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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes Plasma proteins Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
3
Cytoband
q28
Chromosome location (bp)
189631389 - 189897276
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator, Developmental protein, DNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. [provided by RefSeq, Aug 2016]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
A0A0S2Z4N5 [Target identity:100%; Query identity:100%] Tumor protein 63 (p63)
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Congenital malformations of face and neck Congenital malformations of the musculoskeletal system Congenital malformations of skin Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001501[skeletal system development] GO:0001736[establishment of planar polarity] GO:0001738[morphogenesis of a polarized epithelium] GO:0001942[hair follicle development] GO:0002039[p53 binding] GO:0002064[epithelial cell development] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003684[damaged DNA binding] GO:0003690[double-stranded DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005791[rough endoplasmic reticulum] GO:0006338[chromatin remodeling] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006366[transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0007219[Notch signaling pathway] GO:0007283[spermatogenesis] GO:0007389[pattern specification process] GO:0007499[ectoderm and mesoderm interaction] GO:0007568[aging] GO:0008284[positive regulation of cell population proliferation] GO:0008544[epidermis development] GO:0009887[animal organ morphogenesis] GO:0009913[epidermal cell differentiation] GO:0009954[proximal/distal pattern formation] GO:0010259[multicellular organism aging] GO:0010481[epidermal cell division] GO:0010482[regulation of epidermal cell division] GO:0010838[positive regulation of keratinocyte proliferation] GO:0019904[protein domain specific binding] GO:0030216[keratinocyte differentiation] GO:0030326[embryonic limb morphogenesis] GO:0030425[dendrite] GO:0030850[prostate gland development] GO:0030855[epithelial cell differentiation] GO:0030859[polarized epithelial cell differentiation] GO:0031069[hair follicle morphogenesis] GO:0032502[developmental process] GO:0032991[protein-containing complex] GO:0033147[negative regulation of intracellular estrogen receptor signaling pathway] GO:0035115[embryonic forelimb morphogenesis] GO:0035116[embryonic hindlimb morphogenesis] GO:0036342[post-anal tail morphogenesis] GO:0042475[odontogenesis of dentin-containing tooth] GO:0042771[intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802[identical protein binding] GO:0043005[neuron projection] GO:0043281[regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043565[sequence-specific DNA binding] GO:0043589[skin morphogenesis] GO:0043616[keratinocyte proliferation] GO:0045617[negative regulation of keratinocyte differentiation] GO:0045669[positive regulation of osteoblast differentiation] GO:0045747[positive regulation of Notch signaling pathway] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0048485[sympathetic nervous system development] GO:0048646[anatomical structure formation involved in morphogenesis] GO:0048807[female genitalia morphogenesis] GO:0048863[stem cell differentiation] GO:0050699[WW domain binding] GO:0051262[protein tetramerization] GO:0051402[neuron apoptotic process] GO:0060197[cloacal septation] GO:0060513[prostatic bud formation] GO:0060529[squamous basal epithelial stem cell differentiation involved in prostate gland acinus development] GO:0061436[establishment of skin barrier] GO:0072089[stem cell proliferation] GO:0090398[cellular senescence] GO:0097371[MDM2/MDM4 family protein binding] GO:0098773[skin epidermis development] GO:1904674[positive regulation of somatic stem cell population maintenance] GO:1904888[cranial skeletal system development] GO:2000271[positive regulation of fibroblast apoptotic process] GO:2000381[negative regulation of mesoderm development] GO:2000648[positive regulation of stem cell proliferation] GO:2001235[positive regulation of apoptotic signaling pathway]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Congenital malformations of face and neck Congenital malformations of the musculoskeletal system Congenital malformations of skin Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0002039[p53 binding] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0007219[Notch signaling pathway] GO:0010482[regulation of epidermal cell division] GO:0032502[developmental process] GO:0042802[identical protein binding] GO:0045669[positive regulation of osteoblast differentiation] GO:0045747[positive regulation of Notch signaling pathway] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0050699[WW domain binding] GO:0051262[protein tetramerization] GO:0061436[establishment of skin barrier] GO:0097371[MDM2/MDM4 family protein binding] GO:2000271[positive regulation of fibroblast apoptotic process]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Congenital malformations of face and neck Congenital malformations of the musculoskeletal system Congenital malformations of skin Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0002039[p53 binding] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0007219[Notch signaling pathway] GO:0010482[regulation of epidermal cell division] GO:0032502[developmental process] GO:0042802[identical protein binding] GO:0045669[positive regulation of osteoblast differentiation] GO:0045747[positive regulation of Notch signaling pathway] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0050699[WW domain binding] GO:0051262[protein tetramerization] GO:0061436[establishment of skin barrier] GO:0097371[MDM2/MDM4 family protein binding] GO:1902808[positive regulation of cell cycle G1/S phase transition] GO:2000271[positive regulation of fibroblast apoptotic process] GO:2000773[negative regulation of cellular senescence]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Congenital malformations of face and neck Congenital malformations of the musculoskeletal system Congenital malformations of skin Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0002039[p53 binding] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0007219[Notch signaling pathway] GO:0010482[regulation of epidermal cell division] GO:0032502[developmental process] GO:0042802[identical protein binding] GO:0045669[positive regulation of osteoblast differentiation] GO:0045747[positive regulation of Notch signaling pathway] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0050699[WW