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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes Plasma proteins RAS pathway related proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
12
Cytoband
q23.2
Chromosome location (bp)
102395874 - 102481744
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation 1,2. Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb (By similarity). Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 3,4,5,6. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via promotion of STUB1/CHIP-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Growth factor
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P05019 [Direct mapping] Insulin-like growth factor I
Show all
MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins Plasma proteins RAS pathway related proteins Disease related genes Human disease related genes Cancers Cancers of the lung and pleura Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0001501[skeletal system development] GO:0001775[cell activation] GO:0001837[epithelial to mesenchymal transition] GO:0001932[regulation of protein phosphorylation] GO:0005158[insulin receptor binding] GO:0005159[insulin-like growth factor receptor binding] GO:0005178[integrin binding] GO:0005179[hormone activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0007165[signal transduction] GO:0007265[Ras protein signal transduction] GO:0007517[muscle organ development] GO:0008083[growth factor activity] GO:0008283[cell population proliferation] GO:0008284[positive regulation of cell population proliferation] GO:0009408[response to heat] GO:0009441[glycolate metabolic process] GO:0010468[regulation of gene expression] GO:0010560[positive regulation of glycoprotein biosynthetic process] GO:0010613[positive regulation of cardiac muscle hypertrophy] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0014065[phosphatidylinositol 3-kinase signaling] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014834[skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration] GO:0014896[muscle hypertrophy] GO:0014904[myotube cell development] GO:0014911[positive regulation of smooth muscle cell migration] GO:0016942[insulin-like growth factor binding protein complex] GO:0030166[proteoglycan biosynthetic process] GO:0030335[positive regulation of cell migration] GO:0031093[platelet alpha granule lumen] GO:0032148[activation of protein kinase B activity] GO:0032691[negative regulation of interleukin-1 beta production] GO:0032720[negative regulation of tumor necrosis factor production] GO:0034392[negative regulation of smooth muscle cell apoptotic process] GO:0035630[bone mineralization involved in bone maturation] GO:0035867[alphav-beta3 integrin-IGF-1-IGF1R complex] GO:0042060[wound healing] GO:0042104[positive regulation of activated T cell proliferation] GO:0042531[positive regulation of tyrosine phosphorylation of STAT protein] GO:0042567[insulin-like growth factor ternary complex] GO:0043066[negative regulation of apoptotic process] GO:0043388[positive regulation of DNA binding] GO:0043410[positive regulation of MAPK cascade] GO:0043491[protein kinase B signaling] GO:0043568[positive regulation of insulin-like growth factor receptor signaling pathway] GO:0045445[myoblast differentiation] GO:0045669[positive regulation of osteoblast differentiation] GO:0045725[positive regulation of glycogen biosynthetic process] GO:0045821[positive regulation of glycolytic process] GO:0045840[positive regulation of mitotic nuclear division] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046326[positive regulation of glucose import] GO:0046579[positive regulation of Ras protein signal transduction] GO:0048009[insulin-like growth factor receptor signaling pathway] GO:0048015[phosphatidylinositol-mediated signaling] GO:0048146[positive regulation of fibroblast proliferation] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0050679[positive regulation of epithelial cell proliferation] GO:0050714[positive regulation of protein secretion] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0050821[protein stabilization] GO:0051450[myoblast proliferation] GO:0051897[positive regulation of protein kinase B signaling] GO:0060283[negative regulation of oocyte development] GO:0061051[positive regulation of cell growth involved in cardiac muscle cell development] GO:0070371[ERK1 and ERK2 cascade] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0070382[exocytic vesicle] GO:0070886[positive regulation of calcineurin-NFAT signaling cascade] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:0150079[negative regulation of neuroinflammatory response] GO:1902430[negative regulation of amyloid-beta formation] GO:1904075[positive regulation of trophectodermal cell proliferation] GO:1904646[cellular response to amyloid-beta] GO:1904707[positive regulation of vascular associated smooth muscle cell proliferation] GO:1905460[negative regulation of vascular associated smooth muscle cell apoptotic process] GO:2000679[positive regulation of transcription regulatory region DNA binding] GO:2001237[negative regulation of extrinsic apoptotic signaling pathway]
