GENERAL INFORMATIONi
Gene namei FERMT2
Synonyms KIND2, mig-2, PLEKHC1, UNC112B
Gene descriptioni FERM domain containing kindlin 2
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 14
Cytoband q22.1
Chromosome location (bp) 52857268 - 52952435
Number of transcriptsi 11
Ensembl ENSG00000073712 (version 109)
Entrez gene 10979
HGNC HGNC:15767
UniProt Q96AC1 (UniProt - Evidence at protein level)
neXtProt NX_Q96AC1
GeneCards FERMT2
Antibodypedia FERMT2 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. show less
Biological process (UniProt)i Cell adhesion, Cell shape, Wnt signaling pathway
Ligand (UniProt)i Lipid-binding
Gene summary (Entrez)i Enables several functions, including actin binding activity; phosphatidylinositol-3,4,5-trisphosphate binding activity; and type I transforming growth factor beta receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of cell differentiation; and positive regulation of cellular component biogenesis. Acts upstream of or within cell adhesion and protein localization to cell junction. Located in cytosol; focal adhesion; and nucleoplasm. Is extrinsic component of cytoplasmic side of plasma membrane. Part of adherens junction and plasma membrane. Biomarker of acute myeloid leukemia. [provided by Alliance of Genome Resources, Apr 2022] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
FERMT2-201
ENSP00000340391
ENST00000341590
Q96AC1
[Direct mapping] Fermitin family homolog 2
Show all
A0A024R687
[Target identity:100%; Query identity:100%] Pleckstrin homology domain containing, family C (With FERM domain) member 1, isoform CRA_b
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0003779 [actin binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008289 [lipid binding]
GO:0008360 [regulation of cell shape]
GO:0009986 [cell surface]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0019901 [protein kinase binding]
GO:0022604 [regulation of cell morphogenesis]
GO:0030054 [cell junction]
GO:0030055 [cell-substrate junction]
GO:0030335 [positive regulation of cell migration]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031258 [lamellipodium membrane]
GO:0031674 [I band]
GO:0033622 [integrin activation]
GO:0033625 [positive regulation of integrin activation]
GO:0034334 [adherens junction maintenance]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0034713 [type I transforming growth factor beta receptor binding]
GO:0035505 [positive regulation of myosin light chain kinase activity]
GO:0042995 [cell projection]
GO:0043116 [negative regulation of vascular permeability]
GO:0043547 [positive regulation of GTPase activity]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0046332 [SMAD binding]
GO:0048041 [focal adhesion assembly]
GO:0051015 [actin filament binding]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0051894 [positive regulation of focal adhesion assembly]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060173 [limb development]
GO:0060548 [negative regulation of cell death]
GO:0070161 [anchoring junction]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0072657 [protein localization to membrane]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1900182 [positive regulation of protein localization to nucleus]
GO:1902414 [protein localization to cell junction]
GO:1902462 [positive regulation of mesenchymal stem cell proliferation]
GO:1903691 [positive regulation of wound healing, spreading of epidermal cells]
Show all
 680 aa
77.9 kDa 		No 0
FERMT2-202
ENSP00000342858
ENST00000343279
Q96AC1
[Direct mapping] Fermitin family homolog 2
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008289 [lipid binding]
GO:0008360 [regulation of cell shape]
GO:0009986 [cell surface]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0019901 [protein kinase binding]
GO:0022604 [regulation of cell morphogenesis]
GO:0030054 [cell junction]
GO:0030055 [cell-substrate junction]
GO:0030335 [positive regulation of cell migration]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031258 [lamellipodium membrane]
GO:0031674 [I band]
GO:0033622 [integrin activation]
GO:0033625 [positive regulation of integrin activation]
GO:0034334 [adherens junction maintenance]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0034713 [type I transforming growth factor beta receptor binding]
GO:0035505 [positive regulation of myosin light chain kinase activity]
GO:0042995 [cell projection]
GO:0043116 [negative regulation of vascular permeability]
GO:0043547 [positive regulation of GTPase activity]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0046332 [SMAD binding]
GO:0048041 [focal adhesion assembly]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0051894 [positive regulation of focal adhesion assembly]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060548 [negative regulation of cell death]
GO:0070161 [anchoring junction]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0072657 [protein localization to membrane]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1900182 [positive regulation of protein localization to nucleus]
GO:1902414 [protein localization to cell junction]
GO:1902462 [positive regulation of mesenchymal stem cell proliferation]
GO:1903691 [positive regulation of wound healing, spreading of epidermal cells]
Show all
 687 aa
78.7 kDa 		No 0
FERMT2-203
ENSP00000378993
ENST00000395631
Q96AC1
[Direct mapping] Fermitin family homolog 2
Show all
A0A024R687
[Target identity:100%; Query identity:100%] Pleckstrin homology domain containing, family C (With FERM domain) member 1, isoform CRA_b
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008289 [lipid binding]
GO:0008360 [regulation of cell shape]
GO:0009986 [cell surface]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0019901 [protein kinase binding]
GO:0022604 [regulation of cell morphogenesis]
GO:0030054 [cell junction]
GO:0030055 [cell-substrate junction]
GO:0030335 [positive regulation of cell migration]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031258 [lamellipodium membrane]
GO:0031674 [I band]
GO:0033622 [integrin activation]
GO:0033625 [positive regulation of integrin activation]
GO:0034334 [adherens junction maintenance]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0034713 [type I transforming growth factor beta receptor binding]
