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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Protein classi
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes Plasma proteins Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
q21.2
Chromosome location (bp)
40624962 - 40648654
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Required for the coactivation of estrogen responsive promoters by SWI/SNF complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Chromatin regulator, DNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Neurogenesis
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q969G3 [Direct mapping] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Other all-alpha-helical DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Human disease related genes Cancers Cancers of eye, brain, and central nervous system Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000228[nuclear chromosome] GO:0000776[kinetochore] GO:0000785[chromatin] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003713[transcription coactivator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006325[chromatin organization] GO:0006337[nucleosome disassembly] GO:0006338[chromatin remodeling] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007399[nervous system development] GO:0008080[N-acetyltransferase activity] GO:0016363[nuclear matrix] GO:0016514[SWI/SNF complex] GO:0016586[RSC-type complex] GO:0016922[nuclear receptor binding] GO:0030071[regulation of mitotic metaphase/anaphase transition] GO:0031492[nucleosomal DNA binding] GO:0032991[protein-containing complex] GO:0035060[brahma complex] GO:0045582[positive regulation of T cell differentiation] GO:0045597[positive regulation of cell differentiation] GO:0045663[positive regulation of myoblast differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0047485[protein N-terminus binding] GO:0070316[regulation of G0 to G1 transition] GO:0071564[npBAF complex] GO:0071565[nBAF complex] GO:0140092[bBAF complex] GO:1902459[positive regulation of stem cell population maintenance] GO:2000045[regulation of G1/S transition of mitotic cell cycle] GO:2000781[positive regulation of double-strand break repair] GO:2000819[regulation of nucleotide-excision repair]
Q969G3 [Direct mapping] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
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A0A024R1S7 [Target identity:100%; Query identity:100%] SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1, isoform CRA_a
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Other all-alpha-helical DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Human disease related genes Cancers Cancers of eye, brain, and central nervous system Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Q969G3 [Direct mapping] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Other all-alpha-helical DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Human disease related genes Cancers Cancers of eye, brain, and central nervous system Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000228[nuclear chromosome] GO:0000776[kinetochore] GO:0000785[chromatin] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003713[transcription coactivator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006325[chromatin organization] GO:0006337[nucleosome disassembly] GO:0006338[chromatin remodeling] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007399[nervous system development] GO:0008080[N-acetyltransferase activity] GO:0016363[nuclear matrix] GO:0016514[SWI/SNF complex] GO:0016586[RSC-type complex] GO:0016922[nuclear receptor binding] GO:0030071[regulation of mitotic metaphase/anaphase transition] GO:0031492[nucleosomal DNA binding] GO:0032991[protein-containing complex] GO:0035060[brahma complex] GO:0045582[positive regulation of T cell differentiation] GO:0045597[positive regulation of cell differentiation] GO:0045663[positive regulation of myoblast differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0047485[protein N-terminus binding] GO:0070316[regulation of G0 to G1 transition] GO:0071564[npBAF complex] GO:0071565[nBAF complex] GO:0140092[bBAF complex] GO:1902459[positive regulation of stem cell population maintenance] GO:2000045[regulation of G1/S transition of mitotic cell cycle] GO:2000781[positive regulation of double-strand break repair] GO:2000819[regulation of nucleotide-excision repair]
Q969G3 [Direct mapping] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Other all-alpha-helical DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Human disease related genes Cancers Cancers of eye, brain, and central nervous system Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000228[nuclear chromosome] GO:0000776[kinetochore] GO:0000785[chromatin] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003713[transcription coactivator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006325[chromatin organization] GO:0006337[nucleosome disassembly] GO:0006338[chromatin remodeling] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007399[nervous system development] GO:0008080[N-acetyltransferase activity] GO:0016363[nuclear matrix] GO:0016514[SWI/SNF complex] GO:0016586[RSC-type complex] GO:0016922[nuclear receptor binding] GO:0030071[regulation of mitotic metaphase/anaphase transition] GO:0031492[nucleosomal DNA binding] GO:0032991[protein-containing complex] GO:0035060[brahma complex] GO:0045582[positive regulation of T cell differentiation] GO:0045597[positive regulation of cell differentiation] GO:0045663[positive regulation of myoblast differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0047485[protein N-terminus binding] GO:0070316[regulation of G0 to G1 transition] GO:0071564[npBAF complex] GO:0071565[nBAF complex] GO:0140092[bBAF complex] GO:1902459[positive regulation of stem cell population maintenance] GO:2000045[regulation of G1/S transition of mitotic cell cycle] GO:2000781[positive regulation of double-strand break repair] GO:2000819[regulation of nucleotide-excision repair]
B4DGM3 [Direct mapping] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1; cDNA FLJ55202, highly similar to SWI/SNF-related matrix-associatedactin-dependent regulator of chromatin subfamily E member 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of eye, brain, and central nervous system Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
