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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
q12.2
Chromosome location (bp)
105744912 - 105894274
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Translation regulation
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001771[immunological synapse formation] GO:0001784[phosphotyrosine residue binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005829[cytosol] GO:0006417[regulation of translation] GO:0007015[actin filament organization] GO:0007165[signal transduction] GO:0007172[signal complex assembly] GO:0007173[epidermal growth factor receptor signaling pathway] GO:0007176[regulation of epidermal growth factor-activated receptor activity] GO:0008093[cytoskeletal anchor activity] GO:0008285[negative regulation of cell population proliferation] GO:0012506[vesicle membrane] GO:0014069[postsynaptic density] GO:0016477[cell migration] GO:0030032[lamellipodium assembly] GO:0030159[signaling receptor complex adaptor activity] GO:0030838[positive regulation of actin filament polymerization] GO:0030971[receptor tyrosine kinase binding] GO:0033137[negative regulation of peptidyl-serine phosphorylation] GO:0035591[signaling adaptor activity] GO:0036493[positive regulation of translation in response to endoplasmic reticulum stress] GO:0042102[positive regulation of T cell proliferation] GO:0042110[T cell activation] GO:0044877[protein-containing complex binding] GO:0045202[synapse] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048013[ephrin receptor signaling pathway] GO:0060996[dendritic spine development] GO:0097110[scaffold protein binding] GO:1902237[positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1903898[negative regulation of PERK-mediated unfolded protein response] GO:1903912[negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation] GO:1990441[negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001784[phosphotyrosine residue binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005829[cytosol] GO:0006417[regulation of translation] GO:0007165[signal transduction] GO:0007172[signal complex assembly] GO:0007173[epidermal growth factor receptor signaling pathway] GO:0007176[regulation of epidermal growth factor-activated receptor activity] GO:0008093[cytoskeletal anchor activity] GO:0008285[negative regulation of cell population proliferation] GO:0016477[cell migration] GO:0030159[signaling receptor complex adaptor activity] GO:0030838[positive regulation of actin filament polymerization] GO:0030971[receptor tyrosine kinase binding] GO:0033137[negative regulation of peptidyl-serine phosphorylation] GO:0035591[signaling adaptor activity] GO:0036493[positive regulation of translation in response to endoplasmic reticulum stress] GO:0042102[positive regulation of T cell proliferation] GO:0042110[T cell activation] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:1902237[positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1903898[negative regulation of PERK-mediated unfolded protein response] GO:1903912[negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation]
E7ERP6 [Direct mapping] Cytoplasmic protein NCK2; NCK adaptor protein 2 isoform 2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
