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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Enzymes FDA approved drug targets Human disease related genes Metabolic proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
8
Cytoband
q22.3
Chromosome location (bp)
102204502 - 102238961
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Oxidoreductase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Deoxyribonucleotide synthesis, DNA damage, DNA repair
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Iron, Metal-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q7LG56 [Direct mapping] Ribonucleoside-diphosphate reductase subunit M2 B
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Enzymes ENZYME proteins Oxidoreductases Metabolic proteins Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Congenital disorders of metabolism Mitochondrial diseases Nervous system diseases Eye disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000731[DNA synthesis involved in DNA repair] GO:0001822[kidney development] GO:0003014[renal system process] GO:0004748[ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0005971[ribonucleoside-diphosphate reductase complex] GO:0006260[DNA replication] GO:0006264[mitochondrial DNA replication] GO:0006281[DNA repair] GO:0006974[cellular response to DNA damage stimulus] GO:0006979[response to oxidative stress] GO:0009185[ribonucleoside diphosphate metabolic process] GO:0009200[deoxyribonucleoside triphosphate metabolic process] GO:0009263[deoxyribonucleotide biosynthetic process] GO:0009265[2'-deoxyribonucleotide biosynthetic process] GO:0010971[positive regulation of G2/M transition of mitotic cell cycle] GO:0014075[response to amine] GO:0016491[oxidoreductase activity] GO:0042802[identical protein binding] GO:0046872[metal ion binding] GO:0055086[nucleobase-containing small molecule metabolic process] GO:0070318[positive regulation of G0 to G1 transition] GO:1902254[negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator]
Q7LG56 [Direct mapping] Ribonucleoside-diphosphate reductase subunit M2 B
Show all
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Congenital disorders of metabolism Mitochondrial diseases Nervous system diseases Eye disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000731[DNA synthesis involved in DNA repair] GO:0004748[ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0005971[ribonucleoside-diphosphate reductase complex] GO:0006260[DNA replication] GO:0006264[mitochondrial DNA replication] GO:0006281[DNA repair] GO:0006974[cellular response to DNA damage stimulus] GO:0009185[ribonucleoside diphosphate metabolic process] GO:0009263[deoxyribonucleotide biosynthetic process] GO:0009265[2'-deoxyribonucleotide biosynthetic process] GO:0010971[positive regulation of G2/M transition of mitotic cell cycle] GO:0016491[oxidoreductase activity] GO:0042802[identical protein binding] GO:0046872[metal ion binding] GO:0055086[nucleobase-containing small molecule metabolic process] GO:0070318[positive regulation of G0 to G1 transition]
Q7LG56 [Direct mapping] Ribonucleoside-diphosphate reductase subunit M2 B
Show all
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Congenital disorders of metabolism Mitochondrial diseases Nervous system diseases Eye disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000731[DNA synthesis involved in DNA repair] GO:0004748[ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0005971[ribonucleoside-diphosphate reductase complex] GO:0006260[DNA replication] GO:0006264[mitochondrial DNA replication] GO:0006281[DNA repair] GO:0006974[cellular response to DNA damage stimulus] GO:0009185[ribonucleoside diphosphate metabolic process] GO:0009263[deoxyribonucleotide biosynthetic process] GO:0009265[2'-deoxyribonucleotide biosynthetic process] GO:0010971[positive regulation of G2/M transition of mitotic cell cycle] GO:0016491[oxidoreductase activity] GO:0042802[identical protein binding] GO:0046872[metal ion binding] GO:0055086[nucleobase-containing small molecule metabolic process] GO:0070318[positive regulation of G0 to G1 transition]
Q7LG56 [Direct mapping] Ribonucleoside-diphosphate reductase subunit M2 B
Show all
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Congenital disorders of metabolism Mitochondrial diseases Nervous system diseases Eye disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000731[DNA synthesis involved in DNA repair] GO:0004748[ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0005971[ribonucleoside-diphosphate reductase complex] GO:0006260[DNA replication] GO:0006264[mitochondrial DNA replication] GO:0006281[DNA repair] GO:0006974[cellular response to DNA damage stimulus] GO:0009185[ribonucleoside diphosphate metabolic process] GO:0009263[deoxyribonucleotide biosynthetic process] GO:0009265[2'-deoxyribonucleotide biosynthetic process] GO:0010971[positive regulation of G2/M transition of mitotic cell cycle] GO:0016491[oxidoreductase activity] GO:0042802[identical protein binding] GO:0046872[metal ion binding] GO:0055086[nucleobase-containing small molecule metabolic process] GO:0070318[positive regulation of G0 to G1 transition]
The Human Protein Atlas project is funded