Q969G3 [Direct mapping] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Other all-alpha-helical DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Human disease related genes Cancers Cancers of eye, brain, and central nervous system Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000228[nuclear chromosome] GO:0000776[kinetochore] GO:0000785[chromatin] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003713[transcription coactivator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006325[chromatin organization] GO:0006337[nucleosome disassembly] GO:0006338[chromatin remodeling] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007399[nervous system development] GO:0008080[N-acetyltransferase activity] GO:0016363[nuclear matrix] GO:0016514[SWI/SNF complex] GO:0016586[RSC-type complex] GO:0016922[nuclear receptor binding] GO:0030071[regulation of mitotic metaphase/anaphase transition] GO:0031492[nucleosomal DNA binding] GO:0032991[protein-containing complex] GO:0035060[brahma complex] GO:0045582[positive regulation of T cell differentiation] GO:0045597[positive regulation of cell differentiation] GO:0045663[positive regulation of myoblast differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0047485[protein N-terminus binding] GO:0070316[regulation of G0 to G1 transition] GO:0071564[npBAF complex] GO:0071565[nBAF complex] GO:0140092[bBAF complex] GO:1902459[positive regulation of stem cell population maintenance] GO:2000045[regulation of G1/S transition of mitotic cell cycle] GO:2000781[positive regulation of double-strand break repair] GO:2000819[regulation of nucleotide-excision repair]
J3QL66 [Direct mapping] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of eye, brain, and central nervous system Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
J3QKS7 [Direct mapping] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of eye, brain, and central nervous system Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
J3KT85 [Direct mapping] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of eye, brain, and central nervous system Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
Q969G3 [Direct mapping] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Other all-alpha-helical DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Human disease related genes Cancers Cancers of eye, brain, and central nervous system Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000228[nuclear chromosome] GO:0000776[kinetochore] GO:0000785[chromatin] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003713[transcription coactivator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006325[chromatin organization] GO:0006337[nucleosome disassembly] GO:0006338[chromatin remodeling] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007399[nervous system development] GO:0008080[N-acetyltransferase activity] GO:0016363[nuclear matrix] GO:0016514[SWI/SNF complex] GO:0016586[RSC-type complex] GO:0016922[nuclear receptor binding] GO:0030071[regulation of mitotic metaphase/anaphase transition] GO:0031492[nucleosomal DNA binding] GO:0032991[protein-containing complex] GO:0035060[brahma complex] GO:0045582[positive regulation of T cell differentiation] GO:0045597[positive regulation of cell differentiation] GO:0045663[positive regulation of myoblast differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0047485[protein N-terminus binding] GO:0070316[regulation of G0 to G1 transition] GO:0071564[npBAF complex] GO:0071565[nBAF complex] GO:0140092[bBAF complex] GO:1902459[positive regulation of stem cell population maintenance] GO:2000045[regulation of G1/S transition of mitotic cell cycle] GO:2000781[positive regulation of double-strand break repair] GO:2000819[regulation of nucleotide-excision repair]
A0A2U3TZQ7 [Direct mapping] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of eye, brain, and central nervous system Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
J3QR61 [Direct mapping] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of eye, brain, and central nervous system Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
J3QKX6 [Direct mapping] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of eye, brain, and central nervous system Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
A0A2R8Y7U4 [Direct mapping] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of eye, brain, and central nervous system Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
Q969G3 [Direct mapping] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Other all-alpha-helical DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Human disease related genes Cancers Cancers of eye, brain, and central nervous system Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000228[nuclear chromosome] GO:0000776[kinetochore] GO:0000785[chromatin] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003713[transcription coactivator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006325[chromatin organization] GO:0006337[nucleosome disassembly] GO:0006338[chromatin remodeling] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007399[nervous system development] GO:0008080[N-acetyltransferase activity] GO:0016363[nuclear matrix] GO:0016514[SWI/SNF complex] GO:0016586[RSC-type complex] GO:0016922[nuclear receptor binding] GO:0030071[regulation of mitotic metaphase/anaphase transition] GO:0031492[nucleosomal DNA binding] GO:0032991[protein-containing complex] GO:0035060[brahma complex] GO:0045582[positive regulation of T cell differentiation] GO:0045597[positive regulation of cell differentiation] GO:0045663[positive regulation of myoblast differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0047485[protein N-terminus binding] GO:0070316[regulation of G0 to G1 transition] GO:0071564[npBAF complex] GO:0071565[nBAF complex] GO:0140092[bBAF complex] GO:1902459[positive regulation of stem cell population maintenance] GO:2000045[regulation of G1/S transition of mitotic cell cycle] GO:2000781[positive regulation of double-strand break repair] GO:2000819[regulation of nucleotide-excision repair]
