GENERAL INFORMATIONi
Gene namei RHOA
Synonyms ARH12, ARHA, Rho12, RHOH12
Gene descriptioni Ras homolog family member A
Protein classi Cancer-related genes
Disease related genes
Enzymes
Human disease related genes
Potential drug targets
RAS pathway related proteins
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 3
Cytoband p21.31
Chromosome location (bp) 49359139 - 49412998
Number of transcriptsi 8
Ensembl ENSG00000067560 (version 109)
Entrez gene 387
HGNC HGNC:667
UniProt P61586 (UniProt - Evidence at protein level)
neXtProt NX_P61586
GeneCards RHOA
Antibodypedia RHOA antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such as cytoskeletal dynamics, cell migration and cell cycle 1. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers 2, 3, 4. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis 5, 6. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion 7, 8. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly 9. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization 10. Regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation; promotes KCNA2 endocytosis 11, 12. Acts as an allosteric activator of guanine nucleotide exchange factor ECT2 by binding in its activated GTP-bound form to the PH domain of ECT2 which stimulates the release of PH inhibition and promotes the binding of substrate RHOA to the ECT2 catalytic center 13. May be an activator of PLCE1 14. In neurons, involved in the inhibition of the initial spine growth. Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity). show less
Molecular function (UniProt)i Hydrolase
Biological process (UniProt)i Cell cycle, Cell division, Host-virus interaction
Ligand (UniProt)i GTP-binding, Magnesium, Nucleotide-binding
Gene summary (Entrez)i This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
RHOA-202
ENSP00000400175
ENST00000418115
P61586
[Direct mapping] Transforming protein RhoA
Show all
A0A024R324
[Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein; Ras homolog gene family, member A, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Human disease related genes
   Congenital malformations
   Congenital malformations of skin
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000902 [cell morphogenesis]
GO:0001666 [response to hypoxia]
GO:0001764 [neuron migration]
GO:0001822 [kidney development]
GO:0001998 [angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure]
GO:0002363 [alpha-beta T cell lineage commitment]
GO:0003100 [regulation of systemic arterial blood pressure by endothelin]
GO:0003189 [aortic valve formation]
GO:0003924 [GTPase activity]
GO:0003925 [G protein activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007010 [cytoskeleton organization]
GO:0007015 [actin filament organization]
GO:0007049 [cell cycle]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0007519 [skeletal muscle tissue development]
GO:0008064 [regulation of actin polymerization or depolymerization]
GO:0008360 [regulation of cell shape]
GO:0009410 [response to xenobiotic stimulus]
GO:0009612 [response to mechanical stimulus]
GO:0009749 [response to glucose]
GO:0010812 [negative regulation of cell-substrate adhesion]
GO:0010975 [regulation of neuron projection development]
GO:0010977 [negative regulation of neuron projection development]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0016787 [hydrolase activity]
GO:0017022 [myosin binding]
GO:0019003 [GDP binding]
GO:0019901 [protein kinase binding]
GO:0019904 [protein domain specific binding]
GO:0021762 [substantia nigra development]
GO:0021795 [cerebral cortex cell migration]
GO:0021861 [forebrain radial glial cell differentiation]
GO:0030027 [lamellipodium]
GO:0030036 [actin cytoskeleton organization]
GO:0030054 [cell junction]
GO:0030154 [cell differentiation]
GO:0030307 [positive regulation of cell growth]
GO:0030334 [regulation of cell migration]
GO:0030335 [positive regulation of cell migration]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030496 [midbody]
GO:0030521 [androgen receptor signaling pathway]
GO:0030667 [secretory granule membrane]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0030865 [cortical cytoskeleton organization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0031122 [cytoplasmic microtubule organization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0031532 [actin cytoskeleton reorganization]
GO:0031982 [vesicle]
GO:0032154 [cleavage furrow]
GO:0032467 [positive regulation of cytokinesis]
GO:0032587 [ruffle membrane]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0033144 [negative regulation of intracellular steroid hormone receptor signaling pathway]
GO:0033688 [regulation of osteoblast proliferation]
GO:0034329 [cell junction assembly]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035385 [Roundabout signaling pathway]
GO:0036089 [cleavage furrow formation]
GO:0038027 [apolipoprotein A-I-mediated signaling pathway]
GO:0042476 [odontogenesis]
GO:0042995 [cell projection]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043149 [stress fiber assembly]
GO:0043197 [dendritic spine]
GO:0043200 [response to amino acid]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043296 [apical junction complex]
