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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes CD markers Disease related genes FDA approved drug targets Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
q23.3
Chromosome location (bp)
161663143 - 161678654
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
IgG-binding protein, Receptor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Host-virus interaction
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P31994 [Direct mapping] Low affinity immunoglobulin gamma Fc region receptor II-b
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CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Biotech drugs Human disease related genes Immune system diseases Allergies and autoimmune diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
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GO:0001540[amyloid-beta binding] GO:0001811[negative regulation of type I hypersensitivity] GO:0001814[negative regulation of antibody-dependent cellular cytotoxicity] GO:0001818[negative regulation of cytokine production] GO:0002266[follicular dendritic cell activation] GO:0002313[mature B cell differentiation involved in immune response] GO:0002316[follicular B cell differentiation] GO:0002436[immune complex clearance by monocytes and macrophages] GO:0002605[negative regulation of dendritic cell antigen processing and presentation] GO:0002622[regulation of B cell antigen processing and presentation] GO:0002638[negative regulation of immunoglobulin production] GO:0002819[regulation of adaptive immune response] GO:0002865[negative regulation of acute inflammatory response to antigenic stimulus] GO:0002922[positive regulation of humoral immune response] GO:0002924[negative regulation of humoral immune response mediated by circulating immunoglobulin] GO:0004888[transmembrane signaling receptor activity] GO:0005515[protein binding] GO:0005886[plasma membrane] GO:0006898[receptor-mediated endocytosis] GO:0006911[phagocytosis, engulfment] GO:0006952[defense response] GO:0006954[inflammatory response] GO:0006955[immune response] GO:0007165[signal transduction] GO:0007166[cell surface receptor signaling pathway] GO:0009617[response to bacterium] GO:0009897[external side of plasma membrane] GO:0010469[regulation of signaling receptor activity] GO:0016020[membrane] GO:0016064[immunoglobulin mediated immune response] GO:0019772[low-affinity IgG receptor activity] GO:0019864[IgG binding] GO:0019886[antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0021549[cerebellum development] GO:0030889[negative regulation of B cell proliferation] GO:0032693[negative regulation of interleukin-10 production] GO:0038096[Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0043031[negative regulation of macrophage activation] GO:0043197[dendritic spine] GO:0043318[negative regulation of cytotoxic T cell degranulation] GO:0044297[cell body] GO:0044877[protein-containing complex binding] GO:0045088[regulation of innate immune response] GO:0046330[positive regulation of JNK cascade] GO:0050765[negative regulation of phagocytosis] GO:0050766[positive regulation of phagocytosis] GO:0050776[regulation of immune response] GO:0050777[negative regulation of immune response] GO:0050859[negative regulation of B cell receptor signaling pathway] GO:0050869[negative regulation of B cell activation] GO:0071219[cellular response to molecule of bacterial origin] GO:0090264[regulation of immune complex clearance by monocytes and macrophages] GO:1901216[positive regulation of neuron death] GO:1902564[negative regulation of neutrophil activation] GO:1902950[regulation of dendritic spine maintenance] GO:1904646[cellular response to amyloid-beta] GO:1905898[positive regulation of response to endoplasmic reticulum stress] GO:2001199[negative regulation of dendritic cell differentiation]
P31994 [Direct mapping] Low affinity immunoglobulin gamma Fc region receptor II-b
Show all
CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Biotech drugs Human disease related genes Immune system diseases Allergies and autoimmune diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0001540[amyloid-beta binding] GO:0001811[negative regulation of type I hypersensitivity] GO:0001814[negative regulation of antibody-dependent cellular cytotoxicity] GO:0001818[negative regulation of cytokine production] GO:0002266[follicular dendritic cell activation] GO:0002313[mature B cell differentiation involved in immune response] GO:0002316[follicular B cell differentiation] GO:0002436[immune complex clearance by monocytes and macrophages] GO:0002605[negative regulation of dendritic cell antigen processing and presentation] GO:0002622[regulation of B cell antigen processing and presentation] GO:0002638[negative regulation of immunoglobulin production] GO:0002819[regulation of adaptive immune response] GO:0002865[negative regulation of acute inflammatory response to antigenic stimulus] GO:0002922[positive regulation of humoral immune response] GO:0002924[negative regulation of humoral immune response mediated by circulating immunoglobulin] GO:0004888[transmembrane signaling receptor activity] GO:0005515[protein binding] GO:0005886[plasma