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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes FDA approved drug targets Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
12
Cytoband
q13.11
Chromosome location (bp)
47782722 - 47833132
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C (By similarity). During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene 1. Positively regulates the transcriptional repressor activity of FOXP3 2. Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding 3. In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response 4. Also acetylates non-histone proteins, such as ALKBH5 5....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Chromatin regulator, Hydrolase, Repressor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000118[histone deacetylase complex] GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001570[vasculogenesis] GO:0003682[chromatin binding] GO:0003714[transcription corepressor activity] GO:0004407[histone deacetylase activity] GO:0005080[protein kinase C binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006325[chromatin organization] GO:0006476[protein deacetylation] GO:0007043[cell-cell junction assembly] GO:0016575[histone deacetylation] GO:0016787[hydrolase activity] GO:0016925[protein sumoylation] GO:0019222[regulation of metabolic process] GO:0019789[SUMO transferase activity] GO:0019901[protein kinase binding] GO:0032703[negative regulation of interleukin-2 production] GO:0033558[protein lysine deacetylase activity] GO:0045668[negative regulation of osteoblast differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0046872[metal ion binding] GO:0071889[14-3-3 protein binding] GO:0090050[positive regulation of cell migration involved in sprouting angiogenesis] GO:0140297[DNA-binding transcription factor binding] GO:1901223[negative regulation of NIK/NF-kappaB signaling]
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118[histone deacetylase complex] GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0004407[histone deacetylase activity] GO:0005080[protein kinase C binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006325[chromatin organization] GO:0006476[protein deacetylation] GO:0016575[histone deacetylation] GO:0016787[hydrolase activity] GO:0016925[protein sumoylation] GO:0019222[regulation of metabolic process] GO:0019789[SUMO transferase activity] GO:0019901[protein kinase binding] GO:0032703[negative regulation of interleukin-2 production] GO:0033558[protein lysine deacetylase activity] GO:0045668[negative regulation of osteoblast differentiation] GO:0046872[metal ion binding] GO:0071889[14-3-3 protein binding] GO:0090050[positive regulation of cell migration involved in sprouting angiogenesis] GO:0140297[DNA-binding transcription factor binding] GO:1901223[negative regulation of NIK/NF-kappaB signaling]
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118[histone deacetylase complex] GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0004407[histone deacetylase activity] GO:0005080[protein kinase C binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006325[chromatin organization] GO:0006476[protein deacetylation] GO:0016575[histone deacetylation] GO:0016787[hydrolase activity] GO:0016925[protein sumoylation] GO:0019222[regulation of metabolic process] GO:0019789[SUMO transferase activity] GO:0019901[protein kinase binding] GO:0032703[negative regulation of interleukin-2 production] GO:0033558[protein lysine deacetylase activity] GO:0045668[negative regulation of osteoblast differentiation] GO:0046872[metal ion binding] GO:0071889[14-3-3 protein binding] GO:0090050[positive regulation of cell migration involved in sprouting angiogenesis] GO:0140297[DNA-binding transcription factor binding] GO:1901223[negative regulation of NIK/NF-kappaB signaling]
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118[histone deacetylase complex] GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0004407[histone deacetylase activity] GO:0005080[protein kinase C binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006325[chromatin organization] GO:0006476[protein deacetylation] GO:0016575[histone deacetylation] GO:0016787[hydrolase activity] GO:0016925[protein sumoylation] GO:0019222[regulation of metabolic process] GO:0019789[SUMO transferase activity] GO:0019901[protein kinase binding] GO:0032703[negative regulation of interleukin-2 production] GO:0033558[protein lysine deacetylase activity] GO:0045668[negative regulation of osteoblast differentiation] GO:0046872[metal ion binding] GO:0071889[14-3-3 protein binding] GO:0090050[positive regulation of cell migration involved in sprouting angiogenesis] GO:0140297[DNA-binding transcription factor binding] GO:1901223[negative regulation of NIK/NF-kappaB signaling]
The Human Protein Atlas project is funded
