GENERAL INFORMATIONi
Gene namei FGFR2
Synonyms BEK, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25
Gene descriptioni Fibroblast growth factor receptor 2
Protein classi Cancer-related genes
CD markers
Disease related genes
Enzymes
FDA approved drug targets
Human disease related genes
Plasma proteins
RAS pathway related proteins
Predicted locationi Secreted, Membrane, Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 10
Cytoband q26.13
Chromosome location (bp) 121478332 - 121598458
Number of transcriptsi 25
Ensembl ENSG00000066468 (version 109)
Entrez gene 2263
HGNC HGNC:3689
UniProt P21802 (UniProt - Evidence at protein level)
neXtProt NX_P21802
GeneCards FGFR2
Antibodypedia FGFR2 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. show less
Molecular function (UniProt)i Heparin-binding, Kinase, Receptor, Transferase, Tyrosine-protein kinase
Biological process (UniProt)i Apoptosis
Ligand (UniProt)i ATP-binding, Nucleotide-binding
Gene summary (Entrez)i The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
FGFR2-201
ENSP00000337665
ENST00000336553
H7BXU9
[Direct mapping] Receptor protein-tyrosine kinase
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Human disease related genes
   Cancers
   Cancers of the digestive system
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Other congenital malformations
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor receptor activity]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
Show all
 669 aa
75.2 kDa 		Yes 1
FGFR2-202
ENSP00000263451
ENST00000346997
P21802
[Direct mapping] Fibroblast growth factor receptor 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Human disease related genes
   Cancers
   Cancers of the digestive system
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Other congenital malformations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000166 [nucleotide binding]
GO:0001525 [angiogenesis]
GO:0001657 [ureteric bud development]
GO:0001701 [in utero embryonic development]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0003148 [outflow tract septum morphogenesis]
GO:0003149 [membranous septum morphogenesis]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007409 [axonogenesis]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008589 [regulation of smoothened signaling pathway]
GO:0009791 [post-embryonic development]
GO:0009880 [embryonic pattern specification]
GO:0009887 [animal organ morphogenesis]
GO:0009986 [cell surface]
GO:0010518 [positive regulation of phospholipase activity]
GO:0010839 [negative regulation of keratinocyte proliferation]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016331 [morphogenesis of embryonic epithelium]
GO:0016740 [transferase activity]
GO:0017134 [fibroblast growth factor binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0021769 [orbitofrontal cortex development]
GO:0021847 [ventricular zone neuroblast division]
GO:0021860 [pyramidal neuron development]
GO:0022612 [gland morphogenesis]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030282 [bone mineralization]
GO:0030324 [lung development]
GO:0030855 [epithelial cell differentiation]
GO:0030901 [midbrain development]
GO:0030916 [otic vesicle formation]
GO:0031069 [hair follicle morphogenesis]
GO:0031410 [cytoplasmic vesicle]
GO:0032808 [lacrimal gland development]
GO:0033674 [positive regulation of kinase activity]
GO:0033688 [regulation of osteoblast proliferation]
GO:0035265 [organ growth]
GO:0035602 [fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell]
GO:0035603 [fibroblast growth factor receptor signaling pathway involved in hemopoiesis]
GO:0035604 [fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow]
GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development]
GO:0042472 [inner ear morphogenesis]
GO:0042476 [odontogenesis]
GO:0042803 [protein homodimerization activity]
GO:0043235 [receptor complex]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045165 [cell fate commitment]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045787 [positive regulation of cell cycle]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046777 [protein autophosphorylation]
GO:0048286 [lung alveolus development]
GO:0048557 [embryonic digestive tract morphogenesis]
GO:0048562 [embryonic organ morphogenesis]
GO:0048565 [digestive tract development]
GO:0048568 [embryonic organ development]
GO:0048608 [reproductive structure development]
GO:0048701 [embryonic cranial skeleton morphogenesis]
GO:0048705 [skeletal system morphogenesis]
GO:0048730 [epidermis morphogenesis]
GO:0048755 [branching morphogenesis of a nerve]
GO:0048762 [mesenchymal cell differentiation]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051150 [regulation of smooth muscle cell differentiation]
GO:0051781 [positive regulation of cell division]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060076 [excitatory synapse]
GO:0060174 [limb bud formation]
GO:0060348 [bone development]
GO:0060349 [bone morphogenesis]
GO:0060442 [branching involved in prostate gland morphogenesis]
GO:0060445 [branching involved in salivary gland morphogenesis]
GO:0060449 [bud elongation involved in lung branching]
GO:0060463 [lung lobe morphogenesis]
GO:0060484 [lung-associated mesenchyme development]
GO:0060501 [positive regulation of epithelial cell proliferation involved in lung morphogenesis]
GO:0060512 [prostate gland morphogenesis]
GO:0060523 [prostate epithelial cord elongation]
GO:0060527 [prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis]
GO:0060529 [squamous basal epithelial stem cell differentiation involved in prostate gland acinus development]
GO:0060595 [fibroblast growth factor receptor signaling pathway involved in mammary gland specification]
GO:0060601 [lateral sprouting from an epithelium]
GO:0060615 [mammary gland bud formation]
GO:0060664 [epithelial cell proliferation involved in salivary gland morphogenesis]
GO:0060667 [branch elongation involved in salivary gland morphogenesis]
GO:0060670 [branching involved in labyrinthine layer morphogenesis]
GO:0060688 [regulation of morphogenesis of a branching structure]
GO:0060915 [mesenchymal cell differentiation involved in lung development]
GO:0060916 [mesenchymal cell proliferation involved in lung development]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 819 aa
91.8 kDa 		Yes 1
FGFR2-203
ENSP00000309878
ENST00000351936
P21802
[Direct mapping] Fibroblast growth factor receptor 2
Show all
A0A0A0MR25
[Direct mapping] Fibroblast growth factor receptor
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Human disease related genes
   Cancers
   Cancers of the digestive system
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Other congenital malformations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000166 [nucleotide binding]
GO:0001525 [angiogenesis]
GO:0001657 [ureteric bud development]
GO:0001701 [in utero embryonic development]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0003148 [outflow tract septum morphogenesis]
GO:0003149 [membranous septum morphogenesis]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007409 [axonogenesis]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008589 [regulation of smoothened signaling pathway]
GO:0009791 [post-embryonic development]
GO:0009880 [embryonic pattern specification]
GO:0009887 [animal organ morphogenesis]
GO:0009986 [cell surface]
GO:0010518 [positive regulation of phospholipase activity]
GO:0010839 [negative regulation of keratinocyte proliferation]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016331 [morphogenesis of embryonic epithelium]
GO:0016740 [transferase activity]
GO:0017134 [fibroblast growth factor binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0021769 [orbitofrontal cortex development]
GO:0021847 [ventricular zone neuroblast division]
GO:0021860 [pyramidal neuron development]
GO:0022612 [gland morphogenesis]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030282 [bone mineralization]
GO:0030324 [lung development]
GO:0030855 [epithelial cell differentiation]
GO:0030901 [midbrain development]
GO:0030916 [otic vesicle formation]
GO:0031069 [hair follicle morphogenesis]
GO:0031410 [cytoplasmic vesicle]
GO:0032808 [lacrimal gland development]
GO:0033674 [positive regulation of kinase activity]
GO:0033688 [regulation of osteoblast proliferation]
GO:0035265 [organ growth]
GO:0035602 [fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell]
GO:0035603 [fibroblast growth factor receptor signaling pathway involved in hemopoiesis]
GO:0035604 [fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow]
GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development]
GO:0042472 [inner ear morphogenesis]
GO:0042476 [odontogenesis]
GO:0042803 [protein homodimerization activity]