GO:0043297 [apical junction assembly]
GO:0043366 [beta selection]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043542 [endothelial cell migration]
GO:0043931 [ossification involved in bone maturation]
GO:0044319 [wound healing, spreading of cells]
GO:0045198 [establishment of epithelial cell apical/basal polarity]
GO:0045471 [response to ethanol]
GO:0045665 [negative regulation of neuron differentiation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045727 [positive regulation of translation]
GO:0045785 [positive regulation of cell adhesion]
GO:0045792 [negative regulation of cell size]
GO:0045907 [positive regulation of vasoconstriction]
GO:0045987 [positive regulation of smooth muscle contraction]
GO:0046039 [GTP metabolic process]
GO:0046638 [positive regulation of alpha-beta T cell differentiation]
GO:0048812 [neuron projection morphogenesis]
GO:0050773 [regulation of dendrite development]
GO:0050919 [negative chemotaxis]
GO:0051022 [Rho GDP-dissociation inhibitor binding]
GO:0051301 [cell division]
GO:0051384 [response to glucocorticoid]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0051893 [regulation of focal adhesion assembly]
GO:0051924 [regulation of calcium ion transport]
GO:0060071 [Wnt signaling pathway, planar cell polarity pathway]
GO:0060193 [positive regulation of lipase activity]
GO:0060548 [negative regulation of cell death]
GO:0061383 [trabecula morphogenesis]
GO:0070062 [extracellular exosome]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071345 [cellular response to cytokine stimulus]
GO:0071803 [positive regulation of podosome assembly]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0071944 [cell periphery]
GO:0090051 [negative regulation of cell migration involved in sprouting angiogenesis]
GO:0090307 [mitotic spindle assembly]
GO:0090324 [negative regulation of oxidative phosphorylation]
GO:0097049 [motor neuron apoptotic process]
GO:0097498 [endothelial tube lumen extension]
GO:0098794 [postsynapse]
GO:0098978 [glutamatergic synapse]
GO:0099159 [regulation of modification of postsynaptic structure]
GO:0101003 [ficolin-1-rich granule membrane]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
GO:1902766 [skeletal muscle satellite cell migration]
GO:1903427 [negative regulation of reactive oxygen species biosynthetic process]
GO:1903673 [mitotic cleavage furrow formation]
GO:1904695 [positive regulation of vascular associated smooth muscle contraction]
GO:1904706 [negative regulation of vascular associated smooth muscle cell proliferation]
GO:1904753 [negative regulation of vascular associated smooth muscle cell migration]
GO:1904996 [positive regulation of leukocyte adhesion to vascular endothelial cell]
GO:1905244 [regulation of modification of synaptic structure]
GO:1905274 [regulation of modification of postsynaptic actin cytoskeleton]
GO:1990869 [cellular response to chemokine]
GO:2000177 [regulation of neural precursor cell proliferation]
GO:2000406 [positive regulation of T cell migration]
GO:2000672 [negative regulation of motor neuron apoptotic process]
Show all
 193 aa
21.8 kDa 		No 0
RHOA-203
ENSP00000413587
ENST00000422781
C9JX21
[Direct mapping] Transforming protein RhoA
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Human disease related genes
   Congenital malformations
   Congenital malformations of skin
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0007264 [small GTPase mediated signal transduction]
Show all
 187 aa
21.2 kDa 		No 0
RHOA-205
ENSP00000408402
ENST00000445425
P61586
[Direct mapping] Transforming protein RhoA
Show all
C9JNR4
[Direct mapping] Transforming protein RhoA
A0A024R324
[Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein; Ras homolog gene family, member A, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Human disease related genes
   Congenital malformations
   Congenital malformations of skin
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003189 [aortic valve formation]
GO:0003924 [GTPase activity]
GO:0003925 [G protein activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007015 [actin filament organization]
GO:0007049 [cell cycle]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0008360 [regulation of cell shape]
GO:0010812 [negative regulation of cell-substrate adhesion]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0016787 [hydrolase activity]
GO:0017022 [myosin binding]
GO:0019901 [protein kinase binding]
GO:0021762 [substantia nigra development]
GO:0030027 [lamellipodium]
GO:0030036 [actin cytoskeleton organization]
GO:0030054 [cell junction]
GO:0030334 [regulation of cell migration]
GO:0030425 [dendrite]
GO:0030496 [midbody]
GO:0030667 [secretory granule membrane]
GO:0030865 [cortical cytoskeleton organization]
GO:0031122 [cytoplasmic microtubule organization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0031532 [actin cytoskeleton reorganization]
GO:0031982 [vesicle]
GO:0032154 [cleavage furrow]
GO:0032467 [positive regulation of cytokinesis]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0033688 [regulation of osteoblast proliferation]
GO:0034329 [cell junction assembly]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035385 [Roundabout signaling pathway]
