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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Calcium/calmodulin dependent protein kinase II alpha
Protein classi
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Enzymes Human disease related genes Plasma proteins Potential drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
5
Cytoband
q32
Chromosome location (bp)
150219491 - 150290093
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation 1. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development 2. Also regulates the migration of developing neurons 3. Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity 4. Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway 5. In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway 6. Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2018]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q9UQM7 [Direct mapping] Calcium/calmodulin-dependent protein kinase type II subunit alpha
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Q7LDD5 [Target identity:100%; Query identity:100%] Calcium/calmodulin-dependent protein kinase
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Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Human disease related genes Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000082[G1/S transition of mitotic cell cycle] GO:0000166[nucleotide binding] GO:0002931[response to ischemia] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004683[calmodulin-dependent protein kinase activity] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0005954[calcium- and calmodulin-dependent protein kinase complex] GO:0006468[protein phosphorylation] GO:0006816[calcium ion transport] GO:0010666[positive regulation of cardiac muscle cell apoptotic process] GO:0014069[postsynaptic density] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0030425[dendrite] GO:0030666[endocytic vesicle membrane] GO:0035254[glutamate receptor binding] GO:0035458[cellular response to interferon-beta] GO:0038166[angiotensin-activated signaling pathway] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042995[cell projection] GO:0043005[neuron projection] GO:0043197[dendritic spine] GO:0045202[synapse] GO:0046427[positive regulation of receptor signaling pathway via JAK-STAT] GO:0046777[protein autophosphorylation] GO:0046872[metal ion binding] GO:0046928[regulation of neurotransmitter secretion] GO:0048168[regulation of neuronal synaptic plasticity] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051346[negative regulation of hydrolase activity] GO:0051928[positive regulation of calcium ion transport] GO:0060996[dendritic spine development] GO:0106310[protein serine kinase activity] GO:0110165[cellular anatomical entity] GO:1902108[regulation of mitochondrial membrane permeability involved in apoptotic process] GO:1990443[peptidyl-threonine autophosphorylation] GO:2000124[regulation of endocannabinoid signaling pathway] GO:2001222[regulation of neuron migration]
Q9UQM7 [Direct mapping] Calcium/calmodulin-dependent protein kinase type II subunit alpha
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A8K161 [Target identity:100%; Query identity:100%] Calcium/calmodulin-dependent protein kinase
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Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Human disease related genes Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000082[G1/S transition of mitotic cell cycle] GO:0000166[nucleotide binding] GO:0002931[response to ischemia] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004683[calmodulin-dependent protein kinase activity] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0005954[calcium- and calmodulin-dependent protein kinase complex] GO:0006468[protein phosphorylation] GO:0006816[calcium ion transport] GO:0010666[positive regulation of cardiac muscle cell apoptotic process] GO:0014069[postsynaptic density] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0030425[dendrite] GO:0030666[endocytic vesicle membrane] GO:0035254[glutamate receptor binding] GO:0035458[cellular response to interferon-beta] GO:0038166[angiotensin-activated signaling pathway] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042995[cell projection] GO:0043005[neuron projection] GO:0043197[dendritic spine] GO:0045202[synapse] GO:0046427[positive regulation of receptor signaling pathway via JAK-STAT] GO:0046777[protein autophosphorylation] GO:0046872[metal ion binding] GO:0046928[regulation of neurotransmitter secretion] GO:0048168[regulation of neuronal synaptic plasticity] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051346[negative regulation of hydrolase activity] GO:0051928[positive regulation of calcium ion transport] GO:0060996[dendritic spine development] GO:0106310[protein serine kinase activity] GO:0110165[cellular anatomical entity] GO:1902108[regulation of mitochondrial membrane permeability involved in apoptotic process] GO:1990443[peptidyl-threonine autophosphorylation] GO:2000124[regulation of endocannabinoid signaling pathway] GO:2001222[regulation of neuron migration]
The Human Protein Atlas project is funded
