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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
19
Cytoband
p13.3
Chromosome location (bp)
1107637 - 1174268
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast. Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL-mediated osteoclast fusion via a DCSTAMP-dependent pathway. May also be required in the regulation of osteoblast differentiation (By similarity). Involved in the transcriptional corepression of NF-kappaB in macrophages 1. Plays a role as a regulator in the pro-inflammatory cascade 2....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator, Repressor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Predicted to enable chromatin DNA binding activity and histone binding activity. Involved in several processes, including cellular response to interleukin-6; macrophage activation involved in immune response; and negative regulation of transcription, DNA-templated. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q9Y2G9 [Direct mapping] Protein strawberry notch homolog 2
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THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0001503[ossification] GO:0002281[macrophage activation involved in immune response] GO:0005575[cellular_component] GO:0005634[nucleus] GO:0006355[regulation of DNA-templated transcription] GO:0030154[cell differentiation] GO:0030282[bone mineralization] GO:0030316[osteoclast differentiation] GO:0031490[chromatin DNA binding] GO:0042393[histone binding] GO:0045892[negative regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048583[regulation of response to stimulus] GO:0050727[regulation of inflammatory response] GO:0061430[bone trabecula morphogenesis] GO:0071222[cellular response to lipopolysaccharide] GO:0071348[cellular response to interleukin-11] GO:0071354[cellular response to interleukin-6] GO:0072674[multinuclear osteoclast differentiation] GO:0072675[osteoclast fusion] GO:1990830[cellular response to leukemia inhibitory factor]
Q9Y2G9 [Direct mapping] Protein strawberry notch homolog 2
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THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0001503[ossification] GO:0002281[macrophage activation involved in immune response] GO:0005575[cellular_component] GO:0005634[nucleus] GO:0006355[regulation of DNA-templated transcription] GO:0030154[cell differentiation] GO:0030316[osteoclast differentiation] GO:0031490[chromatin DNA binding] GO:0042393[histone binding] GO:0045892[negative regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048583[regulation of response to stimulus] GO:0050727[regulation of inflammatory response] GO:0071222[cellular response to lipopolysaccharide] GO:0071348[cellular response to interleukin-11] GO:0071354[cellular response to interleukin-6] GO:1990830[cellular response to leukemia inhibitory factor]
K7ES28 [Direct mapping] Protein strawberry notch homolog 2
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THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
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GO:0006355[regulation of DNA-templated transcription] GO:0048583[regulation of response to stimulus] GO:0050727[regulation of inflammatory response]
The Human Protein Atlas project is funded
