GENERAL INFORMATIONi
Gene namei CD74
Synonyms CLIP, DHLAG
Gene descriptioni CD74 molecule
Protein classi Cancer-related genes
CD markers
Disease related genes
Potential drug targets
Transporters
Predicted locationi Membrane
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 5
Cytoband q33.1
Chromosome location (bp) 150401637 - 150412969
Number of transcriptsi 3
Ensembl ENSG00000019582 (version 109)
Entrez gene 972
HGNC HGNC:1697
UniProt P04233 (UniProt - Evidence at protein level)
neXtProt NX_P04233
GeneCards CD74
Antibodypedia CD74 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. show less
Molecular function (UniProt)i Chaperone
Biological process (UniProt)i Adaptive immunity, Immunity
Gene summary (Entrez)i The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
CD74-201
ENSP00000009530
ENST00000009530
P04233
[Direct mapping] HLA class II histocompatibility antigen gamma chain Class-II-associated invariant chain peptide
Show all
CD markers
Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0000139 [Golgi membrane]
GO:0001516 [prostaglandin biosynthetic process]
GO:0001540 [amyloid-beta binding]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001961 [positive regulation of cytokine-mediated signaling pathway]
GO:0002250 [adaptive immune response]
GO:0002286 [T cell activation involved in immune response]
GO:0002376 [immune system process]
GO:0002606 [positive regulation of dendritic cell antigen processing and presentation]
GO:0002792 [negative regulation of peptide secretion]
GO:0002830 [positive regulation of type 2 immune response]
GO:0002906 [negative regulation of mature B cell apoptotic process]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005770 [late endosome]
GO:0005771 [multivesicular body]
GO:0005773 [vacuole]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006952 [defense response]
GO:0006955 [immune response]
GO:0008283 [cell population proliferation]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0010628 [positive regulation of gene expression]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016064 [immunoglobulin mediated immune response]
GO:0019882 [antigen processing and presentation]
GO:0019883 [antigen processing and presentation of endogenous antigen]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0019955 [cytokine binding]
GO:0023026 [MHC class II protein complex binding]
GO:0030336 [negative regulation of cell migration]
GO:0030658 [transport vesicle membrane]
GO:0030666 [endocytic vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0030890 [positive regulation of B cell proliferation]
GO:0031394 [positive regulation of prostaglandin biosynthetic process]
GO:0032588 [trans-Golgi network membrane]
GO:0032722 [positive regulation of chemokine production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032991 [protein-containing complex]
GO:0033674 [positive regulation of kinase activity]
GO:0034341 [response to type II interferon]
GO:0035691 [macrophage migration inhibitory factor signaling pathway]
GO:0035692 [macrophage migration inhibitory factor receptor complex]
GO:0035693 [NOS2-CD74 complex]
GO:0035718 [macrophage migration inhibitory factor binding]
GO:0042289 [MHC class II protein binding]
GO:0042609 [CD4 receptor binding]
GO:0042613 [MHC class II protein complex]
GO:0042658 [MHC class II protein binding, via antigen binding groove]
GO:0042802 [identical protein binding]
GO:0043030 [regulation of macrophage activation]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043202 [lysosomal lumen]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator]
GO:0044183 [protein folding chaperone]
GO:0045058 [T cell selection]
GO:0045059 [positive thymic T cell selection]
GO:0045060 [negative thymic T cell selection]
GO:0045581 [negative regulation of T cell differentiation]
GO:0045582 [positive regulation of T cell differentiation]
GO:0045657 [positive regulation of monocyte differentiation]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0046598 [positive regulation of viral entry into host cell]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050821 [protein stabilization]
GO:0050998 [nitric-oxide synthase binding]
GO:0051085 [chaperone cofactor-dependent protein refolding]
GO:0060907 [positive regulation of macrophage cytokine production]
GO:0065003 [protein-containing complex assembly]
GO:0070062 [extracellular exosome]
GO:0070206 [protein trimerization]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090023 [positive regulation of neutrophil chemotaxis]
GO:0098553 [lumenal side of endoplasmic reticulum membrane]
GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:2000343 [positive regulation of chemokine (C-X-C motif) ligand 2 production]
GO:2000448 [positive regulation of macrophage migration inhibitory factor signaling pathway]
Show all
 296 aa
33.5 kDa 		No 1
CD74-202
ENSP00000230685
ENST00000353334
P04233
[Direct mapping] HLA class II histocompatibility antigen gamma chain Class-II-associated invariant chain peptide
Show all
CD markers
Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0000139 [Golgi membrane]
GO:0001516 [prostaglandin biosynthetic process]
GO:0001540 [amyloid-beta binding]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001961 [positive regulation of cytokine-mediated signaling pathway]
GO:0002250 [adaptive immune response]
GO:0002286 [T cell activation involved in immune response]
GO:0002376 [immune system process]
GO:0002792 [negative regulation of peptide secretion]
GO:0002830 [positive regulation of type 2 immune response]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005770 [late endosome]
GO:0005773 [vacuole]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006955 [immune response]
