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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
X
Cytoband
p22.2
Chromosome location (bp)
11117651 - 11665920
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
GTPase activation
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of actin polymerization at the plasma membrane during several cellular processes. This protein is thought to have two independent functions, one as a GTPase-activating protein with specificity for RhoA, and another as a cytoskeletal protein that promotes actin remodeling. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
O43182 [Direct mapping] Rho GTPase-activating protein 6
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005096[GTPase activator activity] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005884[actin filament] GO:0007015[actin filament organization] GO:0007165[signal transduction] GO:0007202[activation of phospholipase C activity] GO:0007266[Rho protein signal transduction] GO:0010518[positive regulation of phospholipase activity] GO:0015629[actin cytoskeleton] GO:0016004[phospholipase activator activity] GO:0017124[SH3 domain binding] GO:0030041[actin filament polymerization] GO:0043087[regulation of GTPase activity] GO:0043274[phospholipase binding] GO:0051056[regulation of small GTPase mediated signal transduction] GO:0051497[negative regulation of stress fiber assembly] GO:0051895[negative regulation of focal adhesion assembly]
O43182 [Direct mapping] Rho GTPase-activating protein 6
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Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005096[GTPase activator activity] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005884[actin filament] GO:0007015[actin filament organization] GO:0007165[signal transduction] GO:0007202[activation of phospholipase C activity] GO:0007266[Rho protein signal transduction] GO:0015629[actin cytoskeleton] GO:0016004[phospholipase activator activity] GO:0017124[SH3 domain binding] GO:0030041[actin filament polymerization] GO:0043087[regulation of GTPase activity] GO:0043274[phospholipase binding] GO:0043547[positive regulation of GTPase activity] GO:0048041[focal adhesion assembly] GO:0051056[regulation of small GTPase mediated signal transduction] GO:0051497[negative regulation of stress fiber assembly] GO:0051895[negative regulation of focal adhesion assembly]
H7BYE6 [Direct mapping] Rho GTPase-activating protein 6
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SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
O43182 [Direct mapping] Rho GTPase-activating protein 6
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SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005096[GTPase activator activity] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005884[actin filament] GO:0007015[actin filament organization] GO:0007165[signal transduction] GO:0007202[activation of phospholipase C activity] GO:0007266[Rho protein signal transduction] GO:0015629[actin cytoskeleton] GO:0016004[phospholipase activator activity] GO:0017124[SH3 domain binding] GO:0030041[actin filament polymerization] GO:0043087[regulation of GTPase activity] GO:0043274[phospholipase binding] GO:0051056[regulation of small GTPase mediated signal transduction] GO:0051497[negative regulation of stress fiber assembly] GO:0051895[negative regulation of focal adhesion assembly]
O43182 [Direct mapping] Rho GTPase-activating protein 6
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096[GTPase activator activity] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005884[actin filament] GO:0007015[actin filament organization] GO:0007165[signal transduction] GO:0007202[activation of phospholipase C activity] GO:0007266[Rho protein signal transduction] GO:0010518[positive regulation of phospholipase activity] GO:0015629[actin cytoskeleton] GO:0016004[phospholipase activator activity] GO:0017124[SH3 domain binding] GO:0030041[actin filament polymerization] GO:0043087[regulation of GTPase activity] GO:0043274[phospholipase binding] GO:0051056[regulation of small GTPase mediated signal transduction] GO:0051497[negative regulation of stress fiber assembly] GO:0051895[negative regulation of focal adhesion assembly]
The Human Protein Atlas project is funded
