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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Enzymes Plasma proteins Potential drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
11
Cytoband
q22.2
Chromosome location (bp)
102317450 - 102339403
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Transferase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Apoptosis, Ubl conjugation pathway
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q13489 [Direct mapping] Baculoviral IAP repeat-containing protein 3
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Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Potential drug targets Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0007166[cell surface receptor signaling pathway] GO:0007249[I-kappaB kinase/NF-kappaB signaling] GO:0007283[spermatogenesis] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0031398[positive regulation of protein ubiquitination] GO:0032991[protein-containing complex] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0034121[regulation of toll-like receptor signaling pathway] GO:0038061[NIK/NF-kappaB signaling] GO:0039535[regulation of RIG-I signaling pathway] GO:0042981[regulation of apoptotic process] GO:0043027[cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044877[protein-containing complex binding] GO:0045088[regulation of innate immune response] GO:0045121[membrane raft] GO:0046872[metal ion binding] GO:0050727[regulation of inflammatory response] GO:0051726[regulation of cell cycle] GO:0052548[regulation of endopeptidase activity] GO:0060544[regulation of necroptotic process] GO:0060546[negative regulation of necroptotic process] GO:0061630[ubiquitin protein ligase activity] GO:0070424[regulation of nucleotide-binding oligomerization domain containing signaling pathway] GO:2000116[regulation of cysteine-type endopeptidase activity]
Q13489 [Direct mapping] Baculoviral IAP repeat-containing protein 3
Show all
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Potential drug targets Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0007166[cell surface receptor signaling pathway] GO:0007249[I-kappaB kinase/NF-kappaB signaling] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0031398[positive regulation of protein ubiquitination] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0034121[regulation of toll-like receptor signaling pathway] GO:0038061[NIK/NF-kappaB signaling] GO:0039535[regulation of RIG-I signaling pathway] GO:0042981[regulation of apoptotic process] GO:0043027[cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0045088[regulation of innate immune response] GO:0046872[metal ion binding] GO:0050727[regulation of inflammatory response] GO:0051726[regulation of cell cycle] GO:0052548[regulation of endopeptidase activity] GO:0060544[regulation of necroptotic process] GO:0060546[negative regulation of necroptotic process] GO:0061630[ubiquitin protein ligase activity] GO:0070424[regulation of nucleotide-binding oligomerization domain containing signaling pathway] GO:2000116[regulation of cysteine-type endopeptidase activity]
Q13489 [Direct mapping] Baculoviral IAP repeat-containing protein 3
Show all
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Potential drug targets Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0007166[cell surface receptor signaling pathway] GO:0007249[I-kappaB kinase/NF-kappaB signaling] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0031398[positive regulation of protein ubiquitination] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0034121[regulation of toll-like receptor signaling pathway] GO:0038061[NIK/NF-kappaB signaling] GO:0039535[regulation of RIG-I signaling pathway] GO:0042981[regulation of apoptotic process] GO:0043027[cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0045088[regulation of innate immune response] GO:0046872[metal ion binding] GO:0050727[regulation of inflammatory response] GO:0051726[regulation of cell cycle] GO:0052548[regulation of endopeptidase activity] GO:0060544[regulation of necroptotic process] GO:0060546[negative regulation of necroptotic process] GO:0061630[ubiquitin protein ligase activity] GO:0070424[regulation of nucleotide-binding oligomerization domain containing signaling pathway] GO:2000116[regulation of cysteine-type endopeptidase activity]
Q13489 [Direct mapping] Baculoviral IAP repeat-containing protein 3
Show all
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Potential drug targets Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0007166[cell surface receptor signaling pathway] GO:0007249[I-kappaB kinase/NF-kappaB signaling] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0031398[positive regulation of protein ubiquitination] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0034121[regulation of toll-like receptor signaling pathway] GO:0038061[NIK/NF-kappaB signaling] GO:0039535[regulation of RIG-I signaling pathway] GO:0042981[regulation of apoptotic process] GO:0043027[cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0045088[regulation of innate immune response] GO:0046872[metal ion binding] GO:0050727[regulation of inflammatory response] GO:0051726[regulation of cell cycle] GO:0052548[regulation of endopeptidase activity] GO:0060544[regulation of necroptotic process] GO:0060546[negative regulation of necroptotic process] GO:0061630[ubiquitin protein ligase activity] GO:0070424[regulation of nucleotide-binding oligomerization domain containing signaling pathway] GO:2000116[regulation of cysteine-type endopeptidase activity]
The Human Protein Atlas project is funded
