GENERAL INFORMATIONi
Gene namei NEDD4
Synonyms KIAA0093, MGC176705, NEDD4-1, RPF1
Gene descriptioni NEDD4 E3 ubiquitin protein ligase
Protein classi Enzymes
Metabolic proteins
Transporters
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 15
Cytoband q21.3
Chromosome location (bp) 55826922 - 55993660
Number of transcriptsi 5
Ensembl ENSG00000069869 (version 109)
Entrez gene 4734
HGNC HGNC:7727
UniProt P46934 (UniProt - Evidence at protein level)
neXtProt NX_P46934
GeneCards NEDD4
Antibodypedia NEDD4 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins 1, 2, 3. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes (By similarity). Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes 4. Promotes ubiquitination of RAPGEF2 5. According to 6 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in 7 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD (By similarity). Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development (By similarity). Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2 8. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 9. Ubiquitinates DAZAP2, leading to its proteasomal degradation 10. Ubiquitinates POLR2A 11. Functions as a platform to recruit USP13 to form an NEDD4-USP13 deubiquitination complex that plays a critical role in cleaving the 'Lys-48'-linked ubiquitin chains of VPS34 and then stabilizing VPS34, thus promoting the formation of autophagosomes 12. show less
Molecular function (UniProt)i Transferase
Biological process (UniProt)i Host-virus interaction, Neurogenesis, Ubl conjugation pathway
Gene summary (Entrez)i This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN. [provided by RefSeq, Jul 2016] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
NEDD4-201
ENSP00000345530
ENST00000338963
P46934
[Direct mapping] E3 ubiquitin-protein ligase NEDD4
Show all
Enzymes
   ENZYME proteins
   Transferases
Metabolic proteins
Transporters
   Accessory Factors Involved in Transport
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000209 [protein polyubiquitination]
GO:0000785 [chromatin]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006622 [protein targeting to lysosome]
GO:0007041 [lysosomal transport]
GO:0007399 [nervous system development]
GO:0007528 [neuromuscular junction development]
GO:0010766 [negative regulation of sodium ion transport]
GO:0010768 [negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016241 [regulation of macroautophagy]
GO:0016327 [apicolateral plasma membrane]
GO:0016567 [protein ubiquitination]
GO:0016740 [transferase activity]
GO:0019871 [sodium channel inhibitor activity]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0030948 [negative regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0031175 [neuron projection development]
GO:0031623 [receptor internalization]
GO:0031698 [beta-2 adrenergic receptor binding]
GO:0032801 [receptor catabolic process]
GO:0032991 [protein-containing complex]
GO:0034644 [cellular response to UV]
GO:0034765 [regulation of ion transmembrane transport]
GO:0042391 [regulation of membrane potential]
GO:0042921 [glucocorticoid receptor signaling pathway]
GO:0043130 [ubiquitin binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043162 [ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway]
GO:0043197 [dendritic spine]
GO:0044111 [formation of structure involved in a symbiotic process]
GO:0045732 [positive regulation of protein catabolic process]
GO:0046755 [viral budding]
GO:0046824 [positive regulation of nucleocytoplasmic transport]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048814 [regulation of dendrite morphogenesis]
GO:0050807 [regulation of synapse organization]
GO:0050815 [phosphoserine residue binding]
GO:0050816 [phosphothreonine residue binding]
GO:0050847 [progesterone receptor signaling pathway]
GO:0051592 [response to calcium ion]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070062 [extracellular exosome]
GO:0070063 [RNA polymerase binding]
GO:0070064 [proline-rich region binding]
GO:0070534 [protein K63-linked ubiquitination]
GO:1901016 [regulation of potassium ion transmembrane transporter activity]
GO:2000650 [negative regulation of sodium ion transmembrane transporter activity]
Show all
 1247 aa
140.7 kDa 		No 0
NEDD4-202
ENSP00000410613
ENST00000435532
P46934
[Direct mapping] E3 ubiquitin-protein ligase NEDD4
Show all
Enzymes
   ENZYME proteins
   Transferases
Metabolic proteins
Transporters
   Accessory Factors Involved in Transport
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000209 [protein polyubiquitination]
GO:0000785 [chromatin]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006622 [protein targeting to lysosome]
GO:0007041 [lysosomal transport]
GO:0007399 [nervous system development]
GO:0007528 [neuromuscular junction development]
GO:0010766 [negative regulation of sodium ion transport]
GO:0010768 [negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016241 [regulation of macroautophagy]
GO:0016327 [apicolateral plasma membrane]
GO:0016567 [protein ubiquitination]
GO:0016740 [transferase activity]
GO:0019871 [sodium channel inhibitor activity]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0030948 [negative regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0031175 [neuron projection development]
GO:0031623 [receptor internalization]
GO:0031698 [beta-2 adrenergic receptor binding]
GO:0032801 [receptor catabolic process]
GO:0032991 [protein-containing complex]
GO:0034644 [cellular response to UV]
GO:0034765 [regulation of ion transmembrane transport]
GO:0042391 [regulation of membrane potential]
GO:0042921 [glucocorticoid receptor signaling pathway]
GO:0043130 [ubiquitin binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043162 [ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway]
GO:0043197 [dendritic spine]
GO:0044111 [formation of structure involved in a symbiotic process]
GO:0045732 [positive regulation of protein catabolic process]
GO:0046755 [viral budding]
