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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Candidate cardiovascular disease genes CD markers Disease related genes Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
10
Cytoband
q23.31
Chromosome location (bp)
88953813 - 89029605
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase CASP8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs CASP8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Calmodulin-binding, Receptor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Apoptosis
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P25445 [Direct mapping] Tumor necrosis factor receptor superfamily member 6
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CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Candidate cardiovascular disease genes Disease related genes Human disease related genes Cancers Cancers of the digestive system Skin cancers Cancers of haematopoietic and lymphoid tissues Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
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GO:0001934[positive regulation of protein phosphorylation] GO:0004888[transmembrane signaling receptor activity] GO:0005031[tumor necrosis factor receptor activity] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005576[extracellular region] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006915[apoptotic process] GO:0006924[activation-induced cell death of T cells] GO:0006955[immune response] GO:0007165[signal transduction] GO:0009897[external side of plasma membrane] GO:0009986[cell surface] GO:0016020[membrane] GO:0016604[nuclear body] GO:0019900[kinase binding] GO:0031264[death-inducing signaling complex] GO:0031265[CD95 death-inducing signaling complex] GO:0032872[regulation of stress-activated MAPK cascade] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0034198[cellular response to amino acid starvation] GO:0036337[Fas signaling pathway] GO:0038023[signaling receptor activity] GO:0042802[identical protein binding] GO:0042981[regulation of apoptotic process] GO:0043065[positive regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0045121[membrane raft] GO:0065003[protein-containing complex assembly] GO:0070062[extracellular exosome] GO:0071260[cellular response to mechanical stimulus] GO:0071455[cellular response to hyperoxia] GO:0097049[motor neuron apoptotic process] GO:0097191[extrinsic apoptotic signaling pathway] GO:0097192[extrinsic apoptotic signaling pathway in absence of ligand] GO:0097527[necroptotic signaling pathway] GO:0110165[cellular anatomical entity] GO:2001235[positive regulation of apoptotic signaling pathway] GO:2001269[positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
P25445 [Direct mapping] Tumor necrosis factor receptor superfamily member 6
Show all
CD markers Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Candidate cardiovascular disease genes Disease related genes Human disease related genes Cancers Cancers of the digestive system Skin cancers Cancers of haematopoietic and lymphoid tissues Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0001934[positive regulation of protein phosphorylation] GO:0004888[transmembrane signaling receptor activity] GO:0005031[tumor necrosis factor receptor activity] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005576[extracellular region] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006915[apoptotic process] GO:0006924[activation-induced cell death of T cells] GO:0006955[immune response] GO:0007165[signal transduction] GO:0009897[external side of plasma membrane] GO:0009986[cell surface] GO:0016020[membrane] GO:0016604[nuclear body] GO:0019900[kinase binding] GO:0031264[death-inducing signaling complex] GO:0031265[CD95 death-inducing signaling complex] GO:0032872[regulation of stress-activated MAPK cascade] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0034198[cellular response to amino acid starvation] GO:0036337[Fas signaling pathway] GO:0038023[signaling receptor activity] GO:0042802[identical protein binding] GO:0042981[regulation of apoptotic process] GO:0043065[positive regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0045121[membrane raft] GO:0065003[protein-containing complex assembly] GO:0070062[extracellular exosome] GO:0071260[cellular response to mechanical stimulus] GO:0071455[cellular response to hyperoxia] GO:0097049[motor neuron apoptotic process] GO:0097191[extrinsic apoptotic signaling pathway] GO:0097192[extrinsic apoptotic signaling pathway in absence of ligand] GO:0097527[necroptotic signaling pathway] GO:0110165[cellular anatomical entity] GO:2001235[positive regulation of apoptotic signaling pathway] GO:2001269[positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of the digestive system Skin cancers Cancers of haematopoietic and lymphoid tissues Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