GO:0036089 [cleavage furrow formation]
GO:0038027 [apolipoprotein A-I-mediated signaling pathway]
GO:0042995 [cell projection]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043149 [stress fiber assembly]
GO:0043197 [dendritic spine]
GO:0043296 [apical junction complex]
GO:0043297 [apical junction assembly]
GO:0043542 [endothelial cell migration]
GO:0043931 [ossification involved in bone maturation]
GO:0044319 [wound healing, spreading of cells]
GO:0045198 [establishment of epithelial cell apical/basal polarity]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045792 [negative regulation of cell size]
GO:0050919 [negative chemotaxis]
GO:0051301 [cell division]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0051893 [regulation of focal adhesion assembly]
GO:0060071 [Wnt signaling pathway, planar cell polarity pathway]
GO:0060193 [positive regulation of lipase activity]
GO:0061383 [trabecula morphogenesis]
GO:0070062 [extracellular exosome]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071345 [cellular response to cytokine stimulus]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0071944 [cell periphery]
GO:0090051 [negative regulation of cell migration involved in sprouting angiogenesis]
GO:0090307 [mitotic spindle assembly]
GO:0097498 [endothelial tube lumen extension]
GO:0098794 [postsynapse]
GO:0098978 [glutamatergic synapse]
GO:0099159 [regulation of modification of postsynaptic structure]
GO:0101003 [ficolin-1-rich granule membrane]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
GO:1902766 [skeletal muscle satellite cell migration]
GO:1903673 [mitotic cleavage furrow formation]
GO:1904996 [positive regulation of leukocyte adhesion to vascular endothelial cell]
GO:1905274 [regulation of modification of postsynaptic actin cytoskeleton]
GO:1990869 [cellular response to chemokine]
GO:2000406 [positive regulation of T cell migration]
Show all
 193 aa
21.8 kDa 		No 0
RHOA-206
ENSP00000394483
ENST00000454011
C9JRM1
[Direct mapping] Transforming protein RhoA
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Human disease related genes
   Congenital malformations
   Congenital malformations of skin
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0007264 [small GTPase mediated signal transduction]
Show all
 90 aa
9.7 kDa 		No 0
RHOA-207
ENSP00000504603
ENST00000676712
A0A7I2YQV1
[Direct mapping] Transforming protein RhoA
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Human disease related genes
   Congenital malformations
   Congenital malformations of skin
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0007264 [small GTPase mediated signal transduction]
Show all
 109 aa
12 kDa 		No 0
RHOA-209
ENSP00000504180
ENST00000678200
P61586
[Direct mapping] Transforming protein RhoA
Show all
A0A024R324
[Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein; Ras homolog gene family, member A, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Human disease related genes
   Congenital malformations
   Congenital malformations of skin
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003189 [aortic valve formation]
GO:0003924 [GTPase activity]
GO:0003925 [G protein activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007015 [actin filament organization]
GO:0007049 [cell cycle]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0008360 [regulation of cell shape]
GO:0010812 [negative regulation of cell-substrate adhesion]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0016787 [hydrolase activity]
GO:0017022 [myosin binding]
GO:0019901 [protein kinase binding]
GO:0021762 [substantia nigra development]
GO:0030027 [lamellipodium]
GO:0030036 [actin cytoskeleton organization]
GO:0030054 [cell junction]
GO:0030334 [regulation of cell migration]
GO:0030425 [dendrite]
GO:0030496 [midbody]
GO:0030667 [secretory granule membrane]
GO:0030865 [cortical cytoskeleton organization]
GO:0031122 [cytoplasmic microtubule organization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0031532 [actin cytoskeleton reorganization]
GO:0031982 [vesicle]
GO:0032154 [cleavage furrow]
GO:0032467 [positive regulation of cytokinesis]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0033688 [regulation of osteoblast proliferation]
GO:0034329 [cell junction assembly]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035385 [Roundabout signaling pathway]
GO:0036089 [cleavage furrow formation]
GO:0038027 [apolipoprotein A-I-mediated signaling pathway]
GO:0042995 [cell projection]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043149 [stress fiber assembly]
GO:0043197 [dendritic spine]
GO:0043296 [apical junction complex]
GO:0043297 [apical junction assembly]
GO:0043542 [endothelial cell migration]
GO:0043931 [ossification involved in bone maturation]
GO:0044319 [wound healing, spreading of cells]
GO:0045198 [establishment of epithelial cell apical/basal polarity]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045792 [negative regulation of cell size]
GO:0050919 [negative chemotaxis]
GO:0051301 [cell division]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0051893 [regulation of focal adhesion assembly]
