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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
X
Cytoband
q26.3
Chromosome location (bp)
136146702 - 136211359
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
May have an involvement in muscle development or hypertrophy....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Developmental protein
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Differentiation
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. Expression of these family members occurs in a cell- and tissue-specific mode and these proteins are involved in many cellular processes. Mutations in this gene have been found in patients with Emery-Dreifuss muscular dystrophy. Multiple alternately spliced transcript variants which encode different protein isoforms have been described.[provided by RefSeq, Nov 2009]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q5JXI8 [Direct mapping] Four and a half LIM domains protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Musculoskeletal diseases Muscular diseases Protein evidence (Ezkurdia et al 2014)
Q5JXI2 [Direct mapping] Four and a half LIM domains protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Musculoskeletal diseases Muscular diseases Protein evidence (Ezkurdia et al 2014)
Q13642 [Direct mapping] Four and a half LIM domains protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Human disease related genes Musculoskeletal diseases Muscular diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0003254[regulation of membrane depolarization] GO:0003674[molecular_function] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005925[focal adhesion] GO:0007517[muscle organ development] GO:0009887[animal organ morphogenesis] GO:0010972[negative regulation of G2/M transition of mitotic cell cycle] GO:0030154[cell differentiation] GO:0030308[negative regulation of cell growth] GO:0043268[positive regulation of potassium ion transport] GO:0044325[transmembrane transporter binding] GO:0046872[metal ion binding] GO:1901016[regulation of potassium ion transmembrane transporter activity] GO:2000134[negative regulation of G1/S transition of mitotic cell cycle]
Q13642 [Direct mapping] Four and a half LIM domains protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Human disease related genes Musculoskeletal diseases Muscular diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003254[regulation of membrane depolarization] GO:0003674[molecular_function] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005925[focal adhesion] GO:0007517[muscle organ development] GO:0009887[animal organ morphogenesis] GO:0010972[negative regulation of G2/M transition of mitotic cell cycle] GO:0030154[cell differentiation] GO:0030308[negative regulation of cell growth] GO:0043268[positive regulation of potassium ion transport] GO:0044325[transmembrane transporter binding] GO:0046872[metal ion binding] GO:1901016[regulation of potassium ion transmembrane transporter activity] GO:2000134[negative regulation of G1/S transition of mitotic cell cycle]
Q13642 [Direct mapping] Four and a half LIM domains protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Human disease related genes Musculoskeletal diseases Muscular diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003254[regulation of membrane depolarization] GO:0003674[molecular_function] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005925[focal adhesion] GO:0007517[muscle organ development] GO:0009887[animal organ morphogenesis] GO:0010972[negative regulation of G2/M transition of mitotic cell cycle] GO:0030154[cell differentiation] GO:0030308[negative regulation of cell growth] GO:0043268[positive regulation of potassium ion transport] GO:0044325[transmembrane transporter binding] GO:0046872[metal ion binding] GO:1901016[regulation of potassium ion transmembrane transporter activity] GO:2000134[negative regulation of G1/S transition of mitotic cell cycle]
Q5JXH8 [Direct mapping] Four and a half LIM domains protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Musculoskeletal diseases Muscular diseases Protein evidence (Ezkurdia et al 2014)
Q5JXI3 [Direct mapping] Four and a half LIM domains protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Musculoskeletal diseases Muscular diseases Protein evidence (Ezkurdia et al 2014)
Q5JXI0 [Direct mapping] Four and a half LIM domains protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Musculoskeletal diseases Muscular diseases Protein evidence (Ezkurdia et al 2014)
Q5JXI3 [Direct mapping] Four and a half LIM domains protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Musculoskeletal diseases Muscular diseases Protein evidence (Ezkurdia et al 2014)
Q5JXH7 [Direct mapping] Four and a half LIM domains protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Musculoskeletal diseases Muscular diseases Protein evidence (Ezkurdia et al 2014)
Q5JXH9 [Direct mapping] Four and a half LIM domains protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Musculoskeletal diseases Muscular diseases Protein evidence (Ezkurdia et al 2014)