membrane] GO:0006898[receptor-mediated endocytosis] GO:0006911[phagocytosis, engulfment] GO:0006952[defense response] GO:0006954[inflammatory response] GO:0006955[immune response] GO:0007165[signal transduction] GO:0007166[cell surface receptor signaling pathway] GO:0009617[response to bacterium] GO:0009897[external side of plasma membrane] GO:0010469[regulation of signaling receptor activity] GO:0016020[membrane] GO:0016064[immunoglobulin mediated immune response] GO:0019772[low-affinity IgG receptor activity] GO:0019864[IgG binding] GO:0019886[antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0021549[cerebellum development] GO:0030889[negative regulation of B cell proliferation] GO:0032693[negative regulation of interleukin-10 production] GO:0038096[Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0043031[negative regulation of macrophage activation] GO:0043197[dendritic spine] GO:0043318[negative regulation of cytotoxic T cell degranulation] GO:0044297[cell body] GO:0044877[protein-containing complex binding] GO:0045088[regulation of innate immune response] GO:0046330[positive regulation of JNK cascade] GO:0050765[negative regulation of phagocytosis] GO:0050766[positive regulation of phagocytosis] GO:0050776[regulation of immune response] GO:0050777[negative regulation of immune response] GO:0050859[negative regulation of B cell receptor signaling pathway] GO:0050869[negative regulation of B cell activation] GO:0071219[cellular response to molecule of bacterial origin] GO:0090264[regulation of immune complex clearance by monocytes and macrophages] GO:1901216[positive regulation of neuron death] GO:1902564[negative regulation of neutrophil activation] GO:1902950[regulation of dendritic spine maintenance] GO:1904646[cellular response to amyloid-beta] GO:1905898[positive regulation of response to endoplasmic reticulum stress] GO:2001199[negative regulation of dendritic cell differentiation]
P31994 [Direct mapping] Low affinity immunoglobulin gamma Fc region receptor II-b
Show all
CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Biotech drugs Human disease related genes Immune system diseases Allergies and autoimmune diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0001540[amyloid-beta binding] GO:0001811[negative regulation of type I hypersensitivity] GO:0001814[negative regulation of antibody-dependent cellular cytotoxicity] GO:0001818[negative regulation of cytokine production] GO:0002266[follicular dendritic cell activation] GO:0002313[mature B cell differentiation involved in immune response] GO:0002316[follicular B cell differentiation] GO:0002436[immune complex clearance by monocytes and macrophages] GO:0002605[negative regulation of dendritic cell antigen processing and presentation] GO:0002622[regulation of B cell antigen processing and presentation] GO:0002638[negative regulation of immunoglobulin production] GO:0002819[regulation of adaptive immune response] GO:0002865[negative regulation of acute inflammatory response to antigenic stimulus] GO:0002922[positive regulation of humoral immune response] GO:0002924[negative regulation of humoral immune response mediated by circulating immunoglobulin] GO:0004888[transmembrane signaling receptor activity] GO:0005515[protein binding] GO:0005886[plasma membrane] GO:0006898[receptor-mediated endocytosis] GO:0006911[phagocytosis, engulfment] GO:0006952[defense response] GO:0006954[inflammatory response] GO:0006955[immune response] GO:0007165[signal transduction] GO:0007166[cell surface receptor signaling pathway] GO:0009617[response to bacterium] GO:0009897[external side of plasma membrane] GO:0010469[regulation of signaling receptor activity] GO:0016020[membrane] GO:0016064[immunoglobulin mediated immune response] GO:0019772[low-affinity IgG receptor activity] GO:0019864[IgG binding] GO:0019886[antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0021549[cerebellum development] GO:0030889[negative regulation of B cell proliferation] GO:0032693[negative regulation of interleukin-10 production] GO:0038096[Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0043031[negative regulation of macrophage activation] GO:0043197[dendritic spine] GO:0043318[negative regulation of cytotoxic T cell degranulation] GO:0044297[cell body] GO:0044877[protein-containing complex binding] GO:0045088[regulation of innate immune response] GO:0046330[positive regulation of JNK cascade] GO:0050765[negative regulation of phagocytosis] GO:0050766[positive regulation of phagocytosis] GO:0050776[regulation of immune response] GO:0050777[negative regulation of immune response] GO:0050859[negative regulation of B cell receptor signaling pathway] GO:0050869[negative regulation of B cell activation] GO:0071219[cellular response to molecule of bacterial origin] GO:0090264[regulation of immune complex clearance by monocytes and macrophages] GO:1901216[positive regulation of neuron death] GO:1902564[negative regulation of neutrophil activation] GO:1902950[regulation of dendritic spine maintenance] GO:1904646[cellular response to amyloid-beta] GO:1905898[positive regulation of response to endoplasmic reticulum stress] GO:2001199[negative regulation of dendritic cell differentiation]
The Human Protein Atlas project is funded
