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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
6
Cytoband
p21.31
Chromosome location (bp)
33572547 - 33580293
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Plays a role in the mitochondrial apoptotic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilization by oligomerizing to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Apoptosis, Host-virus interaction
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001776[leukocyte homeostasis] GO:0001782[B cell homeostasis] GO:0001783[B cell apoptotic process] GO:0001836[release of cytochrome c from mitochondria] GO:0001974[blood vessel remodeling] GO:0002262[myeloid cell homeostasis] GO:0002352[B cell negative selection] GO:0003674[molecular_function] GO:0005515[protein binding] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005783[endoplasmic reticulum] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007420[brain development] GO:0007568[aging] GO:0008053[mitochondrial fusion] GO:0008285[negative regulation of cell population proliferation] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0008635[activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c] GO:0009410[response to xenobiotic stimulus] GO:0009620[response to fungus] GO:0010046[response to mycotoxin] GO:0010225[response to UV-C] GO:0010248[establishment or maintenance of transmembrane electrochemical gradient] GO:0010332[response to gamma radiation] GO:0010524[positive regulation of calcium ion transport into cytosol] GO:0010629[negative regulation of gene expression] GO:0014070[response to organic cyclic compound] GO:0016020[membrane] GO:0018105[peptidyl-serine phosphorylation] GO:0031018[endocrine pancreas development] GO:0031072[heat shock protein binding] GO:0031100[animal organ regeneration] GO:0031334[positive regulation of protein-containing complex assembly] GO:0031966[mitochondrial membrane] GO:0032469[endoplasmic reticulum calcium ion homeostasis] GO:0032471[negative regulation of endoplasmic reticulum calcium ion concentration] GO:0033137[negative regulation of peptidyl-serine phosphorylation] GO:0034620[cellular response to unfolded protein] GO:0034644[cellular response to UV] GO:0035108[limb morphogenesis] GO:0042542[response to hydrogen peroxide] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0043065[positive regulation of apoptotic process] GO:0044325[transmembrane transporter binding] GO:0044346[fibroblast apoptotic process] GO:0044877[protein-containing complex binding] GO:0045471[response to ethanol] GO:0045862[positive regulation of proteolysis] GO:0046872[metal ion binding] GO:0046902[regulation of mitochondrial membrane permeability] GO:0046930[pore complex] GO:0046982[protein heterodimerization activity] GO:0048597[post-embryonic camera-type eye morphogenesis] GO:0048872[homeostasis of number of cells] GO:0050673[epithelial cell proliferation] GO:0051087[chaperone binding] GO:0051400[BH domain binding] GO:0051649[establishment of localization in cell] GO:0051726[regulation of cell cycle] GO:0051881[regulation of mitochondrial membrane potential] GO:0060068[vagina development] GO:0060402[calcium ion transport into cytosol] GO:0070059[intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] GO:0070242[thymocyte apoptotic process] GO:0071260[cellular response to mechanical stimulus] GO:0090200[positive regulation of release of cytochrome c from mitochondria] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:0097136[Bcl-2 family protein complex] GO:0097145[BAK complex] GO:0097190[apoptotic signaling pathway] GO:0097192[extrinsic apoptotic signaling pathway in absence of ligand] GO:0097202[activation of cysteine-type endopeptidase activity] GO:1900103[positive regulation of endoplasmic reticulum unfolded protein response] GO:1901029[negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway] GO:1901030[positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway] GO:1902262[apoptotic process involved in blood vessel morphogenesis] GO:1903896[positive regulation of IRE1-mediated unfolded protein response] GO:2001233[regulation of apoptotic signaling pathway]
Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0001836[release of cytochrome c from mitochondria] GO:0003674[molecular_function] GO:0005515[protein binding] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0006915[apoptotic process] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010248[establishment or maintenance of transmembrane electrochemical gradient] GO:0016020[membrane] GO:0031334[positive regulation of protein-containing complex assembly] GO:0032469[endoplasmic reticulum calcium ion homeostasis] GO:0034620[cellular response to unfolded protein] GO:0034644[cellular response to UV] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0043065[positive regulation of apoptotic process] GO:0044325[transmembrane transporter binding] GO:0045862[positive regulation of proteolysis] GO:0046872[metal ion binding] GO:0046902[regulation of mitochondrial membrane permeability] GO:0046930[pore complex] GO:0046982[protein heterodimerization activity] GO:0051881[regulation of mitochondrial membrane potential] GO:0070059[intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] GO:0071260[cellular response to mechanical stimulus] GO:0090200[positive regulation of release of cytochrome c from mitochondria] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:0097136[Bcl-2 family protein complex] GO:0097145[BAK complex] GO:0097190[apoptotic signaling pathway] GO:0097192[extrinsic apoptotic signaling pathway in absence of ligand] GO:0097202[activation of cysteine-type endopeptidase activity] GO:1900103[positive regulation of endoplasmic reticulum unfolded protein response] GO:1901029[negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway] GO:1901030[positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway] GO:1903896[positive regulation of IRE1-mediated unfolded protein response] GO:2001233[regulation of apoptotic signaling pathway]
The Human Protein Atlas project is funded