GO:0043235 [receptor complex]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045165 [cell fate commitment]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045787 [positive regulation of cell cycle]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046777 [protein autophosphorylation]
GO:0048286 [lung alveolus development]
GO:0048557 [embryonic digestive tract morphogenesis]
GO:0048562 [embryonic organ morphogenesis]
GO:0048565 [digestive tract development]
GO:0048568 [embryonic organ development]
GO:0048608 [reproductive structure development]
GO:0048701 [embryonic cranial skeleton morphogenesis]
GO:0048705 [skeletal system morphogenesis]
GO:0048730 [epidermis morphogenesis]
GO:0048755 [branching morphogenesis of a nerve]
GO:0048762 [mesenchymal cell differentiation]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051150 [regulation of smooth muscle cell differentiation]
GO:0051781 [positive regulation of cell division]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060076 [excitatory synapse]
GO:0060174 [limb bud formation]
GO:0060348 [bone development]
GO:0060349 [bone morphogenesis]
GO:0060442 [branching involved in prostate gland morphogenesis]
GO:0060445 [branching involved in salivary gland morphogenesis]
GO:0060449 [bud elongation involved in lung branching]
GO:0060463 [lung lobe morphogenesis]
GO:0060484 [lung-associated mesenchyme development]
GO:0060501 [positive regulation of epithelial cell proliferation involved in lung morphogenesis]
GO:0060512 [prostate gland morphogenesis]
GO:0060523 [prostate epithelial cord elongation]
GO:0060527 [prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis]
GO:0060529 [squamous basal epithelial stem cell differentiation involved in prostate gland acinus development]
GO:0060595 [fibroblast growth factor receptor signaling pathway involved in mammary gland specification]
GO:0060601 [lateral sprouting from an epithelium]
GO:0060615 [mammary gland bud formation]
GO:0060664 [epithelial cell proliferation involved in salivary gland morphogenesis]
GO:0060667 [branch elongation involved in salivary gland morphogenesis]
GO:0060670 [branching involved in labyrinthine layer morphogenesis]
GO:0060688 [regulation of morphogenesis of a branching structure]
GO:0060915 [mesenchymal cell differentiation involved in lung development]
GO:0060916 [mesenchymal cell proliferation involved in lung development]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 819 aa
91.8 kDa 		Yes 1
FGFR2-204
ENSP00000348559
ENST00000356226
P21802
[Direct mapping] Fibroblast growth factor receptor 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Human disease related genes
   Cancers
   Cancers of the digestive system
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Other congenital malformations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000166 [nucleotide binding]
GO:0001525 [angiogenesis]
GO:0001657 [ureteric bud development]
GO:0001701 [in utero embryonic development]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0003148 [outflow tract septum morphogenesis]
GO:0003149 [membranous septum morphogenesis]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007409 [axonogenesis]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008589 [regulation of smoothened signaling pathway]
GO:0009791 [post-embryonic development]
GO:0009880 [embryonic pattern specification]
GO:0009887 [animal organ morphogenesis]
GO:0009986 [cell surface]
GO:0010518 [positive regulation of phospholipase activity]
GO:0010839 [negative regulation of keratinocyte proliferation]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016331 [morphogenesis of embryonic epithelium]
GO:0016740 [transferase activity]
GO:0017134 [fibroblast growth factor binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0021769 [orbitofrontal cortex development]
GO:0021847 [ventricular zone neuroblast division]
GO:0021860 [pyramidal neuron development]
GO:0022612 [gland morphogenesis]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030282 [bone mineralization]
GO:0030324 [lung development]
GO:0030855 [epithelial cell differentiation]
GO:0030901 [midbrain development]
GO:0030916 [otic vesicle formation]
GO:0031069 [hair follicle morphogenesis]
GO:0031410 [cytoplasmic vesicle]
GO:0032808 [lacrimal gland development]
GO:0033674 [positive regulation of kinase activity]
GO:0033688 [regulation of osteoblast proliferation]
GO:0035265 [organ growth]
GO:0035602 [fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell]
GO:0035603 [fibroblast growth factor receptor signaling pathway involved in hemopoiesis]
GO:0035604 [fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow]
GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development]
GO:0042472 [inner ear morphogenesis]
GO:0042476 [odontogenesis]
GO:0042803 [protein homodimerization activity]
GO:0043235 [receptor complex]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045165 [cell fate commitment]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045787 [positive regulation of cell cycle]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046777 [protein autophosphorylation]
GO:0048286 [lung alveolus development]
GO:0048557 [embryonic digestive tract morphogenesis]
GO:0048562 [embryonic organ morphogenesis]
GO:0048565 [digestive tract development]
GO:0048568 [embryonic organ development]
GO:0048608 [reproductive structure development]
GO:0048701 [embryonic cranial skeleton morphogenesis]
GO:0048705 [skeletal system morphogenesis]
GO:0048730 [epidermis morphogenesis]
GO:0048755 [branching morphogenesis of a nerve]
GO:0048762 [mesenchymal cell differentiation]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051150 [regulation of smooth muscle cell differentiation]
GO:0051781 [positive regulation of cell division]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060076 [excitatory synapse]
GO:0060174 [limb bud formation]
GO:0060348 [bone development]
GO:0060349 [bone morphogenesis]
GO:0060442 [branching involved in prostate gland morphogenesis]
GO:0060445 [branching involved in salivary gland morphogenesis]
GO:0060449 [bud elongation involved in lung branching]
GO:0060463 [lung lobe morphogenesis]
GO:0060484 [lung-associated mesenchyme development]
GO:0060501 [positive regulation of epithelial cell proliferation involved in lung morphogenesis]
GO:0060512 [prostate gland morphogenesis]
GO:0060523 [prostate epithelial cord elongation]
GO:0060527 [prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis]
GO:0060529 [squamous basal epithelial stem cell differentiation involved in prostate gland acinus development]
GO:0060595 [fibroblast growth factor receptor signaling pathway involved in mammary gland specification]
GO:0060601 [lateral sprouting from an epithelium]
GO:0060615 [mammary gland bud formation]
GO:0060664 [epithelial cell proliferation involved in salivary gland morphogenesis]
GO:0060667 [branch elongation involved in salivary gland morphogenesis]
GO:0060670 [branching involved in labyrinthine layer morphogenesis]
GO:0060688 [regulation of morphogenesis of a branching structure]
GO:0060915 [mesenchymal cell differentiation involved in lung development]
GO:0060916 [mesenchymal cell proliferation involved in lung development]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 704 aa
79.2 kDa 		Yes 1
FGFR2-205
ENSP00000350166
ENST00000357555
P21802
[Direct mapping] Fibroblast growth factor receptor 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Human disease related genes
   Cancers
   Cancers of the digestive system
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Other congenital malformations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000166 [nucleotide binding]
GO:0001525 [angiogenesis]
GO:0001657 [ureteric bud development]
GO:0001701 [in utero embryonic development]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0003148 [outflow tract septum morphogenesis]
GO:0003149 [membranous septum morphogenesis]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007409 [axonogenesis]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008589 [regulation of smoothened signaling pathway]
GO:0009791 [post-embryonic development]
GO:0009880 [embryonic pattern specification]
GO:0009887 [animal organ morphogenesis]
GO:0009986 [cell surface]
GO:0010518 [positive regulation of phospholipase activity]
GO:0010839 [negative regulation of keratinocyte proliferation]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016331 [morphogenesis of embryonic epithelium]
GO:0016740 [transferase activity]
GO:0017134 [fibroblast growth factor binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0021769 [orbitofrontal cortex development]
GO:0021847 [ventricular zone neuroblast division]
GO:0021860 [pyramidal neuron development]
GO:0022612 [gland morphogenesis]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030282 [bone mineralization]
