Subcellular - LAMC2 - The Human Protein Atlas

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LAMC2

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STRUCT & INT

LAMC2

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	LAMC2
Gene descriptionⁱ Full gene name according to HGNC.	Laminin subunit gamma 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Main locationⁱ Main subcellular location(s) and reliability score(s) for the encoded protein(s) in human cells. The main location(s) may be characterized by presence in all tested cell lines and/or ihigher staining intensity compared to the potential additional location(s). If available, links to overrepresentation analyses in Reactome, a free, open-source, curated and peer reviewed biological pathway database, are provided. An analysis is done for the corresponding gene set of the proteome localizing to the main and additional locations of the protein on this page, respectively.	Localized to the Endoplasmic reticulum (approved), Golgi apparatus (approved)
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data.	Protein predicted to be secreted
Single-cell variationⁱ Single-cell variations in protein expression levels or distribution observed between cells within the same images of human cells stained by immunocytochemistry.	Single-cell variation in protein expression observed.
Cell cycle dependencyⁱ Cell-cycle dependance of single-cell varations in RNA and/or protein expression as observed in an additional assay for characterizing single-cell varations. "NA" indicates a lack of such data.	Variation in protein and transcript expression do not correlate to the cell-cycle.
Reliability scoreⁱ Overall gene reliability score for the subcellular location(s) of the encoded protein(s). The score indicates the level of reliability of the annotated protein localization based on agreement with available experimental gene/protein characterization data in the UniProtKB/Swiss-Prot database and presence of antibody validation assays for immunocytochemistry.	Approved
Antibodiesⁱ Antibodies used for this assay. Click on an antibody for more information.	HPA024638 , HPA046539 , HPA046540
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ASSAYSⁱ

Summaryⁱ

Mainly localized to the Golgi apparatus and endoplasmic reticulum.

Main locationⁱ

Endoplasmic reticulum (approved), Golgi apparatus (approved)

Human cell lines

Single cell variation

RNA expression

HUMAN CELL LINESⁱ


	Toggle channelsⁱ Buttons for turning on and off the different channels in the multi-color images. The intensity toggle shows the pixel intensity range in 16 different colors for the selected channel. The object toggle shows the computational segmentation of the cells used for further analysis in the HPA project. For samples where cell cycle dependency for the protein is suggested according to a correlation assay the predicted cell cycle position of each cell is displayed when using the object toggle.	Low High

Antibodyⁱ Antibody used for analysis. Clicking the antibody ID links to the antibody validation page.	Cell lineⁱ Cell line used for analysis. Read more about the cell lines in the Human Protein Atlas.	Cell line RNA Expression (nTPM)ⁱ RNA expression level in the cell line based on normalised RNA sequencing data. Genes with a value above 1 NX are considered to be expressed.	Locationⁱ Observed subcellular location(s).	Single-cell variationⁱ Observed single-cell variation(s) in the staining pattern. Variation in protein expression levels can be observed as varaiations in the intensity of the immunofluorescent signal, while spatial variations can be observed as variations in subcellular distribution of the protein.
HPA024638	A-431	787.5	Golgi apparatus	Yes
HPA024638	A-431	787.5	Cytosol	Yes
HPA024638	HaCaT	238.9	Nucleoplasm
HPA024638	HaCaT	238.9	Cytosol
HPA024638	U2OS	20.7	Golgi apparatus	Yes
HPA046539	A-431	787.5	Endoplasmic reticulum	Yes
HPA046539	RT-4	116.2	Nucleoplasm
HPA046539	RT-4	116.2	Golgi apparatus
HPA046539	U2OS	20.7	Endoplasmic reticulum	Yes
HPA046539	U2OS	20.7	Golgi apparatus	Yes
HPA046540	A-431	787.5	Endoplasmic reticulum	Yes
HPA046540	A-431	787.5	Vesicles
HPA046540	HaCaT	238.9	Endoplasmic reticulum	Yes
HPA046540	U2OS	20.7	Endoplasmic reticulum	Yes