Q13642 [Direct mapping] Four and a half LIM domains protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Human disease related genes Musculoskeletal diseases Muscular diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003254[regulation of membrane depolarization] GO:0003674[molecular_function] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005925[focal adhesion] GO:0007517[muscle organ development] GO:0009887[animal organ morphogenesis] GO:0010972[negative regulation of G2/M transition of mitotic cell cycle] GO:0030154[cell differentiation] GO:0030308[negative regulation of cell growth] GO:0043268[positive regulation of potassium ion transport] GO:0044325[transmembrane transporter binding] GO:0046872[metal ion binding] GO:1901016[regulation of potassium ion transmembrane transporter activity] GO:2000134[negative regulation of G1/S transition of mitotic cell cycle]
Q13642 [Direct mapping] Four and a half LIM domains protein 1
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Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepSig predicted secreted proteins Predicted intracellular proteins Plasma proteins Disease related genes Human disease related genes Musculoskeletal diseases Muscular diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0003254[regulation of membrane depolarization] GO:0003674[molecular_function] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005925[focal adhesion] GO:0007517[muscle organ development] GO:0009887[animal organ morphogenesis] GO:0010972[negative regulation of G2/M transition of mitotic cell cycle] GO:0030154[cell differentiation] GO:0030308[negative regulation of cell growth] GO:0043268[positive regulation of potassium ion transport] GO:0044325[transmembrane transporter binding] GO:0046872[metal ion binding] GO:1901016[regulation of potassium ion transmembrane transporter activity] GO:2000134[negative regulation of G1/S transition of mitotic cell cycle]
Q13642 [Direct mapping] Four and a half LIM domains protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Human disease related genes Musculoskeletal diseases Muscular diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003254[regulation of membrane depolarization] GO:0003674[molecular_function] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005925[focal adhesion] GO:0007517[muscle organ development] GO:0009887[animal organ morphogenesis] GO:0010972[negative regulation of G2/M transition of mitotic cell cycle] GO:0030154[cell differentiation] GO:0030308[negative regulation of cell growth] GO:0043268[positive regulation of potassium ion transport] GO:0044325[transmembrane transporter binding] GO:0046872[metal ion binding] GO:1901016[regulation of potassium ion transmembrane transporter activity] GO:2000134[negative regulation of G1/S transition of mitotic cell cycle]
Q13642 [Direct mapping] Four and a half LIM domains protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Human disease related genes Musculoskeletal diseases Muscular diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003254[regulation of membrane depolarization] GO:0003674[molecular_function] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005925[focal adhesion] GO:0007517[muscle organ development] GO:0009887[animal organ morphogenesis] GO:0010972[negative regulation of G2/M transition of mitotic cell cycle] GO:0030154[cell differentiation] GO:0030308[negative regulation of cell growth] GO:0043268[positive regulation of potassium ion transport] GO:0044325[transmembrane transporter binding] GO:0046872[metal ion binding] GO:1901016[regulation of potassium ion transmembrane transporter activity] GO:2000134[negative regulation of G1/S transition of mitotic cell cycle]
A0A0D9SGC5 [Direct mapping] Four and a half LIM domains protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Musculoskeletal diseases Muscular diseases Protein evidence (Ezkurdia et al 2014)
A0A0D9SGB2 [Direct mapping] Four and a half LIM domains protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Musculoskeletal diseases Muscular diseases Protein evidence (Ezkurdia et al 2014)
A0A0D9SFB0 [Direct mapping] Four and a half LIM domains protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Musculoskeletal diseases Muscular diseases Protein evidence (Ezkurdia et al 2014)
A0A0D9SEY7 [Direct mapping] Four and a half LIM domains protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Musculoskeletal diseases Muscular diseases Protein evidence (Ezkurdia et al 2014)
A0A0D9SFZ9 [Direct mapping] Four and a half LIM domains protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Musculoskeletal diseases Muscular diseases Protein evidence (Ezkurdia et al 2014)
A0A0D9SFI6 [Direct mapping] Four and a half LIM domains protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Musculoskeletal diseases Muscular diseases Protein evidence (Ezkurdia et al 2014)
Q13642 [Direct mapping] Four and a half LIM domains protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Human disease related genes Musculoskeletal diseases Muscular diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003254[regulation of membrane depolarization] GO:0003674[molecular_function] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005925[focal adhesion] GO:0007517[muscle organ development] GO:0009887[animal organ morphogenesis] GO:0010972[negative regulation of G2/M transition of mitotic cell cycle] GO:0030154[cell differentiation] GO:0030308[negative regulation of cell growth] GO:0043268[positive regulation of potassium ion transport] GO:0044325[transmembrane transporter binding] GO:0046872[metal ion binding] GO:1901016[regulation of potassium ion transmembrane transporter activity] GO:2000134[negative regulation of G1/S transition of mitotic cell cycle]
