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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
9
Cytoband
q31.3
Chromosome location (bp)
109375466 - 109498313
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Hydrolase, Protein phosphatase
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P26045 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 3
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Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000165[MAPK cascade] GO:0001784[phosphotyrosine residue binding] GO:0004721[phosphoprotein phosphatase activity] GO:0004725[protein tyrosine phosphatase activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0006470[protein dephosphorylation] GO:0008092[cytoskeletal protein binding] GO:0009898[cytoplasmic side of plasma membrane] GO:0016020[membrane] GO:0016311[dephosphorylation] GO:0016787[hydrolase activity] GO:0016791[phosphatase activity] GO:0017080[sodium channel regulator activity] GO:0042059[negative regulation of epidermal growth factor receptor signaling pathway] GO:0045930[negative regulation of mitotic cell cycle] GO:0051045[negative regulation of membrane protein ectodomain proteolysis] GO:0051117[ATPase binding] GO:0097421[liver regeneration] GO:0098902[regulation of membrane depolarization during action potential] GO:2000649[regulation of sodium ion transmembrane transporter activity]
P26045 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 3
Show all
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165[MAPK cascade] GO:0001784[phosphotyrosine residue binding] GO:0004721[phosphoprotein phosphatase activity] GO:0004725[protein tyrosine phosphatase activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0006470[protein dephosphorylation] GO:0008092[cytoskeletal protein binding] GO:0009898[cytoplasmic side of plasma membrane] GO:0016020[membrane] GO:0016311[dephosphorylation] GO:0016787[hydrolase activity] GO:0016791[phosphatase activity] GO:0017080[sodium channel regulator activity] GO:0042059[negative regulation of epidermal growth factor receptor signaling pathway] GO:0045930[negative regulation of mitotic cell cycle] GO:0051045[negative regulation of membrane protein ectodomain proteolysis] GO:0051117[ATPase binding] GO:0098902[regulation of membrane depolarization during action potential] GO:2000649[regulation of sodium ion transmembrane transporter activity]
P26045 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 3
Show all
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165[MAPK cascade] GO:0001784[phosphotyrosine residue binding] GO:0004721[phosphoprotein phosphatase activity] GO:0004725[protein tyrosine phosphatase activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0006470[protein dephosphorylation] GO:0008092[cytoskeletal protein binding] GO:0009898[cytoplasmic side of plasma membrane] GO:0016020[membrane] GO:0016311[dephosphorylation] GO:0016787[hydrolase activity] GO:0016791[phosphatase activity] GO:0017080[sodium channel regulator activity] GO:0042059[negative regulation of epidermal growth factor receptor signaling pathway] GO:0045930[negative regulation of mitotic cell cycle] GO:0051045[negative regulation of membrane protein ectodomain proteolysis] GO:0051117[ATPase binding] GO:0098902[regulation of membrane depolarization during action potential] GO:2000649[regulation of sodium ion transmembrane transporter activity]
The Human Protein Atlas project is funded