GO:0030324 [lung development]
GO:0030855 [epithelial cell differentiation]
GO:0030901 [midbrain development]
GO:0030916 [otic vesicle formation]
GO:0031069 [hair follicle morphogenesis]
GO:0031410 [cytoplasmic vesicle]
GO:0032808 [lacrimal gland development]
GO:0033674 [positive regulation of kinase activity]
GO:0033688 [regulation of osteoblast proliferation]
GO:0035265 [organ growth]
GO:0035602 [fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell]
GO:0035603 [fibroblast growth factor receptor signaling pathway involved in hemopoiesis]
GO:0035604 [fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow]
GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development]
GO:0042472 [inner ear morphogenesis]
GO:0042476 [odontogenesis]
GO:0042803 [protein homodimerization activity]
GO:0043235 [receptor complex]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045165 [cell fate commitment]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045787 [positive regulation of cell cycle]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046777 [protein autophosphorylation]
GO:0048286 [lung alveolus development]
GO:0048557 [embryonic digestive tract morphogenesis]
GO:0048562 [embryonic organ morphogenesis]
GO:0048565 [digestive tract development]
GO:0048568 [embryonic organ development]
GO:0048608 [reproductive structure development]
GO:0048701 [embryonic cranial skeleton morphogenesis]
GO:0048705 [skeletal system morphogenesis]
GO:0048730 [epidermis morphogenesis]
GO:0048755 [branching morphogenesis of a nerve]
GO:0048762 [mesenchymal cell differentiation]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051150 [regulation of smooth muscle cell differentiation]
GO:0051781 [positive regulation of cell division]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060076 [excitatory synapse]
GO:0060174 [limb bud formation]
GO:0060348 [bone development]
GO:0060349 [bone morphogenesis]
GO:0060442 [branching involved in prostate gland morphogenesis]
GO:0060445 [branching involved in salivary gland morphogenesis]
GO:0060449 [bud elongation involved in lung branching]
GO:0060463 [lung lobe morphogenesis]
GO:0060484 [lung-associated mesenchyme development]
GO:0060501 [positive regulation of epithelial cell proliferation involved in lung morphogenesis]
GO:0060512 [prostate gland morphogenesis]
GO:0060523 [prostate epithelial cord elongation]
GO:0060527 [prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis]
GO:0060529 [squamous basal epithelial stem cell differentiation involved in prostate gland acinus development]
GO:0060595 [fibroblast growth factor receptor signaling pathway involved in mammary gland specification]
GO:0060601 [lateral sprouting from an epithelium]
GO:0060615 [mammary gland bud formation]
GO:0060664 [epithelial cell proliferation involved in salivary gland morphogenesis]
GO:0060667 [branch elongation involved in salivary gland morphogenesis]
GO:0060670 [branching involved in labyrinthine layer morphogenesis]
GO:0060688 [regulation of morphogenesis of a branching structure]
GO:0060915 [mesenchymal cell differentiation involved in lung development]
GO:0060916 [mesenchymal cell proliferation involved in lung development]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 707 aa
79.3 kDa 		Yes 1
FGFR2-206
ENSP00000351276
ENST00000358487
P21802
[Direct mapping] Fibroblast growth factor receptor 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Human disease related genes
   Cancers
   Cancers of the digestive system
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Other congenital malformations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000166 [nucleotide binding]
GO:0001525 [angiogenesis]
GO:0001657 [ureteric bud development]
GO:0001701 [in utero embryonic development]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0003148 [outflow tract septum morphogenesis]
GO:0003149 [membranous septum morphogenesis]
GO:0003416 [endochondral bone growth]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007409 [axonogenesis]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008589 [regulation of smoothened signaling pathway]
GO:0009791 [post-embryonic development]
GO:0009880 [embryonic pattern specification]
GO:0009887 [animal organ morphogenesis]
GO:0009986 [cell surface]
GO:0010518 [positive regulation of phospholipase activity]
GO:0010839 [negative regulation of keratinocyte proliferation]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016331 [morphogenesis of embryonic epithelium]
GO:0016740 [transferase activity]
GO:0017134 [fibroblast growth factor binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0021769 [orbitofrontal cortex development]
GO:0021847 [ventricular zone neuroblast division]
GO:0021860 [pyramidal neuron development]
GO:0022612 [gland morphogenesis]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030282 [bone mineralization]
GO:0030324 [lung development]
GO:0030855 [epithelial cell differentiation]
GO:0030901 [midbrain development]
GO:0030916 [otic vesicle formation]
GO:0031069 [hair follicle morphogenesis]
GO:0031410 [cytoplasmic vesicle]
GO:0032496 [response to lipopolysaccharide]
GO:0032808 [lacrimal gland development]
GO:0033674 [positive regulation of kinase activity]
GO:0033688 [regulation of osteoblast proliferation]
GO:0035265 [organ growth]
GO:0035602 [fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell]
GO:0035603 [fibroblast growth factor receptor signaling pathway involved in hemopoiesis]
GO:0035604 [fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow]
GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development]
GO:0042060 [wound healing]
GO:0042472 [inner ear morphogenesis]
GO:0042476 [odontogenesis]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043235 [receptor complex]
GO:0043410 [positive regulation of MAPK cascade]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0045165 [cell fate commitment]
GO:0045471 [response to ethanol]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045787 [positive regulation of cell cycle]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046777 [protein autophosphorylation]
GO:0048286 [lung alveolus development]
GO:0048333 [mesodermal cell differentiation]
GO:0048557 [embryonic digestive tract morphogenesis]
GO:0048562 [embryonic organ morphogenesis]
GO:0048565 [digestive tract development]
GO:0048568 [embryonic organ development]
GO:0048608 [reproductive structure development]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0048701 [embryonic cranial skeleton morphogenesis]
GO:0048705 [skeletal system morphogenesis]
GO:0048730 [epidermis morphogenesis]
GO:0048755 [branching morphogenesis of a nerve]
GO:0048762 [mesenchymal cell differentiation]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0051150 [regulation of smooth muscle cell differentiation]
GO:0051781 [positive regulation of cell division]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060076 [excitatory synapse]
GO:0060174 [limb bud formation]
GO:0060348 [bone development]
GO:0060349 [bone morphogenesis]
GO:0060442 [branching involved in prostate gland morphogenesis]
GO:0060445 [branching involved in salivary gland morphogenesis]
GO:0060449 [bud elongation involved in lung branching]
GO:0060463 [lung lobe morphogenesis]
GO:0060484 [lung-associated mesenchyme development]
GO:0060501 [positive regulation of epithelial cell proliferation involved in lung morphogenesis]
GO:0060512 [prostate gland morphogenesis]
GO:0060523 [prostate epithelial cord elongation]
GO:0060527 [prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis]
GO:0060529 [squamous basal epithelial stem cell differentiation involved in prostate gland acinus development]
GO:0060595 [fibroblast growth factor receptor signaling pathway involved in mammary gland specification]
GO:0060601 [lateral sprouting from an epithelium]
GO:0060615 [mammary gland bud formation]
GO:0060664 [epithelial cell proliferation involved in salivary gland morphogenesis]
GO:0060667 [branch elongation involved in salivary gland morphogenesis]
GO:0060670 [branching involved in labyrinthine layer morphogenesis]
GO:0060688 [regulation of morphogenesis of a branching structure]
GO:0060915 [mesenchymal cell differentiation involved in lung development]
GO:0060916 [mesenchymal cell proliferation involved in lung development]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071300 [cellular response to retinoic acid]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 821 aa
92 kDa 		Yes 1
FGFR2-207
ENSP00000352309
ENST00000359354
P21802
[Direct mapping] Fibroblast growth factor receptor 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
   DeepTMHMM predicted secreted proteins
   DeepSig predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Human disease related genes
