GENERAL INFORMATIONi
Gene namei FYN
Synonyms MGC45350, SLK, SYN
Gene descriptioni FYN proto-oncogene, Src family tyrosine kinase
Protein classi Enzymes
Plasma proteins
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 6
Cytoband q21
Chromosome location (bp) 111660332 - 111873452
Number of transcriptsi 18
Ensembl ENSG00000010810 (version 109)
Entrez gene 2534
HGNC HGNC:4037
UniProt P06241 (UniProt - Evidence at protein level)
neXtProt NX_P06241
GeneCards FYN
Antibodypedia FYN antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance 1, 2, 3, 4, 5, 6, 7. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain 8. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions 9. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin) 10. Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT 11, 12. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage 13. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6 14, 15, 16. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein 17, 18, 19. Involved in reelin signaling by mediating phosphorylation of DAB1 following reelin (RELN)- binding to its receptor (By similarity). Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation 20. Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation 21. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts 22. CSK maintains LCK and FYN in an inactive form (By similarity). Promotes CD28-induced phosphorylation of VAV1 23. In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (By similarity). show less
Molecular function (UniProt)i Developmental protein, Kinase, Transferase, Tyrosine-protein kinase
Biological process (UniProt)i Adaptive immunity, Host-virus interaction, Immunity
Ligand (UniProt)i ATP-binding, Manganese, Metal-binding, Nucleotide-binding
Gene summary (Entrez)i This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
FYN-201
ENSP00000229471
ENST00000229471
P06241
[Direct mapping] Tyrosine-protein kinase Fyn
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000304 [response to singlet oxygen]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0002376 [immune system process]
GO:0002862 [negative regulation of inflammatory response to antigenic stimulus]
GO:0003015 [heart process]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [signaling receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006816 [calcium ion transport]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007411 [axon guidance]
GO:0007612 [learning]
GO:0007631 [feeding behavior]
GO:0008360 [regulation of cell shape]
GO:0010730 [negative regulation of hydrogen peroxide biosynthetic process]
GO:0014069 [postsynaptic density]
GO:0016004 [phospholipase activator activity]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0030154 [cell differentiation]
GO:0030425 [dendrite]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0031802 [type 5 metabotropic glutamate receptor binding]
GO:0035556 [intracellular signal transduction]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042802 [identical protein binding]
GO:0043014 [alpha-tubulin binding]
GO:0043204 [perikaryon]
GO:0043274 [phospholipase binding]
GO:0044297 [cell body]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0046872 [metal ion binding]
GO:0046875 [ephrin receptor binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048156 [tau protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050321 [tau-protein kinase activity]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050852 [T cell receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0070851 [growth factor receptor binding]
GO:0090314 [positive regulation of protein targeting to membrane]
GO:0097038 [perinuclear endoplasmic reticulum]
GO:0097062 [dendritic spine maintenance]
GO:0097110 [scaffold protein binding]
GO:0097386 [glial cell projection]
GO:0097718 [disordered domain specific binding]
GO:1900449 [regulation of glutamate receptor signaling pathway]
GO:1901216 [positive regulation of neuron death]
GO:1902951 [negative regulation of dendritic spine maintenance]
GO:1903202 [negative regulation of oxidative stress-induced cell death]
GO:1904645 [response to amyloid-beta]
GO:1904646 [cellular response to amyloid-beta]
GO:1905232 [cellular response to L-glutamate]
GO:1905430 [cellular response to glycine]
GO:1905477 [positive regulation of protein localization to membrane]
GO:1905664 [regulation of calcium ion import across plasma membrane]
GO:2001056 [positive regulation of cysteine-type endopeptidase activity]
Show all
 482 aa
54.5 kDa 		No 0
FYN-202
ENSP00000346671
ENST00000354650
P06241
[Direct mapping] Tyrosine-protein kinase Fyn
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000304 [response to singlet oxygen]
GO:0001664 [G protein-coupled receptor binding]
GO:0001764 [neuron migration]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0002376 [immune system process]
