We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Enzymes Metabolic proteins Potential drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
X
Cytoband
p11.23
Chromosome location (bp)
48922024 - 48958386
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Deubiquitinating enzyme that functions as a negative regulator of the innate immune system 1,2,3,4. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains 5. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro) 6. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production 7. Controls neuroectodermal differentiation through cleaving 'Lys-48'-linked ubiquitin chains to counteract degradation of select chromatin regulators such as ARID1A, HDAC2 and HCF1 8. Acts as a positive regulator of mTORC1 and mTORC2 signaling following phosphorylation by MTOR: acts by mediating deubiquitination of BTRC, leading to its stability 9....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Hydrolase, Protease, Thiol protease
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Ubl conjugation pathway
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Metabolic proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004843[cysteine-type deubiquitinase activity] GO:0005634[nucleus] GO:0005829[cytosol] GO:0006508[proteolysis] GO:0008233[peptidase activity] GO:0008234[cysteine-type peptidase activity] GO:0014033[neural crest cell differentiation] GO:0016579[protein deubiquitination] GO:0016787[hydrolase activity] GO:0032480[negative regulation of type I interferon production] GO:0032496[response to lipopolysaccharide] GO:0061578[Lys63-specific deubiquitinase activity] GO:0070536[protein K63-linked deubiquitination] GO:0071108[protein K48-linked deubiquitination] GO:0090090[negative regulation of canonical Wnt signaling pathway] GO:0101005[deubiquitinase activity] GO:1904263[positive regulation of TORC1 signaling] GO:1904515[positive regulation of TORC2 signaling] GO:1990380[Lys48-specific deubiquitinase activity]
Q96G74 [Direct mapping] OTU domain-containing protein 5
Show all
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Metabolic proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004843[cysteine-type deubiquitinase activity] GO:0005634[nucleus] GO:0005829[cytosol] GO:0006508[proteolysis] GO:0008233[peptidase activity] GO:0008234[cysteine-type peptidase activity] GO:0014033[neural crest cell differentiation] GO:0016579[protein deubiquitination] GO:0016787[hydrolase activity] GO:0032480[negative regulation of type I interferon production] GO:0032496[response to lipopolysaccharide] GO:0061578[Lys63-specific deubiquitinase activity] GO:0070536[protein K63-linked deubiquitination] GO:0071108[protein K48-linked deubiquitination] GO:0090090[negative regulation of canonical Wnt signaling pathway] GO:0101005[deubiquitinase activity] GO:1904263[positive regulation of TORC1 signaling] GO:1904515[positive regulation of TORC2 signaling] GO:1990380[Lys48-specific deubiquitinase activity]
Q96G74 [Direct mapping] OTU domain-containing protein 5
Show all
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Metabolic proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004843[cysteine-type deubiquitinase activity] GO:0005634[nucleus] GO:0005829[cytosol] GO:0006508[proteolysis] GO:0008233[peptidase activity] GO:0008234[cysteine-type peptidase activity] GO:0014033[neural crest cell differentiation] GO:0016579[protein deubiquitination] GO:0016787[hydrolase activity] GO:0032480[negative regulation of type I interferon production] GO:0032496[response to lipopolysaccharide] GO:0061578[Lys63-specific deubiquitinase activity] GO:0070536[protein K63-linked deubiquitination] GO:0071108[protein K48-linked deubiquitination] GO:0090090[negative regulation of canonical Wnt signaling pathway] GO:0101005[deubiquitinase activity] GO:1904263[positive regulation of TORC1 signaling] GO:1904515[positive regulation of TORC2 signaling] GO:1990380[Lys48-specific deubiquitinase activity]
Q96G74 [Direct mapping] OTU domain-containing protein 5
Show all
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004843[cysteine-type deubiquitinase activity] GO:0005634[nucleus] GO:0005829[cytosol] GO:0006508[proteolysis] GO:0008233[peptidase activity] GO:0008234[cysteine-type peptidase activity] GO:0014033[neural crest cell differentiation] GO:0016579[protein deubiquitination] GO:0016787[hydrolase activity] GO:0032480[negative regulation of type I interferon production] GO:0032496[response to lipopolysaccharide] GO:0061578[Lys63-specific deubiquitinase activity] GO:0070536[protein K63-linked deubiquitination] GO:0071108[protein K48-linked deubiquitination] GO:0090090[negative regulation of canonical Wnt signaling pathway] GO:0101005[deubiquitinase activity] GO:1904263[positive regulation of TORC1 signaling] GO:1904515[positive regulation of TORC2 signaling] GO:1990380[Lys48-specific deubiquitinase activity]
The Human Protein Atlas project is funded
