We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
12
Cytoband
p13.2
Chromosome location (bp)
10699089 - 10723323
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Binds to the GM-CSF promoter. Seems to act as a repressor. Binds also to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
DNA-binding, Repressor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Gene summary (Entrez)i
Useful information about the gene from Entrez
Enables RNA binding activity. Involved in cellular hyperosmotic response; cellular response to tumor necrosis factor; and negative regulation of programmed cell death. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
A0A024RAQ1 [Target identity:100%; Query identity:100%] Cold shock domain protein A, isoform CRA_a
Show all
SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors beta-Barrel DNA-binding domains Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0001701[in utero embryonic development] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003723[RNA binding] GO:0003730[mRNA 3'-UTR binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005923[bicellular tight junction] GO:0006915[apoptotic process] GO:0007283[spermatogenesis] GO:0008584[male gonad development] GO:0009566[fertilization] GO:0010468[regulation of gene expression] GO:0031267[small GTPase binding] GO:0035234[ectopic germ cell programmed cell death] GO:0043021[ribonucleoprotein complex binding] GO:0043066[negative regulation of apoptotic process] GO:0045202[synapse] GO:0046622[positive regulation of organ growth] GO:0048471[perinuclear region of cytoplasm] GO:0048642[negative regulation of skeletal muscle tissue development] GO:0051093[negative regulation of developmental process] GO:0060546[negative regulation of necroptotic process] GO:0070935[3'-UTR-mediated mRNA stabilization] GO:0071356[cellular response to tumor necrosis factor] GO:0071474[cellular hyperosmotic response] GO:1902219[negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress] GO:1905538[polysome binding] GO:2000242[negative regulation of reproductive process] GO:2000767[positive regulation of cytoplasmic translation]
A0A024RAV4 [Target identity:100%; Query identity:100%] Cold shock domain protein A, isoform CRA_b
Show all
SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors beta-Barrel DNA-binding domains Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003723[RNA binding] GO:0003730[mRNA 3'-UTR binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005923[bicellular tight junction] GO:0010468[regulation of gene expression] GO:0031267[small GTPase binding] GO:0048471[perinuclear region of cytoplasm] GO:0060546[negative regulation of necroptotic process] GO:0070935[3'-UTR-mediated mRNA stabilization] GO:0071356[cellular response to tumor necrosis factor] GO:0071474[cellular hyperosmotic response] GO:1902219[negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress] GO:2000767[positive regulation of cytoplasmic translation]
The Human Protein Atlas project is funded