P05019 [Direct mapping] Insulin-like growth factor I
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Q5U743 [Target identity:100%; Query identity:100%] Insulin-like growth factor I
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MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins Plasma proteins RAS pathway related proteins Disease related genes Human disease related genes Cancers Cancers of the lung and pleura Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501[skeletal system development] GO:0001775[cell activation] GO:0001837[epithelial to mesenchymal transition] GO:0001932[regulation of protein phosphorylation] GO:0005158[insulin receptor binding] GO:0005159[insulin-like growth factor receptor binding] GO:0005178[integrin binding] GO:0005179[hormone activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0007165[signal transduction] GO:0007265[Ras protein signal transduction] GO:0007517[muscle organ development] GO:0008083[growth factor activity] GO:0008283[cell population proliferation] GO:0008284[positive regulation of cell population proliferation] GO:0009408[response to heat] GO:0009441[glycolate metabolic process] GO:0010468[regulation of gene expression] GO:0010560[positive regulation of glycoprotein biosynthetic process] GO:0010613[positive regulation of cardiac muscle hypertrophy] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0014065[phosphatidylinositol 3-kinase signaling] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014834[skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration] GO:0014896[muscle hypertrophy] GO:0014904[myotube cell development] GO:0014911[positive regulation of smooth muscle cell migration] GO:0016942[insulin-like growth factor binding protein complex] GO:0030166[proteoglycan biosynthetic process] GO:0030335[positive regulation of cell migration] GO:0031093[platelet alpha granule lumen] GO:0032148[activation of protein kinase B activity] GO:0032691[negative regulation of interleukin-1 beta production] GO:0032720[negative regulation of tumor necrosis factor production] GO:0034392[negative regulation of smooth muscle cell apoptotic process] GO:0035630[bone mineralization involved in bone maturation] GO:0035867[alphav-beta3 integrin-IGF-1-IGF1R complex] GO:0042060[wound healing] GO:0042104[positive regulation of activated T cell proliferation] GO:0042531[positive regulation of tyrosine phosphorylation of STAT protein] GO:0042567[insulin-like growth factor ternary complex] GO:0043066[negative regulation of apoptotic process] GO:0043388[positive regulation of DNA binding] GO:0043410[positive regulation of MAPK cascade] GO:0043491[protein kinase B signaling] GO:0043568[positive regulation of insulin-like growth factor receptor signaling pathway] GO:0045445[myoblast differentiation] GO:0045669[positive regulation of osteoblast differentiation] GO:0045725[positive regulation of glycogen biosynthetic process] GO:0045821[positive regulation of glycolytic process] GO:0045840[positive regulation of mitotic nuclear division] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046326[positive regulation of glucose import] GO:0046579[positive regulation of Ras protein signal transduction] GO:0048009[insulin-like growth factor receptor signaling pathway] GO:0048015[phosphatidylinositol-mediated signaling] GO:0048146[positive regulation of fibroblast proliferation] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0050679[positive regulation of epithelial cell proliferation] GO:0050714[positive regulation of protein secretion] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0050821[protein stabilization] GO:0051450[myoblast proliferation] GO:0051897[positive regulation of protein kinase B signaling] GO:0060283[negative regulation of oocyte development] GO:0061051[positive regulation of cell growth involved in cardiac muscle cell development] GO:0070371[ERK1 and ERK2 cascade] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0070382[exocytic vesicle] GO:0070886[positive regulation of calcineurin-NFAT signaling cascade] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:0150079[negative regulation of neuroinflammatory response] GO:1902430[negative regulation of amyloid-beta formation] GO:1904075[positive regulation of trophectodermal cell proliferation] GO:1904646[cellular response to amyloid-beta] GO:1904707[positive regulation of vascular associated smooth muscle cell proliferation] GO:1905460[negative regulation of vascular associated smooth muscle cell apoptotic process] GO:2000679[positive regulation of transcription regulatory region DNA binding] GO:2001237[negative regulation of extrinsic apoptotic signaling pathway]
