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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Enzymes FDA approved drug targets Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
10
Cytoband
p15.1
Chromosome location (bp)
6427143 - 6580301
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transactivation 1. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways. In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in 'outside-in' signaling and granule secretion signal transduction. May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at 'Ser-504' and 'Ser-532' and negatively regulates its ability to phosphorylate PKB/AKT1. Phosphorylates CCDC88A/GIV and inhibits its guanine nucleotide exchange factor activity 2....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q04759 [Direct mapping] Protein kinase C theta type
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Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0001558[regulation of cell growth] GO:0001772[immunological synapse] GO:0002376[immune system process] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004697[protein kinase C activity] GO:0004698[calcium-dependent protein kinase C activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006355[regulation of DNA-templated transcription] GO:0006468[protein phosphorylation] GO:0006509[membrane protein ectodomain proteolysis] GO:0006954[inflammatory response] GO:0007411[axon guidance] GO:0016020[membrane] GO:0016235[aggresome] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0032212[positive regulation of telomere maintenance via telomerase] GO:0032740[positive regulation of interleukin-17 production] GO:0032743[positive regulation of interleukin-2 production] GO:0032753[positive regulation of interleukin-4 production] GO:0034451[centriolar satellite] GO:0035556[intracellular signal transduction] GO:0035739[CD4-positive, alpha-beta T cell proliferation] GO:0038095[Fc-epsilon receptor signaling pathway] GO:0042110[T cell activation] GO:0046627[negative regulation of insulin receptor signaling pathway] GO:0046872[metal ion binding] GO:0050870[positive regulation of T cell activation] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051973[positive regulation of telomerase activity] GO:0060326[cell chemotaxis] GO:0070233[negative regulation of T cell apoptotic process] GO:0090330[regulation of platelet aggregation] GO:0106310[protein serine kinase activity] GO:1904355[positive regulation of telomere capping] GO:2000318[positive regulation of T-helper 17 type immune response] GO:2000563[positive regulation of CD4-positive, alpha-beta T cell proliferation] GO:2000570[positive regulation of T-helper 2 cell activation]
Q04759 [Direct mapping] Protein kinase C theta type
Show all
Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0001558[regulation of cell growth] GO:0002376[immune system process] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004697[protein kinase C activity] GO:0004698[calcium-dependent protein kinase C activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006355[regulation of DNA-templated transcription] GO:0006468[protein phosphorylation] GO:0006509[membrane protein ectodomain proteolysis] GO:0006954[inflammatory response] GO:0007411[axon guidance] GO:0016020[membrane] GO:0016235[aggresome] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0032212[positive regulation of telomere maintenance via telomerase] GO:0032740[positive regulation of interleukin-17 production] GO:0032753[positive regulation of interleukin-4 production] GO:0034451[centriolar satellite] GO:0035556[intracellular signal transduction] GO:0038095[Fc-epsilon receptor signaling pathway] GO:0046627[negative regulation of insulin receptor signaling pathway] GO:0046872[metal ion binding] GO:0050870[positive regulation of T cell activation] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051973[positive regulation of telomerase activity] GO:0060326[cell chemotaxis] GO:0070233[negative regulation of T cell apoptotic process] GO:0090330[regulation of platelet aggregation] GO:0106310[protein serine kinase activity] GO:1904355[positive regulation of telomere capping] GO:2000318[positive regulation of T-helper 17 type immune response] GO:2000570[positive regulation of T-helper 2 cell activation]
Q04759 [Direct mapping] Protein kinase C theta type
Show all
Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0001558[regulation of cell growth] GO:0002376[immune system process] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004697[protein kinase C activity] GO:0004698[calcium-dependent protein kinase C activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006355[regulation of DNA-templated transcription] GO:0006468[protein phosphorylation] GO:0006509[membrane protein ectodomain proteolysis] GO:0006954[inflammatory response] GO:0007411[axon guidance] GO:0016020[membrane] GO:0016235[aggresome] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0032212[positive regulation of telomere maintenance via telomerase] GO:0032740[positive regulation of interleukin-17 production] GO:0032753[positive regulation of interleukin-4 production] GO:0034451[centriolar satellite] GO:0035556[intracellular signal transduction] GO:0038095[Fc-epsilon receptor signaling pathway] GO:0046627[negative regulation of insulin receptor signaling pathway] GO:0046872[metal ion binding] GO:0050870[positive regulation of T cell activation] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051973[positive regulation of telomerase activity] GO:0060326[cell chemotaxis] GO:0070233[negative regulation of T cell apoptotic process] GO:0090330[regulation of platelet aggregation] GO:0106310[protein serine kinase activity] GO:1904355[positive regulation of telomere capping] GO:2000318[positive regulation of T-helper 17 type immune response] GO:2000570[positive regulation of T-helper 2 cell activation]
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