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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
q37.1
Chromosome location (bp)
230415942 - 230545606
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to 1. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to 2. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
DNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene; one of which encodes a high-mobility group protein. [provided by RefSeq, Aug 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors alpha-Helices exposed by beta-structures Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000723[telomere maintenance] GO:0000781[chromosome, telomeric region] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006978[DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0010596[negative regulation of endothelial cell migration] GO:0016604[nuclear body] GO:0016605[PML body] GO:0019900[kinase binding] GO:0019904[protein domain specific binding] GO:0030870[Mre11 complex] GO:0032897[negative regulation of viral transcription] GO:0034340[response to type I interferon] GO:0034341[response to type II interferon] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043392[negative regulation of DNA binding] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0045185[maintenance of protein location] GO:0045765[regulation of angiogenesis] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0046826[negative regulation of protein export from nucleus] GO:0046983[protein dimerization activity] GO:0060333[type II interferon-mediated signaling pathway] GO:0060337[type I interferon signaling pathway] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070087[chromo shadow domain binding] GO:1902041[regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1902044[regulation of Fas signaling pathway]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors alpha-Helices exposed by beta-structures Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000723[telomere maintenance] GO:0000781[chromosome, telomeric region] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006978[DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0010596[negative regulation of endothelial cell migration] GO:0016604[nuclear body] GO:0016605[PML body] GO:0019900[kinase binding] GO:0019904[protein domain specific binding] GO:0030870[Mre11 complex] GO:0032526[response to retinoic acid] GO:0032897[negative regulation of viral transcription] GO:0034097[response to cytokine] GO:0034340[response to type I interferon] GO:0034341[response to type II interferon] GO:0034399[nuclear periphery] GO:0042802[identical protein binding] GO:0043392[negative regulation of DNA binding] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0045185[maintenance of protein location] GO:0045765[regulation of angiogenesis] GO:0045893[positive regulation of DNA-templated transcription] GO:0046826[negative regulation of protein export from nucleus] GO:0046983[protein dimerization activity] GO:0048384[retinoic acid receptor signaling pathway] GO:0060333[type II interferon-mediated signaling pathway] GO:0060337[type I interferon signaling pathway] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070087[chromo shadow domain binding] GO:1902041[regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1902044[regulation of Fas signaling pathway]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors alpha-Helices exposed by beta-structures Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000723[telomere maintenance] GO:0000781[chromosome, telomeric region] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006978[DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0010596[negative regulation of endothelial cell migration] GO:0016604[nuclear body] GO:0016605[PML body] GO:0019900[kinase binding] GO:0019904[protein domain specific binding] GO:0030870[Mre11 complex] GO:0032897[negative regulation of viral transcription] GO:0034340[response to type I interferon] GO:0034341[response to type II interferon] GO:0042802[identical protein binding] GO:0043392[negative regulation of DNA binding] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0045185[maintenance of protein location] GO:0045765[regulation of angiogenesis] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0046826[negative regulation of protein export from nucleus] GO:0046983[protein dimerization activity] GO:0060333[type II interferon-mediated signaling pathway] GO:0060337[type I interferon signaling pathway] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070087[chromo shadow domain binding] GO:1902041[regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1902044[regulation of Fas signaling pathway]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors alpha-Helices exposed by beta-structures Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000723[telomere maintenance] GO:0000781[chromosome, telomeric region] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006978[DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0010596[negative regulation of endothelial cell migration] GO:0016604[nuclear body] GO:0016605[PML body] GO:0019900[kinase binding] GO:0019904[protein domain specific binding] GO:0030870[Mre11 complex] GO:0034340[response to type I interferon] GO:0034341[response to type II interferon] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043392[negative regulation of DNA binding] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0045185[maintenance of protein location] GO:0045765[regulation of angiogenesis] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046826[negative regulation of protein export from nucleus] GO:0046983[protein dimerization activity] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0060333[type II interferon-mediated signaling pathway] GO:0060337[type I interferon signaling pathway] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070087[chromo shadow domain binding] GO:1902041[regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1902044[regulation of Fas signaling pathway]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors alpha-Helices exposed by beta-structures Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000723[telomere maintenance] GO:0000781[chromosome, telomeric region] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006978[DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0010596[negative regulation of endothelial cell migration] GO:0016604[nuclear body] GO:0016605[PML body] GO:0019900[kinase binding] GO:0019904[protein domain specific binding] GO:0030870[Mre11 complex] GO:0034340[response to type I interferon] GO:0034341[response to type II interferon] GO:0042802[identical protein binding] GO:0043392[negative regulation of DNA binding] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0045185[maintenance of protein location] GO:0045765[regulation of angiogenesis] GO:0045893[positive regulation of DNA-templated transcription] GO:0046826[negative regulation of protein export from nucleus] GO:0046983[protein dimerization activity] GO:0060333[type II interferon-mediated signaling pathway] GO:0060337[type I interferon signaling pathway] GO:0070087[chromo shadow domain binding] GO:1902041[regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1902044[regulation of Fas signaling pathway]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors alpha-Helices exposed by beta-structures Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000723[telomere maintenance] GO:0000781[chromosome, telomeric region] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006978[DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0010596[negative regulation of endothelial cell migration] GO:0016604[nuclear body] GO:0016605[PML body] GO:0019900[kinase binding] GO:0019904[protein domain specific binding] GO:0030870[Mre11 complex] GO:0034340[response to type I interferon] GO:0034341[response to type II interferon] GO:0042802[identical protein binding] GO:0043392[negative regulation of DNA binding] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0045185[maintenance of protein location] GO:0045765[regulation of angiogenesis] GO:0045893[positive regulation of DNA-templated transcription] GO:0046826[negative regulation of protein export from nucleus] GO:0046983[protein dimerization activity] GO:0060333[type II interferon-mediated signaling pathway] GO:0060337[type I interferon signaling pathway] GO:0070087[chromo shadow domain binding] GO:1902041[regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1902044[regulation of Fas signaling pathway]
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