P25445 [Direct mapping] Tumor necrosis factor receptor superfamily member 6
Show all
CD markers Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Candidate cardiovascular disease genes Disease related genes Human disease related genes Cancers Cancers of the digestive system Skin cancers Cancers of haematopoietic and lymphoid tissues Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934[positive regulation of protein phosphorylation] GO:0004888[transmembrane signaling receptor activity] GO:0005031[tumor necrosis factor receptor activity] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005576[extracellular region] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006915[apoptotic process] GO:0006924[activation-induced cell death of T cells] GO:0006955[immune response] GO:0007165[signal transduction] GO:0009897[external side of plasma membrane] GO:0009986[cell surface] GO:0016020[membrane] GO:0016604[nuclear body] GO:0019900[kinase binding] GO:0031264[death-inducing signaling complex] GO:0031265[CD95 death-inducing signaling complex] GO:0032872[regulation of stress-activated MAPK cascade] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0034198[cellular response to amino acid starvation] GO:0036337[Fas signaling pathway] GO:0038023[signaling receptor activity] GO:0042802[identical protein binding] GO:0042981[regulation of apoptotic process] GO:0043065[positive regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0045121[membrane raft] GO:0065003[protein-containing complex assembly] GO:0070062[extracellular exosome] GO:0071260[cellular response to mechanical stimulus] GO:0071455[cellular response to hyperoxia] GO:0097049[motor neuron apoptotic process] GO:0097191[extrinsic apoptotic signaling pathway] GO:0097192[extrinsic apoptotic signaling pathway in absence of ligand] GO:0097527[necroptotic signaling pathway] GO:0110165[cellular anatomical entity] GO:2001235[positive regulation of apoptotic signaling pathway] GO:2001269[positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of the digestive system Skin cancers Cancers of haematopoietic and lymphoid tissues Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of the digestive system Skin cancers Cancers of haematopoietic and lymphoid tissues Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
P25445 [Direct mapping] Tumor necrosis factor receptor superfamily member 6
Show all
CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Candidate cardiovascular disease genes Disease related genes Human disease related genes Cancers Cancers of the digestive system Skin cancers Cancers of haematopoietic and lymphoid tissues Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0001934[positive regulation of protein phosphorylation] GO:0004888[transmembrane signaling receptor activity] GO:0005031[tumor necrosis factor receptor activity] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005576[extracellular region] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006915[apoptotic process] GO:0006924[activation-induced cell death of T cells] GO:0006955[immune response] GO:0007165[signal transduction] GO:0009897[external side of plasma membrane] GO:0009986[cell surface] GO:0016020[membrane] GO:0016604[nuclear body] GO:0019900[kinase binding] GO:0031264[death-inducing signaling complex] GO:0031265[CD95 death-inducing signaling complex] GO:0032872[regulation of stress-activated MAPK cascade] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0034198[cellular response to amino acid starvation] GO:0036337[Fas signaling pathway] GO:0038023[signaling receptor activity] GO:0042802[identical protein binding] GO:0042981[regulation of apoptotic process] GO:0043065[positive regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0045121[membrane raft] GO:0065003[protein-containing complex assembly] GO:0070062[extracellular exosome] GO:0071260[cellular response to mechanical stimulus] GO:0071455[cellular response to hyperoxia] GO:0097049[motor neuron apoptotic process] GO:0097191[extrinsic apoptotic signaling pathway] GO:0097192[extrinsic apoptotic signaling pathway in absence of ligand] GO:0097527[necroptotic signaling pathway] GO:0110165[cellular anatomical entity] GO:2001235[positive regulation of apoptotic signaling pathway] GO:2001269[positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of the digestive system Skin cancers Cancers of haematopoietic and lymphoid tissues Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
SCAMPI predicted membrane proteins DeepTMHMM predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of the digestive system Skin cancers Cancers of haematopoietic and lymphoid tissues Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of the digestive system Skin cancers Cancers of haematopoietic and lymphoid tissues Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of the digestive system Skin cancers Cancers of haematopoietic and lymphoid tissues Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
