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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes FDA approved drug targets Human disease related genes Metabolic proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
10
Cytoband
q11.21
Chromosome location (bp)
45374176 - 45446119
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Catalyzes the oxygenation of arachidonate ((5Z,8Z,11Z,14Z)- eicosatetraenoate) to 5-hydroperoxyeicosatetraenoate (5-HPETE) followed by the dehydration to 5,6-epoxyeicosatetraenoate (Leukotriene A4/LTA4), the first two steps in the biosynthesis of leukotrienes, which are potent mediators of inflammation 1,2,3,4,5,6,7,8,9. Also catalyzes the oxygenation of arachidonate into 8-hydroperoxyicosatetraenoate (8-HPETE) and 12-hydroperoxyicosatetraenoate (12-HPETE) 10. Displays lipoxin synthase activity being able to convert (15S)-HETE into a conjugate tetraene 11. Although arachidonate is the preferred substrate, this enzyme can also metabolize oxidized fatty acids derived from arachidonate such as (15S)-HETE, eicosapentaenoate (EPA) such as (18R)- and (18S)-HEPE or docosahexaenoate (DHA) which lead to the formation of specialized pro-resolving mediators (SPM) lipoxin and resolvins E and D respectively, therefore it participates in anti-inflammatory responses 12,13,14,15,16. Oxidation of DHA directly inhibits endothelial cell proliferation and sprouting angiogenesis via peroxisome proliferator-activated receptor gamma (PPARgamma) (By similarity). It does not catalyze the oxygenation of linoleic acid and does not convert (5S)-HETE to lipoxin isomers 17. In addition to inflammatory processes, it participates in dendritic cell migration, wound healing through an antioxidant mechanism based on heme oxygenase-1 (HO-1) regulation expression, monocyte adhesion to the endothelium via ITGAM expression on monocytes (By similarity). Moreover, it helps establish an adaptive humoral immunity by regulating primary resting B cells and follicular helper T cells and participates in the CD40-induced production of reactive oxygen species (ROS) after CD40 ligation in B cells through interaction with PIK3R1 that bridges ALOX5 with CD40 18. May also play a role in glucose homeostasis, regulation of insulin secretion and palmitic acid-induced insulin resistance via AMPK (By similarity). Can regulate bone mineralization and fat cell differentiation increases in induced pluripotent stem cells (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Dioxygenase, Hydrolase, Oxidoreductase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Leukotriene biosynthesis, Lipid metabolism
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Calcium, Iron, Metal-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC FDA approved drug targets Small molecule drugs Human disease related genes Immune system diseases Allergies and autoimmune diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001676[long-chain fatty acid metabolic process] GO:0001937[negative regulation of endothelial cell proliferation] GO:0002232[leukocyte chemotaxis involved in inflammatory response] GO:0002523[leukocyte migration involved in inflammatory response] GO:0002540[leukotriene production involved in inflammatory response] GO:0004051[arachidonate 5-lipoxygenase activity] GO:0004052[arachidonate 12(S)-lipoxygenase activity] GO:0005506[iron ion binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005635[nuclear envelope] GO:0005641[nuclear envelope lumen] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006629[lipid metabolic process] GO:0006690[icosanoid metabolic process] GO:0006691[leukotriene metabolic process] GO:0006954[inflammatory response] GO:0006959[humoral immune response] GO:0016020[membrane] GO:0016363[nuclear matrix] GO:0016491[oxidoreductase activity] GO:0016525[negative regulation of angiogenesis] GO:0016702[oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen] GO:0016787[hydrolase activity] GO:0019369[arachidonic acid metabolic process] GO:0019370[leukotriene biosynthetic process] GO:0019372[lipoxygenase pathway] GO:0030501[positive regulation of bone mineralization] GO:0031965[nuclear