P05019 [Direct mapping] Insulin-like growth factor I
Show all
MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins Plasma proteins RAS pathway related proteins Disease related genes Human disease related genes Cancers Cancers of the lung and pleura Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501[skeletal system development] GO:0001775[cell activation] GO:0001837[epithelial to mesenchymal transition] GO:0001932[regulation of protein phosphorylation] GO:0005158[insulin receptor binding] GO:0005159[insulin-like growth factor receptor binding] GO:0005178[integrin binding] GO:0005179[hormone activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0007165[signal transduction] GO:0007265[Ras protein signal transduction] GO:0007517[muscle organ development] GO:0008083[growth factor activity] GO:0008283[cell population proliferation] GO:0008284[positive regulation of cell population proliferation] GO:0009408[response to heat] GO:0009441[glycolate metabolic process] GO:0010468[regulation of gene expression] GO:0010560[positive regulation of glycoprotein biosynthetic process] GO:0010613[positive regulation of cardiac muscle hypertrophy] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0014065[phosphatidylinositol 3-kinase signaling] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014834[skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration] GO:0014896[muscle hypertrophy] GO:0014904[myotube cell development] GO:0014911[positive regulation of smooth muscle cell migration] GO:0016942[insulin-like growth factor binding protein complex] GO:0030166[proteoglycan biosynthetic process] GO:0030335[positive regulation of cell migration] GO:0031093[platelet alpha granule lumen] GO:0032148[activation of protein kinase B activity] GO:0032691[negative regulation of interleukin-1 beta production] GO:0032720[negative regulation of tumor necrosis factor production] GO:0034392[negative regulation of smooth muscle cell apoptotic process] GO:0035630[bone mineralization involved in bone maturation] GO:0035867[alphav-beta3 integrin-IGF-1-IGF1R complex] GO:0042060[wound healing] GO:0042104[positive regulation of activated T cell proliferation] GO:0042531[positive regulation of tyrosine phosphorylation of STAT protein] GO:0042567[insulin-like growth factor ternary complex] GO:0043066[negative regulation of apoptotic process] GO:0043388[positive regulation of DNA binding] GO:0043410[positive regulation of MAPK cascade] GO:0043491[protein kinase B signaling] GO:0043568[positive regulation of insulin-like growth factor receptor signaling pathway] GO:0045445[myoblast differentiation] GO:0045669[positive regulation of osteoblast differentiation] GO:0045725[positive regulation of glycogen biosynthetic process] GO:0045821[positive regulation of glycolytic process] GO:0045840[positive regulation of mitotic nuclear division] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046326[positive regulation of glucose import] GO:0046579[positive regulation of Ras protein signal transduction] GO:0048009[insulin-like growth factor receptor signaling pathway] GO:0048015[phosphatidylinositol-mediated signaling] GO:0048146[positive regulation of fibroblast proliferation] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0050679[positive regulation of epithelial cell proliferation] GO:0050714[positive regulation of protein secretion] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0050821[protein stabilization] GO:0051450[myoblast proliferation] GO:0051897[positive regulation of protein kinase B signaling] GO:0060283[negative regulation of oocyte development] GO:0061051[positive regulation of cell growth involved in cardiac muscle cell development] GO:0070371[ERK1 and ERK2 cascade] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0070382[exocytic vesicle] GO:0070886[positive regulation of calcineurin-NFAT signaling cascade] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:0150079[negative regulation of neuroinflammatory response] GO:1902430[negative regulation of amyloid-beta formation] GO:1904075[positive regulation of trophectodermal cell proliferation] GO:1904646[cellular response to amyloid-beta] GO:1904707[positive regulation of vascular associated smooth muscle cell proliferation] GO:1905460[negative regulation of vascular associated smooth muscle cell apoptotic process] GO:2000679[positive regulation of transcription regulatory region DNA binding] GO:2001237[negative regulation of extrinsic apoptotic signaling pathway]
