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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes CD markers FDA approved drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
19
Cytoband
q13.31
Chromosome location (bp)
43646095 - 43670547
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Acts as a receptor for urokinase plasminogen activator 1. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Receptor
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Biotech drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001934[positive regulation of protein phosphorylation] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005788[endoplasmic reticulum lumen] GO:0005789[endoplasmic reticulum membrane] GO:0005886[plasma membrane] GO:0005925[focal adhesion] GO:0006935[chemotaxis] GO:0007165[signal transduction] GO:0007596[blood coagulation] GO:0009986[cell surface] GO:0010755[regulation of plasminogen activation] GO:0016020[membrane] GO:0019898[extrinsic component of membrane] GO:0019899[enzyme binding] GO:0019904[protein domain specific binding] GO:0030155[regulation of cell adhesion] GO:0030162[regulation of proteolysis] GO:0030377[urokinase plasminogen activator receptor activity] GO:0034112[positive regulation of homotypic cell-cell adhesion] GO:0035579[specific granule membrane] GO:0038023[signaling receptor activity] GO:0038195[urokinase plasminogen activator signaling pathway] GO:0042995[cell projection] GO:0043066[negative regulation of apoptotic process] GO:0043388[positive regulation of DNA binding] GO:0045742[positive regulation of epidermal growth factor receptor signaling pathway] GO:0051917[regulation of fibrinolysis] GO:0070161[anchoring junction] GO:0090200[positive regulation of release of cytochrome c from mitochondria] GO:0098637[protein complex involved in cell-matrix adhesion] GO:1905370[serine-type endopeptidase complex] GO:2001243[negative regulation of intrinsic apoptotic signaling pathway] GO:2001268[negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
CD markers Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Biotech drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001934[positive regulation of protein phosphorylation] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005788[endoplasmic reticulum lumen] GO:0005789[endoplasmic reticulum membrane] GO:0005886[plasma membrane] GO:0005925[focal adhesion] GO:0006935[chemotaxis] GO:0007165[signal transduction] GO:0007596[blood coagulation] GO:0009986[cell surface] GO:0010755[regulation of plasminogen activation] GO:0016020[membrane] GO:0019898[extrinsic component of membrane] GO:0019899[enzyme binding] GO:0019904[protein domain specific binding] GO:0030155[regulation of cell adhesion] GO:0030162[regulation of proteolysis] GO:0030377[urokinase plasminogen activator receptor activity] GO:0034112[positive regulation of homotypic cell-cell adhesion] GO:0035579[specific granule membrane] GO:0038023[signaling receptor activity] GO:0038195[urokinase plasminogen activator signaling pathway] GO:0042995[cell projection] GO:0043066[negative regulation of apoptotic process] GO:0043388[positive regulation of DNA binding] GO:0045742[positive regulation of epidermal growth factor receptor signaling pathway] GO:0051917[regulation of fibrinolysis] GO:0070161[anchoring junction] GO:0090200[positive regulation of release of cytochrome c from mitochondria] GO:0098637[protein complex involved in cell-matrix adhesion] GO:1905370[serine-type endopeptidase complex] GO:2001243[negative regulation of intrinsic apoptotic signaling pathway] GO:2001268[negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Biotech drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934[positive regulation of protein phosphorylation] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005788[endoplasmic reticulum lumen] GO:0005789[endoplasmic reticulum membrane] GO:0005886[plasma membrane] GO:0005925[focal adhesion] GO:0006935[chemotaxis] GO:0007165[signal transduction] GO:0007596[blood coagulation] GO:0009986[cell surface] GO:0010755[regulation of plasminogen activation] GO:0016020[membrane] GO:0019898[extrinsic component of membrane] GO:0019899[enzyme binding] GO:0019904[protein domain specific binding] GO:0030155[regulation of cell adhesion] GO:0030162[regulation of proteolysis] GO:0030377[urokinase plasminogen activator receptor activity] GO:0034112[positive regulation of homotypic cell-cell adhesion] GO:0035579[specific granule membrane] GO:0038023[signaling receptor activity] GO:0038195[urokinase plasminogen activator signaling pathway] GO:0042995[cell projection] GO:0043066[negative regulation of apoptotic process] GO:0043388[positive regulation of DNA binding] GO:0045742[positive regulation of epidermal growth factor receptor signaling pathway] GO:0051917[regulation of fibrinolysis] GO:0070161[anchoring junction] GO:0090200[positive regulation of release of cytochrome c from mitochondria] GO:0098637[protein complex involved in cell-matrix adhesion] GO:1905370[serine-type endopeptidase complex] GO:2001243[negative regulation of intrinsic apoptotic signaling pathway] GO:2001268[negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
DeepTMHMM predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
DeepTMHMM predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