membrane] GO:0034440[lipid oxidation] GO:0034774[secretory granule lumen] GO:0036336[dendritic cell migration] GO:0036403[arachidonate 8(S)-lipoxygenase activity] GO:0042593[glucose homeostasis] GO:0042759[long-chain fatty acid biosynthetic process] GO:0043651[linoleic acid metabolic process] GO:0045598[regulation of fat cell differentiation] GO:0046872[metal ion binding] GO:0048471[perinuclear region of cytoplasm] GO:0050727[regulation of inflammatory response] GO:0050728[negative regulation of inflammatory response] GO:0050796[regulation of insulin secretion] GO:0051122[hepoxilin biosynthetic process] GO:0051213[dioxygenase activity] GO:0061044[negative regulation of vascular wound healing] GO:0061045[negative regulation of wound healing] GO:0106014[regulation of inflammatory response to wounding] GO:1900015[regulation of cytokine production involved in inflammatory response] GO:1900407[regulation of cellular response to oxidative stress] GO:1901753[leukotriene A4 biosynthetic process] GO:1903426[regulation of reactive oxygen species biosynthetic process] GO:1903573[negative regulation of response to endoplasmic reticulum stress] GO:1903671[negative regulation of sprouting angiogenesis] GO:1904813[ficolin-1-rich granule lumen] GO:1904999[positive regulation of leukocyte adhesion to arterial endothelial cell] GO:2001301[lipoxin biosynthetic process]
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC FDA approved drug targets Small molecule drugs Human disease related genes Immune system diseases Allergies and autoimmune diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001676[long-chain fatty acid metabolic process] GO:0001937[negative regulation of endothelial cell proliferation] GO:0002232[leukocyte chemotaxis involved in inflammatory response] GO:0002523[leukocyte migration involved in inflammatory response] GO:0004051[arachidonate 5-lipoxygenase activity] GO:0004052[arachidonate 12(S)-lipoxygenase activity] GO:0005506[iron ion binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005635[nuclear envelope] GO:0005641[nuclear envelope lumen] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006629[lipid metabolic process] GO:0006690[icosanoid metabolic process] GO:0006691[leukotriene metabolic process] GO:0006959[humoral immune response] GO:0016020[membrane] GO:0016363[nuclear matrix] GO:0016491[oxidoreductase activity] GO:0016525[negative regulation of angiogenesis] GO:0016702[oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen] GO:0016787[hydrolase activity] GO:0019369[arachidonic acid metabolic process] GO:0019370[leukotriene biosynthetic process] GO:0019372[lipoxygenase pathway] GO:0030501[positive regulation of bone mineralization] GO:0031965[nuclear membrane] GO:0034440[lipid oxidation] GO:0034774[secretory granule lumen] GO:0036336[dendritic cell migration] GO:0036403[arachidonate 8(S)-lipoxygenase activity] GO:0042593[glucose homeostasis] GO:0042759[long-chain fatty acid biosynthetic process] GO:0043651[linoleic acid metabolic process] GO:0045598[regulation of fat cell differentiation] GO:0046872[metal ion binding] GO:0048471[perinuclear region of cytoplasm] GO:0050727[regulation of inflammatory response] GO:0050728[negative regulation of inflammatory response] GO:0050796[regulation of insulin secretion] GO:0051122[hepoxilin biosynthetic process] GO:0051213[dioxygenase activity] GO:0061044[negative regulation of vascular wound healing] GO:0061045[negative regulation of wound healing] GO:0106014[regulation of inflammatory response to wounding] GO:1900015[regulation of cytokine production involved in inflammatory response] GO:1900407[regulation of cellular response to oxidative stress] GO:1901753[leukotriene A4 biosynthetic process] GO:1903426[regulation of reactive oxygen species biosynthetic process] GO:1903573[negative regulation of response to endoplasmic reticulum stress] GO:1903671[negative regulation of sprouting angiogenesis] GO:1904813[ficolin-1-rich granule lumen] GO:1904999[positive regulation of leukocyte adhesion to arterial endothelial cell] GO:2001301[lipoxin biosynthetic process]
The Human Protein Atlas project is funded