P05019 [Direct mapping] Insulin-like growth factor I
Show all
MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins Plasma proteins RAS pathway related proteins Disease related genes Human disease related genes Cancers Cancers of the lung and pleura Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501[skeletal system development] GO:0001775[cell activation] GO:0001837[epithelial to mesenchymal transition] GO:0001932[regulation of protein phosphorylation] GO:0005158[insulin receptor binding] GO:0005159[insulin-like growth factor receptor binding] GO:0005178[integrin binding] GO:0005179[hormone activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0007165[signal transduction] GO:0007265[Ras protein signal transduction] GO:0007517[muscle organ development] GO:0008083[growth factor activity] GO:0008283[cell population proliferation] GO:0008284[positive regulation of cell population proliferation] GO:0009408[response to heat] GO:0009441[glycolate metabolic process] GO:0010468[regulation of gene expression] GO:0010560[positive regulation of glycoprotein biosynthetic process] GO:0010613[positive regulation of cardiac muscle hypertrophy] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0014065[phosphatidylinositol 3-kinase signaling] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014834[skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration] GO:0014896[muscle hypertrophy] GO:0014904[myotube cell development] GO:0014911[positive regulation of smooth muscle cell migration] GO:0016942[insulin-like growth factor binding protein complex] GO:0030166[proteoglycan biosynthetic process] GO:0030335[positive regulation of cell migration] GO:0031093[platelet alpha granule lumen] GO:0032148[activation of protein kinase B activity] GO:0032691[negative regulation of interleukin-1 beta production] GO:0032720[negative regulation of tumor necrosis factor production] GO:0034392[negative regulation of smooth muscle cell apoptotic process] GO:0035630[bone mineralization involved in bone maturation] GO:0035867[alphav-beta3 integrin-IGF-1-IGF1R complex] GO:0042060[wound healing] GO:0042104[positive regulation of activated T cell proliferation] GO:0042531[positive regulation of tyrosine phosphorylation of STAT protein] GO:0042567[insulin-like growth factor ternary complex] GO:0043066[negative regulation of apoptotic process] GO:0043388[positive regulation of DNA binding] GO:0043410[positive regulation of MAPK cascade] GO:0043491[protein kinase B signaling] GO:0043568[positive regulation of insulin-like growth factor receptor signaling pathway] GO:0045445[myoblast differentiation] GO:0045669[positive regulation of osteoblast differentiation] GO:0045725[positive regulation of glycogen biosynthetic process] GO:0045821[positive regulation of glycolytic process] GO:0045840[positive regulation of mitotic nuclear division] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046326[positive regulation of glucose import] GO:0046579[positive regulation of Ras protein signal transduction] GO:0048009[insulin-like growth factor receptor signaling pathway] GO:0048015[phosphatidylinositol-mediated signaling] GO:0048146[positive regulation of fibroblast proliferation] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0050679[positive regulation of epithelial cell proliferation] GO:0050714[positive regulation of protein secretion] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0050821[protein stabilization] GO:0051450[myoblast proliferation] GO:0051897[positive regulation of protein kinase B signaling] GO:0060283[negative regulation of oocyte development] GO:0061051[positive regulation of cell growth involved in cardiac muscle cell development] GO:0070371[ERK1 and ERK2 cascade] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0070382[exocytic vesicle] GO:0070886[positive regulation of calcineurin-NFAT signaling cascade] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:0150079[negative regulation of neuroinflammatory response] GO:1902430[negative regulation of amyloid-beta formation] GO:1904075[positive regulation of trophectodermal cell proliferation] GO:1904646[cellular response to amyloid-beta] GO:1904707[positive regulation of vascular associated smooth muscle cell proliferation] GO:1905460[negative regulation of vascular associated smooth muscle cell apoptotic process] GO:2000679[positive regulation of transcription regulatory region DNA binding] GO:2001237[negative regulation of extrinsic apoptotic signaling pathway]