   Cancers
   Cancers of the digestive system
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Other congenital malformations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000166 [nucleotide binding]
GO:0001525 [angiogenesis]
GO:0001657 [ureteric bud development]
GO:0001701 [in utero embryonic development]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0003148 [outflow tract septum morphogenesis]
GO:0003149 [membranous septum morphogenesis]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007409 [axonogenesis]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008589 [regulation of smoothened signaling pathway]
GO:0009791 [post-embryonic development]
GO:0009880 [embryonic pattern specification]
GO:0009887 [animal organ morphogenesis]
GO:0009986 [cell surface]
GO:0010518 [positive regulation of phospholipase activity]
GO:0010839 [negative regulation of keratinocyte proliferation]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016331 [morphogenesis of embryonic epithelium]
GO:0016740 [transferase activity]
GO:0017134 [fibroblast growth factor binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0021769 [orbitofrontal cortex development]
GO:0021847 [ventricular zone neuroblast division]
GO:0021860 [pyramidal neuron development]
GO:0022612 [gland morphogenesis]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030282 [bone mineralization]
GO:0030324 [lung development]
GO:0030855 [epithelial cell differentiation]
GO:0030901 [midbrain development]
GO:0030916 [otic vesicle formation]
GO:0031069 [hair follicle morphogenesis]
GO:0031410 [cytoplasmic vesicle]
GO:0032808 [lacrimal gland development]
GO:0033674 [positive regulation of kinase activity]
GO:0033688 [regulation of osteoblast proliferation]
GO:0035265 [organ growth]
GO:0035602 [fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell]
GO:0035603 [fibroblast growth factor receptor signaling pathway involved in hemopoiesis]
GO:0035604 [fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow]
GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development]
GO:0042472 [inner ear morphogenesis]
GO:0042476 [odontogenesis]
GO:0042803 [protein homodimerization activity]
GO:0043235 [receptor complex]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045165 [cell fate commitment]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045787 [positive regulation of cell cycle]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046777 [protein autophosphorylation]
GO:0048286 [lung alveolus development]
GO:0048557 [embryonic digestive tract morphogenesis]
GO:0048562 [embryonic organ morphogenesis]
GO:0048565 [digestive tract development]
GO:0048568 [embryonic organ development]
GO:0048608 [reproductive structure development]
GO:0048701 [embryonic cranial skeleton morphogenesis]
GO:0048705 [skeletal system morphogenesis]
GO:0048730 [epidermis morphogenesis]
GO:0048755 [branching morphogenesis of a nerve]
GO:0048762 [mesenchymal cell differentiation]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051150 [regulation of smooth muscle cell differentiation]
GO:0051781 [positive regulation of cell division]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060076 [excitatory synapse]
GO:0060174 [limb bud formation]
GO:0060348 [bone development]
GO:0060349 [bone morphogenesis]
GO:0060442 [branching involved in prostate gland morphogenesis]
GO:0060445 [branching involved in salivary gland morphogenesis]
GO:0060449 [bud elongation involved in lung branching]
GO:0060463 [lung lobe morphogenesis]
GO:0060484 [lung-associated mesenchyme development]
GO:0060501 [positive regulation of epithelial cell proliferation involved in lung morphogenesis]
GO:0060512 [prostate gland morphogenesis]
GO:0060523 [prostate epithelial cord elongation]
GO:0060527 [prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis]
GO:0060529 [squamous basal epithelial stem cell differentiation involved in prostate gland acinus development]
GO:0060595 [fibroblast growth factor receptor signaling pathway involved in mammary gland specification]
GO:0060601 [lateral sprouting from an epithelium]
GO:0060615 [mammary gland bud formation]
GO:0060664 [epithelial cell proliferation involved in salivary gland morphogenesis]
GO:0060667 [branch elongation involved in salivary gland morphogenesis]
GO:0060670 [branching involved in labyrinthine layer morphogenesis]
GO:0060688 [regulation of morphogenesis of a branching structure]
GO:0060915 [mesenchymal cell differentiation involved in lung development]
GO:0060916 [mesenchymal cell proliferation involved in lung development]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 254 aa
28.3 kDa 		Yes 0
FGFR2-208
ENSP00000353262
ENST00000360144
P21802
[Direct mapping] Fibroblast growth factor receptor 2
Show all
A0A141AXF1
[Target identity:100%; Query identity:100%] Fibroblast growth factor receptor
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Human disease related genes
   Cancers
   Cancers of the digestive system
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Other congenital malformations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000166 [nucleotide binding]
GO:0001525 [angiogenesis]
GO:0001657 [ureteric bud development]
GO:0001701 [in utero embryonic development]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0003148 [outflow tract septum morphogenesis]
GO:0003149 [membranous septum morphogenesis]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007409 [axonogenesis]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008589 [regulation of smoothened signaling pathway]
GO:0009791 [post-embryonic development]
GO:0009880 [embryonic pattern specification]
GO:0009887 [animal organ morphogenesis]
GO:0009986 [cell surface]
GO:0010518 [positive regulation of phospholipase activity]
GO:0010839 [negative regulation of keratinocyte proliferation]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016331 [morphogenesis of embryonic epithelium]
GO:0016740 [transferase activity]
GO:0017134 [fibroblast growth factor binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0021769 [orbitofrontal cortex development]
GO:0021847 [ventricular zone neuroblast division]
GO:0021860 [pyramidal neuron development]
GO:0022612 [gland morphogenesis]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030282 [bone mineralization]
GO:0030324 [lung development]
GO:0030855 [epithelial cell differentiation]
GO:0030901 [midbrain development]
GO:0030916 [otic vesicle formation]
GO:0031069 [hair follicle morphogenesis]
GO:0031410 [cytoplasmic vesicle]
GO:0032808 [lacrimal gland development]
GO:0033674 [positive regulation of kinase activity]
GO:0033688 [regulation of osteoblast proliferation]
GO:0035265 [organ growth]
GO:0035602 [fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell]
GO:0035603 [fibroblast growth factor receptor signaling pathway involved in hemopoiesis]
GO:0035604 [fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow]
GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development]
GO:0042472 [inner ear morphogenesis]
GO:0042476 [odontogenesis]
GO:0042803 [protein homodimerization activity]
GO:0043235 [receptor complex]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045165 [cell fate commitment]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045787 [positive regulation of cell cycle]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046777 [protein autophosphorylation]
GO:0048286 [lung alveolus development]
GO:0048557 [embryonic digestive tract morphogenesis]
GO:0048562 [embryonic organ morphogenesis]
GO:0048565 [digestive tract development]
GO:0048568 [embryonic organ development]
GO:0048608 [reproductive structure development]
GO:0048701 [embryonic cranial skeleton morphogenesis]
GO:0048705 [skeletal system morphogenesis]
GO:0048730 [epidermis morphogenesis]
GO:0048755 [branching morphogenesis of a nerve]
GO:0048762 [mesenchymal cell differentiation]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051150 [regulation of smooth muscle cell differentiation]
GO:0051781 [positive regulation of cell division]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060076 [excitatory synapse]
GO:0060174 [limb bud formation]
GO:0060348 [bone development]
GO:0060349 [bone morphogenesis]
GO:0060442 [branching involved in prostate gland morphogenesis]
GO:0060445 [branching involved in salivary gland morphogenesis]
GO:0060449 [bud elongation involved in lung branching]
GO:0060463 [lung lobe morphogenesis]
GO:0060484 [lung-associated mesenchyme development]
GO:0060501 [positive regulation of epithelial cell proliferation involved in lung morphogenesis]
GO:0060512 [prostate gland morphogenesis]
GO:0060523 [prostate epithelial cord elongation]
GO:0060527 [prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis]
