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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes FDA approved drug targets Human disease related genes Nuclear receptors Transcription factors Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
12
Cytoband
q23.1
Chromosome location (bp)
100473708 - 100564414
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Ligand-activated transcription factor. Receptor for bile acids (BAs) such as chenodeoxycholic acid (CDCA), lithocholic acid, deoxycholic acid (DCA) and allocholic acid (ACA). Plays a essential role in BA homeostasis through the regulation of genes involved in BA synthesis, conjugation and enterohepatic circulation. Also regulates lipid and glucose homeostasis and is involved innate immune response 1,2,3,4. The FXR-RXR heterodimer binds predominantly to farnesoid X receptor response elements (FXREs) containing two inverted repeats of the consensus sequence 5'-AGGTCA-3' in which the monomers are spaced by 1 nucleotide (IR-1) but also to tandem repeat DR1 sites with lower affinity, and can be activated by either FXR or RXR-specific ligands. It is proposed that monomeric nuclear receptors such as NR5A2/LRH-1 bound to coregulatory nuclear responsive element (NRE) halfsites located in close proximity to FXREs modulate transcriptional activity (By similarity). In the liver activates transcription of the corepressor NR0B2 thereby indirectly inhibiting CYP7A1 and CYP8B1 (involved in BA synthesis) implicating at least in part histone demethylase KDM1A resulting in epigenomic repression, and SLC10A1/NTCP (involved in hepatic uptake of conjugated BAs). Activates transcription of the repressor MAFG (involved in regulation of BA synthesis) (By similarity). Activates transcription of SLC27A5/BACS and BAAT (involved in BA conjugation), ABCB11/BSEP (involved in bile salt export) by directly recruiting histone methyltransferase CARM1, and ABCC2/MRP2 (involved in secretion of conjugated BAs) and ABCB4 (involved in secretion of phosphatidylcholine in the small intestine) 5,6,7. Activates transcription of SLC27A5/BACS and BAAT (involved in BA conjugation), ABCB11/BSEP (involved in bile salt export) by directly recruiting histone methyltransferase CARM1, and ABCC2/MRP2 (involved in secretion of conjugated BAs) and ABCB4 (involved in secretion of phosphatidylcholine in the small intestine) 8,9,10. In the intestine activates FGF19 expression and secretion leading to hepatic CYP7A1 repression 11,12. The function also involves the coordinated induction of hepatic KLB/beta-klotho expression (By similarity). Regulates transcription of liver UGT2B4 and SULT2A1 involved in BA detoxification; binding to the UGT2B4 promoter seems to imply a monomeric transactivation independent of RXRA 13,14. Modulates lipid homeostasis by activating liver NR0B2/SHP-mediated repression of SREBF1 (involved in de novo lipogenesis), expression of PLTP (involved in HDL formation), SCARB1 (involved in HDL hepatic uptake), APOE, APOC1, APOC4, PPARA (involved in beta-oxidation of fatty acids), VLDLR and SDC1 (involved in the hepatic uptake of LDL and IDL remnants), and inhibiting expression of MTTP (involved in VLDL assembly 15,16,17. Increases expression of APOC2 (promoting lipoprotein lipase activity implicated in triglyceride clearance) 18. Transrepresses APOA1 involving a monomeric competition with NR2A1 for binding to a DR1 element 19,20. Also reduces triglyceride clearance by inhibiting expression of ANGPTL3 and APOC3 (both involved in inhibition of lipoprotein lipase) 21. Involved in glucose homeostasis by modulating hepatic gluconeogenesis through activation of NR0B2/SHP-mediated repression of respective genes. Modulates glycogen synthesis (inducing phosphorylation of glycogen synthase kinase-3) (By similarity). Modulates glucose-stimulated insulin secretion and is involved in insulin resistance 22. Involved in intestinal innate immunity. Plays a role in protecting the distal small intestine against bacterial overgrowth and preservation of the epithelial barrier (By similarity). Down-regulates inflammatory cytokine expression in several types of immune cells including macrophages and mononuclear cells 23. Mediates trans-repression of TLR4-induced cytokine expression; the function seems to require its sumoylation and prevents N-CoR nuclear receptor corepressor clearance from target genes such as IL1B and NOS2 24. Involved in the TLR9-mediated protective mechanism in intestinal inflammation. Plays an anti-inflammatory role in liver inflammation; proposed to inhibit pro-inflammatory (but not antiapoptotic) NF-kappa-B signaling) (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator, DNA-binding, Receptor, Repressor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a ligand-activated transcription factor that shares structural features in common with nuclear hormone receptor family members. This protein functions as a receptor for bile acids, and when bound to bile acids, binds to DNA and regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2016]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Digestive system diseases Liver diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000791[euchromatin] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001080[nitrogen catabolite activation of transcription from RNA polymerase II promoter] GO:0001221[transcription coregulator binding] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002376[immune system process] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006954[inflammatory response] GO:0008270[zinc ion binding] GO:0010903[negative regulation of very-low-density lipoprotein particle remodeling] GO:0010988[regulation of low-density lipoprotein particle clearance] GO:0016922[nuclear receptor binding] GO:0030154[cell differentiation] GO:0030522[intracellular receptor signaling pathway] GO:0032052[bile acid binding] GO:0032689[negative regulation of interferon-gamma production] GO:0032720[negative regulation of tumor necrosis factor production] GO:0032740[positive regulation of interleukin-17 production] GO:0034142[toll-like receptor 4 signaling pathway] GO:0034255[regulation of urea metabolic process] GO:0035356[cellular triglyceride homeostasis] GO:0038181[bile acid receptor activity] GO:0038183[bile acid signaling pathway] GO:0038185[intracellular bile acid receptor signaling pathway] GO:0043066[negative regulation of apoptotic process] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043235[receptor complex] GO:0043565[sequence-specific DNA binding] GO:0045087[innate immune response] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0050728[negative regulation of inflammatory response] GO:0061178[regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0070857[regulation of bile acid biosynthetic process] GO:0071398[cellular response to fatty acid] GO:0071417[cellular response to organonitrogen compound] GO:0090181[regulation of cholesterol metabolic process] GO:1902122[chenodeoxycholic acid binding] GO:1903413[cellular response to bile acid] GO:1905695[positive regulation of phosphatidic acid biosynthetic process] GO:2000213[positive regulation of glutamate metabolic process]
F1DAL1 [Target identity:100%; Query identity:100%] Farnesoid X nuclear receptor; Nuclear receptor subfamily 1, group H, member 4, isoform CRA_b
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Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Digestive system diseases Liver diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000791[euchromatin] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001080[nitrogen catabolite activation of transcription from RNA polymerase II promoter] GO:0001221[transcription coregulator binding] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001678[cellular glucose homeostasis] GO:0002376[immune system process] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006366[transcription by RNA polymerase II] GO:0006954[inflammatory response] GO:0007043[cell-cell junction assembly] GO:0007219[Notch signaling pathway] GO:0008206[bile acid metabolic process] GO:0008270[zinc ion binding] GO:0010804[negative regulation of tumor necrosis factor-mediated signaling pathway] GO:0010903[negative regulation of very-low-density lipoprotein particle remodeling] GO:0010988[regulation of low-density lipoprotein particle clearance] GO:0016922[nuclear receptor binding] GO:0030154[cell differentiation] GO:0030522[intracellular receptor signaling pathway] GO:0032052[bile acid binding] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032689[negative regulation of interferon-gamma production] GO:0032692[negative regulation of interleukin-1 production] GO:0032703[negative regulation of interleukin-2 production] GO:0032715[negative regulation of interleukin-6 production] GO:0032720[negative regulation of tumor necrosis factor production] GO:0032740[positive regulation of interleukin-17 production] GO:0034142[toll-like receptor 4 signaling pathway] GO:0034162[toll-like receptor 9 signaling pathway] GO:0034255[regulation of urea metabolic process] GO:0035356[cellular triglyceride homeostasis] GO:0035774[positive regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0038181[bile acid receptor activity] GO:0038183[bile acid signaling pathway] GO:0038185[intracellular bile acid receptor signaling pathway] GO:0042593[glucose homeostasis] GO:0042632[cholesterol homeostasis] GO:0042742[defense response to bacterium] GO:0043066[negative regulation of apoptotic process] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043235[receptor complex] GO:0043565[sequence-specific DNA binding] GO:0045087[innate immune response] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046628[positive regulation of insulin receptor signaling pathway] GO:0046872[metal ion binding] GO:0046965[nuclear retinoid X receptor binding] GO:0050728[negative regulation of inflammatory response] GO:0055089[fatty acid homeostasis] GO:0061178[regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0070328[triglyceride