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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
5
Cytoband
q11.1
Chromosome location (bp)
51383448 - 51394730
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1 (By similarity). Binds to insulin gene enhancer sequences (By similarity). Essential for heart development. Marker of one progenitor cell population that give rise to the outflow tract, right ventricle, a subset of left ventricular cells, and a large number of atrial cells as well, its function is required for these progenitors to contribute to the heart. Controls the expression of FGF and BMP growth factors in this cell population and is required for proliferation and survival of cells within pharyngeal foregut endoderm and adjacent splanchnic mesoderm as well as for migration of cardiac progenitors into the heart (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator, Developmental protein, DNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P61371 [Direct mapping] Insulin gene enhancer protein ISL-1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Helix-turn-helix domains Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0000987[cis-regulatory region sequence-specific DNA binding] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001755[neural crest cell migration] GO:0003007[heart morphogenesis] GO:0003139[secondary heart field specification] GO:0003148[outflow tract septum morphogenesis] GO:0003151[outflow tract morphogenesis] GO:0003203[endocardial cushion morphogenesis] GO:0003215[cardiac right ventricle morphogenesis] GO:0003266[regulation of secondary heart field cardioblast proliferation] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006366[transcription by RNA polymerase II] GO:0007409[axonogenesis] GO:0007507[heart development] GO:0008283[cell population proliferation] GO:0008284[positive regulation of cell population proliferation] GO:0010468[regulation of gene expression] GO:0010575[positive regulation of vascular endothelial growth factor production] GO:0010718[positive regulation of epithelial to mesenchymal transition] GO:0016922[nuclear receptor binding] GO:0021520[spinal cord motor neuron cell fate specification] GO:0021522[spinal cord motor neuron differentiation] GO:0021524[visceral motor neuron differentiation] GO:0021559[trigeminal nerve development] GO:0021983[pituitary gland development] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030331[nuclear estrogen receptor binding] GO:0031016[pancreas development] GO:0031103[axon regeneration] GO:0031290[retinal ganglion cell axon guidance] GO:0031333[negative regulation of protein-containing complex assembly] GO:0032024[positive regulation of insulin secretion] GO:0032725[positive regulation of granulocyte macrophage colony-stimulating factor production] GO:0032729[positive regulation of interferon-gamma production] GO:0032730[positive regulation of interleukin-1 alpha production] GO:0032731[positive regulation of interleukin-1 beta production] GO:0032735[positive regulation of interleukin-12 production] GO:0032755[positive regulation of interleukin-6 production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0033147[negative regulation of intracellular estrogen receptor signaling pathway] GO:0035066[positive regulation of histone acetylation] GO:0042531[positive regulation of tyrosine phosphorylation of STAT protein] GO:0043388[positive regulation of DNA binding] GO:0043425[bHLH transcription factor binding] GO:0043524[negative regulation of neuron apoptotic process] GO:0043565[sequence-specific DNA binding] GO:0045597[positive regulation of cell differentiation] GO:0045665[negative regulation of neuron differentiation] GO:0045766[positive regulation of angiogenesis] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0048663[neuron fate commitment] GO:0048665[neuron fate specification] GO:0048762[mesenchymal cell differentiation] GO:0048863[stem cell differentiation] GO:0048880[sensory system development] GO:0048935[peripheral nervous system neuron development] GO:0048936[peripheral nervous system neuron axonogenesis] GO:0050680[negative regulation of epithelial cell proliferation] GO:0050728[negative regulation of inflammatory response] GO:0055010[ventricular cardiac muscle tissue morphogenesis] GO:0060037[pharyngeal system development] GO:0060070[canonical Wnt signaling pathway] GO:0060379[cardiac muscle cell myoblast differentiation] GO:0060384[innervation] GO:0060413[atrial septum morphogenesis] GO:0060913[cardiac cell fate determination] GO:0060931[sinoatrial node cell development] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0071385[cellular response to glucocorticoid stimulus] GO:0071657[positive regulation of granulocyte colony-stimulating factor production] GO:0086091[regulation of heart rate by cardiac conduction] GO:0090090[negative regulation of canonical Wnt signaling pathway] GO:1901258[positive regulation of macrophage colony-stimulating factor production] GO:1990837[sequence-specific double-stranded DNA binding] GO:1990841[promoter-specific chromatin binding]
The Human Protein Atlas project is funded