GO:0060529 [squamous basal epithelial stem cell differentiation involved in prostate gland acinus development]
GO:0060595 [fibroblast growth factor receptor signaling pathway involved in mammary gland specification]
GO:0060601 [lateral sprouting from an epithelium]
GO:0060615 [mammary gland bud formation]
GO:0060664 [epithelial cell proliferation involved in salivary gland morphogenesis]
GO:0060667 [branch elongation involved in salivary gland morphogenesis]
GO:0060670 [branching involved in labyrinthine layer morphogenesis]
GO:0060688 [regulation of morphogenesis of a branching structure]
GO:0060915 [mesenchymal cell differentiation involved in lung development]
GO:0060916 [mesenchymal cell proliferation involved in lung development]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 680 aa
76.4 kDa 		Yes 1
FGFR2-209
ENSP00000358052
ENST00000369056
P21802
[Direct mapping] Fibroblast growth factor receptor 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Human disease related genes
   Cancers
   Cancers of the digestive system
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Other congenital malformations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000166 [nucleotide binding]
GO:0001525 [angiogenesis]
GO:0001657 [ureteric bud development]
GO:0001701 [in utero embryonic development]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0003148 [outflow tract septum morphogenesis]
GO:0003149 [membranous septum morphogenesis]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007409 [axonogenesis]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008589 [regulation of smoothened signaling pathway]
GO:0009791 [post-embryonic development]
GO:0009880 [embryonic pattern specification]
GO:0009887 [animal organ morphogenesis]
GO:0009986 [cell surface]
GO:0010518 [positive regulation of phospholipase activity]
GO:0010839 [negative regulation of keratinocyte proliferation]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016331 [morphogenesis of embryonic epithelium]
GO:0016740 [transferase activity]
GO:0017134 [fibroblast growth factor binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0021769 [orbitofrontal cortex development]
GO:0021847 [ventricular zone neuroblast division]
GO:0021860 [pyramidal neuron development]
GO:0022612 [gland morphogenesis]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030282 [bone mineralization]
GO:0030324 [lung development]
GO:0030855 [epithelial cell differentiation]
GO:0030901 [midbrain development]
GO:0030916 [otic vesicle formation]
GO:0031069 [hair follicle morphogenesis]
GO:0031410 [cytoplasmic vesicle]
GO:0032808 [lacrimal gland development]
GO:0033674 [positive regulation of kinase activity]
GO:0033688 [regulation of osteoblast proliferation]
GO:0035265 [organ growth]
GO:0035602 [fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell]
GO:0035603 [fibroblast growth factor receptor signaling pathway involved in hemopoiesis]
GO:0035604 [fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow]
GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development]
GO:0042472 [inner ear morphogenesis]
GO:0042476 [odontogenesis]
GO:0042803 [protein homodimerization activity]
GO:0043235 [receptor complex]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045165 [cell fate commitment]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045787 [positive regulation of cell cycle]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046777 [protein autophosphorylation]
GO:0048286 [lung alveolus development]
GO:0048557 [embryonic digestive tract morphogenesis]
GO:0048562 [embryonic organ morphogenesis]
GO:0048565 [digestive tract development]
GO:0048568 [embryonic organ development]
GO:0048608 [reproductive structure development]
GO:0048701 [embryonic cranial skeleton morphogenesis]
GO:0048705 [skeletal system morphogenesis]
GO:0048730 [epidermis morphogenesis]
GO:0048755 [branching morphogenesis of a nerve]
GO:0048762 [mesenchymal cell differentiation]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051150 [regulation of smooth muscle cell differentiation]
GO:0051781 [positive regulation of cell division]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060076 [excitatory synapse]
GO:0060174 [limb bud formation]
GO:0060348 [bone development]
GO:0060349 [bone morphogenesis]
GO:0060442 [branching involved in prostate gland morphogenesis]
GO:0060445 [branching involved in salivary gland morphogenesis]
GO:0060449 [bud elongation involved in lung branching]
GO:0060463 [lung lobe morphogenesis]
GO:0060484 [lung-associated mesenchyme development]
GO:0060501 [positive regulation of epithelial cell proliferation involved in lung morphogenesis]
GO:0060512 [prostate gland morphogenesis]
GO:0060523 [prostate epithelial cord elongation]
GO:0060527 [prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis]
GO:0060529 [squamous basal epithelial stem cell differentiation involved in prostate gland acinus development]
GO:0060595 [fibroblast growth factor receptor signaling pathway involved in mammary gland specification]
GO:0060601 [lateral sprouting from an epithelium]
GO:0060615 [mammary gland bud formation]
GO:0060664 [epithelial cell proliferation involved in salivary gland morphogenesis]
GO:0060667 [branch elongation involved in salivary gland morphogenesis]
GO:0060670 [branching involved in labyrinthine layer morphogenesis]
GO:0060688 [regulation of morphogenesis of a branching structure]
GO:0060915 [mesenchymal cell differentiation involved in lung development]
GO:0060916 [mesenchymal cell proliferation involved in lung development]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 769 aa
86.2 kDa 		Yes 1
FGFR2-210
ENSP00000358054
ENST00000369058
A0A5S6RJB7
[Direct mapping] Receptor protein-tyrosine kinase
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Human disease related genes
   Cancers
   Cancers of the digestive system
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Other congenital malformations
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor receptor activity]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
Show all
 768 aa
86.1 kDa 		Yes 1
FGFR2-211
ENSP00000358055
ENST00000369059
E7EVR7
[Direct mapping] Fibroblast growth factor receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Human disease related genes
   Cancers
   Cancers of the digestive system
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Other congenital malformations
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor receptor activity]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
Show all
 707 aa
79.5 kDa 		Yes 1
FGFR2-212
ENSP00000358056
ENST00000369060
P21802
[Direct mapping] Fibroblast growth factor receptor 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
   DeepTMHMM predicted secreted proteins
   DeepSig predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Human disease related genes
   Cancers
   Cancers of the digestive system
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Other congenital malformations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000166 [nucleotide binding]
GO:0001525 [angiogenesis]
GO:0001657 [ureteric bud development]
GO:0001701 [in utero embryonic development]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0003148 [outflow tract septum morphogenesis]
GO:0003149 [membranous septum morphogenesis]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007409 [axonogenesis]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008589 [regulation of smoothened signaling pathway]
GO:0009791 [post-embryonic development]
GO:0009880 [embryonic pattern specification]
GO:0009887 [animal organ morphogenesis]
GO:0009986 [cell surface]
GO:0010518 [positive regulation of phospholipase activity]
GO:0010839 [negative regulation of keratinocyte proliferation]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016331 [morphogenesis of embryonic epithelium]
GO:0016740 [transferase activity]
GO:0017134 [fibroblast growth factor binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0021769 [orbitofrontal cortex development]
GO:0021847 [ventricular zone neuroblast division]
GO:0021860 [pyramidal neuron development]
GO:0022612 [gland morphogenesis]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030282 [bone mineralization]
GO:0030324 [lung development]
GO:0030855 [epithelial cell differentiation]
GO:0030901 [midbrain development]
GO:0030916 [otic vesicle formation]
GO:0031069 [hair follicle morphogenesis]
GO:0031410 [cytoplasmic vesicle]
GO:0032808 [lacrimal gland development]
GO:0033674 [positive regulation of kinase activity]
GO:0033688 [regulation of osteoblast proliferation]
GO:0035265 [organ growth]
GO:0035602 [fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell]
GO:0035603 [fibroblast growth factor receptor signaling pathway involved in hemopoiesis]
