Single cell type - NME1-NME2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NME1-NME2
Gene descriptionⁱ Full gene name according to HGNC.	NME1-NME2 readthrough
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Squamous epithelial cells, Excitatory neurons, Cone photoreceptor cells, Inhibitory neurons, Basal squamous epithelial cells, Oligodendrocyte precursor cells, Plasma cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.91
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Not available
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

Single cell type

Immune cells

Expression clustering

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Squamous epithelial cells, Excitatory neurons, Cone photoreceptor cells, Inhibitory neurons, Basal squamous epithelial cells, Oligodendrocyte precursor cells, Plasma cells)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

NME1-NME2 is part of cluster 49 Non-specific - Transcription with confidenceⁱ 1
378 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZNF749	Zinc finger protein 749	0.6172	49
GSTT2	Glutathione S-transferase theta 2 (gene/pseudogene)	0.5882	49
ZNF658	Zinc finger protein 658	0.5771	49
NDUFC2-KCTD14	NDUFC2-KCTD14 readthrough	0.5722	49
NME2	NME/NM23 nucleoside diphosphate kinase 2	0.5665	49
FASTKD1	FAST kinase domains 1	0.5421	23
MRPS24	Mitochondrial ribosomal protein S24	0.5301	49
ZNG1B	Zn regulated GTPase metalloprotein activator 1B	0.5298	49
MKKS	MKKS centrosomal shuttling protein	0.5286	49
PDXP	Pyridoxal phosphatase	0.5249	61
ALDOA	Aldolase, fructose-bisphosphate A	0.5191	49
BCKDHA	Branched chain keto acid dehydrogenase E1 subunit alpha	0.5067	49
PRR16	Proline rich 16	0.4991	69
NGRN	Neugrin, neurite outgrowth associated	0.4962	49
PDF	Peptide deformylase, mitochondrial	0.4940	61

IMMUNE CELLS

NME1-NME2 is part of cluster 13 Non-specific - Mitochondria with confidenceⁱ 0.89
458 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PPIAL4A	Peptidylprolyl isomerase A like 4A	1.0000	13
NHP2	NHP2 ribonucleoprotein	0.9762	13
NCKIPSD	NCK interacting protein with SH3 domain	0.9762	13
ZNF789	Zinc finger protein 789	0.9762	13
WDR5	WD repeat domain 5	0.9762	30
TMEM201	Transmembrane protein 201	0.9762	13
PRKRA	Protein activator of interferon induced protein kinase EIF2AK2	0.9762	13
TMEM86B	Transmembrane protein 86B	0.9762	13
PHLDB3	Pleckstrin homology like domain family B member 3	0.9762	13
MTFR2	Mitochondrial fission regulator 2	0.9762	13
CD99	CD99 molecule (Xg blood group)	0.9762	13
MRPL24	Mitochondrial ribosomal protein L24	0.9762	13
HINT2	Histidine triad nucleotide binding protein 2	0.9762	13
C1QBP	Complement C1q binding protein	0.9762	13
KANK1	KN motif and ankyrin repeat domains 1	0.9762	13