-BT-A20O-01A	75 years, male, white, stage:Stage III, dead, 370 days	58.6
TCGA-XF-A9ST-01A	68 years, male, white, stage:Stage III, dead, 128 days	39.6
TCGA-G2-A2EL-01A	77 years, male, white, stage:Stage II, dead, 819 days	12.9
Show allShow less

UROTHELIAL CANCER - Protein expressionⁱ A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

Antibody stainingⁱ Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells. Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.	Antibody CAB002490
Staining
High
Medium
Low
Not detected
Intensity
Strong
Moderate
Weak
Negative
Quantity
>75%
75%-25%
<25%
None
Location
Nuclear
Cytoplasmic/membranous
Cytoplasmic/membranous,nuclear
None
Urothelial carcinoma, High grade
Urothelial carcinoma, Low grade