GO:0035604 [fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow]
GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development]
GO:0042472 [inner ear morphogenesis]
GO:0042476 [odontogenesis]
GO:0042803 [protein homodimerization activity]
GO:0043235 [receptor complex]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045165 [cell fate commitment]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045787 [positive regulation of cell cycle]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046777 [protein autophosphorylation]
GO:0048286 [lung alveolus development]
GO:0048557 [embryonic digestive tract morphogenesis]
GO:0048562 [embryonic organ morphogenesis]
GO:0048565 [digestive tract development]
GO:0048568 [embryonic organ development]
GO:0048608 [reproductive structure development]
GO:0048701 [embryonic cranial skeleton morphogenesis]
GO:0048705 [skeletal system morphogenesis]
GO:0048730 [epidermis morphogenesis]
GO:0048755 [branching morphogenesis of a nerve]
GO:0048762 [mesenchymal cell differentiation]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051150 [regulation of smooth muscle cell differentiation]
GO:0051781 [positive regulation of cell division]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060076 [excitatory synapse]
GO:0060174 [limb bud formation]
GO:0060348 [bone development]
GO:0060349 [bone morphogenesis]
GO:0060442 [branching involved in prostate gland morphogenesis]
GO:0060445 [branching involved in salivary gland morphogenesis]
GO:0060449 [bud elongation involved in lung branching]
GO:0060463 [lung lobe morphogenesis]
GO:0060484 [lung-associated mesenchyme development]
GO:0060501 [positive regulation of epithelial cell proliferation involved in lung morphogenesis]
GO:0060512 [prostate gland morphogenesis]
GO:0060523 [prostate epithelial cord elongation]
GO:0060527 [prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis]
GO:0060529 [squamous basal epithelial stem cell differentiation involved in prostate gland acinus development]
GO:0060595 [fibroblast growth factor receptor signaling pathway involved in mammary gland specification]
GO:0060601 [lateral sprouting from an epithelium]
GO:0060615 [mammary gland bud formation]
GO:0060664 [epithelial cell proliferation involved in salivary gland morphogenesis]
GO:0060667 [branch elongation involved in salivary gland morphogenesis]
GO:0060670 [branching involved in labyrinthine layer morphogenesis]
GO:0060688 [regulation of morphogenesis of a branching structure]
GO:0060915 [mesenchymal cell differentiation involved in lung development]
GO:0060916 [mesenchymal cell proliferation involved in lung development]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 705 aa
79.2 kDa 		Yes 0
FGFR2-213
ENSP00000358057
ENST00000369061
P21802
[Direct mapping] Fibroblast growth factor receptor 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Human disease related genes
   Cancers
   Cancers of the digestive system
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Other congenital malformations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000166 [nucleotide binding]
GO:0001525 [angiogenesis]
GO:0001657 [ureteric bud development]
GO:0001701 [in utero embryonic development]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0003148 [outflow tract septum morphogenesis]
GO:0003149 [membranous septum morphogenesis]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007409 [axonogenesis]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008589 [regulation of smoothened signaling pathway]
GO:0009791 [post-embryonic development]
GO:0009880 [embryonic pattern specification]
GO:0009887 [animal organ morphogenesis]
GO:0009986 [cell surface]
GO:0010518 [positive regulation of phospholipase activity]
GO:0010839 [negative regulation of keratinocyte proliferation]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016331 [morphogenesis of embryonic epithelium]
GO:0016740 [transferase activity]
GO:0017134 [fibroblast growth factor binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0021769 [orbitofrontal cortex development]
GO:0021847 [ventricular zone neuroblast division]
GO:0021860 [pyramidal neuron development]
GO:0022612 [gland morphogenesis]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030282 [bone mineralization]
GO:0030324 [lung development]
GO:0030855 [epithelial cell differentiation]
GO:0030901 [midbrain development]
GO:0030916 [otic vesicle formation]
GO:0031069 [hair follicle morphogenesis]
GO:0031410 [cytoplasmic vesicle]
GO:0032808 [lacrimal gland development]
GO:0033674 [positive regulation of kinase activity]
GO:0033688 [regulation of osteoblast proliferation]
GO:0035265 [organ growth]
GO:0035602 [fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell]
GO:0035603 [fibroblast growth factor receptor signaling pathway involved in hemopoiesis]
GO:0035604 [fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow]
GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development]
GO:0042472 [inner ear morphogenesis]
GO:0042476 [odontogenesis]
GO:0042803 [protein homodimerization activity]
GO:0043235 [receptor complex]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045165 [cell fate commitment]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045787 [positive regulation of cell cycle]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046777 [protein autophosphorylation]
GO:0048286 [lung alveolus development]
GO:0048557 [embryonic digestive tract morphogenesis]
GO:0048562 [embryonic organ morphogenesis]
GO:0048565 [digestive tract development]
GO:0048568 [embryonic organ development]
GO:0048608 [reproductive structure development]
GO:0048701 [embryonic cranial skeleton morphogenesis]
GO:0048705 [skeletal system morphogenesis]
GO:0048730 [epidermis morphogenesis]
GO:0048755 [branching morphogenesis of a nerve]
GO:0048762 [mesenchymal cell differentiation]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051150 [regulation of smooth muscle cell differentiation]
GO:0051781 [positive regulation of cell division]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060076 [excitatory synapse]
GO:0060174 [limb bud formation]
GO:0060348 [bone development]
GO:0060349 [bone morphogenesis]
GO:0060442 [branching involved in prostate gland morphogenesis]
GO:0060445 [branching involved in salivary gland morphogenesis]
GO:0060449 [bud elongation involved in lung branching]
GO:0060463 [lung lobe morphogenesis]
GO:0060484 [lung-associated mesenchyme development]
GO:0060501 [positive regulation of epithelial cell proliferation involved in lung morphogenesis]
GO:0060512 [prostate gland morphogenesis]
GO:0060523 [prostate epithelial cord elongation]
GO:0060527 [prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis]
GO:0060529 [squamous basal epithelial stem cell differentiation involved in prostate gland acinus development]
GO:0060595 [fibroblast growth factor receptor signaling pathway involved in mammary gland specification]
GO:0060601 [lateral sprouting from an epithelium]
GO:0060615 [mammary gland bud formation]
GO:0060664 [epithelial cell proliferation involved in salivary gland morphogenesis]
GO:0060667 [branch elongation involved in salivary gland morphogenesis]
GO:0060670 [branching involved in labyrinthine layer morphogenesis]
GO:0060688 [regulation of morphogenesis of a branching structure]
GO:0060915 [mesenchymal cell differentiation involved in lung development]
GO:0060916 [mesenchymal cell proliferation involved in lung development]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 709 aa
79.8 kDa 		Yes 1
FGFR2-214
ENSP00000404219
ENST00000429361
H7C265
[Direct mapping] Fibroblast growth factor receptor 2
Show all
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Human disease related genes
   Cancers
   Cancers of the digestive system
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Other congenital malformations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0018108 [peptidyl-tyrosine phosphorylation]
Show all
 371 aa
41.9 kDa 		No 0
FGFR2-215
ENSP00000410294
ENST00000457416
P21802
[Direct mapping] Fibroblast growth factor receptor 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Human disease related genes
   Cancers
   Cancers of the digestive system
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Other congenital malformations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000166 [nucleotide binding]
GO:0001525 [angiogenesis]
GO:0001657 [ureteric bud development]
GO:0001701 [in utero embryonic development]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0003148 [outflow tract septum morphogenesis]
GO:0003149 [membranous septum morphogenesis]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007409 [axonogenesis]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008589 [regulation of smoothened signaling pathway]