domain binding] GO:0051262[protein tetramerization] GO:0061436[establishment of skin barrier] GO:0097371[MDM2/MDM4 family protein binding] GO:2000271[positive regulation of fibroblast apoptotic process]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Congenital malformations of face and neck Congenital malformations of the musculoskeletal system Congenital malformations of skin Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0002039[p53 binding] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0007049[cell cycle] GO:0007219[Notch signaling pathway] GO:0010482[regulation of epidermal cell division] GO:0032502[developmental process] GO:0042802[identical protein binding] GO:0045669[positive regulation of osteoblast differentiation] GO:0045747[positive regulation of Notch signaling pathway] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0050699[WW domain binding] GO:0051262[protein tetramerization] GO:0061436[establishment of skin barrier] GO:0097371[MDM2/MDM4 family protein binding] GO:2000271[positive regulation of fibroblast apoptotic process]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Congenital malformations of face and neck Congenital malformations of the musculoskeletal system Congenital malformations of skin Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0002039[p53 binding] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0007219[Notch signaling pathway] GO:0010482[regulation of epidermal cell division] GO:0032502[developmental process] GO:0042802[identical protein binding] GO:0045669[positive regulation of osteoblast differentiation] GO:0045747[positive regulation of Notch signaling pathway] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0050699[WW domain binding] GO:0051262[protein tetramerization] GO:0061436[establishment of skin barrier] GO:0097371[MDM2/MDM4 family protein binding] GO:2000271[positive regulation of fibroblast apoptotic process]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Congenital malformations of face and neck Congenital malformations of the musculoskeletal system Congenital malformations of skin Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0002039[p53 binding] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0007219[Notch signaling pathway] GO:0010482[regulation of epidermal cell division] GO:0032502[developmental process] GO:0042802[identical protein binding] GO:0045669[positive regulation of osteoblast differentiation] GO:0045747[positive regulation of Notch signaling pathway] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0050699[WW domain binding] GO:0051262[protein tetramerization] GO:0061436[establishment of skin barrier] GO:0097371[MDM2/MDM4 family protein binding] GO:2000271[positive regulation of fibroblast apoptotic process]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Translocations Human disease related genes Congenital malformations Congenital malformations of face and neck Congenital malformations of the musculoskeletal system Congenital malformations of skin Other congenital malformations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Congenital malformations of face and neck Congenital malformations of the musculoskeletal system Congenital malformations of skin Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0002039[p53 binding] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0007219[Notch signaling pathway] GO:0010482[regulation of epidermal cell division] GO:0032502[developmental process] GO:0042802[identical protein binding] GO:0045669[positive regulation of osteoblast differentiation] GO:0045747[positive regulation of Notch signaling pathway] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0050699[WW domain binding] GO:0051262[protein tetramerization] GO:0061436[establishment of skin barrier] GO:0097371[MDM2/MDM4 family protein binding] GO:2000271[positive regulation of fibroblast apoptotic process]
A0A0S2Z4N6 [Target identity:100%; Query identity:100%] Tumor protein 63 (p63)
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Congenital malformations of face and neck Congenital malformations of the musculoskeletal system Congenital malformations of skin Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0002039[p53 binding] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0007219[Notch signaling pathway] GO:0010482[regulation of epidermal cell division] GO:0032502[developmental process] GO:0042802[identical protein binding] GO:0045669[positive regulation of osteoblast differentiation] GO:0045747[positive regulation of Notch signaling pathway] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0050699[WW domain binding] GO:0051262[protein tetramerization] GO:0061436[establishment of skin barrier] GO:0097371[MDM2/MDM4 family protein binding] GO:2000271[positive regulation of fibroblast apoptotic process]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Congenital malformations of face and neck Congenital malformations of the musculoskeletal system Congenital malformations of skin Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0002039[p53 binding] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0007219[Notch signaling pathway] GO:0010482[regulation of epidermal cell division] GO:0032502[developmental process] GO:0042802[identical protein binding] GO:0045669[positive regulation of osteoblast differentiation] GO:0045747[positive regulation of Notch signaling pathway] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0050699[WW domain binding] GO:0051262[protein tetramerization] GO:0061436[establishment of skin barrier] GO:0097371[MDM2/MDM4 family protein binding] GO:2000271[positive regulation of fibroblast apoptotic process]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Congenital malformations of face and neck Congenital malformations of the musculoskeletal system Congenital malformations of skin Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0002039[p53 binding] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0007219[Notch signaling pathway] GO:0010482[regulation of epidermal cell division] GO:0032502[developmental process] GO:0042802[identical protein binding] GO:0045669[positive regulation of osteoblast differentiation] GO:0045747[positive regulation of Notch signaling pathway] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0050699[WW domain binding] GO:0051262[protein tetramerization] GO:0061436[establishment of skin barrier] GO:0097371[MDM2/MDM4 family protein binding] GO:2000271[positive regulation of fibroblast apoptotic process]
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