Q13642 [Direct mapping] Four and a half LIM domains protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Human disease related genes Musculoskeletal diseases Muscular diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003254[regulation of membrane depolarization] GO:0003674[molecular_function] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005925[focal adhesion] GO:0007517[muscle organ development] GO:0009887[animal organ morphogenesis] GO:0010972[negative regulation of G2/M transition of mitotic cell cycle] GO:0030154[cell differentiation] GO:0030308[negative regulation of cell growth] GO:0043268[positive regulation of potassium ion transport] GO:0044325[transmembrane transporter binding] GO:0046872[metal ion binding] GO:1901016[regulation of potassium ion transmembrane transporter activity] GO:2000134[negative regulation of G1/S transition of mitotic cell cycle]
Q13642 [Direct mapping] Four and a half LIM domains protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Human disease related genes Musculoskeletal diseases Muscular diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003254[regulation of membrane depolarization] GO:0003674[molecular_function] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005925[focal adhesion] GO:0007517[muscle organ development] GO:0009887[animal organ morphogenesis] GO:0010972[negative regulation of G2/M transition of mitotic cell cycle] GO:0030154[cell differentiation] GO:0030308[negative regulation of cell growth] GO:0043268[positive regulation of potassium ion transport] GO:0044325[transmembrane transporter binding] GO:0046872[metal ion binding] GO:1901016[regulation of potassium ion transmembrane transporter activity] GO:2000134[negative regulation of G1/S transition of mitotic cell cycle]
Q13642 [Direct mapping] Four and a half LIM domains protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Human disease related genes Musculoskeletal diseases Muscular diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003254[regulation of membrane depolarization] GO:0003674[molecular_function] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005925[focal adhesion] GO:0007517[muscle organ development] GO:0009887[animal organ morphogenesis] GO:0010972[negative regulation of G2/M transition of mitotic cell cycle] GO:0030154[cell differentiation] GO:0030308[negative regulation of cell growth] GO:0043268[positive regulation of potassium ion transport] GO:0044325[transmembrane transporter binding] GO:0046872[metal ion binding] GO:1901016[regulation of potassium ion transmembrane transporter activity] GO:2000134[negative regulation of G1/S transition of mitotic cell cycle]
A0A0D9SGD1 [Direct mapping] Four and a half LIM domains protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Musculoskeletal diseases Muscular diseases Protein evidence (Ezkurdia et al 2014)
Q13642 [Direct mapping] Four and a half LIM domains protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Human disease related genes Musculoskeletal diseases Muscular diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003254[regulation of membrane depolarization] GO:0003674[molecular_function] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005925[focal adhesion] GO:0007517[muscle organ development] GO:0009887[animal organ morphogenesis] GO:0010972[negative regulation of G2/M transition of mitotic cell cycle] GO:0030154[cell differentiation] GO:0030308[negative regulation of cell growth] GO:0043268[positive regulation of potassium ion transport] GO:0044325[transmembrane transporter binding] GO:0046872[metal ion binding] GO:1901016[regulation of potassium ion transmembrane transporter activity] GO:2000134[negative regulation of G1/S transition of mitotic cell cycle]
A0A494C1G1 [Direct mapping] Four and a half LIM domains protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Musculoskeletal diseases Muscular diseases Protein evidence (Ezkurdia et al 2014)
Q13642 [Direct mapping] Four and a half LIM domains protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Human disease related genes Musculoskeletal diseases Muscular diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003254[regulation of membrane depolarization] GO:0003674[molecular_function] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005925[focal adhesion] GO:0007517[muscle organ development] GO:0009887[animal organ morphogenesis] GO:0010972[negative regulation of G2/M transition of mitotic cell cycle] GO:0030154[cell differentiation] GO:0030308[negative regulation of cell growth] GO:0043268[positive regulation of potassium ion transport] GO:0044325[transmembrane transporter binding] GO:0046872[metal ion binding] GO:1901016[regulation of potassium ion transmembrane transporter activity] GO:2000134[negative regulation of G1/S transition of mitotic cell cycle]
A0A494C0D6 [Direct mapping] Four and a half LIM domains protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Musculoskeletal diseases Muscular diseases Protein evidence (Ezkurdia et al 2014)
A0A494C0J3 [Direct mapping] Four and a half LIM domains protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Musculoskeletal diseases Muscular diseases Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