GO:0060071 [Wnt signaling pathway, planar cell polarity pathway]
GO:0060193 [positive regulation of lipase activity]
GO:0061383 [trabecula morphogenesis]
GO:0070062 [extracellular exosome]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071345 [cellular response to cytokine stimulus]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0071944 [cell periphery]
GO:0090051 [negative regulation of cell migration involved in sprouting angiogenesis]
GO:0090307 [mitotic spindle assembly]
GO:0097498 [endothelial tube lumen extension]
GO:0098794 [postsynapse]
GO:0098978 [glutamatergic synapse]
GO:0099159 [regulation of modification of postsynaptic structure]
GO:0101003 [ficolin-1-rich granule membrane]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
GO:1902766 [skeletal muscle satellite cell migration]
GO:1903673 [mitotic cleavage furrow formation]
GO:1904996 [positive regulation of leukocyte adhesion to vascular endothelial cell]
GO:1905274 [regulation of modification of postsynaptic actin cytoskeleton]
GO:1990869 [cellular response to chemokine]
GO:2000406 [positive regulation of T cell migration]
Show all
 193 aa
21.8 kDa 		No 0
RHOA-210
ENSP00000503490
ENST00000678921
A0A7I2V3G1
[Direct mapping] Transforming protein RhoA
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Human disease related genes
   Congenital malformations
   Congenital malformations of skin
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0007264 [small GTPase mediated signal transduction]
Show all
 137 aa
15.6 kDa 		No 0
RHOA-211
ENSP00000503282
ENST00000679208
P61586
[Direct mapping] Transforming protein RhoA
Show all
A0A024R324
[Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein; Ras homolog gene family, member A, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Human disease related genes
   Congenital malformations
   Congenital malformations of skin
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003189 [aortic valve formation]
GO:0003924 [GTPase activity]
GO:0003925 [G protein activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007015 [actin filament organization]
GO:0007049 [cell cycle]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0008360 [regulation of cell shape]
GO:0010812 [negative regulation of cell-substrate adhesion]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0016787 [hydrolase activity]
GO:0017022 [myosin binding]
GO:0019901 [protein kinase binding]
GO:0021762 [substantia nigra development]
GO:0030027 [lamellipodium]
GO:0030036 [actin cytoskeleton organization]
GO:0030054 [cell junction]
GO:0030334 [regulation of cell migration]
GO:0030425 [dendrite]
GO:0030496 [midbody]
GO:0030667 [secretory granule membrane]
GO:0030865 [cortical cytoskeleton organization]
GO:0031122 [cytoplasmic microtubule organization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0031532 [actin cytoskeleton reorganization]
GO:0031982 [vesicle]
GO:0032154 [cleavage furrow]
GO:0032467 [positive regulation of cytokinesis]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0033688 [regulation of osteoblast proliferation]
GO:0034329 [cell junction assembly]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035385 [Roundabout signaling pathway]
GO:0036089 [cleavage furrow formation]
GO:0038027 [apolipoprotein A-I-mediated signaling pathway]
GO:0042995 [cell projection]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043149 [stress fiber assembly]
GO:0043197 [dendritic spine]
GO:0043296 [apical junction complex]
GO:0043297 [apical junction assembly]
GO:0043542 [endothelial cell migration]
GO:0043931 [ossification involved in bone maturation]
GO:0044319 [wound healing, spreading of cells]
GO:0045198 [establishment of epithelial cell apical/basal polarity]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045792 [negative regulation of cell size]
GO:0050919 [negative chemotaxis]
GO:0051301 [cell division]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0051893 [regulation of focal adhesion assembly]
GO:0060071 [Wnt signaling pathway, planar cell polarity pathway]
GO:0060193 [positive regulation of lipase activity]
GO:0061383 [trabecula morphogenesis]
GO:0070062 [extracellular exosome]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071345 [cellular response to cytokine stimulus]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0071944 [cell periphery]
GO:0090051 [negative regulation of cell migration involved in sprouting angiogenesis]
GO:0090307 [mitotic spindle assembly]
GO:0097498 [endothelial tube lumen extension]
GO:0098794 [postsynapse]
GO:0098978 [glutamatergic synapse]
GO:0099159 [regulation of modification of postsynaptic structure]
GO:0101003 [ficolin-1-rich granule membrane]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
GO:1902766 [skeletal muscle satellite cell migration]
GO:1903673 [mitotic cleavage furrow formation]
GO:1904996 [positive regulation of leukocyte adhesion to vascular endothelial cell]
GO:1905274 [regulation of modification of postsynaptic actin cytoskeleton]
GO:1990869 [cellular response to chemokine]
GO:2000406 [positive regulation of T cell migration]
Show all
 193 aa
21.8 kDa 		No 0

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