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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Metabolic proteins Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
q35
Chromosome location (bp)
218382029 - 218396894
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Macrophage-specific antiporter that fluxes metal ions in either direction against a proton gradient. Localized to late endosomal lysosomal membranes, delivers bivalent cations from the cytosol into these acidic compartments where they may directly affect antimicrobial activity 1. Involved in iron metabolism and host natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes (Probable)....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Ion transport, Iron transport, Transport
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Iron
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P49279 [Direct mapping] Natural resistance-associated macrophage protein 1
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Metabolic proteins Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) DeepTMHMM predicted membrane proteins
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GO:0001818[negative regulation of cytokine production] GO:0001819[positive regulation of cytokine production] GO:0002309[T cell proliferation involved in immune response] GO:0002606[positive regulation of dendritic cell antigen processing and presentation] GO:0002827[positive regulation of T-helper 1 type immune response] GO:0005381[iron ion transmembrane transporter activity] GO:0005384[manganese ion transmembrane transporter activity] GO:0005764[lysosome] GO:0005770[late endosome] GO:0005886[plasma membrane] GO:0006811[ion transport] GO:0006826[iron ion transport] GO:0006828[manganese ion transport] GO:0006876[cellular cadmium ion homeostasis] GO:0006879[cellular iron ion homeostasis] GO:0006909[phagocytosis] GO:0006954[inflammatory response] GO:0007035[vacuolar acidification] GO:0009617[response to bacterium] GO:0010008[endosome membrane] GO:0010628[positive regulation of gene expression] GO:0015086[cadmium ion transmembrane transporter activity] GO:0015707[nitrite transport] GO:0016020[membrane] GO:0019730[antimicrobial humoral response] GO:0030001[metal ion transport] GO:0030670[phagocytic vesicle membrane] GO:0031902[late endosome membrane] GO:0032147[activation of protein kinase activity] GO:0032496[response to lipopolysaccharide] GO:0032729[positive regulation of interferon-gamma production] GO:0034341[response to type II interferon] GO:0034755[iron ion transmembrane transport] GO:0042060[wound healing] GO:0042116[macrophage activation] GO:0042742[defense response to bacterium] GO:0042803[protein homodimerization activity] GO:0042832[defense response to protozoan] GO:0045342[MHC class II biosynthetic process] GO:0045454[cell redox homeostasis] GO:0045730[respiratory burst] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046873[metal ion transmembrane transporter activity] GO:0046915[transition metal ion transmembrane transporter activity] GO:0048002[antigen processing and presentation of peptide antigen] GO:0048255[mRNA stabilization] GO:0050766[positive regulation of phagocytosis] GO:0050829[defense response to Gram-negative bacterium] GO:0051139[metal cation:proton antiporter activity] GO:0051649[establishment of localization in cell] GO:0055072[iron ion homeostasis] GO:0060586[multicellular organismal iron ion homeostasis] GO:0070574[cadmium ion transmembrane transport] GO:0070821[tertiary granule membrane] GO:0071421[manganese ion transmembrane transport] GO:0101003[ficolin-1-rich granule membrane] GO:1902600[proton transmembrane transport] GO:1903826[L-arginine transmembrane transport]
The Human Protein Atlas project is funded