GO:0002862 [negative regulation of inflammatory response to antigenic stimulus]
GO:0003015 [heart process]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [signaling receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006816 [calcium ion transport]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007411 [axon guidance]
GO:0007612 [learning]
GO:0007631 [feeding behavior]
GO:0008360 [regulation of cell shape]
GO:0010629 [negative regulation of gene expression]
GO:0010730 [negative regulation of hydrogen peroxide biosynthetic process]
GO:0010976 [positive regulation of neuron projection development]
GO:0014069 [postsynaptic density]
GO:0015631 [tubulin binding]
GO:0016004 [phospholipase activator activity]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016567 [protein ubiquitination]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0030154 [cell differentiation]
GO:0030163 [protein catabolic process]
GO:0030425 [dendrite]
GO:0030900 [forebrain development]
GO:0031175 [neuron projection development]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0031802 [type 5 metabotropic glutamate receptor binding]
GO:0035556 [intracellular signal transduction]
GO:0036120 [cellular response to platelet-derived growth factor stimulus]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042531 [positive regulation of tyrosine phosphorylation of STAT protein]
GO:0042802 [identical protein binding]
GO:0043014 [alpha-tubulin binding]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043204 [perikaryon]
GO:0043274 [phospholipase binding]
GO:0044297 [cell body]
GO:0044325 [transmembrane transporter binding]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045471 [response to ethanol]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0046875 [ephrin receptor binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048156 [tau protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048813 [dendrite morphogenesis]
GO:0050321 [tau-protein kinase activity]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050798 [activated T cell proliferation]
GO:0050804 [modulation of chemical synaptic transmission]
GO:0050852 [T cell receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0050966 [detection of mechanical stimulus involved in sensory perception of pain]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0070851 [growth factor receptor binding]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0071944 [cell periphery]
GO:0090314 [positive regulation of protein targeting to membrane]
GO:0097038 [perinuclear endoplasmic reticulum]
GO:0097062 [dendritic spine maintenance]
GO:0097110 [scaffold protein binding]
GO:0097386 [glial cell projection]
GO:0097718 [disordered domain specific binding]
GO:0098685 [Schaffer collateral - CA1 synapse]
GO:1900182 [positive regulation of protein localization to nucleus]
GO:1900449 [regulation of glutamate receptor signaling pathway]
GO:1901216 [positive regulation of neuron death]
GO:1902951 [negative regulation of dendritic spine maintenance]
GO:1903202 [negative regulation of oxidative stress-induced cell death]
GO:1904645 [response to amyloid-beta]
GO:1904646 [cellular response to amyloid-beta]
GO:1905232 [cellular response to L-glutamate]
GO:1905430 [cellular response to glycine]
GO:1905477 [positive regulation of protein localization to membrane]
GO:1905664 [regulation of calcium ion import across plasma membrane]
GO:2001056 [positive regulation of cysteine-type endopeptidase activity]
Show all
 537 aa
60.8 kDa 		No 0
FYN-203
ENSP00000357656
ENST00000368667
P06241
[Direct mapping] Tyrosine-protein kinase Fyn
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000304 [response to singlet oxygen]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0002376 [immune system process]
GO:0002862 [negative regulation of inflammatory response to antigenic stimulus]
GO:0003015 [heart process]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [signaling receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006816 [calcium ion transport]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007411 [axon guidance]
GO:0007612 [learning]
GO:0007631 [feeding behavior]
GO:0008360 [regulation of cell shape]
GO:0010730 [negative regulation of hydrogen peroxide biosynthetic process]
GO:0014069 [postsynaptic density]
GO:0016004 [phospholipase activator activity]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0030154 [cell differentiation]
GO:0030425 [dendrite]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0031802 [type 5 metabotropic glutamate receptor binding]
GO:0035556 [intracellular signal transduction]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042802 [identical protein binding]
GO:0043014 [alpha-tubulin binding]
GO:0043204 [perikaryon]
GO:0043274 [phospholipase binding]