GO:0035505 [positive regulation of myosin light chain kinase activity]
GO:0042995 [cell projection]
GO:0043116 [negative regulation of vascular permeability]
GO:0043547 [positive regulation of GTPase activity]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0046332 [SMAD binding]
GO:0048041 [focal adhesion assembly]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0051894 [positive regulation of focal adhesion assembly]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060548 [negative regulation of cell death]
GO:0070161 [anchoring junction]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0072657 [protein localization to membrane]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1900182 [positive regulation of protein localization to nucleus]
GO:1902414 [protein localization to cell junction]
GO:1902462 [positive regulation of mesenchymal stem cell proliferation]
GO:1903691 [positive regulation of wound healing, spreading of epidermal cells]
Show all
 680 aa
77.9 kDa 		No 0
FERMT2-204
ENSP00000382243
ENST00000399304
Q96AC1
[Direct mapping] Fermitin family homolog 2
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008289 [lipid binding]
GO:0008360 [regulation of cell shape]
GO:0009986 [cell surface]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0019901 [protein kinase binding]
GO:0022604 [regulation of cell morphogenesis]
GO:0030054 [cell junction]
GO:0030055 [cell-substrate junction]
GO:0030335 [positive regulation of cell migration]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031258 [lamellipodium membrane]
GO:0031674 [I band]
GO:0033622 [integrin activation]
GO:0033625 [positive regulation of integrin activation]
GO:0034334 [adherens junction maintenance]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0034713 [type I transforming growth factor beta receptor binding]
GO:0035505 [positive regulation of myosin light chain kinase activity]
GO:0042995 [cell projection]
GO:0043116 [negative regulation of vascular permeability]
GO:0043547 [positive regulation of GTPase activity]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0046332 [SMAD binding]
GO:0048041 [focal adhesion assembly]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0051894 [positive regulation of focal adhesion assembly]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060548 [negative regulation of cell death]
GO:0070161 [anchoring junction]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0072657 [protein localization to membrane]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1900182 [positive regulation of protein localization to nucleus]
GO:1902414 [protein localization to cell junction]
GO:1902462 [positive regulation of mesenchymal stem cell proliferation]
GO:1903691 [positive regulation of wound healing, spreading of epidermal cells]
Show all
 633 aa
72.4 kDa 		No 0
FERMT2-205
ENSP00000451084
ENST00000553373
Q96AC1
[Direct mapping] Fermitin family homolog 2
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008289 [lipid binding]
GO:0008360 [regulation of cell shape]
GO:0009986 [cell surface]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0019901 [protein kinase binding]
GO:0022604 [regulation of cell morphogenesis]
GO:0030054 [cell junction]
GO:0030055 [cell-substrate junction]
GO:0030335 [positive regulation of cell migration]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031258 [lamellipodium membrane]
GO:0031674 [I band]
GO:0033622 [integrin activation]
GO:0033625 [positive regulation of integrin activation]
GO:0034334 [adherens junction maintenance]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0034713 [type I transforming growth factor beta receptor binding]
GO:0035505 [positive regulation of myosin light chain kinase activity]
GO:0042995 [cell projection]
GO:0043116 [negative regulation of vascular permeability]
GO:0043547 [positive regulation of GTPase activity]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0046332 [SMAD binding]
GO:0048041 [focal adhesion assembly]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0051894 [positive regulation of focal adhesion assembly]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060548 [negative regulation of cell death]
GO:0070161 [anchoring junction]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0072657 [protein localization to membrane]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1900182 [positive regulation of protein localization to nucleus]
GO:1902414 [protein localization to cell junction]
GO:1902462 [positive regulation of mesenchymal stem cell proliferation]
GO:1903691 [positive regulation of wound healing, spreading of epidermal cells]
Show all
 687 aa
78.7 kDa 		No 0
FERMT2-206
ENSP00000451134
ENST00000553663
H0YJB6
[Direct mapping] Fermitin family homolog 2
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005856 [cytoskeleton]
GO:0007229 [integrin-mediated signaling pathway]
Show all
 133 aa
15.5 kDa 		No 0
FERMT2-208
ENSP00000450741
ENST00000554152
H0YJ34
[Direct mapping] Fermitin family homolog 2
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0007155 [cell adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0070161 [anchoring junction]
Show all
 640 aa
73.4 kDa 		No 0
FERMT2-209
ENSP00000451268
ENST00000554288
G3V3J0
[Direct mapping] Fermitin family homolog 2
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0007229 [integrin-mediated signaling pathway]
Show all
 155 aa
17.1 kDa 		No 0
FERMT2-210
ENSP00000450506
ENST00000554712
G3V281
[Direct mapping] Fermitin family homolog 2
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007229 [integrin-mediated signaling pathway]
Show all
 153 aa
17.9 kDa 		No 0
FERMT2-212
ENSP00000452472
ENST00000555692
G3V5R2
[Direct mapping] Fermitin family homolog 2
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007229 [integrin-mediated signaling pathway]
Show all
 133 aa
15.8 kDa 		No 0
FERMT2-215
ENSP00000489609
ENST00000635305
A0A0U1RRM8
[Direct mapping] Fermitin family homolog 2
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0007155 [cell adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0070161 [anchoring junction]
Show all
 545 aa
61.8 kDa 		No 0

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