GO:0046824 [positive regulation of nucleocytoplasmic transport]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048814 [regulation of dendrite morphogenesis]
GO:0050807 [regulation of synapse organization]
GO:0050815 [phosphoserine residue binding]
GO:0050816 [phosphothreonine residue binding]
GO:0050847 [progesterone receptor signaling pathway]
GO:0051592 [response to calcium ion]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070062 [extracellular exosome]
GO:0070063 [RNA polymerase binding]
GO:0070064 [proline-rich region binding]
GO:0070534 [protein K63-linked ubiquitination]
GO:1901016 [regulation of potassium ion transmembrane transporter activity]
GO:2000650 [negative regulation of sodium ion transmembrane transporter activity]
Show all
 900 aa
104.2 kDa 		No 0
NEDD4-205
ENSP00000422705
ENST00000506154
P46934
[Direct mapping] E3 ubiquitin-protein ligase NEDD4
Show all
Enzymes
   ENZYME proteins
   Transferases
Metabolic proteins
Transporters
   Accessory Factors Involved in Transport
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000209 [protein polyubiquitination]
GO:0000785 [chromatin]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006622 [protein targeting to lysosome]
GO:0007041 [lysosomal transport]
GO:0007399 [nervous system development]
GO:0007528 [neuromuscular junction development]
GO:0010766 [negative regulation of sodium ion transport]
GO:0010768 [negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016241 [regulation of macroautophagy]
GO:0016327 [apicolateral plasma membrane]
GO:0016567 [protein ubiquitination]
GO:0016740 [transferase activity]
GO:0019871 [sodium channel inhibitor activity]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0030948 [negative regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0031175 [neuron projection development]
GO:0031623 [receptor internalization]
GO:0031698 [beta-2 adrenergic receptor binding]
GO:0032801 [receptor catabolic process]
GO:0032991 [protein-containing complex]
GO:0034644 [cellular response to UV]
GO:0034765 [regulation of ion transmembrane transport]
GO:0042391 [regulation of membrane potential]
GO:0042921 [glucocorticoid receptor signaling pathway]
GO:0043130 [ubiquitin binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043162 [ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway]
GO:0043197 [dendritic spine]
GO:0044111 [formation of structure involved in a symbiotic process]
GO:0045732 [positive regulation of protein catabolic process]
GO:0046755 [viral budding]
GO:0046824 [positive regulation of nucleocytoplasmic transport]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048814 [regulation of dendrite morphogenesis]
GO:0050807 [regulation of synapse organization]
GO:0050815 [phosphoserine residue binding]
GO:0050816 [phosphothreonine residue binding]
GO:0050847 [progesterone receptor signaling pathway]
GO:0051592 [response to calcium ion]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070062 [extracellular exosome]
GO:0070063 [RNA polymerase binding]
GO:0070064 [proline-rich region binding]
GO:0070534 [protein K63-linked ubiquitination]
GO:1901016 [regulation of potassium ion transmembrane transporter activity]
GO:2000650 [negative regulation of sodium ion transmembrane transporter activity]
Show all
 1303 aa
147.4 kDa 		No 0
NEDD4-208
ENSP00000424827
ENST00000508342
P46934
[Direct mapping] E3 ubiquitin-protein ligase NEDD4
Show all
Enzymes
   ENZYME proteins
   Transferases
Metabolic proteins
Transporters
   Accessory Factors Involved in Transport
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000209 [protein polyubiquitination]
GO:0000785 [chromatin]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006622 [protein targeting to lysosome]
GO:0007041 [lysosomal transport]
GO:0007399 [nervous system development]
GO:0007528 [neuromuscular junction development]
GO:0010766 [negative regulation of sodium ion transport]
GO:0010768 [negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016241 [regulation of macroautophagy]
GO:0016327 [apicolateral plasma membrane]
GO:0016567 [protein ubiquitination]
GO:0016740 [transferase activity]
GO:0019871 [sodium channel inhibitor activity]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0030948 [negative regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0031175 [neuron projection development]
GO:0031623 [receptor internalization]
GO:0031698 [beta-2 adrenergic receptor binding]
GO:0032801 [receptor catabolic process]
GO:0032991 [protein-containing complex]
GO:0034644 [cellular response to UV]
GO:0034765 [regulation of ion transmembrane transport]
GO:0042391 [regulation of membrane potential]
GO:0042921 [glucocorticoid receptor signaling pathway]
GO:0043130 [ubiquitin binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043162 [ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway]
GO:0043197 [dendritic spine]
GO:0044111 [formation of structure involved in a symbiotic process]
GO:0045732 [positive regulation of protein catabolic process]
GO:0046755 [viral budding]
GO:0046824 [positive regulation of nucleocytoplasmic transport]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048814 [regulation of dendrite morphogenesis]
GO:0050807 [regulation of synapse organization]
GO:0050815 [phosphoserine residue binding]
GO:0050816 [phosphothreonine residue binding]
GO:0050847 [progesterone receptor signaling pathway]
GO:0051592 [response to calcium ion]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070062 [extracellular exosome]
GO:0070063 [RNA polymerase binding]
GO:0070064 [proline-rich region binding]
GO:0070534 [protein K63-linked ubiquitination]
GO:1901016 [regulation of potassium ion transmembrane transporter activity]
GO:2000650 [negative regulation of sodium ion transmembrane transporter activity]
Show all
 1319 aa
149.1 kDa 		No 0
NEDD4-209
ENSP00000422455
ENST00000508871
H0Y8X6
[Direct mapping] HECT-type E3 ubiquitin transferase
Show all
Metabolic proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0016567 [protein ubiquitination]
Show all
 910 aa
104.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.


contact@proteinatlas.org