GO:0044297 [cell body]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0046872 [metal ion binding]
GO:0046875 [ephrin receptor binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048156 [tau protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050321 [tau-protein kinase activity]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050852 [T cell receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0070851 [growth factor receptor binding]
GO:0090314 [positive regulation of protein targeting to membrane]
GO:0097038 [perinuclear endoplasmic reticulum]
GO:0097062 [dendritic spine maintenance]
GO:0097110 [scaffold protein binding]
GO:0097386 [glial cell projection]
GO:0097718 [disordered domain specific binding]
GO:1900449 [regulation of glutamate receptor signaling pathway]
GO:1901216 [positive regulation of neuron death]
GO:1902951 [negative regulation of dendritic spine maintenance]
GO:1903202 [negative regulation of oxidative stress-induced cell death]
GO:1904645 [response to amyloid-beta]
GO:1904646 [cellular response to amyloid-beta]
GO:1905232 [cellular response to L-glutamate]
GO:1905430 [cellular response to glycine]
GO:1905477 [positive regulation of protein localization to membrane]
GO:1905664 [regulation of calcium ion import across plasma membrane]
GO:2001056 [positive regulation of cysteine-type endopeptidase activity]
Show all
 537 aa
60.8 kDa 		No 0
FYN-204
ENSP00000357667
ENST00000368678
P06241
[Direct mapping] Tyrosine-protein kinase Fyn
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000304 [response to singlet oxygen]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0002376 [immune system process]
GO:0002862 [negative regulation of inflammatory response to antigenic stimulus]
GO:0003015 [heart process]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [signaling receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006816 [calcium ion transport]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007411 [axon guidance]
GO:0007612 [learning]
GO:0007631 [feeding behavior]
GO:0008360 [regulation of cell shape]
GO:0010730 [negative regulation of hydrogen peroxide biosynthetic process]
GO:0014069 [postsynaptic density]
GO:0016004 [phospholipase activator activity]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0030154 [cell differentiation]
GO:0030425 [dendrite]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0031802 [type 5 metabotropic glutamate receptor binding]
GO:0035556 [intracellular signal transduction]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042802 [identical protein binding]
GO:0043014 [alpha-tubulin binding]
GO:0043204 [perikaryon]
GO:0043274 [phospholipase binding]
GO:0044297 [cell body]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0046872 [metal ion binding]
GO:0046875 [ephrin receptor binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048156 [tau protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050321 [tau-protein kinase activity]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050852 [T cell receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0070851 [growth factor receptor binding]
GO:0090314 [positive regulation of protein targeting to membrane]
GO:0097038 [perinuclear endoplasmic reticulum]
GO:0097062 [dendritic spine maintenance]
GO:0097110 [scaffold protein binding]
GO:0097386 [glial cell projection]
GO:0097718 [disordered domain specific binding]
GO:1900449 [regulation of glutamate receptor signaling pathway]
GO:1901216 [positive regulation of neuron death]
GO:1902951 [negative regulation of dendritic spine maintenance]
GO:1903202 [negative regulation of oxidative stress-induced cell death]
GO:1904645 [response to amyloid-beta]
GO:1904646 [cellular response to amyloid-beta]
GO:1905232 [cellular response to L-glutamate]
GO:1905430 [cellular response to glycine]
GO:1905477 [positive regulation of protein localization to membrane]
GO:1905664 [regulation of calcium ion import across plasma membrane]
GO:2001056 [positive regulation of cysteine-type endopeptidase activity]
Show all
 534 aa
60.1 kDa 		No 0
FYN-205
ENSP00000357671
ENST00000368682
P06241
[Direct mapping] Tyrosine-protein kinase Fyn
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000304 [response to singlet oxygen]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0002376 [immune system process]
GO:0002862 [negative regulation of inflammatory response to antigenic stimulus]
GO:0003015 [heart process]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [signaling receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006816 [calcium ion transport]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007411 [axon guidance]
GO:0007612 [learning]
GO:0007631 [feeding behavior]
GO:0008360 [regulation of cell shape]
GO:0010730 [negative regulation of hydrogen peroxide biosynthetic process]
GO:0014069 [postsynaptic density]