GO:0009791 [post-embryonic development]
GO:0009880 [embryonic pattern specification]
GO:0009887 [animal organ morphogenesis]
GO:0009986 [cell surface]
GO:0010518 [positive regulation of phospholipase activity]
GO:0010839 [negative regulation of keratinocyte proliferation]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016331 [morphogenesis of embryonic epithelium]
GO:0016740 [transferase activity]
GO:0017134 [fibroblast growth factor binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0021769 [orbitofrontal cortex development]
GO:0021847 [ventricular zone neuroblast division]
GO:0021860 [pyramidal neuron development]
GO:0022612 [gland morphogenesis]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030282 [bone mineralization]
GO:0030324 [lung development]
GO:0030855 [epithelial cell differentiation]
GO:0030901 [midbrain development]
GO:0030916 [otic vesicle formation]
GO:0031069 [hair follicle morphogenesis]
GO:0031410 [cytoplasmic vesicle]
GO:0032808 [lacrimal gland development]
GO:0033674 [positive regulation of kinase activity]
GO:0033688 [regulation of osteoblast proliferation]
GO:0035265 [organ growth]
GO:0035602 [fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell]
GO:0035603 [fibroblast growth factor receptor signaling pathway involved in hemopoiesis]
GO:0035604 [fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow]
GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development]
GO:0042472 [inner ear morphogenesis]
GO:0042476 [odontogenesis]
GO:0042803 [protein homodimerization activity]
GO:0043235 [receptor complex]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045165 [cell fate commitment]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045787 [positive regulation of cell cycle]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046777 [protein autophosphorylation]
GO:0048286 [lung alveolus development]
GO:0048557 [embryonic digestive tract morphogenesis]
GO:0048562 [embryonic organ morphogenesis]
GO:0048565 [digestive tract development]
GO:0048568 [embryonic organ development]
GO:0048608 [reproductive structure development]
GO:0048701 [embryonic cranial skeleton morphogenesis]
GO:0048705 [skeletal system morphogenesis]
GO:0048730 [epidermis morphogenesis]
GO:0048755 [branching morphogenesis of a nerve]
GO:0048762 [mesenchymal cell differentiation]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051150 [regulation of smooth muscle cell differentiation]
GO:0051781 [positive regulation of cell division]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060076 [excitatory synapse]
GO:0060174 [limb bud formation]
GO:0060348 [bone development]
GO:0060349 [bone morphogenesis]
GO:0060442 [branching involved in prostate gland morphogenesis]
GO:0060445 [branching involved in salivary gland morphogenesis]
GO:0060449 [bud elongation involved in lung branching]
GO:0060463 [lung lobe morphogenesis]
GO:0060484 [lung-associated mesenchyme development]
GO:0060501 [positive regulation of epithelial cell proliferation involved in lung morphogenesis]
GO:0060512 [prostate gland morphogenesis]
GO:0060523 [prostate epithelial cord elongation]
GO:0060527 [prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis]
GO:0060529 [squamous basal epithelial stem cell differentiation involved in prostate gland acinus development]
GO:0060595 [fibroblast growth factor receptor signaling pathway involved in mammary gland specification]
GO:0060601 [lateral sprouting from an epithelium]
GO:0060615 [mammary gland bud formation]
GO:0060664 [epithelial cell proliferation involved in salivary gland morphogenesis]
GO:0060667 [branch elongation involved in salivary gland morphogenesis]
GO:0060670 [branching involved in labyrinthine layer morphogenesis]
GO:0060688 [regulation of morphogenesis of a branching structure]
GO:0060915 [mesenchymal cell differentiation involved in lung development]
GO:0060916 [mesenchymal cell proliferation involved in lung development]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 822 aa
92.1 kDa 		Yes 1
FGFR2-218
ENSP00000474011
ENST00000478859
S4R381
[Direct mapping] Receptor protein-tyrosine kinase
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Human disease related genes
   Cancers
   Cancers of the digestive system
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Other congenital malformations
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0016020 [membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
Show all
 593 aa
66.7 kDa 		No 1
FGFR2-223
ENSP00000484892
ENST00000611527
A0A087X2D1
[Direct mapping] Fibroblast growth factor receptor 2
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
   DeepTMHMM predicted secreted proteins
   DeepSig predicted secreted proteins
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Human disease related genes
   Cancers
   Cancers of the digestive system
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Other congenital malformations
Protein evidence (Ezkurdia et al 2014)
Show all
 64 aa
6.9 kDa 		Yes 0
FGFR2-224
ENSP00000484154
ENST00000613048
D2CGD1
[Direct mapping] Fibroblast growth factor receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Human disease related genes
   Cancers
   Cancers of the digestive system
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Other congenital malformations
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor receptor activity]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
Show all
 732 aa
82.2 kDa 		Yes 1
FGFR2-225
ENSP00000481464
ENST00000613324
A0A087WY21
[Direct mapping] Fibroblast growth factor receptor 2
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Human disease related genes
   Cancers
   Cancers of the digestive system
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Other congenital malformations
Protein evidence (Ezkurdia et al 2014)
Show all
 136 aa
14.7 kDa 		No 0
FGFR2-227
ENSP00000491912
ENST00000638709
A0A1W2PQT9
[Direct mapping] Fibroblast growth factor receptor 2
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Human disease related genes
   Cancers
   Cancers of the digestive system
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Other congenital malformations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0018108 [peptidyl-tyrosine phosphorylation]
Show all
 429 aa
48.7 kDa 		No 0
FGFR2-230
ENSP00000507633
ENST00000682550
P21802
[Direct mapping] Fibroblast growth factor receptor 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Human disease related genes
   Cancers
   Cancers of the digestive system
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Other congenital malformations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000166 [nucleotide binding]
GO:0001525 [angiogenesis]
GO:0001657 [ureteric bud development]
GO:0001701 [in utero embryonic development]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0003148 [outflow tract septum morphogenesis]
GO:0003149 [membranous septum morphogenesis]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007409 [axonogenesis]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008589 [regulation of smoothened signaling pathway]
GO:0009791 [post-embryonic development]
GO:0009880 [embryonic pattern specification]
GO:0009887 [animal organ morphogenesis]
GO:0009986 [cell surface]
GO:0010518 [positive regulation of phospholipase activity]
GO:0010839 [negative regulation of keratinocyte proliferation]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016331 [morphogenesis of embryonic epithelium]
GO:0016740 [transferase activity]
GO:0017134 [fibroblast growth factor binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0021769 [orbitofrontal cortex development]
GO:0021847 [ventricular zone neuroblast division]
GO:0021860 [pyramidal neuron development]
GO:0022612 [gland morphogenesis]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030282 [bone mineralization]
GO:0030324 [lung development]
GO:0030855 [epithelial cell differentiation]
GO:0030901 [midbrain development]
GO:0030916 [otic vesicle formation]
GO:0031069 [hair follicle morphogenesis]
GO:0031410 [cytoplasmic vesicle]
GO:0032808 [lacrimal gland development]
GO:0033674 [positive regulation of kinase activity]
GO:0033688 [regulation of osteoblast proliferation]
GO:0035265 [organ growth]
GO:0035602 [fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell]
GO:0035603 [fibroblast growth factor receptor signaling pathway involved in hemopoiesis]
GO:0035604 [fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow]
GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development]
GO:0042472 [inner ear morphogenesis]
GO:0042476 [odontogenesis]
GO:0042803 [protein homodimerization activity]