GO:0009986 [cell surface]
GO:0010628 [positive regulation of gene expression]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016064 [immunoglobulin mediated immune response]
GO:0019882 [antigen processing and presentation]
GO:0019883 [antigen processing and presentation of endogenous antigen]
GO:0019955 [cytokine binding]
GO:0023026 [MHC class II protein complex binding]
GO:0030336 [negative regulation of cell migration]
GO:0030658 [transport vesicle membrane]
GO:0030666 [endocytic vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0030890 [positive regulation of B cell proliferation]
GO:0031394 [positive regulation of prostaglandin biosynthetic process]
GO:0032588 [trans-Golgi network membrane]
GO:0032722 [positive regulation of chemokine production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032991 [protein-containing complex]
GO:0033674 [positive regulation of kinase activity]
GO:0034341 [response to type II interferon]
GO:0035692 [macrophage migration inhibitory factor receptor complex]
GO:0035718 [macrophage migration inhibitory factor binding]
GO:0042289 [MHC class II protein binding]
GO:0042609 [CD4 receptor binding]
GO:0042613 [MHC class II protein complex]
GO:0042658 [MHC class II protein binding, via antigen binding groove]
GO:0042802 [identical protein binding]
GO:0043030 [regulation of macrophage activation]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043202 [lysosomal lumen]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator]
GO:0044183 [protein folding chaperone]
GO:0045058 [T cell selection]
GO:0045657 [positive regulation of monocyte differentiation]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0046598 [positive regulation of viral entry into host cell]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0060907 [positive regulation of macrophage cytokine production]
GO:0065003 [protein-containing complex assembly]
GO:0070062 [extracellular exosome]
GO:0070206 [protein trimerization]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090023 [positive regulation of neutrophil chemotaxis]
GO:0098553 [lumenal side of endoplasmic reticulum membrane]
GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:2000343 [positive regulation of chemokine (C-X-C motif) ligand 2 production]
GO:2000448 [positive regulation of macrophage migration inhibitory factor signaling pathway]
Show all
 232 aa
26.4 kDa 		No 1
CD74-203
ENSP00000367026
ENST00000377795
P04233
[Direct mapping] HLA class II histocompatibility antigen gamma chain Class-II-associated invariant chain peptide
Show all
CD markers
Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0000139 [Golgi membrane]
GO:0001516 [prostaglandin biosynthetic process]
GO:0001540 [amyloid-beta binding]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001961 [positive regulation of cytokine-mediated signaling pathway]
GO:0002250 [adaptive immune response]
GO:0002286 [T cell activation involved in immune response]
GO:0002376 [immune system process]
GO:0002792 [negative regulation of peptide secretion]
GO:0002830 [positive regulation of type 2 immune response]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005770 [late endosome]
GO:0005773 [vacuole]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006955 [immune response]
GO:0009986 [cell surface]
GO:0010628 [positive regulation of gene expression]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016064 [immunoglobulin mediated immune response]
GO:0019882 [antigen processing and presentation]
GO:0019883 [antigen processing and presentation of endogenous antigen]
GO:0019955 [cytokine binding]
GO:0023026 [MHC class II protein complex binding]
GO:0030336 [negative regulation of cell migration]
GO:0030658 [transport vesicle membrane]
GO:0030666 [endocytic vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0030890 [positive regulation of B cell proliferation]
GO:0031394 [positive regulation of prostaglandin biosynthetic process]
GO:0032588 [trans-Golgi network membrane]
GO:0032722 [positive regulation of chemokine production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032991 [protein-containing complex]
GO:0033674 [positive regulation of kinase activity]
GO:0034341 [response to type II interferon]
GO:0035692 [macrophage migration inhibitory factor receptor complex]
GO:0035718 [macrophage migration inhibitory factor binding]
GO:0042289 [MHC class II protein binding]
GO:0042609 [CD4 receptor binding]
GO:0042613 [MHC class II protein complex]
GO:0042658 [MHC class II protein binding, via antigen binding groove]
GO:0042802 [identical protein binding]
GO:0043030 [regulation of macrophage activation]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043202 [lysosomal lumen]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator]
GO:0044183 [protein folding chaperone]
GO:0045058 [T cell selection]
GO:0045657 [positive regulation of monocyte differentiation]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0046598 [positive regulation of viral entry into host cell]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0060907 [positive regulation of macrophage cytokine production]
GO:0065003 [protein-containing complex assembly]
GO:0070062 [extracellular exosome]
GO:0070206 [protein trimerization]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090023 [positive regulation of neutrophil chemotaxis]
GO:0098553 [lumenal side of endoplasmic reticulum membrane]
GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:2000343 [positive regulation of chemokine (C-X-C motif) ligand 2 production]
GO:2000448 [positive regulation of macrophage migration inhibitory factor signaling pathway]
Show all
 160 aa
18.3 kDa 		No 1

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