GO:0016004 [phospholipase activator activity]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0030154 [cell differentiation]
GO:0030425 [dendrite]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0031802 [type 5 metabotropic glutamate receptor binding]
GO:0035556 [intracellular signal transduction]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042802 [identical protein binding]
GO:0043014 [alpha-tubulin binding]
GO:0043204 [perikaryon]
GO:0043274 [phospholipase binding]
GO:0044297 [cell body]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0046872 [metal ion binding]
GO:0046875 [ephrin receptor binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048156 [tau protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050321 [tau-protein kinase activity]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050852 [T cell receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0070851 [growth factor receptor binding]
GO:0090314 [positive regulation of protein targeting to membrane]
GO:0097038 [perinuclear endoplasmic reticulum]
GO:0097062 [dendritic spine maintenance]
GO:0097110 [scaffold protein binding]
GO:0097386 [glial cell projection]
GO:0097718 [disordered domain specific binding]
GO:1900449 [regulation of glutamate receptor signaling pathway]
GO:1901216 [positive regulation of neuron death]
GO:1902951 [negative regulation of dendritic spine maintenance]
GO:1903202 [negative regulation of oxidative stress-induced cell death]
GO:1904645 [response to amyloid-beta]
GO:1904646 [cellular response to amyloid-beta]
GO:1905232 [cellular response to L-glutamate]
GO:1905430 [cellular response to glycine]
GO:1905477 [positive regulation of protein localization to membrane]
GO:1905664 [regulation of calcium ion import across plasma membrane]
GO:2001056 [positive regulation of cysteine-type endopeptidase activity]
Show all
 534 aa
60.1 kDa 		No 0
FYN-206
ENSP00000429590
ENST00000462598
E5RHX7
[Direct mapping] Tyrosine-protein kinase Fyn
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
 70 aa
7.5 kDa 		No 0
FYN-207
ENSP00000427993
ENST00000462856
E5RFS5
[Direct mapping] Tyrosine-protein kinase Fyn
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
Show all
 232 aa
26 kDa 		No 0
FYN-212
ENSP00000428983
ENST00000484067
E5RK23
[Direct mapping] Tyrosine-protein kinase Fyn
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 106 aa
11.4 kDa 		No 0
FYN-213
ENSP00000430455
ENST00000487824
E5RJX7
[Direct mapping] Tyrosine-protein kinase Fyn
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
 64 aa
7 kDa 		No 0
FYN-218
ENSP00000429866
ENST00000517419
E5RH71
[Direct mapping] Tyrosine-protein kinase Fyn
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
Show all
 175 aa
19.3 kDa 		No 0
FYN-219
ENSP00000428695
ENST00000518295
E5RGT0
[Direct mapping] Tyrosine-protein kinase Fyn
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 153 aa
16.8 kDa 		No 0
FYN-220
ENSP00000429813
ENST00000518630
E5RHF7
[Direct mapping] Tyrosine-protein kinase Fyn
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 118 aa
12.8 kDa 		No 0
FYN-221
ENSP00000429294
ENST00000520518
E5RIX5
[Direct mapping] Tyrosine-protein kinase Fyn
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Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
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 186 aa
20.5 kDa 		No 0
FYN-222
ENSP00000428042
ENST00000521062
E5RFM6
[Direct mapping] Tyrosine-protein kinase Fyn
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Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
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 103 aa
11.1 kDa 		No 0
FYN-224
ENSP00000430364
ENST00000523238
E5RFM0
[Direct mapping] Tyrosine-protein kinase Fyn
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Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
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 152 aa
16.7 kDa 		No 0
FYN-226
ENSP00000428045
ENST00000523570
E5RFM4
[Direct mapping] Tyrosine-protein kinase Fyn
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 116 aa
12.6 kDa 		No 0
FYN-227
ENSP00000429992
ENST00000523574
E5RGM6
[Direct mapping] Tyrosine-protein kinase Fyn
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Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0006897 [endocytosis]
GO:0051666 [actin cortical patch localization]
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 139 aa
15.2 kDa 		No 0
FYN-228
ENSP00000428493
ENST00000524310
E5RI25
[Direct mapping] Tyrosine-protein kinase Fyn
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Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0006897 [endocytosis]
GO:0051666 [actin cortical patch localization]
Show all
 145 aa
15.8 kDa 		No 0

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The Human Protein Atlas

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