GO:0043235 [receptor complex]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045165 [cell fate commitment]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045787 [positive regulation of cell cycle]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046777 [protein autophosphorylation]
GO:0048286 [lung alveolus development]
GO:0048557 [embryonic digestive tract morphogenesis]
GO:0048562 [embryonic organ morphogenesis]
GO:0048565 [digestive tract development]
GO:0048568 [embryonic organ development]
GO:0048608 [reproductive structure development]
GO:0048701 [embryonic cranial skeleton morphogenesis]
GO:0048705 [skeletal system morphogenesis]
GO:0048730 [epidermis morphogenesis]
GO:0048755 [branching morphogenesis of a nerve]
GO:0048762 [mesenchymal cell differentiation]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051150 [regulation of smooth muscle cell differentiation]
GO:0051781 [positive regulation of cell division]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060076 [excitatory synapse]
GO:0060174 [limb bud formation]
GO:0060348 [bone development]
GO:0060349 [bone morphogenesis]
GO:0060442 [branching involved in prostate gland morphogenesis]
GO:0060445 [branching involved in salivary gland morphogenesis]
GO:0060449 [bud elongation involved in lung branching]
GO:0060463 [lung lobe morphogenesis]
GO:0060484 [lung-associated mesenchyme development]
GO:0060501 [positive regulation of epithelial cell proliferation involved in lung morphogenesis]
GO:0060512 [prostate gland morphogenesis]
GO:0060523 [prostate epithelial cord elongation]
GO:0060527 [prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis]
GO:0060529 [squamous basal epithelial stem cell differentiation involved in prostate gland acinus development]
GO:0060595 [fibroblast growth factor receptor signaling pathway involved in mammary gland specification]
GO:0060601 [lateral sprouting from an epithelium]
GO:0060615 [mammary gland bud formation]
GO:0060664 [epithelial cell proliferation involved in salivary gland morphogenesis]
GO:0060667 [branch elongation involved in salivary gland morphogenesis]
GO:0060670 [branching involved in labyrinthine layer morphogenesis]
GO:0060688 [regulation of morphogenesis of a branching structure]
GO:0060915 [mesenchymal cell differentiation involved in lung development]
GO:0060916 [mesenchymal cell proliferation involved in lung development]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 704 aa
79.2 kDa 		Yes 1
FGFR2-231
ENSP00000506848
ENST00000682772
A0A1W2PQT9
[Direct mapping] Fibroblast growth factor receptor 2
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Human disease related genes
   Cancers
   Cancers of the digestive system
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Other congenital malformations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0018108 [peptidyl-tyrosine phosphorylation]
Show all
 429 aa
48.7 kDa 		No 0
FGFR2-234
ENSP00000507074
ENST00000683035
A0A804HIH8
[Direct mapping] Fibroblast growth factor receptor 2
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
   DeepTMHMM predicted secreted proteins
   DeepSig predicted secreted proteins
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Human disease related genes
   Cancers
   Cancers of the digestive system
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Other congenital malformations
Protein evidence (Ezkurdia et al 2014)
Show all
 153 aa
16.7 kDa 		Yes 0
FGFR2-235
ENSP00000508257
ENST00000683211
P21802
[Direct mapping] Fibroblast growth factor receptor 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Human disease related genes
   Cancers
   Cancers of the digestive system
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Other congenital malformations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000166 [nucleotide binding]
GO:0001525 [angiogenesis]
GO:0001657 [ureteric bud development]
GO:0001701 [in utero embryonic development]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0003148 [outflow tract septum morphogenesis]
GO:0003149 [membranous septum morphogenesis]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007409 [axonogenesis]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008589 [regulation of smoothened signaling pathway]
GO:0009791 [post-embryonic development]
GO:0009880 [embryonic pattern specification]
GO:0009887 [animal organ morphogenesis]
GO:0009986 [cell surface]
GO:0010518 [positive regulation of phospholipase activity]
GO:0010839 [negative regulation of keratinocyte proliferation]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016331 [morphogenesis of embryonic epithelium]
GO:0016740 [transferase activity]
GO:0017134 [fibroblast growth factor binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0021769 [orbitofrontal cortex development]
GO:0021847 [ventricular zone neuroblast division]
GO:0021860 [pyramidal neuron development]
GO:0022612 [gland morphogenesis]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030282 [bone mineralization]
GO:0030324 [lung development]
GO:0030855 [epithelial cell differentiation]
GO:0030901 [midbrain development]
GO:0030916 [otic vesicle formation]
GO:0031069 [hair follicle morphogenesis]
GO:0031410 [cytoplasmic vesicle]
GO:0032808 [lacrimal gland development]
GO:0033674 [positive regulation of kinase activity]
GO:0033688 [regulation of osteoblast proliferation]
GO:0035265 [organ growth]
GO:0035602 [fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell]
GO:0035603 [fibroblast growth factor receptor signaling pathway involved in hemopoiesis]
GO:0035604 [fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow]
GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development]
GO:0042472 [inner ear morphogenesis]
GO:0042476 [odontogenesis]
GO:0042803 [protein homodimerization activity]
GO:0043235 [receptor complex]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045165 [cell fate commitment]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045787 [positive regulation of cell cycle]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046777 [protein autophosphorylation]
GO:0048286 [lung alveolus development]
GO:0048557 [embryonic digestive tract morphogenesis]
GO:0048562 [embryonic organ morphogenesis]
GO:0048565 [digestive tract development]
GO:0048568 [embryonic organ development]
GO:0048608 [reproductive structure development]
GO:0048701 [embryonic cranial skeleton morphogenesis]
GO:0048705 [skeletal system morphogenesis]
GO:0048730 [epidermis morphogenesis]
GO:0048755 [branching morphogenesis of a nerve]
GO:0048762 [mesenchymal cell differentiation]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051150 [regulation of smooth muscle cell differentiation]
GO:0051781 [positive regulation of cell division]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060076 [excitatory synapse]
GO:0060174 [limb bud formation]
GO:0060348 [bone development]
GO:0060349 [bone morphogenesis]
GO:0060442 [branching involved in prostate gland morphogenesis]
GO:0060445 [branching involved in salivary gland morphogenesis]
GO:0060449 [bud elongation involved in lung branching]
GO:0060463 [lung lobe morphogenesis]
GO:0060484 [lung-associated mesenchyme development]
GO:0060501 [positive regulation of epithelial cell proliferation involved in lung morphogenesis]
GO:0060512 [prostate gland morphogenesis]
GO:0060523 [prostate epithelial cord elongation]
GO:0060527 [prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis]
GO:0060529 [squamous basal epithelial stem cell differentiation involved in prostate gland acinus development]
GO:0060595 [fibroblast growth factor receptor signaling pathway involved in mammary gland specification]
GO:0060601 [lateral sprouting from an epithelium]
GO:0060615 [mammary gland bud formation]
GO:0060664 [epithelial cell proliferation involved in salivary gland morphogenesis]
GO:0060667 [branch elongation involved in salivary gland morphogenesis]
GO:0060670 [branching involved in labyrinthine layer morphogenesis]
GO:0060688 [regulation of morphogenesis of a branching structure]
GO:0060915 [mesenchymal cell differentiation involved in lung development]
GO:0060916 [mesenchymal cell proliferation involved in lung development]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 819 aa
91.8 kDa 		Yes 1
FGFR2-240
ENSP00000506937
ENST00000684153
A0A804HI76
[Direct mapping] Fibroblast growth factor receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Human disease related genes
   Cancers
   Cancers of the digestive system
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Other congenital malformations
Protein evidence (Ezkurdia et al 2014)
   DeepTMHMM predicted membrane proteins
Show all
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor receptor activity]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
Show all
 670 aa
75.6 kDa 		Yes 1

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