homeostasis] GO:0070857[regulation of bile acid biosynthetic process] GO:0071222[cellular response to lipopolysaccharide] GO:0071398[cellular response to fatty acid] GO:0071417[cellular response to organonitrogen compound] GO:0071638[negative regulation of monocyte chemotactic protein-1 production] GO:0090181[regulation of cholesterol metabolic process] GO:1902122[chenodeoxycholic acid binding] GO:1903413[cellular response to bile acid] GO:1904179[positive regulation of adipose tissue development] GO:1905695[positive regulation of phosphatidic acid biosynthetic process] GO:2000213[positive regulation of glutamate metabolic process] GO:2001250[positive regulation of ammonia assimilation cycle]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Digestive system diseases Liver diseases
B6ZGS9 [Target identity:100%; Query identity:100%] Farnesoid X receptor; Nuclear receptor subfamily 1, group H, member 4, isoform CRA_a
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Nuclear receptors Transporters Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Digestive system diseases Liver diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000791[euchromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001080[nitrogen catabolite activation of transcription from RNA polymerase II promoter] GO:0001221[transcription coregulator binding] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002376[immune system process] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006954[inflammatory response] GO:0008270[zinc ion binding] GO:0010903[negative regulation of very-low-density lipoprotein particle remodeling] GO:0010988[regulation of low-density lipoprotein particle clearance] GO:0016922[nuclear receptor binding] GO:0030154[cell differentiation] GO:0030522[intracellular receptor signaling pathway] GO:0032052[bile acid binding] GO:0032689[negative regulation of interferon-gamma production] GO:0032720[negative regulation of tumor necrosis factor production] GO:0032740[positive regulation of interleukin-17 production] GO:0034142[toll-like receptor 4 signaling pathway] GO:0034255[regulation of urea metabolic process] GO:0035356[cellular triglyceride homeostasis] GO:0038181[bile acid receptor activity] GO:0038183[bile acid signaling pathway] GO:0038185[intracellular bile acid receptor signaling pathway] GO:0043066[negative regulation of apoptotic process] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043235[receptor complex] GO:0043565[sequence-specific DNA binding] GO:0045087[innate immune response] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0050728[negative regulation of inflammatory response] GO:0061178[regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0070857[regulation of bile acid biosynthetic process] GO:0071398[cellular response to fatty acid] GO:0071417[cellular response to organonitrogen compound] GO:0090181[regulation of cholesterol metabolic process] GO:1902122[chenodeoxycholic acid binding] GO:1903413[cellular response to bile acid] GO:1905695[positive regulation of phosphatidic acid biosynthetic process] GO:2000213[positive regulation of glutamate metabolic process]
Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Digestive system diseases Liver diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000791[euchromatin] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001080[nitrogen catabolite activation of transcription from RNA polymerase II promoter] GO:0001221[transcription coregulator binding] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002376[immune system process] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006954[inflammatory response] GO:0008270[zinc ion binding] GO:0010903[negative regulation of very-low-density lipoprotein particle remodeling] GO:0010988[regulation of low-density lipoprotein particle clearance] GO:0016922[nuclear receptor binding] GO:0030154[cell differentiation] GO:0030522[intracellular receptor signaling pathway] GO:0032052[bile acid binding] GO:0032689[negative regulation of interferon-gamma production] GO:0032720[negative regulation of tumor necrosis factor production] GO:0032740[positive regulation of interleukin-17 production] GO:0034142[toll-like receptor 4 signaling pathway] GO:0034255[regulation of urea metabolic process] GO:0035356[cellular triglyceride homeostasis] GO:0038181[bile acid receptor activity] GO:0038183[bile acid signaling pathway] GO:0038185[intracellular bile acid receptor signaling pathway] GO:0043066[negative regulation of apoptotic process] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043235[receptor complex] GO:0043565[sequence-specific DNA binding] GO:0045087[innate immune response] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0050728[negative regulation of inflammatory response] GO:0061178[regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0070857[regulation of bile acid biosynthetic process] GO:0071398[cellular response to fatty acid] GO:0071417[cellular response to organonitrogen compound] GO:0090181[regulation of cholesterol metabolic process] GO:1902122[chenodeoxycholic acid binding] GO:1903413[cellular response to bile acid] GO:1905695[positive regulation of phosphatidic acid biosynthetic process] GO:2000213[positive regulation of glutamate metabolic process]
SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Digestive system diseases Liver diseases
Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Digestive system diseases Liver diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000791[euchromatin] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001080[nitrogen catabolite activation of transcription from RNA polymerase II promoter] GO:0001221[transcription coregulator binding] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002376[immune system process] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006954[inflammatory response] GO:0008270[zinc ion binding] GO:0010903[negative regulation of very-low-density lipoprotein particle remodeling] GO:0010988[regulation of low-density lipoprotein particle clearance] GO:0016922[nuclear receptor binding] GO:0030154[cell differentiation] GO:0030522[intracellular receptor signaling pathway] GO:0032052[bile acid binding] GO:0032689[negative regulation of interferon-gamma production] GO:0032720[negative regulation of tumor necrosis factor production] GO:0032740[positive regulation of interleukin-17 production] GO:0034142[toll-like receptor 4 signaling pathway] GO:0034255[regulation of urea metabolic process] GO:0035356[cellular triglyceride homeostasis] GO:0038181[bile acid receptor activity] GO:0038183[bile acid signaling pathway] GO:0038185[intracellular bile acid receptor signaling pathway] GO:0043066[negative regulation of apoptotic process] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043235[receptor complex] GO:0043565[sequence-specific DNA binding] GO:0045087[innate immune response] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0050728[negative regulation of inflammatory response] GO:0061178[regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0070857[regulation of bile acid biosynthetic process] GO:0071398[cellular response to fatty acid] GO:0071417[cellular response to organonitrogen compound] GO:0090181[regulation of cholesterol metabolic process] GO:1902122[chenodeoxycholic acid binding] GO:1903413[cellular response to bile acid] GO:1905695[positive regulation of phosphatidic acid biosynthetic process] GO:2000213[positive regulation of glutamate metabolic process]
F1DAL1 [Target identity:100%; Query identity:100%] Farnesoid X nuclear receptor; Nuclear receptor subfamily 1, group H, member 4, isoform CRA_b
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Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Digestive system diseases Liver diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000791[euchromatin] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001080[nitrogen catabolite activation of transcription from RNA polymerase II promoter] GO:0001221[transcription coregulator binding] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002376[immune system process] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006954[inflammatory response] GO:0008270[zinc ion binding] GO:0010903[negative regulation of very-low-density lipoprotein particle remodeling] GO:0010988[regulation of low-density lipoprotein particle clearance] GO:0016922[nuclear receptor binding] GO:0030154[cell differentiation] GO:0030522[intracellular receptor signaling pathway] GO:0032052[bile acid binding] GO:0032689[negative regulation of interferon-gamma production] GO:0032720[negative regulation of tumor necrosis factor production] GO:0032740[positive regulation of interleukin-17 production] GO:0034142[toll-like receptor 4 signaling pathway] GO:0034255[regulation of urea metabolic process] GO:0035356[cellular triglyceride homeostasis] GO:0038181[bile acid receptor activity] GO:0038183[bile acid signaling pathway] GO:0038185[intracellular bile acid receptor signaling pathway] GO:0043066[negative regulation of apoptotic process] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043235[receptor complex] GO:0043565[sequence-specific DNA binding] GO:0045087[innate immune response] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0050728[negative regulation of inflammatory response] GO:0061178[regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0070857[regulation of bile acid biosynthetic process] GO:0071398[cellular response to fatty acid] GO:0071417[cellular response to organonitrogen compound] GO:0090181[regulation of cholesterol metabolic process] GO:1902122[chenodeoxycholic acid binding] GO:1903413[cellular response to bile acid] GO:1905695[positive regulation of phosphatidic acid biosynthetic process] GO:2000213[positive regulation of glutamate metabolic process]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Digestive system diseases Liver diseases
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