P05019 [Direct mapping] Insulin-like growth factor I
Show all
Q5U743 [Target identity:100%; Query identity:100%] Insulin-like growth factor I
Show all
MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins Plasma proteins RAS pathway related proteins Disease related genes Human disease related genes Cancers Cancers of the lung and pleura Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501[skeletal system development] GO:0001775[cell activation] GO:0001837[epithelial to mesenchymal transition] GO:0001932[regulation of protein phosphorylation] GO:0005158[insulin receptor binding] GO:0005159[insulin-like growth factor receptor binding] GO:0005178[integrin binding] GO:0005179[hormone activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0007165[signal transduction] GO:0007265[Ras protein signal transduction] GO:0007517[muscle organ development] GO:0008083[growth factor activity] GO:0008283[cell population proliferation] GO:0008284[positive regulation of cell population proliferation] GO:0009408[response to heat] GO:0009441[glycolate metabolic process] GO:0010468[regulation of gene expression] GO:0010560[positive regulation of glycoprotein biosynthetic process] GO:0010613[positive regulation of cardiac muscle hypertrophy] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0014065[phosphatidylinositol 3-kinase signaling] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014834[skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration] GO:0014896[muscle hypertrophy] GO:0014904[myotube cell development] GO:0014911[positive regulation of smooth muscle cell migration] GO:0016942[insulin-like growth factor binding protein complex] GO:0030166[proteoglycan biosynthetic process] GO:0030335[positive regulation of cell migration] GO:0031093[platelet alpha granule lumen] GO:0032148[activation of protein kinase B activity] GO:0032691[negative regulation of interleukin-1 beta production] GO:0032720[negative regulation of tumor necrosis factor production] GO:0034392[negative regulation of smooth muscle cell apoptotic process] GO:0035630[bone mineralization involved in bone maturation] GO:0035867[alphav-beta3 integrin-IGF-1-IGF1R complex] GO:0042060[wound healing] GO:0042104[positive regulation of activated T cell proliferation] GO:0042531[positive regulation of tyrosine phosphorylation of STAT protein] GO:0042567[insulin-like growth factor ternary complex] GO:0043066[negative regulation of apoptotic process] GO:0043388[positive regulation of DNA binding] GO:0043410[positive regulation of MAPK cascade] GO:0043491[protein kinase B signaling] GO:0043568[positive regulation of insulin-like growth factor receptor signaling pathway] GO:0045445[myoblast differentiation] GO:0045669[positive regulation of osteoblast differentiation] GO:0045725[positive regulation of glycogen biosynthetic process] GO:0045821[positive regulation of glycolytic process] GO:0045840[positive regulation of mitotic nuclear division] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046326[positive regulation of glucose import] GO:0046579[positive regulation of Ras protein signal transduction] GO:0048009[insulin-like growth factor receptor signaling pathway] GO:0048015[phosphatidylinositol-mediated signaling] GO:0048146[positive regulation of fibroblast proliferation] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0050679[positive regulation of epithelial cell proliferation] GO:0050714[positive regulation of protein secretion] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0050821[protein stabilization] GO:0051450[myoblast proliferation] GO:0051897[positive regulation of protein kinase B signaling] GO:0060283[negative regulation of oocyte development] GO:0061051[positive regulation of cell growth involved in cardiac muscle cell development] GO:0070371[ERK1 and ERK2 cascade] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0070382[exocytic vesicle] GO:0070886[positive regulation of calcineurin-NFAT signaling cascade] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:0150079[negative regulation of neuroinflammatory response] GO:1902430[negative regulation of amyloid-beta formation] GO:1904075[positive regulation of trophectodermal cell proliferation] GO:1904646[cellular response to amyloid-beta] GO:1904707[positive regulation of vascular associated smooth muscle cell proliferation] GO:1905460[negative regulation of vascular associated smooth muscle cell apoptotic process] GO:2000679[positive regulation of transcription regulatory region DNA binding] GO:2001237[negative regulation of extrinsic apoptotic signaling pathway]
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