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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Enzymes FDA approved drug targets Human disease related genes Plasma proteins RAS pathway related proteins Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
5
Cytoband
q35.3
Chromosome location (bp)
180601506 - 180649624
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Angiogenesis
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cardiovascular diseases Vascular diseases Congenital malformations Congenital malformations of the circulatory system Congenital malformations of skin Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000166[nucleotide binding] GO:0001525[angiogenesis] GO:0001934[positive regulation of protein phosphorylation] GO:0001938[positive regulation of endothelial cell proliferation] GO:0001944[vasculature development] GO:0001945[lymph vessel development] GO:0001946[lymphangiogenesis] GO:0002040[sprouting angiogenesis] GO:0002244[hematopoietic progenitor cell differentiation] GO:0003016[respiratory system process] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005021[vascular endothelial growth factor receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005576[extracellular region] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007585[respiratory gaseous exchange by respiratory system] GO:0008284[positive regulation of cell population proliferation] GO:0010575[positive regulation of vascular endothelial growth factor production] GO:0010595[positive regulation of endothelial cell migration] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0019838[growth factor binding] GO:0019903[protein phosphatase binding] GO:0030335[positive regulation of cell migration] GO:0033674[positive regulation of kinase activity] GO:0035924[cellular response to vascular endothelial growth factor stimulus] GO:0038084[vascular endothelial growth factor signaling pathway] GO:0042327[positive regulation of phosphorylation] GO:0042803[protein homodimerization activity] GO:0043066[negative regulation of apoptotic process] GO:0043235[receptor complex] GO:0043408[regulation of MAPK cascade] GO:0043410[positive regulation of MAPK cascade] GO:0046330[positive regulation of JNK cascade] GO:0046777[protein autophosphorylation] GO:0048010[vascular endothelial growth factor receptor signaling pathway] GO:0048286[lung alveolus development] GO:0048514[blood vessel morphogenesis] GO:0060312[regulation of blood vessel remodeling] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0090037[positive regulation of protein kinase C signaling]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cardiovascular diseases Vascular diseases Congenital malformations Congenital malformations of the circulatory system Congenital malformations of skin Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000166[nucleotide binding] GO:0001525[angiogenesis] GO:0001934[positive regulation of protein phosphorylation] GO:0001938[positive regulation of endothelial cell proliferation] GO:0001944[vasculature development] GO:0001945[lymph vessel development] GO:0001946[lymphangiogenesis] GO:0002040[sprouting angiogenesis] GO:0002244[hematopoietic progenitor cell differentiation] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005021[vascular endothelial growth factor receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005576[extracellular region] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0008284[positive regulation of cell population proliferation] GO:0010575[positive regulation of vascular endothelial growth factor production] GO:0010595[positive regulation of endothelial cell migration] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0019838[growth factor binding] GO:0019903[protein phosphatase binding] GO:0030335[positive regulation of cell migration] GO:0033674[positive regulation of kinase activity] GO:0035924[cellular response to vascular endothelial growth factor stimulus] GO:0038084[vascular endothelial growth factor signaling pathway] GO:0042327[positive regulation of phosphorylation] GO:0042803[protein homodimerization activity] GO:0043066[negative regulation of apoptotic process] GO:0043235[receptor complex] GO:0043408[regulation of MAPK cascade] GO:0043410[positive regulation of MAPK cascade] GO:0046330[positive regulation of JNK cascade] GO:0046777[protein autophosphorylation] GO:0048010[vascular endothelial growth factor receptor signaling pathway] GO:0048514[blood vessel morphogenesis] GO:0060312[regulation of blood vessel remodeling] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0090037[positive regulation of protein kinase C signaling]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Human disease related genes Cardiovascular diseases Vascular diseases Congenital malformations Congenital malformations of the circulatory system Congenital malformations of skin Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
