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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Rho associated coiled-coil containing protein kinase 1
Protein classi
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes FDA approved drug targets Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
18
Cytoband
q11.1
Chromosome location (bp)
20946906 - 21111813
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity 1,2,3,4,5,6,7,8,9. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A 10,11,12,13,14,15,16,17,18,19,20. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing 21. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress 22. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation 23. Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation 24. Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Promotes keratinocyte terminal differentiation 25. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q13464 [Direct mapping] Rho-associated protein kinase 1
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Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000139[Golgi membrane] GO:0000166[nucleotide binding] GO:0000281[mitotic cytokinesis] GO:0001726[ruffle] GO:0001837[epithelial to mesenchymal transition] GO:0003180[aortic valve morphogenesis] GO:0003383[apical constriction] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005576[extracellular region] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005814[centriole] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0006468[protein phosphorylation] GO:0006915[apoptotic process] GO:0006939[smooth muscle contraction] GO:0006996[organelle organization] GO:0007159[leukocyte cell-cell adhesion] GO:0007165[signal transduction] GO:0007249[I-kappaB kinase/NF-kappaB signaling] GO:0007266[Rho protein signal transduction] GO:0010494[cytoplasmic stress granule] GO:0010506[regulation of autophagy] GO:0010508[positive regulation of autophagy] GO:0010613[positive regulation of cardiac muscle hypertrophy] GO:0010628[positive regulation of gene expression] GO:0010922[positive regulation of phosphatase activity] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016525[negative regulation of angiogenesis] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0019828[aspartic-type endopeptidase inhibitor activity] GO:0022614[membrane to membrane docking] GO:0030027[lamellipodium] GO:0030036[actin cytoskeleton organization] GO:0030155[regulation of cell adhesion] GO:0030334[regulation of cell migration] GO:0030866[cortical actin cytoskeleton organization] GO:0031032[actomyosin structure organization] GO:0031175[neuron projection development] GO:0031267[small GTPase binding] GO:0032059[bleb] GO:0032060[bleb assembly] GO:0032091[negative regulation of protein binding] GO:0032956[regulation of actin cytoskeleton organization] GO:0032970[regulation of actin filament-based process] GO:0034774[secretory granule lumen] GO:0035306[positive regulation of dephosphorylation] GO:0035509[negative regulation of myosin-light-chain-phosphatase activity] GO:0042326[negative regulation of phosphorylation] GO:0042995[cell projection] GO:0043410[positive regulation of MAPK cascade] GO:0045616[regulation of keratinocyte differentiation] GO:0045664[regulation of neuron differentiation] GO:0046872[metal ion binding] GO:0048156[tau protein binding] GO:0048598[embryonic morphogenesis] GO:0050321[tau-protein kinase activity] GO:0050900[leukocyte migration] GO:0050901[leukocyte tethering or rolling] GO:0051045[negative regulation of membrane protein ectodomain proteolysis] GO:0051451[myoblast migration] GO:0051492[regulation of stress fiber assembly] GO:0051893[regulation of focal adhesion assembly] GO:0051894[positive regulation of focal adhesion assembly] GO:0061157[mRNA destabilization] GO:0070168[negative regulation of biomineral tissue development] GO:0070507[regulation of microtubule cytoskeleton organization] GO:0071559[response to transforming growth factor beta] GO:0072518[Rho-dependent protein serine/threonine kinase activity] GO:0072659[protein localization to plasma membrane] GO:0090128[regulation of synapse maturation] GO:0090521[podocyte cell migration] GO:0097049[motor neuron apoptotic process] GO:0097746[blood vessel diameter maintenance] GO:0098685[Schaffer collateral - CA1 synapse] GO:0106003[amyloid-beta complex] GO:0106310[protein serine kinase activity] GO:0110061[regulation of angiotensin-activated signaling pathway] GO:0140058[neuron projection arborization] GO:1900223[positive regulation of amyloid-beta clearance] GO:1900242[regulation of synaptic vesicle endocytosis] GO:1901888[regulation of cell junction assembly] GO:1902003[regulation of amyloid-beta formation] GO:1902430[negative regulation of amyloid-beta formation] GO:1902992[negative regulation of amyloid precursor protein catabolic process] GO:1903140[regulation of establishment of endothelial barrier] GO:1903347[negative regulation of bicellular tight junction assembly] GO:1905205[positive regulation of connective tissue replacement] GO:1990776[response to angiotensin] GO:2000114[regulation of establishment of cell polarity] GO:2000145[regulation of cell motility] GO:2000672[negative regulation of motor neuron apoptotic process]
The Human Protein Atlas project is funded