Q969G3 [Direct mapping] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
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A0A024R1S7 [Target identity:100%; Query identity:100%] SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1, isoform CRA_a
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Other all-alpha-helical DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Human disease related genes Cancers Cancers of eye, brain, and central nervous system Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000228[nuclear chromosome] GO:0000776[kinetochore] GO:0000785[chromatin] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003713[transcription coactivator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006325[chromatin organization] GO:0006337[nucleosome disassembly] GO:0006338[chromatin remodeling] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007399[nervous system development] GO:0008080[N-acetyltransferase activity] GO:0016363[nuclear matrix] GO:0016514[SWI/SNF complex] GO:0016586[RSC-type complex] GO:0016922[nuclear receptor binding] GO:0030071[regulation of mitotic metaphase/anaphase transition] GO:0031492[nucleosomal DNA binding] GO:0032991[protein-containing complex] GO:0035060[brahma complex] GO:0045582[positive regulation of T cell differentiation] GO:0045597[positive regulation of cell differentiation] GO:0045663[positive regulation of myoblast differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0047485[protein N-terminus binding] GO:0070316[regulation of G0 to G1 transition] GO:0071564[npBAF complex] GO:0071565[nBAF complex] GO:0140092[bBAF complex] GO:1902459[positive regulation of stem cell population maintenance] GO:2000045[regulation of G1/S transition of mitotic cell cycle] GO:2000781[positive regulation of double-strand break repair] GO:2000819[regulation of nucleotide-excision repair]
A0A2R8YDD9 [Direct mapping] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of eye, brain, and central nervous system Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
A0A2R8Y4T4 [Direct mapping] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of eye, brain, and central nervous system Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
Q969G3 [Direct mapping] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Other all-alpha-helical DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Human disease related genes Cancers Cancers of eye, brain, and central nervous system Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000228[nuclear chromosome] GO:0000776[kinetochore] GO:0000785[chromatin] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003713[transcription coactivator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006325[chromatin organization] GO:0006337[nucleosome disassembly] GO:0006338[chromatin remodeling] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007399[nervous system development] GO:0008080[N-acetyltransferase activity] GO:0016363[nuclear matrix] GO:0016514[SWI/SNF complex] GO:0016586[RSC-type complex] GO:0016922[nuclear receptor binding] GO:0030071[regulation of mitotic metaphase/anaphase transition] GO:0031492[nucleosomal DNA binding] GO:0032991[protein-containing complex] GO:0035060[brahma complex] GO:0045582[positive regulation of T cell differentiation] GO:0045597[positive regulation of cell differentiation] GO:0045663[positive regulation of myoblast differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0047485[protein N-terminus binding] GO:0070316[regulation of G0 to G1 transition] GO:0071564[npBAF complex] GO:0071565[nBAF complex] GO:0140092[bBAF complex] GO:1902459[positive regulation of stem cell population maintenance] GO:2000045[regulation of G1/S transition of mitotic cell cycle] GO:2000781[positive regulation of double-strand break repair] GO:2000819[regulation of nucleotide-excision repair]
A0A2R8Y7I9 [Direct mapping] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of eye, brain, and central nervous system Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
A0A2R8YES3 [Direct mapping] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of eye, brain, and central nervous system Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
A0A2R8Y855 [Direct mapping] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of eye, brain, and central nervous system Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
Q969G3 [Direct mapping] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Other all-alpha-helical DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Human disease related genes Cancers Cancers of eye, brain, and central nervous system Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000228[nuclear chromosome] GO:0000776[kinetochore] GO:0000785[chromatin] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003713[transcription coactivator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006325[chromatin organization] GO:0006337[nucleosome disassembly] GO:0006338[chromatin remodeling] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007399[nervous system development] GO:0008080[N-acetyltransferase activity] GO:0016363[nuclear matrix] GO:0016514[SWI/SNF complex] GO:0016586[RSC-type complex] GO:0016922[nuclear receptor binding] GO:0030071[regulation of mitotic metaphase/anaphase transition] GO:0031492[nucleosomal DNA binding] GO:0032991[protein-containing complex] GO:0035060[brahma complex] GO:0045582[positive regulation of T cell differentiation] GO:0045597[positive regulation of cell differentiation] GO:0045663[positive regulation of myoblast differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0047485[protein N-terminus binding] GO:0070316[regulation of G0 to G1 transition] GO:0071564[npBAF complex] GO:0071565[nBAF complex] GO:0140092[bBAF complex] GO:1902459[positive regulation of stem cell population maintenance] GO:2000045[regulation of G1/S transition of mitotic cell cycle] GO:2000781[positive regulation of double-strand break repair] GO:2000819[regulation of nucleotide-excision repair]
A0A2R8Y765 [Direct mapping] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of eye, brain, and central nervous system Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
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